Contents

pp v-vi

Contributors

pp vii-x

Foreword by Sir Gregory Winter

pp xi-xii

Preface

pp xiii-xiv

RECOMBINANT ANTIBODIES FOR IMMUNOTHERAPY

pp xv-xvi

PART I - HUMANIZED ANTIBODIES

pp 1-2

1 - Humanization of Recombinant Antibodies

pp 3-19

2 - Immunogenicity Assessment of Antibody Therapeutics

pp 20-42

3 - In Vitro Screening for Antibody Immunogenicity

pp 43-52

PART II - GENERATION AND SCREENING OF ANTIBODY LIBRARIES

pp 53-54

4 - Antibody Libraries from Naïve V Gene Sources

pp 55-65

5 - Antibodies from IgM Libraries

pp 66-74

6 - Generation and Screening of the Synthetic Human Combinatorial Antibody Library HuCAL GOLD

pp 75-86

PART III - TRANSGENIC HUMAN ANTIBODY REPERTOIRES

pp 87-88

7 - Therapeutic Antibodies from XenoMouse Transgenic Mice

pp 89-99

8 - VelocImmune: Immunoglobulin Variable Region Humanized Mice

pp 100-108

PART IV - ANTIBODY EFFECTOR FUNCTION

pp 109-110

9 - Mechanisms of Tumor Cell Killing by Therapeutic Antibodies

pp 111-123

10 - Optimization of Fc Domains to Enhance Antibody Therapeutics

pp 124-143

11 - Glycoengineered Therapeutic Antibodies

pp 144-154

PART V - ARMING ANTIBODIES

pp 155-156

12 - Monoclonal Antibodies for the Delivery of Cytotoxic Drugs

pp 157-173

13 - Immunotherapy with Radio-immune Conjugates

pp 174-189

14 - Immunotherapeutic Antibody Fusion Proteins

pp 190-200

PART VI - NOVEL ANTIBODY FORMATS

pp 201-202

15 - Alternative Antibody Formats

pp 203-215

16 - Single-Domain Antibodies

pp 216-230

17 - Engineering of Non-CDR Loops in Immunoglobulin Domains

pp 231-240

PART VII - ANTIGEN-BINDING REPERTOIRES OF NON-IMMUNOGLOBULIN PROTEINS

pp 241-242