Skip to main content Accessibility help
×
Home

Hypothalamic protein profiles associated with inhibited feed intake of ducks fed with insufficient dietary arginine

  • C. Wang (a1) (a2), A. J. Zheng (a3), M. Xie (a1), W. Huang (a1), J. J. Xie (a1) and S. S. Hou (a1)...

Abstract

An experiment was conducted to investigate the effect of arginine on feed intake regulation. One hundred and twenty six 1-day-old male White Pekin ducks (Anas platyrhynchos domestica) were randomly were allotted to one of two dietary treatments. The birds were fed diets containing 0.71% (deficient) or 1.27% (sufficient) arginine for 3 weeks. At 21 days of age, feed intake was determined and hypothalamic protein profiles were analyzed using isobaric tags for relative and absolute quantification technique. The birds fed with arginine-deficient diet had a lower final live BW and cumulative feed intake (P<0.01) than those fed with arginine-sufficient diet. A total of 16 proteins were identified in the hypothalamus with >1.5-fold expressional changes between arginine-deficient and -sufficient dietary treatments. Nine of these proteins were upregulated and seven of them were downregulated. The identified proteins could be regrouped into six categories: protein processing, carbohydrate metabolism and energy production, transporter, cytoskeleton, immunity and neuronal development. Dietary arginine deficiency decreased expression of proteins involved in energy production (glycine amidinotransferase, aldolase B fructose-bisphosphate, aconitase, transaldolase, 6-phosphofructokinase type C-like) and oxygen transportation (haemoglobin subunit α expression). The proteomic alterations described here provides valuable insights into the interactions of arginine with appetite.

Copyright

Corresponding author

E-mail: houss@263.net

References

Hide All
Anand, BK and Brobeck, JR 1951. Hypothalamic control of food intake in rats and cats. The Yale Journal of Biology and Medicine 24, 123141.
Austic, RE and Nesheim, MC 1970. Role of kidney arginase in variations of the arginine requirement of chicks. Journal of Nutrition 100, 855867.
Austic, RE and Scott, RL 1975. Involvement of food intake in the lysine-arginine antagonism in chicks. Journal of Nutrition 105, 11221131.
Baskin, DG, Figlewicz Lattemann, D, Seeley, RJ, Woods, SC, Porte, D Jr and Schwartz, MW 1999. Insulin and leptin: dual adiposity signals to the brain for the regulation of food intake and body weight. Brain Reseach 848, 114123.
Bax, M, Chambon, C, Marty-Gasset, N, Remignon, H, Fernandez, X and Molette, C 2012. Proteomic profile evolution during steatosis development in ducks. Poultry Science 91, 112120.
Bessman, SP and Carpenter, CL 1985. The creatine-creatine phosphate energy shuttle. Annual Review of Biochemistry 54, 831862.
Blevins, JE, Dixon, KD, Hernandez, EJ, Barrett, JA and Gietzen, DW 2000. Effects of threonine injections in the lateral hypothalamus on intake of amino acid imbalanced diets in rats. Brain Research 879, 6572.
Cheung, CC, Clifton, DK and Steiner, RA 1997. Proopiomelanocortin neurons are direct targets for leptin in the hypothalamus. Endocrinology 138, 44894492.
Farr, SA, Banks, WA, Kumar, VB and Morley, JE 2005. Orexin-A-induced feeding is dependent on nitric oxide. Peptides 26, 759765.
Gaskin, FS, Farr, SA, Banks, WA, Kumar, VB and Morley, JE 2003. Ghrelin-induced feeding is dependent on nitric oxide. Peptides 24, 913918.
Gropp, E, Shanabrough, M, Borok, E, Xu, AW, Janoschek, R, Buch, T, Plum, L, Balthasar, N, Hampel, B and Waisman, A 2005. Agouti-related peptide-expressing neurons are mandatory for feeding. Nature Neuroscience 8, 12891291.
Jobgen, WS, Fried, SK, Fu, WJ, Meininger, CJ and Wu, G 2006. Regulatory role for the arginine-nitric oxide pathway in metabolism of energy substrates. Journal of Nutritional Biochemistry 17, 571588.
Kalra, SP, Dube, MG, Sahu, A, Phelpsf, CP and Kalra, PS 1991. Neuropeptide Y secretion increases in the paraventricular nucleus in association with increased appetite for food. Proceedings of the National Academy of Sciences of the United States of America 88, 1093110935.
Kamegai, J, Tamura, H, Shimizu, T, Ishii, S, Sugihara, H and Wakabayashi, I 2001. Chronic central infusion of ghrelin increases hypothalamic neuropeptide Y and agouti-related protein mRNA levels and body weight in rats. Diabetes 50, 24382443.
Kaul, G, Pattan, G and Rafeequi, T 2011. Eukaryotic elongation factor-2 (eEF2): its regulation and peptide chain elongation. Cell Biochemistry and Function 29, 227234.
Kwak, H, Austic, R and Dietert, R 1999. Influence of dietary arginine concentration on lymphoid organ growth in chickens. Poultry Science 78, 15361541.
Leung, P and Rogers, QR 1980. Hyperphagia after ventral tegmental lesions and food intake responses of rats fed disproportionate amounts of dietary amino acids. Physiology & Behavior 25, 457464.
Li, J, Yan, L, Zheng, X, Liu, G, Zhang, N and Wang, Z 2008. Effect of high dietary copper on weight gain and neuropeptide Y level in the hypothalamus of pigs. Journal of Trace Elements in Medicine and Biology 22, 3338.
Minturn, JE, Fryer, H, Geschwind, DH and Hockfield, S 1995. TOAD-64, a gene expressed early in neuronal differentiation in the rat, is related to unc-33, a C. elegans gene involved in axon outgrowth. Journal of Neuroscience 15, 67576766.
Morley, JE, Farr, SA, Sell, RL, Hileman, SM and Banks, WA 2011. Nitric oxide is a central component in neuropeptide regulation of appetite. Peptides 32, 776780.
National Research Council. 1994. Nutrient requirements of poultry. National Academies Press, Washington, DC, USA.
Prescott, SM, Zimmerman, GA and McIntyre, TM 1990. Platelet-activating factor. Journal of Biological Chemistry 265, 1738117384.
Raimondi, L, Alfarano, C, Pacini, A, Livi, S, Ghelardini, C, DeSiena, G and Pirisino, R 2007. Methylamine‐dependent release of nitric oxide and dopamine in the CNS modulates food intake in fasting rats. British Journal of Pharmacology 150, 10031010.
Rostovtseva, T and Colombini, M 1996. ATP flux is controlled by a voltage-gated channel from the mitochondrial outer membrane. Journal of Biological Chemistry 271, 2800628008.
Shiraishi, S, Nakamura, YN, Iwamoto, H, Haruno, A, Sato, Y, Mori, S, Ikeuchi, Y, Chikushi, J, Hayashi, T and Sato, M 2006. S-myotrophin promotes the hypertrophy of skeletal muscle of mice in vivo. International Journal of Biochemistry & Cell Biology 38, 11141122.
Sjoeblom, B, Salmazo, A and Djinovic-Carugo, K 2008. Alpha-actinin structure and regulation. Cellular and Molecular Life Sciences 65, 26882701.
Stewart, M 2007. Molecular mechanism of the nuclear protein import cycle. Nature Reviews Molecular Cell Biology 8, 195208.
Taksande, B, Kotagale, N, Nakhate, K, Mali, P, Kokare, D, Hirani, K, Subhedar, N, Chopde, C and Ugale, R 2011. Agmatine in the hypothalamic paraventricular nucleus stimulates feeding in rats: involvement of neuropeptide Y. British Journal of Pharmacology 164, 704718.
Tan, B, Y, Yin, Liu, ZQ, Li, XG, Xu, HJ, Kong, XF, R, Huang, Tang, WJ, Shinzato, I, Smith, SB and Wu, GY 2009. Dietary l-arginine supplementation increases muscle gain and reduces body fat mass in growing-finishing pigs. Amino Acids 37, 169175.
Tan, W and Colombini, M 2007. VDAC closure increases calcium ion flux. Biochimica et Biophysica Acta-Biomembranes 1768, 25102515.
Wang, C, Xie, M, Huang, W, Yu, JY and Hou, SS 2013. Dietary arginine from 15 to 35 days of age affects feed intake and carcass yield in White Pekin ducks. Animal Production Science 53, 10411045.
Wu, G and Morris, SM 1998. Arginine metabolism: nitric oxide and beyond. Biochemical Journal 336, 117.
Wu, GY, Bazer, FW, Davis, TA, Kim, SW, Li, P, Rhoads, JM, Satterfield, MC, Smith, SB, Spencer, TE and Yin, YL 2009. Arg metabolism and nutrition in growth, health and disease. Amino Acids 37, 153168.
Yang, S and Denbow, D 2007. Interaction of leptin and nitric oxide on food intake in broilers and Leghorns. Physiology & Behavior 92, 651657.
Zheng, A, Liu, G, Zhang, Y, Hou, S, Chang, W, Zhang, S, Cai, H and Chen, G 2012. Proteomic analysis of liver development of lean Pekin duck (Anas platyrhynchos domestica). Journal of Proteomics 75, 53965413.

Keywords

Hypothalamic protein profiles associated with inhibited feed intake of ducks fed with insufficient dietary arginine

  • C. Wang (a1) (a2), A. J. Zheng (a3), M. Xie (a1), W. Huang (a1), J. J. Xie (a1) and S. S. Hou (a1)...

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed