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  • Print publication year: 2013
  • Online publication date: April 2013

3 - Mechanical Control of Adult Mesenchymal Stem Cells in Cardiac Applications

from Section I - Basic Principles of Regenerative Pharmacology

References

1. NovotnyN, et al. Stem cell therapy in myocardial repair and remodeling. J Am Coll Surg 2008; 207(3): 423–434.
2. NagayaN, et al. Model of dilated cardiomyopathy transplantation of mesenchymal stem cells improves cardiac function in a rat. Circulation 2005; 112: 1128–1135.
3. PerinEC, et al. Transendocardial, autologous bone marrow cell transplantation for severe, chronic ischemic heart failure. Circulation 2003; 107(18): 2294–2302.
4. YuLH, et al. Improvement of cardiac function and remodeling by transplanting adipose tissue-derived stromal cells into a mouse model of acute myocardial infarction. Int J Cardiol 2010; 139(2): 166–172.
5. HuX, et al. Transplantation of hypoxia-preconditioned mesenchymal stem cells improves infarcted heart function via enhanced survival of implanted cells and angiogenesis. J Thorac Cardiovasc Surg 2008; 135(4): 799–808.
6. ZhouY, et al. Marrow stromal cells differentiate into vasculature after allogeneic transplantation into ischemic myocardium. Ann Thorac Surg 2011; 91(4): 1206–1212.
7. MathieuM, et al. Cell therapy with autologous bone marrow mononuclear stem cells is associated with superior cardiac recovery compared with use of nonmodified mesenchymal stem cells in a canine model of chronic myocardial infarction. J Thorac Cardiovasc Surg 2009; 138(3): 646–653.
8. GnecchiM, et al. Early beneficial effects of bone marrow-derived mesenchymal stem cells overexpressing akt on cardiac metabolism after myocardial infarction. Stem Cells 2009; 27(4): 971–979.
9. WangD, et al. Mesenchymal stem cell injection ameliorates the inducibility of ventricular arrhythmias after myocardial infarction in rats. J Cardiol 2011; 152(3): 314–320.
10. ZhouY, et al. Direct injection of autologous mesenchymal stromal cells improves myocardial function. Biochem Biophys Res Comm 2009; 390(3): 902–907.
11. MeluzinJ, et al. Intracoronary delivery of bone marrow cells to the acutely infarcted myocardium. Cardiology 2009; 112: 98–106.
12. OhnishiS, et al. Mesenchymal stem cells attenuate cardiac fibroblast proliferation and collagen synthesis through paracrine actions. FEBS Lett 2007; 581: 3961–3966.
13. SegersVFM, LeeRT. Stem cell therapy for cardiac disease. Nature 2008; 451: 937–942.
14. GnecchiM, et al. Paracrine mechanisms in adult stem cell signaling and therapy. Circ Res 2008; 103: 1204–1219.
15. TeradaN, et al. Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion. Nature 2002; 416: 542–545.
16. Avitabile D, et al. Human cord blood CD34+ progenitor cells acquire functional cardiac properties through a cell fusion process. Am J Physiol Heart Circ 2011; 300(5): H1875–1884.
17. NygrenJ, et al. Bone-marrow derived hematopoietic cells generate cardiomyocytes at a low frequency through cell fusion, but not transdifferentiation. Nat Med 2004; 10(5): 494–501.
18. AcquistapaceA, et al. Human mesenchymal stem cells reprogram adult cardiomyocytes towards a progenitor-like state through partial cell fusion and mitochondria transfer. Stem Cells 2011; 29(5): 812–824.
19. XuW, et al. Mesenchymal stem cells from adult human bone marrow differentiate into a cardiomyocyte phenotype in vitro. Exp Biol Med 2004; 229: 623–631.
20. LuT, et al. Cardiomyocyte differentiation of rat bone marrow multipotent progenitor cells is associated with downregulation of Oct-4 expression. Tissue Eng Part A 2010; 16(10): 3111–3117.
21. SongY, et al. VEGF is critical for spontaneous differentiation of stem cells into cardiomyocytes. Biochem Biophys Res Comm 2007; 354: 999–1003.
22. ShakeJ, et al. Mesenchymal stem cell implantation in a swine myocardial infarct model: engraftment and functional effects. Ann Thorac Surg 2002; 73: 1919–1926.
23. BerkB, FujiwaraK, LehouxS. ECM remodeling in hypertensive heart disease. J Clin Invest 2007; 117(3): 568–75.
24. WangM, et al. STAT3 mediates bone marrow mesenchymal stem cell VEGF production. J Mol Cell Cardiol 2007; 42 1009–1015.
25. HerrmannJL, et al. IL-6 and TGF-alpha costimulate mesenchymal stem cell VEGF production by ERK, JNK, and PI3K-mediated mechanisms. Shock 2011; 35(5): 512–516.
26. MacKennaD, et al. Role of mechanical factors in modulating cardiac fibroblast function and extracellular matrix synthesis. Cardiovasc Res 2000; 46: 257–263.
27. EnglerA, et al. Matrix elasticity directs stem cell lineage specification. Cell 2006; 126: 677–689.
28. BatorskyA, et al. Encapsulation of adult human mesenchymal stem cells within collagen-agarose microenvironments. Biotechnol Bioeng 2005; 92(4): 492–500.
29. WatanabeH, et al. Multiphysics simulation of left ventricular filling dynamics using fluid-structure interaction finite element method. Biophys J 2004; 87: 2074–2085.
30. OertelH, et al. Modeling Human Cardiac Fluid Mechanics. 2nd ed. Universitatsverlag Karlsruhe, Germany, 2006.
31. HamiltonD, et al. Characterization of the response of bone marrow-derived progenitor cells to cyclic strain: implications for vascular tissue-engineering applications. Tissue Eng 2004; 10(3/4).
32. KobayashiN, et al. Mechanical stress promotes the expression of smooth muscle-like properties in marrow stromal cells. Exp Hematol 2004; 32: 1238–1245.
33. ParkJ, et al. Mechanobiology of mesenchymal stem cells and their use in cardiovascular repair. Frontiers Biosci 12 (2007), 5098–5116.
34. ParkJ, et al. Differential effects of equiaxial and uniaxial strain on mesenchymal stem cells. Biotechnol Bioeng 2004; 88(3).
35. KongCR, et al. Mechanoelectrical excitation by fluid jets in monolayers of cultured cardiac myocytes. J Appl Physiol 2005; 98: 2328–2336.
36. WangH, et al. Shear stress induces endothelial differentiation from a murine embryonic mesenchymal progenitor cell line. Arterioscler Thromb Vasc Biol 2005; 25: 1817–1823.
37. WangX, LiQ. The roles of mesenchymal stem cells (MSC) therapy in ischemic heart diseases. Biochem Biophys Res Comm 359 (2007) 189–193.
38. Barallobre-BarreiroJ, et al. Gene expression profiles following intracoronary injection of mesenchymal stromal cells using a porcine model of chronic myocardial infarction. Cytotherapy 2011; 13(4): 407–418.
39. GyöngyösiM, et al. Hypoxia-inducible factor 1-alpha release after intracoronary versus intramyocardial stem cell therapy in myocardial infarction. J Cardiovasc Transl Res 2010; 3(2): 114–121.
40. GermainP, et al. Myocardial flow reserve parametric map, assessed by first-pass MRI compartmental analysis at the chronic stage of infarction. J Magn Reson Imaging 2001; 13(3): 352–360.
41. GyöngyösiM, et al. Delayed recovery of myocardial blood flow after intracoronary stem cell administration. Stem Cell Rev 2011; 7(3): 616–623.
42. MiyaharaY, et al. Monolayered mesenchymal stem cells repair scarred myocardium after myocardial infarction. Nat Med 2006; 12(4): 459–465.
43. SimpsonD, et al. A tissue engineering approach to progenitor cell delivery results in significant cell engraftment and improved myocardial remodeling. Stem Cells 2007; 25: 2350–2357.
44. ZhangGE, et al. Enhancing a PEGylated fibrin biomatrix. Tissue Eng Part A 2008; 14(6).
45. WangB, et al. Fabrication of cardiac patch with decellularized porcine myocardial scaffold and bone marrow mononuclear cells. J Biomed Mat Res A 2010; 94A(4): 1100–1110.
46. MangiA, et al. Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts. Nat Med 2003; 9(9): 1195–1201.
47. MirotsouM, et al. Secreted frizzled related protein 2 (Sfrp2) is the key Akt-mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair. PNAS 2007; 104(5): 1643–1648.
48. GraussR, et al. Forced myocardin expression enhances the therapeutic effect of human mesenchymal stem cells after transplantation in ischemic mouse hearts. Stem Cells 2008; 26: 1083–1093.
49. BaoC, et al. Enhancement of the survival of engrafted mesenchymal stem cells in the ischemic heart by TNFR gene transfection. Biochem Cell Biol 2010; 88(4): 629–634.
50. GnecchiM, et al. Early beneficial effects of bone marrow-derived mesenchymal stem cells overexpressing Akt on cardiac metabolism after myocardial infarction. Stem Cells 2009; 27(4): 971–979.
51. NoiseuxN, et al. Mesenchymal stem cells overexpressing Akt dramatically repair infarcted myocardium and improve cardiac function despite infrequent cellular fusion or differentiation. Molec Ther 2006; 14(6): 840–850.
52. FischerKM, et al. Cardiac progenitor cell commitment is inhibited by nuclear Akt expression. Circ Res 2011; 108(8): 960–970.
53. HatzistergosKE, et al. Bone marrow mesenchymal stem cells stimulate cardiac stem cell proliferation and differentiation. Circ Res 2010; 107(7): 913–22.
54. TangJM, et al. VEGF/SDF-1 promotes cardiac stem cell mobilization and myocardial repair in the infarcted heart. Cardiovasc Res 2011;.
55. BarileL, et al. Bone marrow-derived cells can acquire cardiac stem cells properties in damaged heart. J Cell Mol Med 2011; 15(1): 63–71.
56. NguyenBK, et al. Improved function and myocardial repair of infarcted heart by intracoronary injection of mesenchymal stem cell-derived growth factors. J Cardiovasc Transl Res 2010; 3(5): 547–558.
57. DaiW, et al. Role of a paracrine action of mesenchymal stem cells in the improvement of left ventricular function after coronary artery occlusion in rats. Regen Med 2007; 2(1): 63–68.
58. AngoulvantD, et al. Mesenchymal stem cell conditioned media attenuates in vitro and ex vivo myocardial reperfusion injury. J Heart Lung Transplant 2011; 30(1): 95–102.
59. BreitbachM, et al. Potential risks of bone marrow cell transplantation into infarcted hearts. Blood 2007; 110: 1362–1369.
60. KnippenbergM, et al. Adipose tissue-derived mesenchymal stem cells acquire bone cell-like responsiveness to fluid shear stress on osteogenic stimulation. Tissue Eng 2005; 11(11): 1780–1788.
61. SumanasingheR, et al. Osteogenic differentiation of human mesenchymal stem cells in collagen matrices: effect of uniaxial cyclic tensile strain on bone morphogenetic protein (BMP-2) mRNA expression. Tissue Eng 2006; 12(12): 3459–3465.
62. HuangCY, et al. Effects of cyclic compressive loading on chondrogenesis of rabbit bone-marrow derived mesenchymal stem cells. Stem Cells 2004; 22(3): 313–323.
63. Lorenzen-SchmidtI, et al. Chronotropic response of cultured neonatal rat ventricular myocytes to short-term fluid shear. Cell Biochem Biophys 2006; 46(2).
64. CarlsonS, et al. Cardiac mesenchymal stem cells contribute to scar formation after myocardial infarction. Circ Res 2011; 91(1): 99–107.
65. LasalaGP, et al. Combination stem cell therapy for the treatment of medically refractory coronary ischemia: a Phase I study. Cardiovasc Revasc Med 2011; 12(1): 29–34.
66. HareJM, et al. A randomized, double-blind, placebo-controlled, dose-escalation study of intravenous adult human mesenchymal stem cells (prochymal) after acute myocardial infarction. J Am Coll Cardiol 2009; 54(24): 2277–2286.
67. TaberL, et al. Mechanics of ventricular torsion. JBiomech 1996; 29(6): 745–752.
68. TendulkarA, HarkenA. Mechanics of the normal heart. J Card Surg 2006; 21: 615–620.
69. MehlhomU, et al. Myocardial fluid balance. Eur J Cardiothorac Surg 2001; 20: 1220–1230.
70. LeGriceIJ, et al. Transverse shear along myocardial cleavage planes provides a mechanism for normal systolic wall thickening. Circ Res 1995; 77: 182–193.
71. AshikagaH, et al. Changes in regional myocardial volume during the cardiac cycle: implications for transmural blood flow and cardiac structure. AJP Heart Circ Phys 2008; 295(2): H610–H618.
72. LeGriceIJ, et al. Laminar structure of the heart: ventricular myocyte arrangement and connective tissue architecture in the dog. Am J Physiol Heart Circ 1995; 269(38): H571–H582.
73. HarringtonK, et al. Direct measurement of transmural laminar architecture in the anterolateral wall of the ovine left ventricle: new implications for wall thickening mechanics. Am J Physiol Heart Circ 2005; 288: 1324–1330.
74. ArtsT, et al. Relating myocardial laminar architecture to shear strain and muscle fiber orientation. Am J Physiol Heart Circ 2001; 280: H2222–H2229.
75. DvirT, et al. Activation of the ERK1/2 cascade via pulsatile interstitial fluid flow promotes cardiac tissue assembly. Tissue Eng 2007; 13(9): 2185–2193.
76. StewartRH, et al. Regulation of microvascular filtration in the myocardium by interstitial fluid pressure. Am J Physiol Regulatory Integrative Comp Physiol 1996; 271: 1465–1469.
77. RabbanySY, et al. Intramyocardial pressure: interaction of myocardial fluid pressure and fiber stress. AJP Heart CircPhysiol 1989; 257(2): H357–H364.
78. DavisKL, et al. Effects of myocardial edema on the development of myocardial interstitial fibrosis. Microcirculation 2000; 7(4): 269–280.
79. HolmesJ, et al. Structure and mechanics of healing myocardial infarcts. Annu Rev Biomed Eng 2005. 7: 223–253.
80. WangJ, et al. Left ventricular twist mechanics in a canine model of reversible congestive heart failure: a pilot study. J Am Soc Echocardio 2009; 22: 95–98.
81. AikawaY, et al. Regional wall stress predicts ventricular remodeling after anteroseptal myocardial infarction in the Healing and Early Afterload Reducing Trial (HEART): An echocardiography-based structural analysis. Am Heart J 2001; 141: 234–42.
82. NishimuraS, et al. Single cell mechanics of rat cardiomyocytes under isometric, unloaded, and physiologically loaded conditions. Am J Physiol Heart Circ Physiol 2004; 287: H196–H202.
83. TracquiP, et al. Theoretical analysis of the adaptive contractile behaviour of a single cardiomyocyte cultured on elastic substrates with varying stiffness. J Theor Biol 2008; 255(1): 92–105.
84. GaliePA, et al. Reduced serum content and increased matrix stiffness promote the cardiac myofibroblast transition in 3D collagen matrices. Cardiovasc Pathol 2011; 20(6): 325–333.
85. SongG, et al. Mechanical stretch promotes proliferation of rat bone marrow mesenchymal stem cells. Colloids and surfaces B:Biointerfaces 2007; 58: 271–277.
86. DoyleAM, et al. Human mesenchymal stem cells form multicellular structures in response to applied cyclic strain. Ann Biomed Eng 2009; 37(4): 783–793.
87. FarngE, et al. The effects of GDF-5 and uniaxial strain on mesenchymal stem cells in 3-D culture. Clin Orthop Relat Res 2008; 466: 1930–1937.
88. DutyA, et al. Cyclic mechanical compression increases mineralization of cell-seeded polymer scaffolds in vivo. J Biomech Eng 2007; 129: 531–539.
89. BhangSH, et al. Cyclic mechanical strain promotes transforming-growth-factor-β1-mediated cardiomyogenic marker expression in bone-marrow-derived mesenchymal stem cells in vitro. Biotech Appl Biochem 2010; 55(4): 191–197.
90. KobayashiN, et al. Mechanical stress promotes the expression of smooth muscle-like properties in marrow stromal cells. Exp Hematol 2004; 32: 1238–1245.
91. ZhaoF, et al. Perfusion affects the tissue developmental patterns of human mesenchymal stem cells in 3D scaffolds. J Cell Physiol 2009; 219: 421–429.
92. EngelmayrG, et al. Cyclic flexure and laminar flow synergistically accelerate mesenchymal stem cell-mediated engineered tissue formation: Implications for engineered heart valve tissues. Biomaterials 2006; 27: 6083–6095.
93. O’CearbhaillED, et al. Response of mesenchymal stem cells to the biomechanical environment of the endothelium on a flexible tubular silicone substrate. Biomaterials 2008; 29: 1610–1619.
94. TanS, et al. Viscoelastic behavior of human mesenchymal stem cells. BMC Cell Biol 2008; 9: 40.
95. RosováI, et al. Hypoxic preconditioning results in increased motility and improved therapeutic potential of human mesenchymal stem cells. Stem Cells 2008; 26(8): 2173–2182.