Skip to main content Accessibility help

Advances in research on the prenatal development of skeletal muscle in animals in relation to the quality of muscle-based food. II – Genetic factors related to animal performance and advances in methodology

  • C. Rehfeldt (a1), M. F. W. Te Pas (a2), K. Wimmers (a1), J. M. Brameld (a3), P. M. Nissen (a4), C. Berri (a5), L. M. P. Valente (a6), D. M. Power (a7), B. Picard (a8), N. C. Stickland (a9) and N. Oksbjerg (a4)...


Selective breeding is an effective tool to improve livestock. Several selection experiments have been conducted to study direct selection responses as well as correlated responses in traits of skeletal muscle growth and function. Moreover, comparisons of domestic with wild-type species and of extreme breeds provide information on the genetic background of the skeletal muscle phenotype. Structural muscular components that differed with increasing distance in lean growth or meat quality in mammals were found to be myofibre number, myofibre size, proportions of fibre types as well as the numbers and proportions of secondary and primary fibres. Furthermore, markers of satellite cell proliferation, metabolic enzyme activities, glycogen and fat contents, the expression of myosin heavy chain isoforms, of activated AMPKα and other proteins in skeletal muscle tissue and circulating IGF1 and IGF-binding proteins have been identified to be involved in selection responses observed in pigs, cattle and/or chicken. The use of molecular methods for selective breeding of fish has only recently been adopted in aquaculture and studies of the genetic basis of growth and flesh quality traits are scarce. Some of the molecular markers of muscle structure/metabolism in livestock have also been identified in fish, but so far no studies have linked them with selection response. Genome scans have been applied to identify genomic regions exhibiting quantitative trait loci that control traits of interest, for example, muscle structure and meat quality in pigs and growth rate in chicken. As another approach, polymorphisms in candidate genes reveal the relationship between genetic variation and target traits. Thus, in large-scale studies with pigs’ associations of polymorphisms in the HMGA2, CA3, EPOR, NME1 and TTN genes with traits of carcass and meat quality were detected. Other studies revealed the significance of mutations in the IGF2 and RYR1 genes for carcass lean and muscle fibre traits in pigs. Mutations in the myostatin (MSTN) gene in fish were also examined. Advances in research of the genetic and environmental control of traits related to meat quality and growth have been made by the application of holistic ‘omics’ techniques that studied the whole muscle-specific genome, transcriptome and proteome in relation to muscle and meat traits, the development of new methods for muscle fibre typing and the adaptation of biophysical measures to develop parameters of muscle fibre traits as well as the application of in vitro studies. Finally, future research priorities in the field are defined.


Corresponding author


Hide All

Authoring on behalf of all members of the COST action 925:



Hide All
Archives of Animal Breeding 2005. Special Issue, vol. 48, 1–150.
Archives of Animal Breeding 2006. Special Issue, vol. 49, 1–154.
Archives of Animal Breeding 2007. Special Issue, vol. 50, 1–98.
Archives of Animal Breeding 2008. Special Issue 1, vol. 51, 1–91.
Ashmore, CR, Tompkins, G, Doerr, L 1972. Postnatal development of muscle fiber types in domestic animals. Journal of Animal Science 34, 3741.
Andersen, NK, Ravn, LS, Guy, JH, Edwards, SA, Harrison, AP 2008. Postnatal changes in electromyographic signals during piglet growth, and in relation to muscle fibre types. Livestock Science 115, 301312.
Bai, Q, McGillivray, C, da Costa, N, Dornan, S, Evans, G, Stear, MJ, Chang, KC 2003. Development of a porcine skeletal muscle cDNA microarray: analysis of differential transcript expression in phenotypically distinct muscles. BMC Genomics 4, 8.
Beccavin, C, Chevalier, B, Cogburn, LA, Simon, J, Duclos, MJ 2001. Insulin-like growth factors and body growth in chickens divergently selected for high or low growth rate. Journal of Endocrinology 168, 297306.
Bee, G, Deruy, JY 2008. Birth weight affects muscle fiber size and myosin heavy-chain isoform gene expression in the longissimus muscle of slaughter pigs. Proceedings of the Society of Nutrition Physiology 17, 112.
Bee, G, Solomon, MB, Czerwinski, SM, Long, C, Pursel, VG 1999. Correlation between histochemically assessed fiber type distribution and isomyosin and myosin heavy chain content in porcine skeletal muscles. Journal of Animal Science 77, 21042111.
Bérard, J, Kreuzer, M, Écolan, P, Lefaucheur, L, Bee, G 2008. Effect of foetus weight at day 70 of gestation on muscle fiber number, myosin heavy chain isoform expression and proteomic pattern in three porcine muscles. A preliminary study. In Globalisierung und Klimawandel: Verändern sie die Tierernährung in der Schweiz? Tagungsbericht, Schriftenreihe aus dem INW 30, 120–123.
Bernard, C, Cassar-Malek, I, Le Cunff, M, Dubroeucq, H, Renand, G, Hocquette, J-F 2007. New indicators of beef sensory quality revealed by expression of specific genes. Journal of Agricultural and Food Chemistry 55, 52295237.
Berri, C, Godet, E, Haj Hattab, N, Duclos, MJ 2006. Growth and differentiation of the chicken Pectoralis major muscle: effect of genotype and early nutrition. Archives of Animal Breeding 49 (Special Issue), 3132.
Berri, C, Le Bihan-Duval, E, Debut, M, Sante-Lhoutellier, V, Baéza, E, Gigaud, V, Jego, Y, Duclos, MJ 2007. Consequence of muscle hypertrophy on characteristics of Pectoralis major muscle and breast meat quality of broiler chickens. Journal of Animal Science 85, 20052011.
Berri, C, Le Bihan-Duval, E, Baéza, E, Chartrin, P, Picgirard, L, Jehl, N, Quentin, M, Picard, M, Duclos, MJ 2005. Further processing characteristics of breast and leg meat from fast-, medium and slow-growing commercial chickens. Animal Research 54, 123134.
Bouley, J, Chambon, C, Picard, B 2004. Mapping of bovine skeletal muscle proteins using two-dimensional gel electrophoresis and mass spectrometry. Proteomics 4, 18111824.
Bouley, J, Meunier, B, Chambon, C, De Smet, S, Hocquette, JF, Picard, B 2005. Proteomic analysis of bovine skeletal muscle hypertrophy. Proteomics 5, 490500.
Brooke, MH, Kaiser, KK 1970. Muscle fiber types: how many and what kind? Archives of Neurology 23, 369379.
Bünger, L, Ott, G, Varga, L, Schlote, W, Rehfeldt, C, Williams, JL, Hill, WG 2004. Marker-assisted introgression of the Compact mutant myostatin allele into a mouse line with extreme growth – effects on body composition and muscularity. Genetic Research 84, 161173.
Cagnazzo, M, Te Pas, MFW, Priem, J, de Wit, A, Pool, MH, Davoli, R, Russo, V 2006. Comparison of prenatal muscle tissue expression profiles of two pig breeds differing in muscle characteristics. Journal of Animal Science 84, 110.
Canario, AVM, Bargelloni, L, Volckaert, F, Houston, RD, Massault, C, Guiguen, Y 2008. Genomics toolbox for farmed fish. Reviews in Fisheries Science 16, 315.
Cassar-Malek, I, Passelaigue, F, Bernard, C, Léger, J, Hocquette, JF 2007. Target genes of myostatin loss-of-function in muscles of late bovine fetuses. BMC Genomics 8, 63.
Castillo, J, Codina, M, Martinez, ML, Navarro, I, Gutierrez, J 2004. Metabolic and mitogenic effects of IGF-I and insulin on muscle cells of rainbow trout. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 286, R935941.
Castillo, J, Ammendrup-Johnsen, I, Codina, M, Navarro, I, Gutierrez, J 2006. IGF-I and insulin receptor signal transduction in trout muscle cells. American Journal of Physiology – Regulatory Integrative and Comparative Physiology 290, R1683R1690.
Cerisuelo, A, Sala, R, Nürnberg, G, Baucells, M, Rehfeldt, C 2007. How many muscle samples are required to obtain reliable estimations of muscle fibre characteristics from pig longissimus muscle? Meat Science 76, 583587.
Chang, KC, Fernandes, K 1997. Developmental expression and 5′ cloning of the porcine 2x and 2b myosin heavy chain genes. DNA and Cell Biology 16, 14291437.
Chantry-Darmon, C, Urien, C, Hayes, H, Bertaud, M, Chadi-Taourit, S, Chardon, P, Vaiman, D, Rogel-Gaillard, C 2005. Construction of a cytogenetically anchored microsatellite map in rabbit. Mammalian Genome 16, 442459.
Chaze, T, Bouley, J, Chambon, C, Barboiron, C, Picard, B 2006. Mapping of alkaline proteins in bovine skeletal muscle. Proteomics 6, 25712575.
Chaze, T, Meunier, B, Chambon, C, Jurie, C, Picard, B 2008. In vivo proteome dynamics during early bovine myogenesis. Proteomics 8, 42364248.
Chelh, I, Meunier, B, Picard, B, Reecy, JM, Chevalier, C, Hocquette, J-F, Cassar-Malek, I 2009. Molecular profiles of quadriceps muscle in myostatin-null mice reveal PI3K and apoptotic pathways as myostatin targets. BMC Genomics 10, 196.
Circa, AV, Eknath, AE, Taduan, AG 1995. Genetic improvement of farmed tilapias: the growth performance of the GIFT strain of Nile tilapia (Oreochromis niloticus) in rice-fish environments. Aquaculture 137, 329330.
Codina, M, de la Serrana, DG, Sanchez-Gurmaches, J, Montserrat, N, Chistyakova, O, Navarro, I, Gutierrez, J 2008. Metabolic and mitogenic effects of IGF-II in rainbow trout (Oncorhynchus mykiss) myocytes in culture and the role of IGF-II in the PI3K/Akt and MAPK signalling pathways. General and Comparative Endocrinology 157, 116124.
Cogburn, LA, Wang, X, Carre, W, Rejto, L, Aggrey, SE, Duclos, MJ, Simon, J, Porter, TE 2004. Functional genomics in chickens: development of integrated-systems microarrays for transcriptional profiling and discovery of regulatory pathways. Comparative and Functional Genomics 5, 253261.
Cogburn, LA, Porter, TE, Duclos, MJ, Simon, J, Burgess, S, Zhu, JJ, Cheng, H, Dodgson, JB, Burnside, J 2007. Functional genomics of the chicken: a model organism. Poultry Science 86, 20592094.
Da Costa, N, Blackley, R, Alzuherri, H, Chang, KC 2002. Quantifying the temporospatial expression of postnatal porcine skeletal myosin heavy chain genes. Journal of Histochemistry and Cytochemistry 50, 353364.
Demars, J, Riquet, J, Sanchez, MP, Billon, Y, Hocquette, JF, Lebret, B, Iannuccelli, N, Bidanel, JP, Milan, D, Gondret, F 2007. Metabolic and histochemical characteristics of fat and muscle tissues in homozygous or heterozygous pigs for the body composition QTL located on chromosome 7. Physiological Genomics 30, 232241.
De-Santis, C, Jerry, DR 2007. Candidate growth genes in finfish – where should we be looking? Aquaculture 272, 2238.
Deveaux, V, Picard, B, Bouley, J, Cassar-Malek, I 2003. Location of myostatin expression during bovine myogenesis in vivo and in vitro. Reproduction Nutrition Development 43, 527542.
Duclos, MJ, Berri, C, Hattab, NJ 2005. Selection for growth rate alters the expression of rapid myosin heavy chain isoforms in chicken breast muscle. Archives of Animal Breeding 48 (Special Issue), 76.
Duclos, M, Berri, C, Le Bihan-Duval, E 2007. Muscle growth and meat quality. Journal of Applied Poultry Research 16, 107112.
Duclos, MJ, Molette, C, Guernec, A, Rémignon, H, Berri, C 2006. Cellular aspects of breast muscle development in chickens with high or low growth rate. Archives of Animal Breeding 49 (Special Issue), 147151.
Duclos, MJ, Chevalier, B, Remignon, H, Ricard, FH, Goddard, C, Simon, J 1996. Divergent selection for high or low growth rate modifies the response of muscle cells to serum or insulin-like growth factor-I in vitro. Growth Regulation 6, 176184.
Ernst, CW, Rilington, VD, Raney, NE, Yao, J, Sipkovsky, SS, Saama, PM, Tempelman, RJ, Coussens, PM 2002. Use of cDNA microarrays to detect differentially expressed genes in developing pig skeletal muscle. Abstracts for the Plant, Animal & Microbe Genomes X Conference, San Diego, CA, USA, 702pp.
Fiedler, I, Dietl, G, Rehfeldt, C, Wegner, J, Ender, K 2004. Muscle fibre traits as additional selection criteria for muscle growth and meat quality in pig – results of a simulated selection. Journal of Animal Breeding and Genetics 121, 331344.
Gardan, D, Gondret, F, Van den Maagdenberg, K, Buys, N, De Smet, S, Louveau, I 2008. Lipid metabolism and cellular features of skeletal muscle and subcutaneous adipose tissue in pigs differing in IGF-II genotype. Domestic Animal Endocrinology 34, 4553.
Gil, M, Delday, MI, Gispert, M, Font i Furnols, M, Maltin, CM, Plastow, GS, Klont, R, Sosnicki, AA, Carrión, D 2008. Relationships between biochemical characteristics and meat quality of longissimus thoracis and semimembranosus muscles in five porcine lines. Meat Science 3, 927933.
Gjedrem, T 2000. Genetic improvement of cold-water fish species. Aquaculture Research 31, 2533.
Gjoen, HM, Bentsen, HB 1997. Past, present, and future of genetic improvement in salmon aquaculture. ICES Journal of Marine Science 54, 10091014.
Goddard, C, Wilkie, RS, Dunn, IC 1988. The relationship between insulin-like growth factor-1, growth hormone, thyroid hormones and insulin in chickens selected for growth. Domestic Animal Endocrinology 5, 165176.
Gondret, F, Larzul, C, Combes, S, de Rochambeau, H 2005. Carcass composition, bone mechanical properties, and meat quality traits in relation to growth rate in rabbits. Journal of Animal Science 83, 15261535.
Graziotti, GH, Ríos, CM, Rivero, JL 2001. Evidence for three fast myosin heavy chain isoforms in type II skeletal muscle fibers in the adult Llama (Lama glama). Journal of Histochemistry and Cytochemistry 49, 10331044.
Guernec, A, Berri, C, Chevalier, B, Wacrenier-Céré, N, Le Bihan-Duval, E, Duclos, MJ 2003. Muscle development, insulin-like growth factor-I and myostatin mRNA levels in chickens selected for increased breast muscle yield. Growth Hormone and IGF Research 13, 818.
Harrison, AP, Latorre, R, Dauncey, MJ 1997. Postnatal development and differentiation of myofibres in functionally diverse porcine skeletal muscles. Reproduction and Fertility Development 9, 731740.
Hemmings, K, Parr, T, Buttery, P, Brameld, J 2008a. Development and evaluation of a real-time PCR method for determining skeletal muscle fibre type composition in sheep. Proceedings of the British Society for Animal Science, 47.
Hemmings, K, Parr, T, Buttery, P, Brameld, J 2008b. Development of a real-time PCR method for determining skeletal muscle fibre type composition in sheep. Archives of Animal Breeding 51 (Special Issue 1), 30.
Henckel, P, Oksbjerg, N, Erlandsen, E, Barton-Gade, P, Bejerholm, C 1997. Histo- and biochemical characteristics of the Longissimus dorsi muscle in pigs and their relationships to performance and meat quality. Meat Science 47, 311321.
Hurley, MS, Flux, C, Salter, AM, Brameld, JM 2006. Effects of fatty acids on skeletal muscle cell differentiation in vitro. British Journal of Nutrition 95, 623630.
Kalbe, C, Mau, M, Rehfeldt, C 2008. Developmental changes and the impact of isoflavones on mRNA expression of IGF-I receptor, EGF receptor and related growth factors in porcine skeletal muscle cell cultures. Growth Hormone & IGF Research 18, 424433.
Kalbe, C, Mau, M, Wollenhaupt, K, Rehfeldt, C 2007. Evidence for estrogen receptor α and β expression in skeletal muscle of pigs. Histochemistry and Cell Biology 127, 95107.
Knibb, W 2000. Genetic improvement of marine fish – which method for industry? Aquaculture Research 31, 1123.
Kwiecinska, P, Rosziewicz, B, ̡okociejewska, M, Orzechowski, A 2005. Elevated expression of NF-κB and Bcl-2 proteins in C2C12 myocytes during myogenesis is affected by PD98059, LY294002 or SB203580 treatments. Cell Biology International 29, 319331.
Larzul, C, Gondret, F, Combes, S, de Rochambeau, H 2005. Divergent selection on 63-day body weight in the rabbit: response on growth, carcass and muscle traits. Genetics Selection Evolution 37, 105122.
Le Bihan-Duval, E, Beaumont, C, Colleau, JJ 1996. Genetic parameters of the twisted legs syndrome in broiler chickens. Genetics Selection Evolution 28, 177195.
Le Bihan-Duval, E, Berri, C, Pitel, F, Nadaf, J, Sibut, V, Jenkins, C, Duclos, MJ 2007. A general approach combining QTL research and gene expression profiling to identify genes controlling chicken meat quality. Sciences des Aliments 27, 143152.
Le Bihan-Duval, E, Debut, M, Berri, CM, Sellier, N, Sante-Lhoutellier, V, Jego, Y, Beaumont, C 2008. Chicken meat quality: genetic variability and relationship with growth and muscle characteristics. BMC Genetics 9, 6.
Lefaucheur, L 2006. Myofibre typing and its relationships to growth performance and meat quality. Archives of Animal Breeding 49 (Special Issue), 417.
Lefaucheur, L, Ecolan, P 2005. Pattern of muscle fiber formation in Large White and Meishan pigs. Archives of Animal Breeding 48 (Special Issue), 117122.
Lefaucheur, L, Ecolan, P 2007. Changes in muscle proteome during development in the pig. Archives of Animal Breeding 50 (Special Issue), 1516.
Lefaucheur, L, Milan, D, Ecolan, P, Le Callennec, C 2004. Myosin heavy chain composition of different skeletal muscles in Large White and Meishan pigs. Journal of Animal Science 82, 19311941.
Lefaucheur, L, Ecolan, P, Lebret, B, Damon, M, Louveau, I, Sellier, P, Gilbert, H 2005. Influence of divergent selection on residual feed intake in the growing pig on muscle compositional traits. Archives of Animal Breeding 51 (Special Issue 1), 117122.
Lefaucheur, L, Lebret, B, Ecolan, P, Galian, M, Damon, M, Louveau, I, Prunier, A, Sellier, P, Gilbert, H 2008. Sélection divergente pour la consommation alimentaire résiduelle chez le porc: effets sur les propriétés musculaires et la qualité de la viande. Journées de la Recherche Porcine en France 40, 8384.
Liu, ZJ, Cordes, JF 2004. DNA marker technologies and their applications in aquaculture genetics. Aquaculture 238, 137.
Liu, J, Damon, M, Guitton, N, Guisle, I, Ecolan, P, Vincent, A, Cherel, P, Gondret, F 2009. Differentially-expressed genes in pig longissimus muscles with contrasting levels of fat, as identified by combined transcriptomic, reverse transcription PCR, and proteomic analyses. Journal of Agricultural and Food Chemistry 57, 38083817.
Liu, G, Jennen, DG, Tholen, E, Juengst, H, Kleinwachter, T, Holker, M, Tesfaye, D, Un, G, Schreinemachers, HJ, Muráni, E, Ponsuksili, S, Kim, JJ, Schellander, K, Wimmers, K 2007. A genome scan reveals QTL for growth, fatness, leanness and meat quality in a Duroc–Piétrain resource population. Animal Genetics 38, 241252.
Maak, S, Neumann, K, Swalve, HH 2006. Identification and analysis of putative regulatory sequences for the MYF5/MYF6 locus in different vertebrate species. Gene 379, 141147.
Mau, M, Kalbe, C, Viergutz, T, Nürnberg, G, Rehfeldt, C 2008a. Effects of dietary isoflavones on proliferation and DNA integrity of myoblasts derived from newborn piglets. Pediatric Research 63, 3945.
Mau, M, Kalbe, C, Wollenhaupt, K, Nürnberg, G, Rehfeldt, C 2008b. IGF-I- and EGF dependent porcine myoblast proliferation is influenced by the dietary isoflavones genistein and daidzein. Domestic Animal Endocrinology 35, 281289.
Moghadam, HK, Poissant, J, Fotherby, H, Haidle, L, Ferguson, MM, Danzmann, RG 2007. Quantitative trait loci for body weight, condition factor and age at sexual maturation in Arctic charr (Salvelinus alpinus): comparative analysis with rainbow trout (Oncorhynchus mykiss) and Atlantic salmon (Salmo salar). Molecular Genetics and Genomics 277, 647661.
Montserrat, N, Sánchez-Gurmaches, J, García de la Serrana, D, Navarro, M, Gutiérrez, J 2007. IGF-I binding and receptor signal transduction in primary cell culture of muscle cells of gilthead sea bream: changes throughout in vitro development. Cell and Tissue Research 330, 503513.
Muráni, E, Ponsuksili, S, Wimmers, K 2007a. Investigation of genetic and epigenetic mechanisms underlying stage- and breed-specific differences in the transcription of S 1gene during porcine myogenesis. Archives of Animal Breeding 50 (Special Issue), 4956.
Muráni, E, Muraniova, M, Ponsuksili, S, Schellander, K, Wimmers, K 2007b. Identification of genes differentially expressed during prenatal development of skeletal muscle in two pig breeds differing in muscularity. BMC Developmental Biology 7, 109.
Muráni, E, Westphal, P, Ponsuksili, S, Wimmers, K 2008. Investigation of the porcine SMAD7 gene as a functional-positional candidate for muscle-related traits. Archives of Animal Breeding 51 (Special Issue 1), 71.
Nadaf, J, Gilbert, H, Pitel, F, Berri, CM, Féve, K, Beaumont, C, Duclos, MJ, Vignal, A, Porter, TE, Simon, J, Aggrey, SE, Cogburn, LA, Le Bihan-Duval, E 2007. Identification of QTL controlling meat quality traits in an F2 cross between two chicken lines selected for either low or high growth rate. BMC Genomics 8, 155.
Nissen, PM, Oksbjerg, N 2009. In vitro primary satellite cell growth and differentiation within litters of pigs. Animal 5, 703709.
Nissen, PM, Sørensen, IL, Vestergaard, M, Oksbjerg, N 2005. Effects of sow nutrition on maternal and foetal serum growth factors and on foetal myogenesis. Animal Science 80, 299306.
Oliván, M, Martínez, A, Osoro, K, Sañudo, C, Panea, B, Olleta, JL, Campo, MM, Oliver, MA, Serra, X, Gil, M, Piedrafita, J 2004. Effect of muscular hypertrophy on physico-chemical, biochemical and texture traits of meat from yearling bulls. Meat Science 68, 567575.
Orzechowski, A, ̡okociejewska, M, Pawlikowska, P, Kruszewski, M 2005. Preincubation with sodium ascorbate potentiates insulin-dependent PKB/Akt and c-Jun phosphorylation in L6 rat myoblasts challenged with reactive oxygen/nitrogen species. Life Sciences 77, 496511.
Pawlikowska, P, Gajakowska, B, Orzechowski, A 2007a. Mitofusin (Mfn2) – a key player in insulin-dependent myogenesis in vitro. Cell and Tissue Research 327, 571581.
Pawlikowska, P, ̡okociejewska, M, Hocquette, JF, Orzechowski, A 2007b. Changes in the expression of proteins involved in insulin signalling and metabolic properties of energy supply elucidate skeletal muscle-type specific resistance to glucocorticoid-induced muscle cachexia. In Energy and protein metabolism and nutrition (ed. I Ortigues-Marty, N Miraux and W Brand-Williams), pp. 177179. EAAP publication No. 124, Wageningen Academic Publishers, The Netherlands.
Peter, JB, Barnard, RJ, Edgerton, VR, Gillespie, CA, Stempel, KE 1972. Metabolic profiles of three fiber types of skeletal muscle in guinea pigs and rabbits. Biochemistry 11, 26272633.
Picard, B, Jurie, C, Duris, MP, Renand, G 2005. Consequences of selection for higher growth rate on muscle fibre properties in cattle. Livestock Production Sciences 102, 107120.
Picard, B, Lefaucheur, L, Berri, C, Duclos, MJ 2002. Muscle fibre ontogenesis in farm animal species. Reproduction Nutrition and Development 42, 415431.
Ponsuksili, S, Nguyen Trong, Ngu, Muráni, E, Schellander, K, Wimmers, K 2008. Relative abundance of MyHC isoform transcripts and its association with muscularity and meat quality. Archives of Animal Breeding 51 (Special Issue 1), 40.
Puolanne, E, Räsänen, P 2008. A method for determining the muscle fibre length. Archives of Animal Breeding 51 (Special Issue 1), 4144.
Räsänen, P, Puolanne, E 2004. A method for determining the muscle fibre length. Proceedings o the 50th International Congress of Meat Science and Technology. August 8–13, 2004 – Helsinki, Finland, pp. 258–260.
Ramirez, JA, Oliver, MA, Pla, M, Guerrero, L, Ariño, B, Blasco, A, Pascual, M, Gil, M 2004. Effect of selection for growth rate on biochemical, quality and texture characteristics of meat from rabbits. Meat Science 67, 617624.
Rehfeldt, C, Fiedler, I, Stickland, NC 2004a. Number and size of muscle fibres in relation to meat production. In Muscle development of livestock animals – physiology, genetics, and meat quality(ed. MFW Te Pas, ME Everts and HP Haagsman), pp. 138. CABI Publishing, Wallingford, UK.
Rehfeldt, C, Renne, U, Wittstock, M, Mix, E, Zettl, UK 2004b. Long-term growth selection of mice changes the intrinsic susceptibility of myogenic cells to apoptosis. Journal of Muscle Research and Cell Motility 25, 177185.
Rehfeldt, C, Henning, M, Fiedler, I 2008. Consequences of pig domestication for skeletal muscle growth and cellularity. Livestock Science 116, 3041.
Rehfeldt, C, Ott, G, Gerrard, DE, Varga, L, Schlote, W, Williams, JL, Renne, U, Bünger, L 2005. Effects of the Compact mutant myostatin allele Mstn (Cmpt-dl1Abc) introgressed into a high growth mouse line on skeletal muscle cellularity. Journal of Muscle Research and Cell Motility 26, 103112.
Rehfeldt, C, Te Pas, MFW, Wimmers, K, Brameld, JM, Nissen, PM, Berri, C, Valente, LMP, Power, D, Picard, B, Stickland, NC, Oksbjerg, N 2011. Advances in research on the prenatal development of skeletal muscle in animals in relation to the quality of muscle-based food. I. Regulation of myogenesis and environmental impact. Animal, doi:10.1017/S1751731110002089.
Reid, DP, Szanto, A, Glebe, B, Danzmann, RG, Ferguson, MM 2005. QTL for body weight and condition factor in Atlantic salmon (Salmo salar): comparative analysis with rainbow trout (Oncorhynchus mykiss) and Arctic charr (Salvelinus alpinus). Heredity 94, 166172.
Rescan, P-Y, Montfort, J, Rallière, C, Le Cam, A, Esquerré, D, Hugot, K 2007. Dynamic gene expression in fish muscle during recovery growth induced by a fasting–refeeding schedule. BMC Genomics 8, 438.
