Book contents
- Perinatal Neuropathology
- Perinatal Neuropathology
- Copyright page
- Contents
- Preface
- Acknowledgments
- Abbreviations
- Section I Techniques and Practical Considerations
- Section 2 Human Nervous System Development
- Neuroanatomic Site Development
- Chapter 19 Human Nervous System Development: Embryonic and Early Fetal Events
- Chapter 20 Cerebral Cortex, Including Germinal Matrix
- Chapter 21 White Matter, Including Myelination
- Chapter 22 Cerebellum: Development of the Rhombic Lip, Cerebellar Cortex, Dentate Nucleus
- Chapter 23 Spinal Cord
- Chapter 24 Skeletal Muscle and Peripheral Nerve
- Chapter 25 Fetal and Infant Eye
- Growth Parameters
- Section 3 Stillbirth
- Section 4 Disruptions / Hypoxic-Ischemic Injury
- Section 5 Malformations
- Section 6 Perinatal Neurooncology
- Section 7 Spinal and Neuromuscular Disorders
- Section 8 Eye Disorders
- Section 9 Infections: In Utero Infections
- Section 10 Metabolic / Toxic Disorders: Storage Diseases
- Section 11 Forensic Neuropathology
- Appendix 1 Technical Considerations in Perinatal CNS
- Index
- References
Chapter 21 - White Matter, Including Myelination
from Neuroanatomic Site Development
Published online by Cambridge University Press: 07 August 2021
- Perinatal Neuropathology
- Perinatal Neuropathology
- Copyright page
- Contents
- Preface
- Acknowledgments
- Abbreviations
- Section I Techniques and Practical Considerations
- Section 2 Human Nervous System Development
- Neuroanatomic Site Development
- Chapter 19 Human Nervous System Development: Embryonic and Early Fetal Events
- Chapter 20 Cerebral Cortex, Including Germinal Matrix
- Chapter 21 White Matter, Including Myelination
- Chapter 22 Cerebellum: Development of the Rhombic Lip, Cerebellar Cortex, Dentate Nucleus
- Chapter 23 Spinal Cord
- Chapter 24 Skeletal Muscle and Peripheral Nerve
- Chapter 25 Fetal and Infant Eye
- Growth Parameters
- Section 3 Stillbirth
- Section 4 Disruptions / Hypoxic-Ischemic Injury
- Section 5 Malformations
- Section 6 Perinatal Neurooncology
- Section 7 Spinal and Neuromuscular Disorders
- Section 8 Eye Disorders
- Section 9 Infections: In Utero Infections
- Section 10 Metabolic / Toxic Disorders: Storage Diseases
- Section 11 Forensic Neuropathology
- Appendix 1 Technical Considerations in Perinatal CNS
- Index
- References
Summary
The forerunner of the human cerebral hemispheric white matter is the intermediate zone, situated between the ventricular zone and cortical plate. It is traversed radially by migrating cell precursors of neurons, glia, and microglia originating in the ventricular zone and germinal matrix, according to a complex timetable beginning in the first trimester (see Chapters 19–21). Full completion of white matter development, that is, full myelination, continues into the third decade of postnatal life, representing one of the longest maturation tempos of any structure in the human body. The intermediate zone also hosts the axonal processes of projection neurons, which elongate and later find their way to their sites of synapse, relying on help from subplate neurons, also locally present in the region. Oligodendroglial progenitors populating the intermediate zone undergo in parallel their own metamorphoses, to eventually synthesize myelin proteins and lipids, and progressively enwrap the axons to optimize their conductance. In this chapter, we will review briefly the elements of this process that are important for understanding later pathologies involving the fetal and infant white matter (Chapter 34).
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- Perinatal Neuropathology , pp. 101 - 106Publisher: Cambridge University PressPrint publication year: 2021