Skip to main content Accessibility help
×
Home

Bioavailability of vitamin C from mashed potatoes and potato chips after oral administration in healthy Japanese men

  • Yoshitaka Kondo (a1), Chihana Higashi (a2), Mizuki Iwama (a1), Katsuyuki Ishihara (a2), Setsuko Handa (a1), Hiroyuki Mugita (a2), Naoki Maruyama (a1), Hidenori Koga (a2) and Akihito Ishigami (a1)...

Abstract

Potato (Solanum tuberosum) tubers contain vitamin C (VC) and commercial potato chips have more VC content per wet weight by dehydration during frying. However, intestinal absorption of VC from orally ingested potatoes and its transfer to the blood remains questionable. The present study was designed to determine whether the dietary consumption of potatoes affects VC concentration in plasma and urinary excretion of VC in human subjects. After overnight fasting, five healthy Japanese men between 22 and 27 years of age consumed 87 g mashed potatoes and 282 g potato chips. Each portion contained 50 mg of VC, 50 mg VC in mineral water and mineral water. Before and after a single episode of ingestion, blood and urine samples were collected every 30 min or 1 h for 8 h. When measured by subtraction of the initial baseline value before administration of potatoes from the values measured throughout the 8 h test period, plasma VC concentrations increased almost linearly up to 3 h. Subsequently, the values of potato-fed subjects were higher than those of water, but did not differ significantly from those of VC in water (P = 0·14 and P = 0·5). Less VC tended to be excreted in urine during the 8 h test than VC in water alone (17·0 (sem 7·5) and 25·9 (sem 8·8) v. 47·9 (sem 17·9) μmol/mmol creatinine). Upon human consumption, mashed potatoes and potato chips provide VC content that is effectively absorbed in the intestine and transferred to the blood. Clearly, potatoes are a readily available source of dietary VC.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Bioavailability of vitamin C from mashed potatoes and potato chips after oral administration in healthy Japanese men
      Available formats
      ×

      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Bioavailability of vitamin C from mashed potatoes and potato chips after oral administration in healthy Japanese men
      Available formats
      ×

      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Bioavailability of vitamin C from mashed potatoes and potato chips after oral administration in healthy Japanese men
      Available formats
      ×

Copyright

Corresponding author

*Corresponding author: Dr Y. Kondo, fax +81 3 3579 4776, email kondo@tmig.or.jp

References

Hide All
1 Camire, ME, Kubow, S & Donnelly, DJ (2009) Potatoes and human health. Crit Rev Food Sci Nutr 49, 823840.
2 The Council for Science and Technology; Ministry of Education, Culture, Sports, Science and Technology, Japan (2010) Standard Tables of Food Composition in Japan. Tokyo, Japan: National Printing Bureau.
3 Linster, CL & Van Schaftingen, E (2007) Vitamin C. Biosynthesis, recycling and degradation in mammals. FEBS J 274, 122.
4 Joshipura, KJ, Hu, FB, Manson, JE, et al. (2001) The effect of fruit and vegetable intake on risk for coronary heart disease. Ann Intern Med 134, 11061114.
5 Kurl, S, Tuomainen, TP, Laukkanen, JA, et al. (2002) Plasma vitamin C modifies the association between hypertension and risk of stroke. Stroke 33, 15681573.
6 Yokoyama, T, Date, C, Kokubo, Y, et al. (2000) Serum vitamin C concentration was inversely associated with subsequent 20-year incidence of stroke in a Japanese rural community. The Shibata study. Stroke 31, 22872294.
7 Myint, PK, Luben, RN, Welch, AA, et al. (2008) Plasma vitamin C concentrations predict risk of incident stroke over 10 y in 20 649 participants of the European Prospective Investigation into Cancer Norfolk prospective population study. Am J Clin Nutr 87, 6469.
8 Joshipura, KJ, Ascherio, A, Manson, JE, et al. (1999) Fruit and vegetable intake in relation to risk of ischemic stroke. JAMA 282, 12331239.
9 Jacques, PF, Taylor, A, Hankinson, SE, et al. (1997) Long-term vitamin C supplement use and prevalence of early age-related lens opacities. Am J Clin Nutr 66, 911916.
10 Yoshida, M, Takashima, Y, Inoue, M, et al. (2007) Prospective study showing that dietary vitamin C reduced the risk of age-related cataracts in a middle-aged Japanese population. Eur J Nutr 46, 118124.
11 Harding, AH, Wareham, NJ, Bingham, SA, et al. (2008) Plasma vitamin C level, fruit and vegetable consumption, and the risk of new-onset type 2 diabetes mellitus: the European prospective investigation of cancer–Norfolk prospective study. Arch Intern Med 168, 14931499.
12 Afkhami-Ardekani, M & Shojaoddiny-Ardekani, A (2007) Effect of vitamin C on blood glucose, serum lipids & serum insulin in type 2 diabetes patients. Indian J Med Res 126, 471474.
13 Sasazuki, S, Sasaki, S, Tsubono, Y, et al. (2006) Effect of vitamin C on common cold: randomized controlled trial. Eur J Clin Nutr 60, 917.
14 Han, JS, Kozukue, N, Young, KS, et al. (2004) Distribution of ascorbic acid in potato tubers and in home-processed and commercial potato foods. J Agric Food Chem 52, 65166521.
15 Burg, P & Fraile, P (1995) Vitamin C destruction during the cooking of a potato dish. Lebensm-Wiss u Technol 28, 506514.
16 Miyoshi, T, Ishihara, K, Nakamura, K, et al. (2006) Antioxidative compounds in potato chips. JSCS 39, 277282.
17 Wilson, JX (2005) Regulation of vitamin C transport. Annu Rev Nutr 25, 105125.
18 May, JM, Qu, ZC & Qiao, H (2009) Transfer of ascorbic acid across the vascular endothelium: mechanism and self-regulation. Am J Physiol Cell Physiol 297, C169C178.
19 Reidling, JC, Subramanian, VS, Dahhan, T, et al. (2008) Mechanisms and regulation of vitamin C uptake: studies of the hSVCT systems in human liver epithelial cells. Am J Physiol Gastrointest Liver Physiol 295, G1217G1227.
20 Levine, M, Conry-Cantilena, C, Wang, Y, et al. (1996) Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance. Proc Natl Acad Sci U S A 93, 37043709.
21 Levine, M, Wang, Y, Padayatty, SJ, et al. (2001) A new recommended dietary allowance of vitamin C for healthy young women. Proc Natl Acad Sci U S A 98, 98429846.
22 Higasa, S, Tsujimura, M, Hiraoka, M, et al. (2007) Polymorphism of glutathione S-transferase P1 gene affects human vitamin C metabolism. Biochem Biophys Res Commun 364, 708713.
23 Bates, CJ, Jones, KS & Bluck, LJ (2004) Stable isotope-labelled vitamin C as a probe for vitamin C absorption by human subjects. Br J Nutr 91, 699705.
24 Johnston, CS & Luo, B (1994) Comparison of the absorption and excretion of three commercially available sources of vitamin C. J Am Diet Assoc 94, 779781.
25 Sato, Y, Uchiki, T, Iwama, M, et al. (2010) Determination of dehydroascorbic acid in mouse tissues and plasma by using tris(2-carboxyethyl)phosphine hydrochloride as reductant in metaphosphoric acid/ethylenediaminetetraacetic acid solution. Biol Pharm Bull 33, 364369.
26 Fabiny, DL & Ertingshausen, G (1971) Automated reaction-rate method for determination of serum creatinine with the CentrifiChem. Clin Chem 17, 696700.
27 McErlain, L, Marson, H, Ainsworth, P, et al. (2001) Ascorbic acid loss in vegetables: adequacy of a hospital cook-chill system. Int J Food Sci Nutr 52, 205211.
28 Tsujimura, M, Higasa, S, Nakayama, K, et al. (2008) Vitamin C activity of dehydroascorbic acid in humans – association between changes in the blood vitamin C concentration or urinary excretion after oral loading. J Nutr Sci Vitaminol (Tokyo) 54, 315320.
29 Tsujimura, M & Higasa, S (2007) Vitamin C activity of l-dehydroascorbic acid in human. Time-dependent vitamin C concentration in blood and urinary excretion after the oral load. Vitamins 81, 489496.
30 Tsujimura, M, Watanabe, S, Michinaka, K, et al. (1972) Metabolism of ascorbic acid and dehydroascorbic acid in man. Vitamins 45, 136147.
31 Tsujimura, M, Higasa, S, Aono, K, et al. (2006) Vitamin C activity of l-dehydroascorbic acid in human. Time-dependent vitamin C urinary excretion after the oral load. Vitamins 70, 241248.
32 Ministry of Health, Labour, and Welfare, Japan (2005) Dietary Reference Intakes for Japanese, 2005. Tokyo, Japan: Daiichi Shuppan Publishing Co, Ltd.
33 Mangels, AR, Block, G, Frey, CM, et al. (1993) The bioavailability to humans of ascorbic acid from oranges, orange juice and cooked broccoli is similar to that of synthetic ascorbic acid. J Nutr 123, 10541061.
34 van het Hof, KH, Tijburg, LB, Pietrzik, K, et al. (1999) Influence of feeding different vegetables on plasma levels of carotenoids, folate and vitamin C. Effect of disruption of the vegetable matrix. Br J Nutr 82, 203212.
35 Sanchez-Moreno, C, Cano, MP, de Ancos, B, et al. (2003) Effect of orange juice intake on vitamin C concentrations and biomarkers of antioxidant status in humans. Am J Clin Nutr 78, 454460.
36 Sanchez-Moreno, C, Cano, MP, de Ancos, B, et al. (2006) Mediterranean vegetable soup consumption increases plasma vitamin C and decreases F2-isoprostanes, prostaglandin E2 and monocyte chemotactic protein-1 in healthy humans. J Nutr Biochem 17, 183189.
37 Sanchez-Moreno, C, Cano, MP, de Ancos, B, et al. (2004) Pulsed electric fields-processed orange juice consumption increases plasma vitamin C and decreases F2-isoprostanes in healthy humans. J Nutr Biochem 15, 601607.
38 Wrieden, WL, Hannah, MK, Bolton-Smith, C, et al. (2000) Plasma vitamin C and food choice in the third Glasgow MONICA population survey. J Epidemiol Community Health 54, 355360.
39 Corti, A, Casini, AF & Pompella, A (2010) Cellular pathways for transport and efflux of ascorbate and dehydroascorbate. Arch Biochem Biophys 500, 107115.
40 Wu, X, Zeng, LH, Taniguchi, T, et al. (2007) Activation of PKA and phosphorylation of sodium-dependent vitamin C transporter 2 by prostaglandin E2 promote osteoblast-like differentiation in MC3T3-E1 cells. Cell Death Differ 14, 17921801.

Keywords

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed