Book contents
- Frontmatter
- Contents
- Contributors
- Preface
- Foreword
- 1 Uterine fibroids: epidemiology and an overview
- 2 Histopathology of uterine leiomyomas
- 3 Imaging of uterine leiomyomas
- 4 Abdominal myomectomy
- 5 Laparoscopic managment of uterine myoma
- 6 Hysteroscopic myomectomy
- 7 Myomas in pregnancy
- 8 Expectant and medical management of uterine fibroids
- 9 Hysterectomy for uterine fibroid
- 10 History of embolization of uterine myoma
- 11 Uterine artery embolization – vascular anatomic considerations and procedure techniques
- 12 Pain management during and after uterine artery embolization
- 13 Patient selection, indications and contraindications
- 14 Results of uterine artery embolization
- 15 Side effects and complications of embolization
- 16 Reproductive function after uterine artery embolization
- 17 Reasons and prevention of embolization failure
- 18 Future of embolization and other therapies from gynecologic perspectives
- 19 The future of fibroid embolotherapy: a radiological perspective
- Index
- Plate section
2 - Histopathology of uterine leiomyomas
Published online by Cambridge University Press: 10 November 2010
- Frontmatter
- Contents
- Contributors
- Preface
- Foreword
- 1 Uterine fibroids: epidemiology and an overview
- 2 Histopathology of uterine leiomyomas
- 3 Imaging of uterine leiomyomas
- 4 Abdominal myomectomy
- 5 Laparoscopic managment of uterine myoma
- 6 Hysteroscopic myomectomy
- 7 Myomas in pregnancy
- 8 Expectant and medical management of uterine fibroids
- 9 Hysterectomy for uterine fibroid
- 10 History of embolization of uterine myoma
- 11 Uterine artery embolization – vascular anatomic considerations and procedure techniques
- 12 Pain management during and after uterine artery embolization
- 13 Patient selection, indications and contraindications
- 14 Results of uterine artery embolization
- 15 Side effects and complications of embolization
- 16 Reproductive function after uterine artery embolization
- 17 Reasons and prevention of embolization failure
- 18 Future of embolization and other therapies from gynecologic perspectives
- 19 The future of fibroid embolotherapy: a radiological perspective
- Index
- Plate section
Summary
Uterine leiomyomas are monoclonal smooth muscle tumors. Early research on isoform analysis of glucose-6-phosphate dehydrogenase in the smooth muscle cells of uterine leiomyomas pointed to the monoclonal nature of this tumor. Each leiomyoma lesion in the uterus may have a distinct isoform and are presumed to arise independently. Cytogenetic abnormalities of several chromosomes have been identified within these smooth muscle tumors with normal karyotype in the adjacent non-tumorous regions. These cytogenetic mutations have been identified in about 40% of uterine leiomyomas. Some of the mutations involve genes involved in cellular growth regulation. Correlation between the genotype of the leiomyomas and the phenotype has not led to conclusive observations.
Gross morphology
Uterine leiomyomas are usually well-circumscribed tumors. They can occur in any part of the uterus, including the cervix. They may also occur in the round ligaments. Generally they are divided into subserosal, intramural, and submucosal. The subserosal and submucosal uterine leiomyomas can become pedunculated. The submucosal uterine leiomyomas can protrude into the uterine cavity or become pedunculated, and protrude through the cervix. Uterine leiomyomas can become separated from the uterus, and can be found in different areas such as the retroperitoneal space between the leaves of the broad ligament of the uterus.
- Type
- Chapter
- Information
- Uterine FibroidsEmbolization and other Treatments, pp. 11 - 15Publisher: Cambridge University PressPrint publication year: 2003