Skip to main content Accessibility help
×
Home

Acute effects of ingestion of black tea on postprandial platelet aggregation in human subjects

  • Jonathan M. Hodgson (a1), Ian B. Puddey (a1), Valerie Burke (a1), Lawrence J. Beilin (a1), Trevor A. Mori (a1) and Shin-Yee Chan (a1)...

Abstract

Results of population studies suggest that black tea can reduce cardiovascular risk. Effects of black-tea polyphenols to reduce platelet aggregability may help to explain any benefits. Given that black tea is often consumed with and after meals, and man spends much of his life in the postprandial state, the objective of the present study was to investigate the acute effects of ingestion of black tea on postprandial platelet aggregation ex vivo. Twenty healthy participants had platelet aggregation and blood lipids assessed before and 4 h after the ingestion of 50 g dairy fat on two occasions in random order, corresponding to black tea or hot water. Black tea or hot water (one cup) was consumed immediately following the dairy fat, then after 1·5 and 3·0 h. Platelet aggregation ex vivo was assessed in platelet-rich plasma in response to three concentrations of collagen (0·2, 0·6, 2·0 μg/ml) and ADP (2, 4, 8 μM). Urinary concentrations of 4-O-methylgallic acid were used as an indicator that tea polyphenols were absorbed. Serum total cholesterol and triacylglycerol concentrations increased significantly 4 h after ingesting the dairy fat, but there was no significant difference between black tea and hot-water treatments on the cholesterol or triacylglycerol responses. Urinary 4-O-methylgallic acid concentrations were significantly increased following ingestion of black tea (P=0·0001) but not water. Black tea in comparison to hot water did not inhibit collagen or ADP-induced postprandial platelet aggregation. The results of this study do not support the suggestion that reduced postprandial platelet aggregability contributes to any benefits of black tea on cardiovascular risk.

    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Acute effects of ingestion of black tea on postprandial platelet aggregation in human subjects
      Available formats
      ×

      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Acute effects of ingestion of black tea on postprandial platelet aggregation in human subjects
      Available formats
      ×

      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Acute effects of ingestion of black tea on postprandial platelet aggregation in human subjects
      Available formats
      ×

Copyright

Corresponding author

*Corresponding author: Dr Jonathan Hodgson, fax +61 8 9224 0246, email jonathan@cyllene.uwa.edu.au

References

Hide All
Aviram, M, Furman, B & Brook, JG (1985) Chylomicrons from patients with type V hyperlipoproteinemia inhibit platelet function. Atherosclerosis 56, 157167.
Bisovsky, S, Richter, H, Fitscha, P, O'Grady, J & Sinzinger, H (1992) Postprandial hyperlipemia does not inhibit platelet aggregation. Prostaglandins Leukotrienes and Essential Fatty Acids 47, 331332.
Broijersen, A, Karpe, F, Hamsten, A, Goodall, AH & Hjemdahl, P (1998) Alimentary lipemia enhances the membrane expression of platelet P-selectin without affecting other markers of platelet activation. Atherosclerosis 137, 107113.
Conquer, JA, Maiani, G, Azzini, E, Raguzzini, A & Holub, BJ (1998) Supplementation with quercetin markedly increases plasma quercetin concentration without effect on selected risk factors for heart disease in healthy subjects. Journal of Nutrition 128, 593597.
Duffy, SJ, Vita, JA, Holbrook, M, Swerdloff, PL & Keaney, JF Jr (2001) Effect of acute and chronic tea consumption on platelet aggregation in patients with coronary artery disease. Arteriosclerosis Thrombosis and Vascular Biology 21, 10841089.
Formica, JV & Regelson, W (1995) Review of the biology of quercetin and related bioflavonoids. Food and Chemical Toxicology 33, 10611080.
Freese, R & Mutanen, M (1995) Postprandial changes in platelet function and coagulation factors after high-fat meals with different fatty acid compositions. European Journal of Clinical Nutrition 49, 658664.
Hertog, MG, Feskens, EJ, Hollman, PC, Katan, MB & Kromhout, D (1993) Dietary antioxidant flavonoids and risk of coronary heart disease. Lancet 342, 10071011.
Hertog, MGL & Hollman, PCH (1996) Potential health effects of the dietary flavonol quercetin. European Journal of Clinical Nutrition 50, 6371.
Hodgson, JM, Morton, LW, Puddey, IB, Beilin, LJ & Croft, KD (2000 a) Gallic acid metabolites are markers of black tea intake in humans. Journal of Agricultural and Food Chemistry 48, 22762280.
Hodgson, JM, Proudfoot, JM, Croft, KD, Puddey, IB, Mori, TA & Beilin, LJ (1999) Comparison of the effects of black and green tea on in vitro lipoprotein oxidation in human serum. Journal of the Science of Food and Agriculture 79, 561566.
Hodgson, JM, Puddey, IB, Croft, KD, Burke, V, Mori, TA, Abu-Amsha Caccetta, R & Beilin, LJ (2000 b) Acute effects of ingestion of black and green tea on lipoprotein oxidation. American Journal of Clinical Nutrition 71, 11031107.
Hodgson, JM, Puddey, IB, Mori, TA, Burke, V, Baker, R & Beilin, LJ (2001) Effects of regular ingestion of black tea on haemostasis and cell adhesion molecules in humans. European Journal of Clinical Nutrition 55, 881886.
Janssen, K, Mensink, RP, Cox, FJ, Harryvan, JL, Hovenier, R, Hollman, PC & Katan, MB (1998) Effects of the flavonoids quercetin and apigenin on hemostasis in healthy volunteers: results from an in vitro and a dietary supplement study. American Journal of Clinical Nutrition 67, 255262.
Kang, WS, Lim, IH, Yuk, DY, Chung, KH, Park, JB, Yoo, HS & Yun, YP (1999) Antithrombotic activities of green tea catechins and (-)-epigallocatechin gallate. Thrombosis Research 96, 229237.
Keli, SO, Hertog, MGL, Feskens, EJM & Kromhout, D (1996) Dietary flavonoids, antioxidant vitamins, and incidence of stroke. Archives of Internal Medicine 156, 637642.
Miller, GJ, Martin, JC, Mitropoulos, KA, Reeves, BE, Thompson, RL, Meade, TW, Cooper, JA & Cruickshank, JK (1991) Plasma factor VII is activated by postprandial triglyceridemia, irrespective of dietary fat composition. Atherosclerosis 86, 163171.
Mutanen, M & Freese, R (2001) Fats, lipids and blood coagulation. Current Opinion in Lipidology 12, 2529.
Neiva, TJC, Morais, L, Polack, M, Simoes, CMO & D'Amico, EA (1999) Effects of catechins on human blood platelet aggregation and lipid peroxidation. Phytotherapy Research 13, 597600.
Nimpf, J, Malle, E, Leopold, B, Wurm, H & Kostner, GM (1989) Postprandial hyperlipemia inhibits platelet aggregation without affecting prostanoid metabolism. Prostaglandins Leukotrienes and Essential Fatty Acids 37, 713.
Pace-Asciak, CR, Hahn, S, Diamandis, EP, Soleas, G & Goldberg, DM (1995) The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: implications for protection against coronary heart disease. Clinica Chimica Acta 235, 207219.
Salomaa, V, Rasi, V, Pekkanen, J, Jauhiainen, M, Vahtera, E, Pietinen, P, Korhonen, H, Kuulasmaa, K & Ehnholm, C (1993) The effects of saturated fat and n-6 polyunsaturated fat on postprandial lipemia and hemostatic activity. Atherosclerosis 103, 111.
Silveira, A, Karpe, F, Blomback, M, Steiner, G, Walldius, G & Hamsten, A (1994) Activation of coagulation factor VII during alimentary lipemia. Arteriosclerosis and Thrombosis 14, 6069.
van het Hof, KH, Kivits, GA, Weststrate, JA & Tijburg, LB (1998) Bioavailability of catechins from tea: the effect of milk. European Journal of Clinical Nutrition 52, 356359.

Keywords

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed