Book contents
- Perinatal Neuropathology
- Perinatal Neuropathology
- Copyright page
- Contents
- Preface
- Acknowledgments
- Abbreviations
- Section I Techniques and Practical Considerations
- Section 2 Human Nervous System Development
- Section 3 Stillbirth
- Section 4 Disruptions / Hypoxic-Ischemic Injury
- Section 5 Malformations
- Neural Tube Defects and Patterning Defects
- Chapter 37 Defects of Neural Tube Closure and Axial Mesodermal Defects
- Chapter 38 Disorders of Early Midline Patterning
- Hydrocephalus
- Neuronal Migration Disorders
- Genetic Syndromes and Phakomatoses
- Section 6 Perinatal Neurooncology
- Section 7 Spinal and Neuromuscular Disorders
- Section 8 Eye Disorders
- Section 9 Infections: In Utero Infections
- Section 10 Metabolic / Toxic Disorders: Storage Diseases
- Section 11 Forensic Neuropathology
- Appendix 1 Technical Considerations in Perinatal CNS
- Index
- References
Chapter 37 - Defects of Neural Tube Closure and Axial Mesodermal Defects
from Neural Tube Defects and Patterning Defects
Published online by Cambridge University Press: 07 August 2021
- Perinatal Neuropathology
- Perinatal Neuropathology
- Copyright page
- Contents
- Preface
- Acknowledgments
- Abbreviations
- Section I Techniques and Practical Considerations
- Section 2 Human Nervous System Development
- Section 3 Stillbirth
- Section 4 Disruptions / Hypoxic-Ischemic Injury
- Section 5 Malformations
- Neural Tube Defects and Patterning Defects
- Chapter 37 Defects of Neural Tube Closure and Axial Mesodermal Defects
- Chapter 38 Disorders of Early Midline Patterning
- Hydrocephalus
- Neuronal Migration Disorders
- Genetic Syndromes and Phakomatoses
- Section 6 Perinatal Neurooncology
- Section 7 Spinal and Neuromuscular Disorders
- Section 8 Eye Disorders
- Section 9 Infections: In Utero Infections
- Section 10 Metabolic / Toxic Disorders: Storage Diseases
- Section 11 Forensic Neuropathology
- Appendix 1 Technical Considerations in Perinatal CNS
- Index
- References
Summary
One of the critical early steps in the development of the central nervous system (CNS) is the closure of the neural tube and subsequent coverage by mesenchymal and epithelial components. Failure of these steps results in dorsal axis anomalies of the CNS (1). Furthermore, coverage of the CNS by mesenchymal and epithelial components is necessary for the development of the skull and vertebral column, which are in turn necessary for the protection of the CNS. It is not always clear if the main abnormality is one of actual neural tube closure, or a failure of the CNS coverings to properly form and contain the CNS. Factors external to the fetus, such as adherent amniotic membranes, can cause injury or malformation to the developing CNS.
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- Information
- Perinatal Neuropathology , pp. 211 - 222Publisher: Cambridge University PressPrint publication year: 2021