Boushey, J, Beresford, SAA, Omenn, GS & Motulsky, AG (1995) A quantitative assessment of plasma homocysteine as a risk factor for cardiovascular disease. Probable benefits of increasing folic acid intakes. Journal of the American Medical Association 274, 1049–1057.
Brattström, L, Lindgren, A, Israelsson, B, Andersson, A & Hultberg, B (1994) Homocysteine and cysteine: determinants of plasma levels in middle-aged and elderly subjects. Journal of Internal Medicine 236, 633–641.
Brönstrup, A, Hages, M, Prinz Langenohl, R & Pietrzik, K (1998) Effects of folic acid and combinations of folic acid and vitamin B-12 on plasma homocysteine concentrations in healthy, young women. American Journal of Clinical Nutrition 68, 1104–1110.
Brouwer, IA, van Dusseldorp, M, Thomas, CMG, Duran, M, Hautvast, GAJ, Eskes, TKAB & Steegers-Theunissen, PM (1999) Low-dose folic acid supplementation decreases plasma homocysteine concentrations: a randomized trial. American Journal of Clinical Nutrition 69, 99–104.
Chadefaux-Vakemans, B, Kara, MA & Thuillier, L (1996) Does the prevalent mutation 677C → T in the methylenetetrahydrofolate reductase gene account for hyperhomocysteine related to cardio-vascular disease?. Journal of Inherited Metabolism Disease 19, Suppl. 1, 25Abst.
Chango, A, Boisson, F, Barbé, F, Quilliot, D, Droesch, S, Pfister, M, Frémont, S, Rosenblatt, DS & Nicolas, JP (2000) The effect of 677C → T and 1298A → C mutations on plasma homocysteine and 5,10-methylenetetrahydrofolate reductase activity in healthy subjects. British Journal of Nutrition 83, 593–596.
Christensen, B, Frosst, P, Lussier-Cacan, S, Selhub, J, Goyette, P, Rosenblatt, D, Genest, J Jr & Rozen, R (1997) Correlation of a common mutation in the methylenetetrahydrofolate reductase (MTHFR) gene with plasma homocysteine in patients with premature coronary artery disease. Arteriosclerosis Thrombosis and Vascular Biology 17, 569–573.
Christidès, JP & Potier de Courcy, G (1987) Teneur en acide folique des aliments. 2–Optimisation du dosage microbiologique des folates dans les aliments (Folic acid content in food. 2–Optimization of microbiological assays for the determination of folate in food). Sciences des Aliments 7, 7–22.
Clarke, R, Woodhouse, P, Ulvik, A, Frost, C, Sherliker, P, Refsum, H, Ueland, PM & Khaw, KT (1998) Variability and determinants of total homocysteine concentrations in plasma in an elderly population. Clinical Chemistry 44, 102–107.
den Heijer, M, Brouwer, IA & Bos, GMJ (1998) Vitamin supplementation reduces blood homocysteine levels. A controlled trial in patients with venous thrombosis and healthy volunteers. Arteriosclerosis Thrombosis and Vascular Biology 18, 356–361.
Faure-Delanef, L, Quéré, I, Chassé, JF, Guerassimenko, O, Lesaulnier, M, Bellet, H, Zittoun, J, Kamoun, P & Cohen, D (1997) Methylenetetrahydrofolate reductase thermolabile variant and human longevity. American Journal of Human Genetics 60, 999–1001.
Frosst, P, Blom, HJ, Milos, R, Goyette, P, Sheppard, CA, Matthews, RG, Boers, GJA, den Heijer, M, Kluijtmans, LAJ, van den Heuvel, LP and Rozen, R (1995) A candidate genetic risk factor for vascular disease: a common mutation MTHFR. Nature Genetics 10, 111–113.
Harmon, DL, Woodside, JV, Yarnell, JWG, McMaster, D, Young, IS, McCrum, EE, Gey, KF, Whitehead, AS & Evans, AE (1996) The common 'thermolabile' variant of methylenetetrahydrofolate reductase is a major determinant of mild hyperhomocysteinaemia. Quarterly Journal of Medicine 89, 571–577.
Hercberg, S, Préziosi, P, Briançon, S, Galan, P, Triol, I, Malvy, D, Roussel, A-M & Favier, A (1998) A primary prevention trial using nutritional doses of antioxidant vitamins and minerals in cardiovascular diseases and cancers in a general population: the SU.VI.MAX study-design, methods, and participant characteristics. Controlled Clinical Trials 19, 336–351.
