Book contents
- Perinatal Neuropathology
- Perinatal Neuropathology
- Copyright page
- Contents
- Preface
- Acknowledgments
- Abbreviations
- Section I Techniques and Practical Considerations
- Section 2 Human Nervous System Development
- Neuroanatomic Site Development
- Chapter 19 Human Nervous System Development: Embryonic and Early Fetal Events
- Chapter 20 Cerebral Cortex, Including Germinal Matrix
- Chapter 21 White Matter, Including Myelination
- Chapter 22 Cerebellum: Development of the Rhombic Lip, Cerebellar Cortex, Dentate Nucleus
- Chapter 23 Spinal Cord
- Chapter 24 Skeletal Muscle and Peripheral Nerve
- Chapter 25 Fetal and Infant Eye
- Growth Parameters
- Section 3 Stillbirth
- Section 4 Disruptions / Hypoxic-Ischemic Injury
- Section 5 Malformations
- Section 6 Perinatal Neurooncology
- Section 7 Spinal and Neuromuscular Disorders
- Section 8 Eye Disorders
- Section 9 Infections: In Utero Infections
- Section 10 Metabolic / Toxic Disorders: Storage Diseases
- Section 11 Forensic Neuropathology
- Appendix 1 Technical Considerations in Perinatal CNS
- Index
- References
Chapter 23 - Spinal Cord
from Neuroanatomic Site Development
Published online by Cambridge University Press: 07 August 2021
- Perinatal Neuropathology
- Perinatal Neuropathology
- Copyright page
- Contents
- Preface
- Acknowledgments
- Abbreviations
- Section I Techniques and Practical Considerations
- Section 2 Human Nervous System Development
- Neuroanatomic Site Development
- Chapter 19 Human Nervous System Development: Embryonic and Early Fetal Events
- Chapter 20 Cerebral Cortex, Including Germinal Matrix
- Chapter 21 White Matter, Including Myelination
- Chapter 22 Cerebellum: Development of the Rhombic Lip, Cerebellar Cortex, Dentate Nucleus
- Chapter 23 Spinal Cord
- Chapter 24 Skeletal Muscle and Peripheral Nerve
- Chapter 25 Fetal and Infant Eye
- Growth Parameters
- Section 3 Stillbirth
- Section 4 Disruptions / Hypoxic-Ischemic Injury
- Section 5 Malformations
- Section 6 Perinatal Neurooncology
- Section 7 Spinal and Neuromuscular Disorders
- Section 8 Eye Disorders
- Section 9 Infections: In Utero Infections
- Section 10 Metabolic / Toxic Disorders: Storage Diseases
- Section 11 Forensic Neuropathology
- Appendix 1 Technical Considerations in Perinatal CNS
- Index
- References
Summary
Neuromesodermal progenitors (NMps) emerge from the caudal lateral epiblast adjacent to the primitive streak and the node. NMps are molecularly defined as cells that co-express Sox2 and T/Bra and, thus, harbor the dual possibility of becoming neural or mesodermal. The study of NMps is important not only because of their central role in elongating the embryonic body axis but also because of the potential to recapitulate NMps in vitro and thereby generate spinal cord neurons in culture. Because NMps can be derived in vitro from human pluripotent cells, research in this area can provide new insight into embryo development and contribute to a better understanding of the human spinal cord development [1].
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- Perinatal Neuropathology , pp. 111 - 114Publisher: Cambridge University PressPrint publication year: 2021