Multiple sclerosis (MS) is one of the most common neurological diseases in young adults. A first evidence for an effective drug treatment for MS derived from a large randomised-controlled study published by Rose and co-workers, showing a benefit of adrenocorticotrophic hormone (ACTH) in treatment of relapses. Rehabilitation play an important role in a comprehensive management of MS in order to reduce the consequences of the disease on functional impairment, personal activities and social participation and in order to enable persons to live an independent life with the highest possible quality of life in spite of the disease. Today, there is good evidence, that rehabilitation measures are effective in MS improving disability, handicap and quality of life despite progression of disease. Timing and mode of rehabilitation measures should be selected individually depending on disease phase, functional deficits and personal needs.