Hoffbrand, AV, Newcombe, FA & Mollin, DL (1966) Method of assay of red cell folate activity and the value of the assay as a test for folate deficiency. Journal of Clinical Pathology 19, 17–28.
Jacques, PF, Bostom, AG, Williams, RR, Ellison, RC, Eckfeldt, JH, Rosenberg, IH, Selhub, J & Rozen, R (1996) Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations. Circulation 93, 7–9.
Miller, JW, Nadeau, MR, Smith, D & Selhub, J (1994) Vitamin B6 deficiency vs folate deficiency: comparison of responses to methionine loading in rats. American Journal of Clinical Nutrition 55, 1033–1039.
Molloy, AM, Daly, S, Mills, JL, Kirke, PN, Whitehead, AS, Ramsbottom, D, Conley, MR, Weir, DG & Scott, JM (1997) Thermolabile variant of 5,10-methylenetetrahydrofolate reductase associated with low red-cell folates: implications for folate intake recommendations. Lancet 349, 1591–1593.
Molloy, AM, Mills, JL, Kirke, PN, Whitehead, AS, Weir, DG & Scott, JM (1998) Whole-blood folate values in subjects with different methylenetetrahydrofolate reductase genotypes: differences between the radioassay and microbiological assays. Clinical Chemistry 44, 186–188.
Nygard, O, Refsum, H, Ueland, PM, Stensvold, I, Nordrehaug, JE, Kvale, G & Vollset, SE (1997) Coffee consumption and plasma total homocysteine: The Hordaland Homocysteine Study. American Journal of Clinical Nutrition 65, 136–143.
Nygard, O, Refsum, H, Ueland, PM & Vollset, SE (1998) Major lifestyle determinants of plasma total homocysteine distribution: the Hordaland homocysteine study. American Journal of Clinical Nutrition 67, 263–270.
Parodi, PW (1997) The French paradox unmasked: the role of folate. Medical Hypotheses 49, 313–318.
Pepe, G, Comacho Vanegas, O, Giusti, B, Brunelli, T, Marcucci, R, Attanasio, M, Rickards, O, de Stefano, GF, Prisco, D, Gensini, GF & Abbate, R (1998) Heterogeneity in world distribution of the thermolabile C677T mutation in 5,10-methylenetetrahydrofolate reductase. American Journal of Human Genetics 63, 917–920.
Rosenblatt, DS, (1995) Inherited disorders of folate transport and metabolism. In The Metabolic and Molecular Bases of Inherited Disease, pp. 3111–3128 [Scriver, CR, Beaudet, AL, Sly, WS and Valle, D, editors].New York: McGraw Hill.
Schneider, JA, Rees, DC, Liu, YT & Clegg, JB (1998) Worldwide distribution of a common methylenetetrahydrofolate reductase mutation. American Journal of Human Genetics 62, 1258–1260.
Selhub, J (1997) Mild hyperhomocysteinemia and arterial occlusive disease. Haematologica 82, 129–132.
Ubbink, JB, Serfontein, WJ & de Villiers, LS (1986) Analytical recovery of protein-bound pyridoxal-5′-phosphate in plasma analysis. Journal of Chromatography 375, 399–404.
Ubbink, JB, Vermaak, WJH, van der Merwe, A, Becker, PJ, Delport, R & Potgieter, HC (1994) Vitamin requirements for the treatment of hyperhomocysteinemia in humans. Journal of Nutrition 124, 1927–1933.
van der Put, NMJ, Gabreëls, F, Stevens, MB, Smeitink, JAM, Trijbels, FJM, Eskes, TKAB, van der Heuvel, LP & Blom, HJ (1998) A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects?. American Journal of Human Genetics 62, 1044–1051.
Weisberg, I, Tran, P, Christensen, B, Sibani, S & Rozen, R (1998) A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity. Molecular Genetics and Metabolism 64, 169–172.
Zittoun, J, Tonetti, C, Bories, D, Pignon, JM & Tullier, M (1998) Plasma homocysteine levels related to interactions between folate status and methylenetetrahydrofolate reductase: a study in 52 healthy subjects. Metabolism 47, 1413–1418.