Skip to main content Accessibility help
×
Hostname: page-component-848d4c4894-tn8tq Total loading time: 0 Render date: 2024-07-05T04:53:44.711Z Has data issue: false hasContentIssue false

Chapter 10 - Evaluation and management of dementia

from Section II - Geriatric syndromes

Published online by Cambridge University Press:  05 June 2016

Jan Busby-Whitehead
Affiliation:
University of North Carolina
Christine Arenson
Affiliation:
Thomas Jefferson University, Philadelphia
Samuel C. Durso
Affiliation:
The Johns Hopkins University School of Medicine
Daniel Swagerty
Affiliation:
University of Kansas
Laura Mosqueda
Affiliation:
University of Southern California
Maria Fiatarone Singh
Affiliation:
University of Sydney
William Reichel
Affiliation:
Georgetown University, Washington DC
Get access

Summary

Diagnostic criteria for dementia are separated into major and minor neurocognitive disorders. In major neurocognitive disorder, cognitive symptoms show a significant decline from a previous level of functioning in at least one cognitive domain. The prevalence of dementia increases with age, rising from 15% of those 65-74 years to more than 38% of those 85 and older. Estimated annual economic cost of dementia is $214 billion. Alzheimer’s dementia is the most common form of dementia. Cerebrovascular disease contributes to various subtypes of dementia. Although a definitive diagnosis of a syndrome often requires a postmortem examination, a comprehensive approach with a thorough history-taking, physical examination, tailored laboratory work and imaging studies, and neuropsychiatric testing when appropriate permit a probable diagnosis in the majority of cases. Despite the availability of diagnostic guidelines, routine screening of older adults is not recommended. Advances in understanding the pathophysiology of dementia have led to more targeted pharmacological therapies
Type
Chapter
Information
Reichel's Care of the Elderly
Clinical Aspects of Aging
, pp. 125 - 147
Publisher: Cambridge University Press
Print publication year: 2016

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 5th ed. Arlington, VA: American Psychiatric Publishing; 2013.Google Scholar
Alzheimer’s Association. 2014 Alzheimer’s disease facts and figures. Alzheimer’s & Dementia. 2014;146.Google Scholar
Elliott, AF, Burgio, LD, Decoster, J. Enhancing caregiver health: findings from the resources for enhancing Alzheimer’s caregiver health II intervention. J Am Geriatr Soc. 2010;58:30–7.Google Scholar
Corrada, MM, Brookmeyer, R, Paganini-Hill, A, et al. Dementia incidence continues to increase with age in the oldest old: the 90+ study. Ann Neurol. 2010; 67:114–21.Google Scholar
Vincent, GK, Velkoff, VA. The next four decades: The older population in the united sates: 2010–2050. Current Population Reports. Washington, DC: US Department of Commerce Economics and Statistics Administration. 2010.Google Scholar
Llewellyn, DJ, Lang, IA, Langa, KM, et al. Vitamin D and risk of cognitive decline in elderly persons. Arch Intern Med. 2010;170:1135–41.Google Scholar
Norton, MC, Smith, KR, Ostbye, T, et al. Greater risk of dementia when spouse has dementia? The cache county study. J Am Geriatr Soc. 2010;58:895900.Google Scholar
Fratiglioni, L, Paillard-Borg, S, Winblad, B. An active and socially integrated lifestyle in late life might protect against dementia. Lancet Neurol. 2004;3:343–53.Google Scholar
Simonsick, EM. Fitness and cognition: encouraging findings and methodological considerations for future work. J Am Geriatr Soc. 2003;51:570–1.Google Scholar
Coyle, JT. Use it or lose it – do effortful mental activities protect against dementia? NEJM. 2003;348:2489–90.Google Scholar
Buchman, AS, Boyle, PA, Yu, L, et al. Total daily physical activity and the risk of AD and cognitive decline in older adults. Neurology. 2012;78:1323–9.Google Scholar
Yaffe, K, Fiocco, AJ, Lindquist, K, et al. Predictors of maintaining cognitive function in older adults: the health ABC study. Neurology. 2009;72:2029–35Google Scholar
Jellinger, KA. Morphologic diagnosis of “vascular dementia” – a critical update. Journal of the Neurological Sciences.2008;270: 112.Google Scholar
Knopman, DS, Boeve, BF, Petersen, RC. Essential of the proper diagnoses of mild cognitive impairment, dementia, and major subtypes of dementia. Mayo Clin Proc. 2003;78:12901308.Google Scholar
Snowden, JS. Semantic dysfunction in frontotemporal lobar degeneration. Dement Geriatr Cogn Disord. 1999;10(Suppl 1):33–6.Google Scholar
Morris, JC. Dementia update 2005. Alzheimer Dis Assoc Disord. 2005;19:100–17.CrossRefGoogle ScholarPubMed
Jack, CR Jr, Albert, MS, Knopman, DS, et al. Introduction to the recommendations from the national institute on aging – Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement. 2011;7:257–62.Google Scholar
Hebert, LE, Weuve, J, Scherr, PA, Evans, DA. Alzheimer disease in the United States (2010–2050) estimated using the 2010 census. Neurology. 2013;80:1778–83.CrossRefGoogle ScholarPubMed
Barnes, DE, Yaffe, K, Byers, AL, et al. Midlife vs late-life depressive symptoms and risk of dementia: Differential effects for Alzheimer disease and vascular dementia. Arch Gen Psychiatry. 2012;69:493–8.Google Scholar
Querfurth, HW, Laferla, FM. Mechanisms of disease: Alzheimer’s disease. NEJM. 2010;362:1844–5.Google Scholar
Cummings, JL, Vinters, HV, Cole, GM, et al. Alzheimer’s disease: etiologies, pathophysiology, cognitive reserve, and treatment opportunities. Neurology. 1998;51(Suppl 1):S2S17.Google Scholar
Mash, DC, Flynn, DD, Potter, LT. Loss of M2 muscarine receptors in the cerebral cortex in Alzheimer’s disease and experimental cholinergic degeneration. Science. 1985;228:1115–17.Google Scholar
Cummings, JL. Alzheimer’s disease. NEJM. 2004;351:5667.Google Scholar
Gandy, S. The role of cerebral amyloid beta accumulation in common forms of Alzheimer disease. J Clin Invest. 2005;115(5):1121–9.Google Scholar
Tanzi, RE. Tangles and neurodegenerative disease – a surprising twist. NEJM. 2005;353:1853–5.CrossRefGoogle ScholarPubMed
Santacruz, K, Lewis, J, Spires, T, et al. Tau suppression in a neuro-degenerative mouse model improves memory function. Science. 2005;309:476–81.Google Scholar
Gorelick, PB, Scuteri, A, Black, SE, et al. Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the American Heart Association/American Stroke. Stroke. 2011;42:2672–713.Google Scholar
Larson, EB, Shadlen, MF, Wang, L, et al. Survival after initial diagnosis of Alzheimer disease. Ann Intern Med. 2004;140:501–9.Google Scholar
Román, GC. Vascular neurocognitive disorder. In: Gabbard’s Treatments of Psychiatric Disorders, 5th ed. Arlington, VA: American Psychiatric Publishing; 2014Google Scholar
Duthie, EH, Glatt, SL. Understanding and treating multi-infarct dementia. Clin Geriatr Med. 1988;4:749–66.Google Scholar
Moorhouse, P, Rockwood, K. Vascular cognitive impairment: current concepts and clinical developments. Lancet Neurol. 2008;7:246–55.Google Scholar
Rincon, F, Wright, CB. Vascular cognitive impairment. Curr Opin Neurol. 2013;26:2936.Google Scholar
Dichgans, M, Zietemann, V. Prevention of vascular cognitive impairment. Stroke. 2012;43:3137–46.Google Scholar
The Lund and Manchester Groups. Clinical and neuropathological criteria for frontotemporal dementia. J Neurol Neurosurg Psychiatry. 1994;57:416–18.Google Scholar
Whitwell, JL, Jack, CR Jr, Senjem, ML, Josephs, KA. Patterns of atrophy in pathologically confirmed FTLD with and without motor neuron degeneration. Neurology. 2006;66:102–4.Google Scholar
Rabinovici, GD, Miller, BL. Frontotemporal lobar degeneration epidemiology, pathophysiology, diagnosis and management. CNS Drugs. 2010;24:375–98.Google Scholar
McMurtray, AM, Chen, AK, Shapira, JS, et al. Variations in regional SPECT hypoperfusion and clinical features in frontotemporal dementia. Neurology.2006;66:517–22.Google Scholar
Mendez, MF, McMurtray, A, Chen, AK, et al. Functional neuroimaging and presenting psychiatric features in frontotemporal dementia. J Neurol Neurosurg Psychiatry. 2006;77:47.Google Scholar
Vanderzee, J, Rademakers, R, Engelborghs, S, et al. A Belgian ancestral haplotype harbours a highly prevalent mutation for 17q21-linked tau-negative FTLD. Brain. 2006;129:841–52.Google Scholar
Mackenzie, IR, Baker, M, West, G, et al. A family with tau-negative frontotemporal dementia and neuronal intranuclear inclusions linked to chromosome 17. Brain. 2006;129:853–67.Google Scholar
Huey, ED, Putnam, KT, Grafman, J. A systematic review of neurotransmitter deficits and treatments in frontotemporal dementia. Neurology. 2006;66:1722.Google Scholar
McKhann, GM, Albert, MS, Grossman, M, et al. Clinical and pathological diagnosis of frontotemporal dementia: report of the Work Group on Frontotemporal Dementia and Pick’s Disease. Arch Neurol. 2001;58:1803–9.Google Scholar
Neary, D, Snowden, JS, Northen, B, et al. Dementia of frontal lobe type. J Neurol Neurosurg Psychiatry. 1988;51:353–61.Google Scholar
Chare, L, Hodges, JR, Leyton, CE, et al. New criteria for frontotemporal dementia syndromes: Clinical and pathological diagnostic implications. Journal of Neurology, Neurosurgery & Psychiatry. 2014;85:865–70.CrossRefGoogle ScholarPubMed
Hodges, JR, Davies, RR, Xuereb, JH, et al. Clinicopathological correlates in frontotemporal dementia. Ann Neurol. 2004;56:399406.Google Scholar
Eslinger, PJ, Dennis, K, Moore, P, et al. Metacognitive deficits in frontotemporal dementia. J Neurol Neurosurg Psychiatry. 2005;76:1630–5.Google Scholar
Bonner, MF, Ash, S, Grossman, M. The new classification of primary progressive aphasia into semantic, logopenic, or nonfluent/agrammatic variants. Current Neurology & Neuroscience Reports. 2010;10:484–90.Google Scholar
Campbell, S, Stephens, S, Ballard, C. Dementia with Lewy bodies: clinical features and treatment. Drugs Aging. 2001;18:397407.Google Scholar
McKeith, IG. Spectrum of Parkinson’s disease, Parkinson’s dementia, and Lewy body dementia. Neurol Clin. 2000;18:865902.Google Scholar
Savica, R, Grossardt, BR, Bower, JH, et al. Incidence of dementia with Lewy bodies and Parkinson disease dementia. JAMA Neurology. 2013;70:1396–402.Google Scholar
Halliday, GM, Song, YJ, Harding, AJ. Striatal beta-amyloid in dementia with Lewy bodies but not parkinson’s disease. J Neural Transm. 2011;118:713–9.Google Scholar
Kalaitzakis, ME, Walls, AJ, Pearce, RK, et al. Striatal abeta peptide deposition mirrors dementia and differentiates DLB and PDD from other parkinsonian syndromes. Neurobiol Dis. 2011;41:377–84.Google Scholar
Kantarci, K, Lowe, VJ, Boeve, BF, et al. Multimodality imaging characteristics of dementia with Lewy bodies. Neurobiol Aging. 2012;33:2091–105.Google Scholar
Klein, JC, Eggers, C, Kalbe, E, et al. Neurotransmitter changes in dementia with Lewy bodies and parkinson disease dementia in vivo. Neurology. 2010;74:885–92.Google Scholar
Shimada, H, Shinotoh, H, Hirano, S, et al. Beta-amyloid in Lewy body disease is related to Alzheimer’s disease-like atrophy. Movement Disorders. 2013;28:169–75.Google Scholar
Kupsch, AR, Bajaj, N, Weiland, F, et al. Impact of DaTscan SPECT imaging on clinical management, diagnosis, confidence of diagnosis, quality of life, health resource use and safety in patients with clinically uncertain parkinsonian syndromes: A prospective 1-year follow-up of an open-label controlled study. J Neurol Neurosurg Psychiatry. 2012;83:620–8.Google Scholar
Lim, SM, Katsifis, A, Villemagne, VL, et al. The 18 F-FDG PET cingulate island sign and comparison to 123I-beta-CIT SPECT for diagnosis of dementia with Lewy bodies. Journal of Nuclear Medicine. 2009;50:1638–45.CrossRefGoogle ScholarPubMed
O’Brien, JT, McKeith, IG, Walker, Z, et al. Diagnostic accuracy of 123I-FP-CIT SPECT in possible dementia with Lewy bodies. British Journal of Psychiatry. 2009;194:34–9.Google Scholar
Ferman, TJ, Boeve, BF, Smith, GE, et al. Inclusion of RBD improves the diagnostic classification of dementia with Lewy bodies. Neurology. 2011;77:875–82.Google Scholar
Aarsland, D, Andersen, K, Larsen, JP, et al. Risk of dementia in Parkinson’s disease: a community-based, prospective study. Neurology. 2001;56:730–6.Google Scholar
Stern, Y, Marder, K, Tang, MX, Mayeux, R. Antecedent clinical features associated with dementia in Parkinson’s disease. Neurology.1993;43:1690–2.Google Scholar
Emre, M. Dementia in Parkinson’s disease: cause and treatment. Curr Opin Neurol. 2004;17:399404.Google Scholar
Aarsland, D, Perry, R, Brown, A, et al. Neuropathology of dementia in Parkinson’s disease: a prospective, community-based study. Ann Neurol. 2005;58:773–6.Google Scholar
Quinn, N. Parkinsonism–recognition and differential diagnosis. BMJ. 1995; 310:447–52.Google Scholar
Litvan, I, Campbell, G, Mangone, CA, et al. Which clinical features differentiate progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome) from related disorders? A clinicopathological study. Brain. 1997;120(Pt 1):6574.Google Scholar
Verny, M, Jellinger, KA, Hauw, JJ, et al. Progressive supranuclear palsy: a clinicopathological study of 21 cases. Acta Neuropathol (Berl). 1996;91:427–31.Google Scholar
Maher, ER, Lees, AJ. The clinical features and natural history of the Steele-Richardson-Olszewski syndrome (progressive supranuclear palsy). Neurology. 1986;36:1005–8.Google Scholar
Centers for Disease Control. Creutzfeldt-Jakob disease (CJD). Available at: www.cdc.gov/ncidod/dvrd/cjd (accessed April 28, 2015).Google Scholar
World Health Organization (WHO). WHO manual for surveillance of human transmissible spongiform encephalopathies including variant Creutzfeldt-Jakob disease, 2003. Available at: www.who.int/bloodproducts/TSE-manual2003.pdf (accessed December 2, 2015).Google Scholar
Rinne, ML, McGinnis, SM, Samuels, MA, et al. Clinical problem-solving: a startling decline. N Engl J Med. 2012;366:836–42.Google Scholar
Chohan, G, Pennington, C, Mackenzie, JM, et al. The role of cerebrospinal fluid 14–3-3 and other proteins in the diagnosis of sporadic Creutzfeldt-Jakob disease in the UK: a 10-year review. Journal of Neurology, Neurosurgery & Psychiatry. 2010;81: 1243–8.Google Scholar
Heath, CA, Cooper, SA, Murray, K, et al. Validation of diagnostic criteria for variant Creutzfeldt-Jakob disease. Ann Neurol. 2010;67:761–70.Google Scholar
Vitali, P, Maccagnano, E, Caverzasi, E, et al. Diffusion-weighted MRI hyperintensity patterns differentiate CJD from other rapid dementias. Neurology. 2011 May;76:1711–19.Google Scholar
Chapman, DP, Williams, SM, Strine, TW, et al. Dementia and its implications for public health. Available at: www.cdc.gov/pcd/issues/2006/apr/05_0167.htm (accessed May 25, 2008).Google Scholar
Wivel, ME. NIMH report: NIH consensus conference stresses need to identify reversible causes of dementia. Hosp Community Psychiatry. 1988;39:22–3.Google Scholar
Clarfield, AM. The decreasing prevalence of reversible dementias: an updated meta-analysis. Arch Intern Med. 2003;163:2219–29.Google Scholar
Clarfield, AM. The reversible dementias: do they reverse? Ann Intern Med. 1988;109:476–86.Google Scholar
Williams, MA, Relkin, NR. Diagnosis and management of idiopathic normal-pressure hydrocephalus. Neurol Clin Pract. 2013;3:375–85.Google Scholar
Kiefer, M, Unterberg, A. The differential diagnosis and treatment of normal-pressure hydrocephalus. Dtsch Arztebl Int. 2012;109:1525.Google Scholar
Tueth, MJ, Cheong, JA. Delirium: diagnosis and treatment in the older patient. Geriatrics. 1993;48:7580.Google Scholar
Inouye, SK, Westendorp, RG, Saczynski, JS. Delirium in elderly people. Lancet. 2014;8(383):911–22.Google Scholar
Petersen, RC, Roberts, RO, Knopman, DS, et al. Prevalence of mild cognitive impairment is higher in men: the Mayo Clinic study of aging. Neurology. 2010;75:889–97.Google Scholar
Sachdev, PS, Lipnicki, DM, Crawford, J, et al. Risk profiles of subtypes of mild cognitive impairment: the Sydney memory and ageing study. J Am Geriatr Soc. 2012;60:2433.Google Scholar
Roberts, RO, Geda, YE, Knopman, DS, et al. The incidence of MCI differs by subtype and is higher in men: the Mayo Clinic study of aging. Neurology. 2012;78:342–51.Google Scholar
Roberts, RO, Geda, YE, Knopman, DS, et al. Cardiac disease associated with increased risk of nonamnestic cognitive impairment: stronger effect on women. JAMA Neurology. 2013;70:374–82.Google Scholar
Mitchell, AJ, Shiri-Feshki, M. Rate of progression of mild cognitive impairment to dementia – meta-analysis of 41 robust inception cohort studies. Acta Psychiatr Scand. 2009;119:252–65.Google Scholar
Boyle, PA, Buchman, AS, Wilson, RS, et al. The APOE epsilon4 allele is associated with incident mild cognitive impairment among community-dwelling older persons. Neuroepidemiology. 2010;34:43–9.Google Scholar
De Meyer, G, Shapiro, F, Vanderstichele, H, et al. Diagnosis-independent Alzheimer disease biomarker signature in cognitively normal elderly people. Arch Neurol. 2010;67:949–56.Google Scholar
Heister, D, Brewer, JB, Magda, S, et al. for the Alzheimer’s Disease Neuroimaging Initiative. Predicting MCI outcome with clinically available MRI and CSF biomarkers. Neurology. 2011;77:1619–28.Google Scholar
Landau, SM, Harvey, D, Madison, CM, et al. Comparing predictors of conversion and decline in mild cognitive impairment. Neurology. 2010;75:230–8.Google Scholar
Lo, RY, Hubbard, AE, Shaw, LM, et al. Longitudinal change of biomarkers in cognitive decline. Arch Neurol. 2011;68:1257–66.Google Scholar
Van Rossum, IA, Vos, SJ, Burns, L, et al. Injury markers predict time to dementia in subjects with MCI and amyloid pathology. Neurology. 2012;79:1809–16.Google Scholar
Vemuri, P, Wiste, HJ, Weigand, SD, et al. Serial MRI and CSF biomarkers in normal aging, MCI, and AD. Neurology. 2010;75:143–51.CrossRefGoogle ScholarPubMed
Small, GW, Rabins, PV, Barry, PP, et al. Diagnosis and treatment of Alzheimer’s disease and related disorders. JAMA. 1997;278:1363–71.Google Scholar
Auer, S, Reisberg, B. The GDS/FAST system. Int Psychogeriatr. 1997;9:167–71.Google Scholar
Folstein, M, Anthony, JC, Parchad, I, et al. The meaning of cognitive impairment in the elderly. J Am Geriatr Soc. 1985;33:228–35.Google Scholar
Hancock, P, Larner, AJ. Test your memory test: diagnostic utility in a memory clinic population. Int J Geriatr Psychiatry. 2011;26:976–80.Google Scholar
Grigoletto, F, Zappala, G, Anderson, DW, et al. Norms for the mini-mental state examination in a healthy population. Neurology. 1999;53:315–20.Google Scholar
Dufouil, C, Clayton, D, Brayne, C, et al. Population norms for the MMSE in the very old: estimates based on longitudinal data. Neurology. 2000;55:1609–13.Google Scholar
Karlawish, JH, Casarett, DJ, James, BD, et al. The ability of persons with Alzheimer disease (AD) to make a decision about taking an AD treatment. Neurology. 2005;64:1514–19.Google Scholar
Pruchno, RA, Smyer, MA, Rose, MS, et al. Competence of long-term care residents to participate in decisions about their medical care: a brief, objective assessment. Gerontologist. 1995;35: 622–9.Google Scholar
Stahelin, HB, Monsch, AU, Spiegel, R. Early diagnosis of dementia via a two-step screening and diagnostic procedure. Int Pyschogeriatr. 1997;9:123–30.Google Scholar
Powlishta, KK, Von Dras, DD, Stanford, A, et al. The clock drawing test is a poor screen for very mild dementia. Neurology. 2002;59:898903.Google Scholar
Borson, S, Scanlan, J, Brush, M, et al. The Mini-Cog: a cognitive “vital signs” measure for dementia screening in multi-lingual elderly. Int J Geriatr Psychiatry. 2000;15:1021–7.Google Scholar
Borson, S, Scanlan, J, Chen, P, et al. The Mini-Cog as a screen for dementia: validation in a population-based sample. J Am Geriatr Soc. 2003;51:1451–4.Google Scholar
Nasreddine, Z, Phillips, N, Bédirian, V, et al. The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc. 2005; 53:695–9.Google Scholar
Fujiwara, Y, Suzuki, H, Yasunaga, M, et al. Brief screening tool for mild cognitive impairment in older Japanese: validation of the Japanese version of the Montreal Cognitive Assessment. Geriatrics & Gerontology International. 2010;10:225–32.Google Scholar
Larner, AJ. Screening utility of the Montreal Cognitive Assessment (MoCA): in place of – or as well as – the MMSE? International Psychogeriatrics. 2012;24:391–6.Google Scholar
Dong, Y, Sharma, VK, Venketasubramanian, N, et al. The Montreal Cognitive Assessment (MoCA) is superior to the Mini-Mental State Examination (MMSE) for the detection of vascular cognitive impairment after acute stroke. J. Neurol. Sci. 2010;299:1518.Google Scholar
Godefroy, O, Fickl, A, Roussel, M, et al. Is the Montreal Cognitive Assessment superior to the Mini-Mental State Examination to detect poststroke cognitive impairment? A study with neuropsychological evaluation. Stroke. 2011;42:1712–16.Google Scholar
Pendlebury, ST, Cuthbertson, FC, Welch, SJ, et al. Underestimation of cognitive impairment by Mini-Mental State Examination versus the Montreal Cognitive Assessment in patients with transient ischemic attack and stroke: a population-based study. Stroke. 2010;41:1290–3.Google Scholar
Petersen, RC, Smith, GE, Ivnik, RJ, et al. Apolipoprotein E status as a predictor of the development of Alzheimer’s disease in memory-impaired individuals. JAMA. 1995;273:1274–8.Google Scholar
Chandler, MJ, Lacritz, LH, Hynan, LS, et al. A total score for the CERAD neuropsychological battery. Neurology. 2005;65:102–6.Google Scholar
McGurn, B, Starr, JM, Topfer, JA, et al. Pronunciation of irregular words is preserved in dementia, validating premorbid IQ estimation. Neurology. 2004;62:1184–6Google Scholar
Weyting, MD, Bossuyt, PM, van Crevel, H. Reversible dementia: more than 10% or less than 1%? A quantitative review. J Neurol. 1995;242:466–71.Google Scholar
Mapstone, M, Cheema, AK, Fiandaca, MS, et al. Plasma phospholipids identify antecedent memory impairment in older adults. Nat Med. 2014;20:415–18.Google Scholar
Goldman, JS, Hahn, SE, Catania, JW, et al. Genetic counseling and testing for Alzheimer disease: joint practice guidelines of the American College of Medical Genetics and the National Society of Genetic Counselors. Genet Med. 2011;13:597605.Google Scholar
Henderson, AS, Easteal, S, Jorm, AF. Apolipoprotein E allele epsilon 4, dementia, and cognitive decline in a population sample. Lancet. 1995;346:1387–90.Google Scholar
Galasko, D. Cerebrospinal fluid biomarkers in Alzheimer disease: a fractional improvement? Arch Neurol. 2003;60:1195–6.Google Scholar
Albert, M, DeCarli, C, DeKosky, S, et al. The use of MRI and PET for the clinical diagnosis of dementia and investigation of cognitive impairment: consensus report. Available at: www.alz.org/national/documents/Imaging_consensus_report.pdf (accessed May 25, 2008).Google Scholar
Killiany, RJ, Gomez-Isla, T, Moss, M, et al. Use of structural magnetic resonance imaging to predict who will get Alzheimer’s disease. Ann Neurol. 2000;47:430–9.Google Scholar
Adak, S, Illouz, K, Gorman, W, et al. Predicting the rate of cognitive decline in aging and early Alzheimer disease. Neurology. 2004;63:108–14.Google Scholar
Weiner, MW, Veitch, DP, Aisen, PS, et al. The Alzheimer’s disease neuroimaging initiative: a review of papers published since its inception. Alzheimer’s & Dementia. 2012;8(1 Suppl):S168.Google Scholar
Wu, X, Chen, K, Yao, L, et al. Assessing the reliability to detect cerebral hypometabolism in probable Alzheimer’s disease and amnestic mild cognitive impairment. J Neurosci Methods. 2010;192:277–85.CrossRefGoogle ScholarPubMed
McKhann, GM, Knopman, DS, Chertkow, H, et al. The diagnosis of dementia due to Alzheimer’s disease: recommendations from the National Institute on Aging – Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement. 2011;7:263–9.Google Scholar
Klunk, WE, Engler, H, Nordberg, A, et al. Imaging brain amyloid in Alzheimer’s disease with Pittsburgh Compound-B. Ann Neurol. 2004;55:306–19.Google Scholar
Jack, CR Jr, Lowe, VJ, Weigand, SD, et al. Serial PIB and MRI in normal, mild cognitive impairment and Alzheimer’s disease: implications for sequence of pathological events in Alzheimer’s disease. Brain. 2009;132:1355–65.Google Scholar
Cordell, CB, Borson, S, Boustani, M, et al. Alzheimer’s Association recommendations for operationalizing the detection of cognitive impairment during the Medicare annual wellness visit in a primary care setting. Alzheimers Dement. 2013;9:141–50.Google Scholar
Lin, JS, O’Connor, E, Rossom, RC, et al. Screening for cognitive impairment in older adults: a systematic review for the US Preventive Services Task Force. Annals of Internal Medicine. 2013;159(9)601–12.Google Scholar
Trinh, NH, Hoblyn, J, Mohanty, S, et al. Efficacy of cholinesterase inhibitors in the treatment of neuropsychiatric symptoms and functional impairment in Alzheimer disease: a meta-analysis. JAMA. 2003;289(2):210–16.Google Scholar
Kaduszkiewicz, H, Zimmermann, T, Beck-Bornhold, HP, et al. Cholinesterase inhibitors for patients with Alzheimer’s disease: systematic review of randomised clinical trials. BMJ. 2005;331:321–7.Google Scholar
Doody, RS, Stevens, JC, Beck, C, et al. Practice parameter: management of dementia (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology. 2001;56:1154–66.Google Scholar
Geldmacher, DS, Provenzano, G, McRae, T, et al. Donepezil is associated with delayed nursing home placement in patients with Alzheimer’s disease. J Am Geriatr Soc. 2003;51:937–44.Google Scholar
Grossberg, GT. The ABC of Alzheimer’s disease: behavioral symptoms and their treatment. Int Psychogeriatr. 2002;14(Suppl 1):2749.Google Scholar
Courtney, C, Farrell, D, Gray, R, et al. Long-term donepezil treatment in 565 patients with Alzheimer’s disease (AD2000): randomized double-blind trial. Lancet. 2004;363:2105–15.Google Scholar
Gill, SS, Anderson, GM, Fischer, HD, et al. Syncope and its consequences in patients with dementia receiving cholinesterase inhibitors: a population-based cohort study. Arch Intern Med. 2009;169:867–73.Google Scholar
Schneider, LS, Dagerman, KS, Higgins, JP, et al. Lack of evidence for the efficacy of memantine in mild Alzheimer disease. Arch Neurol. 2011;68:991–8.Google Scholar
McShane, R, Areosa Sastre, A, Miakaran, N. Memantine for dementia. Cochrane Database Syst Rev. 2006;2:CD003154.Google Scholar
Ridha, BH, Josephs, KA, Rossor, MN. Delusions and hallucinations in dementia with Lewy bodies: worsening with memantine. Neurology. 2005;65:481–2.Google Scholar
Reisberg, B, Doody, R, Stoffler, A, et al. Memantine in moderate-to-severe Alzheimer’s disease. NEJM. 2003;348:1333–41.Google Scholar
Doody, RS, Farlow, M, Aisen, PS, Alzheimer’s Disease Cooperative Study Data Analysis and Publication Committee. Phase 3 trials of solanezumab and bapineuzumab for Alzheimer’s disease. N Engl J Med. 2014;370:1460.Google Scholar
Salloway, S, Sperling, R, Fox, NC, et al. Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer’s disease. N Engl J Med. 2014;370:322–33.Google Scholar
Miller, ER, Pastor-Barriuso, R, Dalal, D, et al. Meta-analysis: high dosage vitamin E supplementation may increase all-cause mortality. Ann Intern Med. 2005;142:3746.Google Scholar
Dysken, MW, Sano, M, Asthana, S, et al. Effect of vitamin E and memantine on functional decline in Alzheimer disease: the TEAM-AD VA cooperative randomized trial. JAMA. 2014;1;311:3344.Google Scholar
Aisen, PS, Saumier, D, Briand, R, et al. A phase II study targeting amyloid-B with 3-APS in mild-to-moderate Alzheimer disease. Neurology. 2006;67:1757–63.Google Scholar
Scharf, S, Mander, A, Ugoni, A, et al. A double-blind, placebo-controlled trial of diclofenac/misoprostol in Alzheimer’s disease. Neurology. 1999;53:197201.Google Scholar
Rich, JB, Rasmusson, DX, Folstein, MF, et al. Nonsteroidal anti-inflammatory drugs in Alzheimer’s disease. Neurology. 1995;45:51–5.Google Scholar
Coker, LH, Espeland, MA, Hogan, PE, et al. Change in brain and lesion after CEE therapies: the WHIMS-MRI studies. Neurology. 2014;82:427–34.Google Scholar
Coker, LH, Espeland, MA, Rapp, SR, et al. Postmenopausal hormone therapy and cognitive outcomes: the Women’s Health Initiative Memory Study (WHIMS). J Steroid Biochem Mol Biol. 2010;118:304–10.Google Scholar
Birks, J, Grimley, EV, Van Dongen, M. Ginkgo biloba for cognitive impairment and dementia. Cochrane Database Syst Rev. 2002;CD003120.Google Scholar
Snitz, BE, O’Meara, ES, Carlson, MC, et al. Ginkgo biloba for preventing cognitive decline in older adults: a randomized trial. JAMA. 2009;302:2663–70.Google Scholar
Angell, M, Kassirer, JP. Alternative medicine – the risks of untested and unregulated remedies. NEJM. 1998;339:839–41.CrossRefGoogle ScholarPubMed
Briones, TL, Darwish, H. Decrease in age-related tau hyperphosphorylation and cognitive improvement following vitamin D supplementation are associated with modulation of brain energy metabolism and redox state. Neuroscience. 2014;262:143–55.Google Scholar
Briones, TL, Darwish, H. Vitamin D mitigates age-related cognitive decline through the modulation of pro-inflammatory state and decrease in amyloid burden. J Neuroinflammation. 2012;9:244.Google Scholar
Craft, S, Baker, LD, Montine, TJ, et al. Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment: a pilot clinical trial. Arch Neurol. 2012;69:2938.Google Scholar
Newhouse, P, Kellar, K, Aisen, P, et al. Nicotine treatment of mild cognitive impairment: A 6-month double-blind pilot clinical trial. Neurology. 2012;78:91101.Google Scholar
Salloway, S, Sperling, R, Brashear, HR. Phase 3 trials of solanezumab and bapineuzumab for Alzheimer’s disease. N Engl J Med. 2014;370:1459–60.Google Scholar
Blennow, K, Zetterberg, H, Rinne, JO, et al. AAB-001 201/202 Investigators: effect of immunotherapy with bapineuzumab on cerebrospinal fluid biomarker levels in patients with mild to moderate Alzheimer disease. Arch Neurol. 2012;69:1002–10.Google Scholar
Farlow, M, Arnold, SE, van Dyck, CH, et al. Safety and biomarker effects of solanezumab in patients with Alzheimer’s disease. Alzheimer’s & Dementia. 2012;8:261–71.Google Scholar
Dodel, R, Rominger, A, Bartenstein, P, et al. Intravenous immunoglobulin for treatment of mild-to-moderate Alzheimer’s disease: a phase 2, randomised, double-blind, placebo-controlled, dose-finding trial. Lancet Neurology. 2013;12:233–43.Google Scholar
Shah, S, Federoff, HJ. Therapeutic potential of vaccines for Alzheimer’s disease. Immunotherapy. 2011;3:287–98.Google Scholar
Wiessner, C, Wiederhold, KH, Tissot, AC, et al. The second-generation active abeta immunotherapy CAD106 reduces amyloid accumulation in APP transgenic mice while minimizing potential side effects. Journal of Neuroscience. 2011;31:9323–31.Google Scholar
Winblad, B, Andreasen, N, Minthon, L, et al. Safety, tolerability, and antibody response of active abeta immunotherapy with CAD106 in patients with alzheimer’s disease: Randomised, double-blind, placebo-controlled, first-in-human study. Lancet Neurology. 2012;11:597604.Google Scholar
Wilson, RS, Mendes De Leon, CF, Barnes, LL, et al. Participation in cognitively stimulating activities and risk of incident Alzheimer disease. JAMA. 2002;287:742–8.Google Scholar
Wilson, RS, Bennett, DA, Bienias, JL, et al. Cognitive activity and incident AD in a population-based sample of older persons. Neurology. 2002;59:1910–14.Google Scholar
Verghese, J, Lipton, RB, Katz, MJ, et al. Leisure activities and the risk of dementia in the elderly. NEJM. 2003;348:2508–16.Google Scholar
Weuve, J, Kang, JH, Manson, JE, et al. Physical activity, including walking, and cognitive function in older women. JAMA. 2004;292:1454–61.Google Scholar
Van Gelder, BM, Tijhuis, MAR, Kalmijn, S, et al. Physical activity in relation to cognitive decline in elderly men; the FINE study. Neurology. 2004;63:2316–21.Google Scholar
Teri, L, Gibbons, LE, McCurry, SM, et al. Exercise plus behavioral management in patients with Alzheimer disease: a randomized controlled trial. JAMA. 2003;290:2015–22.Google Scholar
Rolland, Y, Rival, L, Pillard, F, et al. Feasibility of regular physical exercise for patients with moderate to severe Alzheimer disease. J Nutr Health Aging. 2000;4:109–13.Google Scholar
Dvorak, RV, Poehlman, ET. Appendicular skeletal muscle mass, physical activity, and cognitive status in patients with Alzheimer’s disease. Neurology. 1998;51:1386–90.Google Scholar
Lauque, S, Arnaud-Battandier, F, Gillette, S, et al. Improvement of weight and fat-free mass with oral nutritional supplementation in patients with Alzheimer’s disease at risk of malnutrition: a prospective randomized study. J Am Geriatr Soc. 2004;52:1702–7.Google Scholar
Scarmeas, N, Luchsinger, JA, Schupf, N, et al. Physical activity, diet, and risk of Alzheimer disease. JAMA. 2009;302:627–37.Google Scholar
Ngandu, T, Lehtisalo, J, Solomon, A, et al. A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial. Lancet. 2015;385(9984):2255–63.Google Scholar
Mohamed, S, Rosenheck, R, Lyketsos, CG, et al. Caregiver burden in Alzheimer disease: cross-sectional and longitudinal patient correlates. Am J Geriatr Psychiatry. 2010;18: 917–27.Google Scholar
Okura, T, Langa, KM. Caregiver burden and neuropsychiatric symptoms in older adults with cognitive impairment: the aging, demographics, and memory study (ADAMS). Alzheimer Dis Assoc Disord. 2011;25: 116–21.Google Scholar
Okura, T, Plassman, BL, Steffens, DC, et al. Prevalence of neuropsychiatric symptoms and their association with functional limitations in older adults in the United States: the aging, demographics, and memory study. J Am Geriatr Soc. 2010;58: 330–7.Google Scholar
Brodaty, H, Arasaratnam, C. Meta-analysis of nonpharmacological interventions for neuropsychiatric symptoms of dementia. Am J Psychiatry. 2012;169:946–53.Google Scholar
Teri, L, Rabins, P, Whitehourse, P, et al. Management of behavior disturbance in Alzheimer disease: current knowledge and future directions. Alzheimer Dis Assoc Disord. 1992;6:7788.Google Scholar
Roca, RP. Managing the behavioral complications of dementia. In: Cobbs, EL, Duthie, EH, Murphy, JB, eds. Geriatric Review Syllabus: A Core Curriculum in Geriatric Medicine. 4th ed., Iowa: Kendall/Hunt; 1999:183–6.Google Scholar
Gitlin, LN, Winter, L, Dennis, MP, Hodgson, N, Hauck, WW. Targeting and managing behavioral symptoms in individuals with dementia: a randomized trial of a nonpharmacological intervention. J Am Geriatr Soc. 2010;58:1465–74.Google Scholar
Lyketsos, CG, Steinberg, M, Tschanz, JT, et al. Mental and behavioral disturbances in dementia. Am J Psychiatry. 2000;157:708–14.Google Scholar
Khachiyants, N, Trinkle, D, Son, SJ, et al. Sundown syndrome in persons with dementia: an update. Psychiatry Investig. 2011;4:275–87.Google Scholar
Cohen-Mansfield, J, Werner, P. Management of verbally disruptive behaviors in nursing home residents. J Gerontol Med Sci. 1996;52:M369–77.Google Scholar
Sloane, PD, Hoeffer, B, Mitchell, CM, et al. Effect of person-centered showering and the towel bath on bathing-associated aggression, agitation, and discomfort in nursing home residents with dementia: a randomized, controlled trial. J Am Geriatr Soc. 2004;52:17951804.Google Scholar
Porsteinsson, AP, Drye, LT, Pollock, BG, et al. Effect of citalopram on agitation in Alzheimer disease: the CitAD randomized clinical trial. JAMA. 2014;311:682–91.Google Scholar
Lonergan, E, Luxenberg, J, Colford, J. Haloperidol for agitation in dementia. Cochrane Database Syst Rev. 2002;CD0003154.Google Scholar
Wilson, MP, Pepper, D, Currier, GW, et al. The psychopharmacology of agitation: consensus statement of the American Association for Emergency Psychiatry Project Beta psychopharmacology workgroup. West J Emerg Med. 2012;13:2634.Google Scholar
Schneider, LS, Tariot, PN, Dagerman, KS, et al. for the CATIE-AD Study Group. Effectiveness of atypical antipsychotic drugs in patients with Alzheimer’s disease. NEJM. 2006;355:15251538.Google Scholar
Sink, KM, Holden, KF, Yaffe, K. Pharmacological treatment of neuropsychiatric symptoms of dementia: a review of the evidence. JAMA. 2005;293:596608.Google Scholar
Lee, PE, Gill, SS, Freedman, M, et al. Atypical antipsychotic drugs in the treatment of behavioural and psychological symptoms of dementia: systematic review. BMJ. 2004;329:75.Google Scholar
Kuehn, BM. FDA warns antipsychotic drugs may be risky for elderly. JAMA. 2005;293:2462.Google Scholar
Schneider, LS, Dagerman, KS, Insel, P. Risk of death with atypical antipsychotic drug treatment for dementia: meta-analysis of randomized placebo-controlled trials. JAMA. 2005;294:1934–42.Google Scholar
Wang, PS, Schneeweiss, S, Avorn, J, et al. Risk of death in elderly users of conventional vs. atypical antipsychotic medications. NEJM. 2005;353:2335–41.Google Scholar
Nelson, JC, Devanand, DP. A systematic review and meta-analysis of placebo-controlled antidepressant studies in people with depression and dementia. J Am Geriatr Soc. 2011;59:577–85.Google Scholar
Weintraub, D, Rosenberg, PB, Drye, LT, et al. Sertraline for the treatment of depression in Alzheimer disease: week-24 outcomes. Am J Geriatr Psychiatry. 2010;18:332–40.Google Scholar
Banerjee, S, Hellier, J, Dewey, M et al. Sertraline or mirtazapine for depression in dementia (HTA-SADD): a randomised, multicentre, double-blind, placebo-controlled trial. Lancet. 2011 Jul 30;378(9789):403–11.Google Scholar
Banerjee, S, Hellier, J, Romeo, R, et al. Study of the use of antidepressants for depression in dementia: the HTA-SADD trial – a multicentre, randomised, double-blind, placebo-controlled trial of the clinical effectiveness and cost-effectiveness of sertraline and mirtazapine. Health Technol Assess. 2013;17:1166.Google Scholar
Coupland, C, Dhiman, P, Morriss, R, et al. Antidepressant use and risk of adverse outcomes in older people: population based cohort study. BMJ. 2011;343:d4551.Google Scholar
Burrows, G, Kremer, C. Mirtazipine: clinical advantages in the treatment of depression. Psychopharmacology. 1997;17(Suppl): 34S39S.Google Scholar
Camargos, E, Louzado, L, Quintas, J. Trazodone improves sleep parameters in Alzheimer disease patients: a randomized, double-blind, and placebo-controlled study. Am J Geriatr Psychiatry. 2014 Dec;22(12):1565–74.Google Scholar
Drachman, DA, Swearer, JM. Driving and Alzheimer’s disease: the risk of crashes [published erratum appears in Neurology. 1994;44:4]. Neurology. 1993;43:2448–56.Google Scholar
Iverson, DJ, Gronseth, GS, Reger, MA, et al. Practice parameter update: evaluation and management of driving risk in dementia. Report of the quality standards subcommittee of the American Academy of Neurology. Neurology. 2010;74:1316–24.Google Scholar
American Geriatric Society Ethics Committee and Clinical Practice and Models of Care Committee. American Geriatrics Society feeding tubes in advance dementia position statement. J Am Geriatr Soc. 2014;62:1590–3.Google Scholar
Mitchell, SL, Teno, JM, Kiely, DK, et al. The clinical course of advanced dementia. N Engl J Med. 2009;361:1529–38.Google Scholar
Gillick, MR. Rethinking the role of tube feeding in patients with advanced dementia. NEJM. 2000;342:206–10.Google Scholar
Arai, Y, Sugiura, M, Washio, M, Miura, H, Kudo, K. Caregiver depression predicts early discontinuation of care for disabled elderly at home. Psychiatry Clin Neurosci. 2001;55:379–82.Google Scholar
Belle, SH, Burgio, L, Burns, R, et al. Enhancing the quality of life of dementia caregivers from different ethnic or racial groups. Ann Intern Med. 2006;145:727–38.Google Scholar
Newcomer, R, Yordi, C, DuNah, R, Fox, P, Wilkinson, A. Effects of the Medicare Alzheimer’s Disease Demonstration on caregiver burden and depression. Health Serv Res. 1999;34:669–89.Google Scholar
Gaugler, JE, Jarrott, SE, Zarit, SH, Stephens, MA, Townsend, A, Greene, R. Respite for dementia caregivers: the effects of adult day service use on caregiving hours and care demands. Int Psychogeriatr. 2003;15:3758.Google Scholar
Kennedy, GJ. Dementia. In: Cassel, CK, Leipzig, R, Cohen, HJ, Larson, EB, Meier, DE. eds. Geriatric Medicine: An Evidence-Based Approach. 4th ed. New York: Springer-Verlag; 2003:1074–93.Google Scholar

Save book to Kindle

To save this book to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×