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  • Print publication year: 2006
  • Online publication date: January 2010

6 - Teratogenic syndromes

Summary

It is quite remarkable that only about 20 of the more than 50,000 drugs and chemicals in common use are proven human teratogens (Jones, 1997, pp. 555–79; Schardein, 2000; Gorlin et al., 2001, pp.14–34). Considerably more – about 180 of 2800 tested – are teratogenic in two or more animal species (Schardein, 2000). The example of Dr. Lenz, the pediatrician who identified thalidomide babies in 1961, emphasizes the need for physicians to be alert and knowledgeable about potential teratogens. The reference of Schardein (2000) and telephone hotlines and websites offer guides to specific teratogens, including ReproTox (www.reprotox.org); TERIS plus Shephard's Catalogue of Teratogenic Agents (http:/ /depts.washington.edu/ ∼terisweb/index.html), International Toxicity Estimates for Risk Database (www. tera.org/iter/), and parent-oriented literature from the Organization of Teratology Information Services (www.otispregnancy.org). Although teratology is a general term for the study of developmental anomalies, it is used here in the more limited sense to describe anomalies caused by environmental agents (physical, chemical, or infectious).

Parents are frequently concerned about environmental exposures to substances such as pesticides or industrial agents when their child has a congenital anomaly. It is again reassuring that only one environmental chemical, methyl mercury, is a proven human teratogen. The many lawsuits concerning agents such as dioxin or Bendectin are truly an American tragedy (Brent, 2004). These unscrupulous awards provide sad testimony to our inadequate science of congenital anomalies. Brent (2004) has reviewed the criteria required to prove that an agent is a human teratogen.

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