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  • Print publication year: 2012
  • Online publication date: January 2013

Chapter 5 - Sleep apnea, stroke risk factors, and the arousal response

References

1. Lloyd-JonesD, AdamsR, MercedesC, et al. Heart disease and stroke statistics-2009 update. A report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 2009; 119: e21–181.
2. OvbiageleB, KidwellCS, SaverJL. Epidemiological impact in the United States of a tissue-based definition of transient ischemic attack. Stroke 2003; 34: 919–24.
3. KleinddorferD, PanagosP, PancioliA, et al. Incidence and short-term prognosis of transient ischemic attack in a population based study. Stroke 2005; 36: 720–3.
4. RivestJ, ReiherJ. Transient ischemic attacks triggered by symptomatic sleep apneas [abstract]. Stroke 1987; 18: 293.
5. PressmanMR, SchetmanWR, FigueroaWG, et al. Transient ischemic attacks and minor stroke during sleep. Stroke 1995; 26: 2361–5.
6. BassettiC, AldrichMS, ChervinRD, et al. Sleep apnea in patients with transient ischemic attack and stroke: a prospective study of 59 patients. Neurology 1996; 47: 1167–73.
7. McArdleN, RihaRL, VennelleM, et al. Sleep-disordered breathing as a risk factor for cerebrovascular disease; a case-control study in patients with transient ischemic attacks. Stroke 2003; 34: 2916–21.
8. ArztM, YoungT, FinnL, et al. Association of sleep-disordered breathing and the occurrence of stroke. Am J Resp Crit Care Med 2005; 172: 1147–51.
9. ShaharE, WhitneyCW, RedlineS, et al. Sleep-disordered breathing and cardiovascular disease. Cross-sectional results of the Sleep Heart Health Study. Am J Resp Crit Care Med 2001; 163: 19–25.
10. YaggiKH, ConcatoJ, KernanWN, et al. Obstructive sleep apnea as a risk factor for stroke and death. N Engl J Med 2005; 19: 2034–41.
11. MuñozR, Durán-CantollaJ, Martínez-VilaE, et al. Severe sleep apnea and risk of ischemic stroke in the elderly. Stroke 2006; 37: 2317–21.
12. ValhamF, MooeT, RabbenT, et al. Increased risk of stroke in patients with coronary artery disease and sleep apnea: a 10-year follow-up. Circulation 2008; 118: 955–60.
13. RedlineS, YenokyanG, GottliebDJ, et al. Obstructive sleep apnea-hypopnea and incident stroke; The Sleep Heart Health Study. Am J Respir Crit Care Med 2010; 182: 269–77.
14. DykenME, SomersVK, YamadaT, et al. Investigating the relationship between sleep apnea and stroke [abstract]. Sleep Res 1992; 21: 30.
15. DykenME, SomersVK, YamadaT, et al. Investigating the relationship between stroke and obstructive sleep apnea. Stroke 1996; 27: 401–7.
16. PartinenM, JamiesonA, GuilleminaultC. Long-term outcome for obstructive sleep apnea syndrome patients: mortality. Chest 1988; 94: 1200–4.
17. PartinenM, GuilleminaultC. Daytime sleepiness and vascular morbidity at seven-year follow-up in obstructive sleep apnea patients. Chest 1990; 97: 27–32.
18. RogerVL, GoAS, Lloyd-JonesD, et al. Heart disease and stroke statistics – 2012 update: a report from the American Heart Association (available online; http://circ.ahajournals.org/content/early/2011/12/15/CIR.0b013e31823ac046).
19. RundekT, GardenerH, XuQ, et al. Insulin resistance and risk of ischemic stroke among nondiabetic individuals from the Northern Manhattan Study. Arch Neurol 2010; 67: 1195–200.
20. AmbrosettiM, LucioniAM, ContiS, et al. Metabolic syndrome in obstructive sleep apnea and related cardiovascular risk. J Cardiovasc Med 2006; 7: 826–9.
21. SasanabeR, BannoK, OtakeK, et al. Metabolic syndrome in Japanese patients with obstructive sleep apnea syndrome. Hypertens Res 2006; 29: 315–22.
22. LamJC, LamB, LamCL, et al. Obstructive sleep apnea and the metabolic syndrome in community-based Chinese adults in Hong Kong. Respir Med 2006; 100: 980–7.
23. CoughlinSR, MawdsleyL, MugarzaJA, et al. Obstructive sleep apnoea is independently associated with an increased prevalence of metabolic syndrome. Eur Heart J 2004; 25: 735–41.
24. KonoM, TatsumiK, SaibaraT, et al. Obstructive sleep apnea syndrome is associated with some components of metabolic syndrome. Chest 2007; 131: 1387–92.
25. VgontzasAN, BixlerEO, ChrousosGP. Sleep apnea is a manifestation of the metabolic syndrome. Sleep Med Rev 2005; 9: 211–24.
26. TishlerPV, LarkinEK, SchluchterMD, et al. Incidence of sleep-disordered breathing in an urban adult population. JAMA 2003; 289: 2230–7.
27. YoungT, PaltaM, DempseyJ, et al. The occurrence of sleep disordered breathing among middle-aged adults. N Engl J Med 1993; 328: 1230–5.
28. PeppardPE, YoungT, PaltaM, et al. Prospective study of the association between sleep-disordered breathing and hypertension. N Engl J Med 2000; 342: 1378–84.
29. AuroraRN, PolakJ, PunjabiNM, et al. Obstructive sleep apnea is associated with insulin resistance independent of visceral fat. Am J Respir Crit Care Med 2011; 183: A6075.
30. DykenME, SomersVK, YamadaT. Hemorrhagic stroke; part of the natural history of severe obstructive sleep apnea [abstract]?Sleep Res 1991; 20: 371.
31. DykenME. Cerebrovascular disease and sleep apnea. In: BradleyDT, FlorasJS, eds. Sleep Disorders and Cardiovascular and Cerebrovascular Disease. New York, NY: Marcel Dekker, 2000, 285–306.
32. SomersVK, MarkAL, AbboudFM. Sympathetic activation by hypoxia and hypercapnia. Implications for sleep apnea [abstract]. Clin Exp Hypertens 1988; A10: 413–22.
33. SomersVK, DykenME, ClaryMP, et al. Sympathetic neural mechanisms in obstructive sleep apnea. J Clin Invest 1995; 96: 1897–904.
34. SomersVK, DykenME, SkinnerJL. Autonomic and hemodynamic responses and interactions during the Mueller maneuver in humans. J Auton Nerv Syst 1993; 44: 253–9.
35. WolkR, SomersVK. Obesity-related cardiovascular disease: implications of obstructive sleep apnea. Diabetes Obes Metab 2006; 8: 250–60.
36. GuilleminaultC, ConnollySJ, WinkleRA. Cardiac arrhythmia and conduction disturbances during sleep in 400 patients with sleep apnea syndrome. Am J Cardiol 1983; 52: 490–4.
37. SomersVK, DykenME, MarkAL, et al. Parasympathetic hyperresponsiveness and bradyarrhythmias during apnea in hypertension. Clin Auton Res 1992; 2: 171–6.
38. GamiAS, PressmanG, CaplesSM, et al. Association of atrial fibrillation and obstructive sleep apnea. Circulation 2004; 110: 364–7.
39. KanagalaR, MuraliNS, FriedmanPA, et al. Obstructive sleep apnea and the recurrence of atrial fibrillation. Circulation 2003; 107: 2589–94.
40. MarshE, BillerJ, AdamsH, et al. Circadian variation in onset of acute ischemic stroke. Arch Neurol 1990; 47: 1178–80.
41. HornyakM, CejnarM, ElamM, et al. Sympathetic muscle nerve activity during sleep in man. Brain 1991; 114: 1281–95.
42. SomersVK, DykenME, MarkAL, et al. Sympathetic nerve activity during sleep in normal humans. N Engl J Med 1993; 328: 303–7.
43. KlingelhoferJ, HajakG, SanderD, et al. Assessment of intracranial hemodynamics in sleep apnea syndrome. Stroke 1992; 23: 1427–33.
44. JennumP, BorgesenSE. Intracranial pressure and obstructive sleep apnea. Chest 1989; 95: 279–83.
45. ToflerGH, BrezinskiD, SchaferAI, et al. Concurrent morning increase in platelet aggregability and the risk of myocardial infarction and sudden cardiac death. N Engl J Med 1987; 316: 1514–18.
46. FletcherEC, MillerJ, SchaafJW, et al. Urinary catecholamines before and after tracheostomy in patients with obstructive sleep apnea and hypertension. Sleep 1987; 10: 35–44.
47. GeiserT, BuckF, MeyerBJ, et al. In vivo platelet activation is increased during sleep in patients with obstructive sleep apnea syndrome. Respiration 2002; 69: 229–34.
48. MinoguchiK, YokoeT, TazakiT, et al. Silent brain infarction and platelet activation in obstructive sleep apnea. Am J Respir Crit Care Med 2007; 175: 612–17.
49. IberC, Ancoli-IsraelS, ChessonA, et al. The AASM Manual for the Scoring of Sleep and Associated Events: Rules, Terminology and Technical Specifications. 1st edn. Westchester, IL: American Academy of Sleep Medicine, 2007.
50. ThomasRJ. Arousals in sleep-disordered breathing: patterns and implications. Sleep 2003; 26: 1042–7.
51. BerryRB, KouchiKG, DerDE, et al. Sleep apnea impairs the arousal response to airway occlusion. Chest 1996; 109: 1490–6.
52. CirignottaF, ZucconiM, MondiniS, et al. Cerebral anoxic attacks in sleep apnea syndrome. Sleep 1989; 12: 400–4.
53. DykenME, YamadaT, GlennCL, et al. Obstructive sleep apnea associated with cerebral hypoxemia and death. Neurology 2004; 62: 491–3.
54. WhiteDP, DouglasNJ, PickettCK, et al. Sleep deprivation and the control of ventilation. Am Rev Respir Dis 1983; 198: 984–6.
55. IssaFG, SullivanCE. The immediate effects of nasal continuous positive airway pressure treatment on sleep pattern in patients with obstructive sleep apnea syndrome. Electroencephalogr Clin Neurophysiol 1986; 63: 10–17.
56. SullivanCE, GrunsteinRR. Continuous positive airways pressure in sleep-disordered breathing. In: KrygerMH, RothT, DementWC, eds. Principles and Practice of Sleep Medicine. Philadelphia, PA: Saunders, 1989, 559–70.
57. Berthon-JonesM, SullivanCE. Ventilation and arousal responses to hypercapnia in normal sleeping humans. J Appl Physiol 1984; 57: 59–67.
58. BuchananGF, RichersonGB. Central serotonin neurons are required for arousal to CO2. Proc Natl Acad Sci U S A 2010; 107: 16 354–9.
59. SeversonCA, WangW, PieriboneVA, et al. Midbrain serotonergic neurons are central pH chemoreceptors. Nat Neurosci 2003; 6: 1139–40.
60. Richerson, GB. Serotonergic neurons as carbon dioxide sensors that maintain pH homeostasis. Nat Rev Neurosci 2004; 5: 449–61.
61. JouvetM. The role of monoamines and acetylcholine-containing neurons in the regulation of the sleep-waking cycle. Ergeb Physiol 1972; 64: 166–307.
62. PrasadB, RadulovackiM, OlopadeC, et al. Prospective trial of efficacy and safety of ondansetron and fluoxetine in patients with obstructive sleep apnea syndrome. Sleep 2010; 33: 982–9.
63. McCannUD, SquambatFP, SwartzAR, et al. Sleep apnea in young abstinent recreational MDMA (“ecstasy”) consumers. Neurology 2009; 73: 2011–17.
64. Berthon-JonesM, SullivanCE. Ventilatory and arousal responses to hypoxia in sleeping humans. Am Rev Respir Dis 1982; 125: 632–9.
65. DarnallRA, SchneiderRW, TobiaCM, et al. Arousal from sleep in response to intermittent hypoxia in infant rodents is modulated by medullary raphe GABAergic mechanisms. Am J Physiol Regul Integr Comp Physiol 2012; 302: R551–60.
66. IssaFG, SullivanCE. Arousal and breathing responses to airway occlusion in healthy sleeping adults. J Appl Physiol 1983; 55: 1113–19.