Ruusunen, M, Puolanne, E 2004. Histochemical properties of fibre types in muscles of wild and domestic pigs and the effect of growth rate on muscle fibre properties. Meat Science 67, 533539.
Scanes, CG, Dunnington, EA, Buonomo, FC, Donoghue, DJ, Siegel, PB 1989. Plasma concentrations of insulin like growth factors (IGF-)I and IGF-II in dwarf and normal chickens of high and low weight selected lines. Growth Development and Aging 53, 151157.
Seo, K, Beever, JE 2001. Monitoring gene expression in swine skeletal muscle. Abstracts of the Plant and Animal Genomes IX Conference, San Diego, CA, USA, 207pp.
Sibut, V, Le Bihan-Duval, E, Tesseraud, S, Godet, E, Bordeau, T, Cailleau-Audouin, E, Chartrin, P, Duclos, MJ, Berri, C 2008. Adenosine monophosphate-activated protein kinase involved in variations of muscle glycogen and breast meat quality between lean and fat chickens. Journal of Animal Science 86, 28882896.
Sirin, E, Sayli, O, Ulutas, Z, Sen, U, Erdogan, SB, Aksoy, Y, Akin, A, Kuran, M 2008. Can functional near infrared spectroscopy (fNIRS) be used for the estimation of the numbers and types of muscle fibres in sheep? Archives of Animal Breeding 51 (Special Issue 1), 4546.
Stickland, NC, Bayol, S, Ashton, C, Rehfeldt, C 2004. Manipulation of muscle fibre number during prenatal development. In:Muscle development of livestock animals – physiology, genetics, and meat quality (ed. MFW Te Pas, ME Everts and HP Haagsman), pp. 6982. CABI Publishing, Wallingford, UK.
Stinckens, A, Van den Maagdenberg, K, Luyten, L, Georges, M, De Smet, S, Buys, N 2007. The RYR1g.1843C>T mutation is associated with the effect of the IGF2 intron-3-g3072G>A mutation on muscle hypertrophy. Animal Genetics 38, 6771.
Te Pas, MFW, Soumillion, A 2001. The use of physiologic and functional genomic information of the regulation of the determination of skeletal muscle mass in livestock breeding strategies to enhance meat production. Current Genomics 2, 285304.
Te Pas, MFW, Hulsegge, I, Pool, MH 2007a. Pathway analysis: combining microarray data and physiological data to study myogenesis. Archives of Animal Breeding 50 (Special Issue), 2731.
Te Pas, MFW, Hulsegge, I, Pool, MH, Coster, A, Heuven, HH, Janss, LLG 2007b. Biochemical pathways analysis of microarray results: regulation of myogenesis. BMC Developmental Biology 7, 66.
Te Pas, MFW, Verburg, FJ, Gerritsen, CLM, de Greef, KH 2000. Messenger ribonucleic acid expression of the MyoD gene family in muscle tissue at slaughter in relation to selection for porcine growth rate. Journal of Animal Science 78, 6977.
Te Pas, MFW, Pool, MH, Hulsegge, I, Janss, LLG 2006. Analysis of the differential transcriptome expression profiles during prenatal muscle tissue development. Archives of Animal Breeding 49 (Special Issue), 110115.
Te Pas, MFW, Jansen, J, Broekman, KCJA, Reimert, H, Heuven, HCM 2008. Post mortem proteome degradation profiles of longissimus muscle in Yorkshire and Duroc. Archives of Animal Breeding 51 (Special Issue 1), 62.
Te Pas, MFW, Harders, FL, Soumillion, A, Born, L, Buist, W, Meuwissen, THE 1999a. Genetic variation at the porcine myf-5 gene locus – lack of association with meat production traits. Mammalian Genome 10, 123127.
Te Pas, MFW, Soumillion, A, Harders, FL, Verburg, FJ, van den Bosch, TJ, Galesloot, P, Meuwissen, THE 1999b. Influences of myogenin genotype on birth weight, growth rate, carcass weight, backfat thickness and lean weight of pigs. Journal of Animal Science 77, 23522356.
Te Pas, MFW, Cagnazzo, M, de Wit, AAC, Priem, J, Pool, M, Davoli, R 2005a. Muscle transcriptomes of Duroc and Piétrain pig breeds during prenatal formation of skeletal muscle tissue using microarray technology. Archives of Animal Breeding 48 (Special Issue), 141147.
Te Pas, MFW, de Wit, A, Priem, J, Cagnazzo, M, Davoli, R, Russo, V, Pool, MH 2005b. Transcriptome expression profiles in prenatal pigs in relation to myogenesis. Journal of Muscle Research and Cell Motility 26, 157165.
