1Kromann, N & Green, A (1980) Epidemiological studies in the Upernavik district, Greenland. Incidence of some chronic diseases 1950–1974. Acta Med Scand 208, 401–406.
2Dyerberg, J & Bang, HO (1979) Haemostatic function and platelet polyunsaturated fatty acids in Eskimos. Lancet 2, 433–435.
3Martin, RE (1998) Docosahexaenoic acid decreases phospholipase A2 activity in the neurites/nerve growth cones of PC12 cells. J Neurosci Res 54, 805–813.
4Simopoulos, AP (2002) Omega-3 fatty acids in inflammation and autoimmune diseases. J Am Coll Nutr 21, 495–505.
5Tamura, Y, Terano, J, Saito, A, et al. (1995) . In Nutrition, Lipids, Health and Disease, p. 169 [Ong, ASH, Niki, E and Packer, L, editors]. Champaign, IL: The American Oil Chemists' Society.
6Kang, JX, Man, SF, Brown, NE, et al. (1992) Essential fatty acid metabolism in cultured human airway epithelial cells. Biochim Biophys Acta 1128, 267–274.
7Harbige, LS (2003) Fatty acids, the immune response, and autoimmunity: a question of n-6 essentiality and the balance between n-6 and n-3. Lipids 38, 323–341.
8Calder, PC (2001) Polyunsaturated fatty acids, inflammation, and immunity. Lipids 36, 1007–1024.
9Glew, R (1997) . In Textbook of Biochemistry, 4th ed., pp. 434 [Devlin, T, editor]. New York: Wiley-Liss.
10Lee, TH, Hoover, RL, Williams, JD, et al. (1985) Effect of dietary enrichment with eicosapentaenoic and docosahexaenoic acids on in vitro neutrophil and monocyte leukotriene generation and neutrophil function. N Engl J Med 312, 1217–1224.
11Mann, J & Skeaff, M (1998) . In Essentials of Human Nutrition, p. 637 [Mann, J and Truswell, S, editors]. Oxford: Oxford University Press.
12Calder, P (2001) . In Fatty Acids and Lipids – New Findings, p. 109 [Hamazaki, T and Okuyama, H, editors]. Basel: Karger.
13Goldman, DW, Pickett, WC & Goetzl, EJ (1983) Human neutrophil chemotactic and degranulating activities of leukotriene B5 (LTB5) derived from eicosapentaenoic acid. Biochem Biophys Res Commun 117, 282–288.
14Jatakanon, A, Uasuf, C, Maziak, W, et al. (1999) Neutrophilic inflammation in severe persistent asthma. Am J Respir Crit Care Med 160, 1532–1539.
15Sun, YC & Chu, HW (2004) Do neutrophils actively participate in airway inflammation and remodeling in asthma? Chin Med J (Engl) 117, 1739–1742.
16Yasui, K, Kobayashi, N, Yamazaki, T, et al. (2005) Neutrophilic inflammation in childhood bronchial asthma. Thorax 60, 704–705.
17Browning, LM, Krebs, JD, Moore, CS, et al. (2007) The impact of long chain n-3 polyunsaturated fatty acid supplementation on inflammation, insulin sensitivity and CVD risk in a group of overweight women with an inflammatory phenotype. Diabetes Obes Metab 9, 70–80.
18Bryan, D, Forsyth, K, Hart, P, et al. (2006) Polyunsatuated fatty acids regulate cytokine and prostaglandin E2 production by respiratory cells in response to mast cell mediators. Lipids 41, 1101–1107.
19Abbate, R, Gori, AM, Martini, F, et al. (1996) n-3 PUFA supplementation, monocyte PCA expression and interleukin-6 production. Prostaglandins Leukot Essent Fatty Acids 54, 439–444.
20Bryan, DL, Forsyth, KD, Hart, PH, et al. (2006) Polyunsaturated fatty acids regulate cytokine and prostaglandin E2 production by respiratory cells in response to mast cell mediators. Lipids 41, 1101–1107.
21Zeitlin, L, Segev, E, Fried, A, et al. (2003) Effects of long-term administration of n-3 polyunsaturated fatty acids (PUFA) and selective estrogen receptor modulator (SERM) derivatives in ovariectomized (OVX) mice. J Cell Biochem 90, 347–360.
22Fritsche, KL, Anderson, M & Feng, C (2000) Consumption of eicosapentaenoic acid and docosahexaenoic acid impair murine interleukin-12 and interferon-gamma production in vivo. J Infect Dis 1821, Suppl. 1, S54–S61.
23Skuladottir, IH, Petursdottir, DH & Hardardottir, I (2007) The effects of omega-3 polyunsaturated fatty acids on TNF-alpha and IL-10 secretion by murine peritoneal cells in vitro. Lipids 42, 699–706.
24Moon, DO, Kim, KC, Jin, CY, et al. (2007) Inhibitory effects of eicosapentaenoic acid on lipopolysaccharide-induced activation in BV2 microglia. Int Immunopharmacol 7, 222–229.
25Horia, E & Watkins, BA (2007) Complementary actions of docosahexaenoic acid and genistein on COX-2, PGE2 and invasiveness in MDA-MB-231 breast cancer cells. Carcinogenesis 28, 809–815.
26Weldon, SM, Mullen, AC, Loscher, CE, et al. (2007) Docosahexaenoic acid induces an anti-inflammatory profile in lipopolysaccharide-stimulated human THP-1 macrophages more effectively than eicosapentaenoic acid. J Nutr Biochem 18, 250–258.
27Jia, Y & Turek, JJ (2005) Altered NF-kappaB gene expression and collagen formation induced by polyunsaturated fatty acids. J Nutr Biochem 16, 500–506.
28Lo, CJ, Chiu, KC, Fu, M, et al. (1999) Fish oil decreases macrophage tumor necrosis factor gene transcription by altering the NF kappa B activity. J Surg Res 82, 216–221.
29Lee, JY, Zhao, L, Youn, HS, et al. (2004) Saturated fatty acid activates but polyunsaturated fatty acid inhibits Toll-like receptor 2 dimerized with Toll-like receptor 6 or 1. J Biol Chem 279, 16971–16979.
30Lee, JY, Sohn, KH, Rhee, SH, et al. (2001) Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4. J Biol Chem 276, 16683–16689.
31Barton, GM & Medzhitov, R (2003) Toll-like receptor signaling pathways. Science 300, 1524–1525.
32Blackwell, TS & Christman, JW (1997) The role of nuclear factor-kappa B in cytokine gene regulation. Am J Respir Cell Mol Biol 17, 3–9.
33Zhu, Z, Tang, W, Ray, A, et al. (1996) Rhinovirus stimulation of interleukin-6 in vivo and in vitro. Evidence for nuclear factor kappa B-dependent transcriptional activation. J Clin Invest 97, 421–430.
34Zhu, Z, Tang, W, Gwaltney, JM Jr, et al. (1997) Rhinovirus stimulation of interleukin-8 in vivo and in vitro: role of NF-kappaB. Am J Physiol 273, L814–L824.
35Calder, P (1996) Immunomodulatory and anti-inflammatory effects of ω-3 polyunsaturated fatty acids. Proc Nutr Soc 55, 737–774.
36Calder, P (1998) Dietary fatty acids and lymphocyte functions. Proc Nutr Soc 57, 487–502.
37Dreschers, S, Dumitru, CA, Adams, C, et al. (2007) The cold case: are rhinoviruses perfectly adapted pathogens? Cell Mol Life Sci 64, 181–191.
38Nicholson, KG, Kent, J & Ireland, DC (1993) Respiratory viruses and exacerbations of asthma in adults. Br Med J 307, 982–986.
39Johnston, SL, Pattemore, PK, Sanderson, G, et al. (1995) Community study of role of viral infections in exacerbations of asthma in 9–11 year old children. Br Med J 310, 1225–1229.
40Grunberg, K, Timmers, MC, de Klerk, EP, et al. (1999) Experimental rhinovirus 16 infection causes variable airway obstruction in subjects with atopic asthma. Am J Respir Crit Care Med 160, 1375–1380.
41Spurrell, JC, Wiehler, S, Zaheer, RS, et al. (2005) Human airway epithelial cells produce IP-10 (CXCL10) in vitro and in vivo upon rhinovirus infection. Am J Physiol Lung Cell Mol Physiol 289, L85–L95.
42Subauste, MC, Jacoby, DB, Richards, SM, et al. (1995) Infection of a human respiratory epithelial cell line with rhinovirus. Induction of cytokine release and modulation of susceptibility to infection by cytokine exposure. J Clin Invest 96, 549–557.
43Gern, JE (2002) Rhinovirus respiratory infections and asthma. Am J Med 112, Suppl. 6A, 19S–27S.
44Yamaya, M & Sasaki, H (2003) Rhinovirus and asthma. Viral Immunol 16, 99–109.
45Calder, PC (2001) Omega 3 polyunsaturated fatty acids, inflammation and immunity. World Rev Nutr Diet 88, 109–116.
46Nair, SS, Leitch, J & Garg, ML (1999) Specific modifications of phosphatidylinositol and nonesterified fatty acid fractions in cultured porcine cardiomyocytes supplemented with n-3 polyunsaturated fatty acids. Lipids 34, 697–704.
47Reed, L & Muench, H (1938) A simple method of estimating fifty percent endpoints. Am J Hygiene 27, 493–497.
48Karber, G (1931) 50 % end-point calculation. Arch Exp Pathol Pharmak 162, 480–483.
49Hatala, MA, Rayburn, J & Rose, DP (1994) Comparison of linoleic acid and eicosapentaenoic acid incorporation into human breast cancer cells. Lipids 29, 831–837.
50Croset, M & Lagarde, M (1986) In vitro incorporation and metabolism of icosapentaenoic and docosahexaenoic acids in human platelets – effect on aggregation. Thromb Haemost 56, 57–62.
51Shahrzad, S, Cadenas, E, Sevanian, A, et al. (2002) Impact of water-dispersible beadlets as a vehicle for the delivery of carotenoids to cultured cells. Biofactors 16, 83–91.
52Sagar, PS, Das, UN, Koratkar, R, et al. (1992) Cytotoxic action of cis-unsaturated fatty acids on human cervical carcinoma (HeLa) cells: relationship to free radicals and lipid peroxidation and its modulation by calmodulin antagonists. Cancer Lett 63, 189–198.
53Kageyama, K, Yamada, R, Otani, S, et al. (2000) Cytotoxicity of docosahexaenoic acid and eicosapentaenoic acid in tumor cells and the dependence on binding to serum proteins and incorporation into intracellular lipids. Oncol Rep 7, 79–83.
54Chi, TY, Chen, GG & Lai, PB (2004) Eicosapentaenoic acid induces Fas-mediated apoptosis through a p53-dependent pathway in hepatoma cells. Cancer J 10, 190–200.
55Zalman, LS, Brothers, MA, Dragovich, PS, et al. (2000) Inhibition of human rhinovirus-induced cytokine production by AG7088, a human rhinovirus 3C protease inhibitor. Antimicrob Agents Chemother 44, 1236–1241.
56Majumder, S, Zhou, LZ, Chaturvedi, P, et al. (1998) p48/STAT-1alpha-containing complexes play a predominant role in induction of IFN-gamma-inducible protein, 10 kDa (IP-10) by IFN-gamma alone or in synergy with TNF-alpha. J Immunol 161, 4736–4744.
57Nazar, AS, Cheng, G, Shin, HS, et al. (1997) Induction of IP-10 chemokine promoter by measles virus: comparison with interferon-gamma shows the use of the same response element but with differential DNA-protein binding profiles. J Neuroimmunol 77, 116–127.
58Wu, C, Ohmori, Y, Bandyopadhyay, S, et al. (1994) Interferon-stimulated response element and NF kappa B sites cooperate to regulate double-stranded RNA-induced transcription of the IP-10 gene. J Interferon Res 14, 357–363.
59Korpi-Steiner, NL, Bates, ME, Lee, WM, et al. (2006) Human rhinovirus induces robust IP-10 release by monocytic cells, which is independent of viral replication but linked to type I interferon receptor ligation and STAT1 activation. J Leukoc Biol 80, 1364–1374.
60Mori, TA & Beilin, LJ (2004) Omega-3 fatty acids and inflammation. Curr Atheroscler Rep 6, 461–467.
61Simopoulos, AP (1991) Omega-3 fatty acids in health and disease and in growth and development. Am J Clin Nutr 54, 438–463.