Book contents
- Frontmatter
- Contents
- List of contributors
- Preface
- 1 The mystique of transplantation: biologic and psychiatric considerations
- 2 Psychosocial screening and selection of candidates for organ transplantation
- 3 Psychosocial issues in living organ donation
- 4 Quality of life in organ transplantation: effects on adult recipients and their families
- 5 Quality of life of geriatric patients following transplantation: short- and long-term outcomes
- 6 Cognitive assessment in organ transplantation
- 7 Pharmacologic issues in organ transplantation: psychopharmacology and neuropsychiatric medication side effects
- 8 Alcoholism and organ transplantation
- 9 Ethics and images in organ transplantation
- 10 Psychoneuroimmunology and organ transplantation: theory and practice
- 11 Pediatric transplantation
- 12 Current trends and new developments in transplantation
- Index
Preface
Published online by Cambridge University Press: 14 September 2009
- Frontmatter
- Contents
- List of contributors
- Preface
- 1 The mystique of transplantation: biologic and psychiatric considerations
- 2 Psychosocial screening and selection of candidates for organ transplantation
- 3 Psychosocial issues in living organ donation
- 4 Quality of life in organ transplantation: effects on adult recipients and their families
- 5 Quality of life of geriatric patients following transplantation: short- and long-term outcomes
- 6 Cognitive assessment in organ transplantation
- 7 Pharmacologic issues in organ transplantation: psychopharmacology and neuropsychiatric medication side effects
- 8 Alcoholism and organ transplantation
- 9 Ethics and images in organ transplantation
- 10 Psychoneuroimmunology and organ transplantation: theory and practice
- 11 Pediatric transplantation
- 12 Current trends and new developments in transplantation
- Index
Summary
The transplant patient faces extraordinary challenges in their emotional and social lives as they undergo the physical transformations associated with the transplantation process. The need for an organ transplant may occur acutely or as a consequence of chronic organ insufficiency, each with its own set of biopsychosocial consequences. The interrelationships between physiology and psychological health are important for bodily health. Even immunological functions show links between brain and other body areas that may bridge emotional and physical states in complex and heretofore poorly understood ways. Pharmacological interventions often cross the bloodbrain barrier, causing psychiatric side effects – for example, during uremia or hypocholesterolemia combined with cyclosporine treatment.
Our book opens with a chapter, “The mystique of transplantation: biologic and psychiatric considerations”, by Thomas Starzl, the distinguished pioneer of liver transplantation from the laboratory to the human situation. Starzl traces the history of immunological barriers that were overcome in order to allow orthotopic organ transplantation, including engraftments of kidney, liver, lung, heart, pancreas, intestine and multiple abdominal viscera. He describes bidirectional immunologic confrontation between graft and host and the important discovery of donor leukocyte chimerism in solid organ transplantation, contrasting it with bone marrow transplantation, where host cells are deliberately cytoablated.
The closing chapter, by Maureen Martin, “Current trends and new developments in transplantation”, addresses new approaches to clinical immunosuppression, based on the concept of chimerism, which use bone marrow and stem cell-derived factors combined with solid organ transplantation.
- Type
- Chapter
- Information
- The Transplant PatientBiological, Psychiatric and Ethical Issues in Organ Transplantation, pp. ix - xiiPublisher: Cambridge University PressPrint publication year: 2000