Tesseraud, S, Pym, RAE, Le Bihan-Duval, E, Duclos, MJ 2003. Response of broilers selected on carcass quality to dietary protein supply: live performance, muscle development and circulating insulin-like growth factors (IGF-I and -II). Poultry Science 82, 10111016.
Theil, PK, Sørensen, IL, Nissen, PM, Oksbjerg, N 2006. Temporal gene expression of growth factors of primary porcine satellite cells during myogenesis in response to exogenous insulin. Animal Science Journal 77, 330337.
Tygesen, MP, Harrison, AP 2005. Nutritional restriction in utero programs postnatal muscle development in lambs. Animal Science Journal 76, 261271.
Tygesen, MP, Harrison, AP, Therkildsen, M 2007. The effect of maternal nutrient restriction during late gestation on muscle fibre size, bone and slaughter parameters in five month old lambs. Livestock Production Science 110, 230241.
Valente, LMP, Moreira, S, Ralliere, C, Ramos, AM, Rescan, PY 2006. Variability of myostatin genes in rainbow trout (Oncorhynchus mykiss) strains exhibiting distinct hyperplastic growth: preliminary results. Archives of Animal Breeding 49 (Special Issue), 103108.
Van den Maagdenberg, K, Claeys, E, Stinckens, A, Buys, N, De Smet, S 2007a. Effect of age, muscle type, and insulin-like growth factor-II genotype on muscle proteolytic and lipolytic enzyme activities in boars. Journal of Animal Science 85, 952960.
Van den Maagdenberg, K, Stinckens, A, Lefaucheur, L, Buys, N, De Smet, S 2007b. The effect of mutations in the insulin-like growth factor-II and ryanodine receptor-1 genes on biochemical and histochemical muscle fibre characteristics in pigs. Meat Science 79, 757799.
Van den Maagdenberg, K, Stinckens, A, Claeys, E, Buys, N, De Smet, S 2008. Effect of the insulin-like growth factor-II and RYR1 genotype in pigs on carcass and meat quality traits. Meat Science 80, 293303.
Van de Wiel, DFM, Zhang, WL 2007. Identification of pork quality parameters by proteomics. Meat Science 77, 4654.
Wimmers, K, Muráni, E, Schellander, K, Ponsuksili, S 2005. Combining QTL- and expression-analysis: identification of functional positional candidate genes for meat quality and carcass traits. Archives of Animal Breeding 48 (Special Issue), 2331.
Wimmers, K, Ngu, NT, Muráni, E, Schellander, K, Ponsuksili, S 2006a. Linkage and expression analysis to elucidate the genetic background of muscle structure and meat quality in the pig. Archives of Animal Breeding 49 (Special Issue), 116125.
Wimmers, K, Fiedler, I, Hardge, T, Muráni, E, Schellander, K, Ponsuksili, S 2006b. QTL for microstructural and biophysical muscle properties and body composition in pigs. BMC Genetics 7, 15.
Wimmers, K, Ngu, NT, Jennen, DG, Tesfaye, D, Muráni, E, Schellander, K, Ponsuksili, S 2008. Relationship between myosin heavy chain isoform expression and muscling in several diverse pig breeds. Journal of Animal Science 86, 795803.
Wimmers, K, Muráni, E, Te Pas, MFW, Chang, KC, Davoli, R, Merks, JWM, Henne, H, Muraniova, M, da Costa, N, Harlizius, B, Schellander, K, Böll, I, Braglia, S, de Wit, AAC, Cagnazzo, M, Fontanesi, L, Prins, D, Ponsuksili, S 2007. Associations of functional candidate genes derived from gene expression profiles of prenatal porcine muscle tissue with meat quality and muscle deposition. Animal Genetics 38, 474484.
Wu, G, Bazer, FW, Datta, S, Gao, H, Johnson, GA, Lassala, A, Li, P, Satterfield, MC, Spencer, TE 2008. Intrauterine growth retardation in livestock: implications, mechanisms and solutions. Archives of Animal Breeding 51 (Special Issue 1), 410.
Zhao, SH, Nettleton, D, Liu, W, Fitzsimmons, C, Ernst, CW, Raney, NE, Tuggle, CK 2003. Complementary DNA macroarray analyses of differential gene expression in porcine fetal and postnatal muscle. Journal of Animal Science 81, 21792188.


Advances in research on the prenatal development of skeletal muscle in animals in relation to the quality of muscle-based food. II – Genetic factors related to animal performance and advances in methodology

  • C. Rehfeldt (a1), M. F. W. Te Pas (a2), K. Wimmers (a1), J. M. Brameld (a3), P. M. Nissen (a4), C. Berri (a5), L. M. P. Valente (a6), D. M. Power (a7), B. Picard (a8), N. C. Stickland (a9) and N. Oksbjerg (a4)...


Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed.