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Preface

Published online by Cambridge University Press:  14 September 2009

Paula T. Trzepacz
Affiliation:
Eli Lilly and Company, Indianapolis and university of Mississippi Medical Center
Andrea F. DiMartini
Affiliation:
University of Pittsburgh
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Summary

The transplant patient faces extraordinary challenges in their emotional and social lives as they undergo the physical transformations associated with the transplantation process. The need for an organ transplant may occur acutely or as a consequence of chronic organ insufficiency, each with its own set of biopsychosocial consequences. The interrelationships between physiology and psychological health are important for bodily health. Even immunological functions show links between brain and other body areas that may bridge emotional and physical states in complex and heretofore poorly understood ways. Pharmacological interventions often cross the bloodbrain barrier, causing psychiatric side effects – for example, during uremia or hypocholesterolemia combined with cyclosporine treatment.

Our book opens with a chapter, “The mystique of transplantation: biologic and psychiatric considerations”, by Thomas Starzl, the distinguished pioneer of liver transplantation from the laboratory to the human situation. Starzl traces the history of immunological barriers that were overcome in order to allow orthotopic organ transplantation, including engraftments of kidney, liver, lung, heart, pancreas, intestine and multiple abdominal viscera. He describes bidirectional immunologic confrontation between graft and host and the important discovery of donor leukocyte chimerism in solid organ transplantation, contrasting it with bone marrow transplantation, where host cells are deliberately cytoablated.

The closing chapter, by Maureen Martin, “Current trends and new developments in transplantation”, addresses new approaches to clinical immunosuppression, based on the concept of chimerism, which use bone marrow and stem cell-derived factors combined with solid organ transplantation.

Type
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The Transplant Patient
Biological, Psychiatric and Ethical Issues in Organ Transplantation
, pp. ix - xii
Publisher: Cambridge University Press
Print publication year: 2000

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  • Preface
  • Edited by Paula T. Trzepacz, Eli Lilly and Company, Indianapolis and university of Mississippi Medical Center, Andrea F. DiMartini, University of Pittsburgh
  • Book: The Transplant Patient
  • Online publication: 14 September 2009
  • Chapter DOI: https://doi.org/10.1017/CBO9780511544385.001
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  • Preface
  • Edited by Paula T. Trzepacz, Eli Lilly and Company, Indianapolis and university of Mississippi Medical Center, Andrea F. DiMartini, University of Pittsburgh
  • Book: The Transplant Patient
  • Online publication: 14 September 2009
  • Chapter DOI: https://doi.org/10.1017/CBO9780511544385.001
Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

  • Preface
  • Edited by Paula T. Trzepacz, Eli Lilly and Company, Indianapolis and university of Mississippi Medical Center, Andrea F. DiMartini, University of Pittsburgh
  • Book: The Transplant Patient
  • Online publication: 14 September 2009
  • Chapter DOI: https://doi.org/10.1017/CBO9780511544385.001
Available formats
×