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The acute effect of D-tagatose on food intake in human subjects

  • Benjamin Buemann (a1), Søren Toubro (a1), Anne Raben (a1), John Blundell (a1) and Arne Astrup (a1)...

Abstract

A double-blind randomized crossover study was performed with nineteen normal-weight men to investigate the effect on subsequent ad libitum food intake of replacing 29 g sucrose with 29 g D-TAGATOSE AS SWEETENER TO A BREAKFAST MEAL. d-Tagatose is a malabsorbed stereoisomer of fructose with potential application as a bulk sweetener. Food intake was measured at lunch offered 4 h after the breakfast meal, during the afternoon with access to abundant snacks, and finally at a supper buffet 9 h after the breakfast. Energy intake at lunch and during the snacking period was similar after ingesting the two sugars, while it was 15 % lower after ingesting d-tagatose than with sucrose at supper (P < 0·05). Gastrointestinal factors such as the osmotic effects of unabsorbed d-tagatose causing distension of the gut might have mediated the acute appetite-suppressing effect. The present paper also refers to data from a preceding study in which we observed an increased self-reported energy intake after ingestion of d-tagatose compared with sucrose which, in fact, suggests a relative hyperphagic effect of d-tagatose. However, self-reported food intake may be biased by selective under-reporting and this subsequent study with a more controlled assessment of food intake was therefore conducted. This present study did not support any hyperphagic effect of d-tagatose, but rather suggests that d-tagatose may contribute to a reduced energy intake.

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Copyright

Corresponding author

*Corresponding author: Dr Benjamin Buemann, fax +45 35 282 483, email bbu@kvl.dk

References

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Black, AE, Goldberg, SA, Jebb, SA, Livingstone, MBE, Cole, TJ and Prentice, AM (1991) Critical evaluation of energy intake data using fundamental principles of energy physiology: 2. Evaluating the results of published surveys. European Journal of Clinical Nutrition 45, 583599.
Blackburn, GL, Kanders, BS, Lavin, PT, Keller, SD and Whatley, J (1997) The effect of aspartame as part of a multidisciplinary weight-control program on short- and long-term control of body weight. American Journal of Clinical Nutrition 65, 409418.
Buemann, B, Toubro, S and Astrup, A (1998) D-Tagatose, a stereoisomer of D-fructose, increases hydrogen production in humans without affecting 24-hour energy expenditure or respiratory exchange ratio. Journal of Nutrition 128, 14811486.
Buemann, B, Toubro, S, Holst, JJ, Rehfeld, JF and Astrup, A (2000) D-Tagatose, a stereoisomer of D-fructose increases blood uric acid concentration Metabolism (In the Press).
Friedman, MI (1997) An energy sensor for control of energy intake. Proceedings of the Nutrition Society 56, 4150.
Kruger, CL, Whittaker, MH, Frankos, VH and Trimmer, GW (1999) 90-Day oral toxicity study of D-tagatose in rats. Regulatory Toxicology and Pharmacology 29, S1S10.
Lærke, HN and Jensen, BB (1999) D-Tagatose has low small intestinal digestibility but high large intestinal fermentability in pigs. Journal of Nutrition 129, 10021009.
Lavin, JH, French, SJ and Read, NW (1997) The effect of sucrose- and aspartame- sweetened drinks on energy intake, hunger and food choice of female, moderately restrained eaters. International Journal of Obesity 21, 3742.
Livingstone, MBE, Prentice, AM, Strain, JJ, Coward, WA, Black, AE, Barker, ME, McKenna PG and Whitehead, RG (1990) Accuracy of weighed dietary records in studies of diet and health. British Medical Journal 300, 708712.
Mifflin, MD, St Jeor, ST, Hill, LA, Scott, BJ, Daugherty, SA and Koh, YO (1990) A new predictive equation for resting energy expenditure in healthy individuals. American Journal of Clinical Nutrition 51, 241247.
Moyer, AE and Rodin, J (1993) Fructose and behavior: does fructose influence food intake and macronutrient selection?. American Journal of Clinical Nutrition 58 (Suppl.), 810S814S.
Raben, A, Tatjana, HV, Møller, C and Astrup, A (1996) Sucrose vs artificial sweeteners: Minor differences in body weight after 10 weeks. International Journal of Obesity 20 (Suppl. 4), 51.
Rawson, NE and Friedman, MI (1994) Phosphate loading prevents the decrease in ATP and increase in food intake produced by 2,5-anhydro-D-mannitol. American Journal of Physiology 266, R1792R1796.
Rawson, NE, Blum, H, Osbakken, MD and Friedman, MI (1994) Hepatic phosphate trapping, decreased ATP, and increased feeding after 2,5-anhydro-D-mannitol. American Journal of Physiology 266, R112R117.
Riquelme, P, Wernette-Hammond, ME, Kneer, NM and Lardy, HA (1984) Mechanism of action of 2,5-anhydro-D-mannitol in hepatocytes. Effects of phosphorylated metabolites on enzymes of carbohydrate metabolism. Journal of Biological Chemistry 259, 51155123.
Rolls, BJ (1991) Effects of intense sweeteners on hunger, food intake, and body weight: a review. American Journal of Clinical Nutrition 53, 872878.
Scharrer, E and Langhans, W (1988) Metabolic and hormonal factors controlling food intake. International Journal of Vitamin and Nutrition Research 58, 249261.
Vincent, MF, Van den Berghe, G and Hers, H-G (1986) Effect of fructose on the concentration of phosphoribosylpyrophosphate in isolated hepatocytes. Advanced Experimental Medical Biology 195(Pt. B), 615621.

Keywords

The acute effect of D-tagatose on food intake in human subjects

  • Benjamin Buemann (a1), Søren Toubro (a1), Anne Raben (a1), John Blundell (a1) and Arne Astrup (a1)...

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