Book contents
- Frontmatter
- Contents
- List of contributors
- Preface to the first edition
- Preface to the second edition
- Acknowledgements
- Abbreviations
- 1 Practical issues in the use of systemic anti-cancer therapy drugs
- 2 Biological treatments in cancer
- 3 Hormones in cancer
- 4 Pathology in cancer
- 5 Radiotherapy planning 1: fundamentals of external beam and brachytherapy
- 6 Radiotherapy planning 2: advanced external beam radiotherapy techniques
- 7 Research in cancer
- 8 Acute oncology 1: oncological emergencies
- 9 Acute oncology 2: cancer of unknown primary
- 10 Palliative|care
- 11 Management of cancer of the head and neck
- 12 Management of cancer of the oesophagus
- 13 Management of cancer of the stomach
- 14 Management of cancer of the liver, gallbladder and biliary tract
- 15 Management of cancer of the exocrine pancreas
- 16 Management of cancer of the colon and rectum
- 17 Management of cancer of the anus
- 18 Management of gastrointestinal stromal tumours
- 19 Management of cancer of the breast
- 20 Management of cancer of the kidney
- 21 Management of cancer of the bladder
- 22 Management of cancer of the prostate
- 23 Management of cancer of the testis
- 24 Management of cancer of the penis
- 25 Management of cancer of the ovary
- 26 Management of cancer of the body of the uterus
- 27 Management of cancer of the cervix
- 28 Management of cancer of the vagina
- 29 Management of cancer of the vulva
- 30 Management of gestational trophoblast tumours
- 31 Management of cancer of the lung
- 32 Management of mesothelioma
- 33 Management of soft tissue and bone tumours in adults
- 34 Management of the lymphomas and myeloma
- 35 Management of cancers of the central nervous system
- 36 Management of skin cancer other than melanoma
- 37 Management of melanoma
- 38 Management of cancer of the thyroid
- 39 Management of neuroendocrine tumours
- 40 Management of cancer in children
- Multiple choice questions
- Multiple choice answers
- Index
- References
36 - Management of skin cancer other than melanoma
Published online by Cambridge University Press: 05 November 2015
- Frontmatter
- Contents
- List of contributors
- Preface to the first edition
- Preface to the second edition
- Acknowledgements
- Abbreviations
- 1 Practical issues in the use of systemic anti-cancer therapy drugs
- 2 Biological treatments in cancer
- 3 Hormones in cancer
- 4 Pathology in cancer
- 5 Radiotherapy planning 1: fundamentals of external beam and brachytherapy
- 6 Radiotherapy planning 2: advanced external beam radiotherapy techniques
- 7 Research in cancer
- 8 Acute oncology 1: oncological emergencies
- 9 Acute oncology 2: cancer of unknown primary
- 10 Palliative|care
- 11 Management of cancer of the head and neck
- 12 Management of cancer of the oesophagus
- 13 Management of cancer of the stomach
- 14 Management of cancer of the liver, gallbladder and biliary tract
- 15 Management of cancer of the exocrine pancreas
- 16 Management of cancer of the colon and rectum
- 17 Management of cancer of the anus
- 18 Management of gastrointestinal stromal tumours
- 19 Management of cancer of the breast
- 20 Management of cancer of the kidney
- 21 Management of cancer of the bladder
- 22 Management of cancer of the prostate
- 23 Management of cancer of the testis
- 24 Management of cancer of the penis
- 25 Management of cancer of the ovary
- 26 Management of cancer of the body of the uterus
- 27 Management of cancer of the cervix
- 28 Management of cancer of the vagina
- 29 Management of cancer of the vulva
- 30 Management of gestational trophoblast tumours
- 31 Management of cancer of the lung
- 32 Management of mesothelioma
- 33 Management of soft tissue and bone tumours in adults
- 34 Management of the lymphomas and myeloma
- 35 Management of cancers of the central nervous system
- 36 Management of skin cancer other than melanoma
- 37 Management of melanoma
- 38 Management of cancer of the thyroid
- 39 Management of neuroendocrine tumours
- 40 Management of cancer in children
- Multiple choice questions
- Multiple choice answers
- Index
- References
Summary
Introduction
Non-melanoma skin cancer is the commonest cancer in the UK. It is usually caused by ultraviolet radiation from chronic sun exposure in a fair-skinned population. Basal cell carcinoma is the most frequent variety (74%), and presents as a superficial tumour that very rarely metastasises. Squamous cell carcinoma (23%) can spread to regional lymph nodes.
Surgical excision is the treatment of choice for the majority of tumours. Non-surgical treatment options include radiotherapy, curettage, imiquimod cream, photodynamic therapy and topical 5-FU therapy. Radiotherapy is an important treatment option for older patients and is preferred to surgery for large superficial tumours, multiple tumours, and in areas around the eye, nose and ear where the cosmetic results may be better and function can be preserved. The radiotherapy technique involves treatment with either superficial X-rays (SXR) or electron therapy. Cure rates are about 95% at 5 years.
The National Institute for Health and Clinical Excellence has published service guidance on the care of these patients (NICE, 2006).
Range of tumours
In the differential diagnosis, the tumour could be benign or malignant, and a malignant tumour could be either primary or secondary.
Premalignant conditions
Premalignant conditions include the following (Soutar and Robertson, 2001):
• actinic keratosis;
• Bowen's disease;
• erythroplasia of Queyrat;
• Paget's disease.
Benign tumours
Benign tumours include the following:
• benign naevus;
• sebaceous cyst;
• epidermal cyst;
• basal cell papilloma (seborrhoeic keratosis);
• vascular angioma;
• keratoacanthoma;
• dermatofi broma .
Malignant tumours
Primary malignant tumours include:
• basal cell carcinoma;
• squamous cell carcinoma;
• Merkel cell carcinoma;
• malignant eccrine porocarcinoma;
• amelanotic melanoma;
• cutaneous T-cell lymphoma;
• primary cutaneous B-cell lymphoma;
• Kaposi's sarcoma;
• angiosarcoma;
• lymphangiosarcoma;
• atypical fi broxanthoma.
Secondary malignant tumours can arise from any primary site, but occur most commonly from breast cancer, lung cancer, colon cancer and melanoma.
Incidence and epidemiology
There were about 100,000 cases of non-melanoma skin cancer in the UK in 2010. This comprises about 20% of all new cancers and there are about 500 deaths annually. More than 5% of the population over age 60 will develop a non-melanoma skin cancer (American Cancer Society, 2003).
- Type
- Chapter
- Information
- Practical Clinical Oncology , pp. 485 - 498Publisher: Cambridge University PressPrint publication year: 2015