2006;7:620–31., The makings of maleness: towards an integrated view of male sexual development. Nature Reviews Genetics
2003;24:152–82., , , et al. Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone. Endocrine Reviews
2007;21:2005–17., , Chaivorapol C, et al. Cell- and gene-specific regulation of primary target genes by the androgen receptor. Genes and Development
1988;240:889–95. The steroid and thyroid hormone receptor superfamily. Science
1999;97:161–3.. A unified nomenclature system for the nuclear receptor superfamily. Cell
1989;86:9534–38., , , et al. Sequence of the intron/exon junctions of the coding region of the human androgen receptor gene and identification of a point mutation in a family with complete androgen sensitivity. Proceedings of the National Academy of Sciences USA
1989;86:327–31., , , Characterization and expression of a cDNA encoding the human androgen receptor. Proceedings of the National Academy of Sciences USA
Structural evidence for ligand specificity in the binding domain of the human androgen receptor. Implications for pathogenic gene mutations. Journal of Biological Chemistry 2000;275:26 164–71., , , et al.
2001;98:4904–9., , , et al. Crystallographic structures of the ligand-binding domains of the androgen receptor and its T877A mutant complexed with the natural agonist dihydrotestosterone. Proceedings of the National Academy of Sciences USA
Crystal structure of the T877A human androgen receptor ligand-binding domain complexed to cyproterone acetate provides insight for ligand-induced conformational changes and structure-based drug design. Journal of Biological Chemistry 2007;282:13 648–55., , , ,
2000;14:121–41., The coregulator exchange in transcriptional functions of nuclear receptors. Genes and Development
1997;387:733–6., , , A signature motif in transcriptional co-activators mediates binding to nuclear receptors. Nature
2003;23:2135–50., Electrostatic modulation in steroid receptor recruitment of LXXLL and FXXLF motifs. Molecular and Cellular Biology
Intermolecular NH2-/carboxyl-terminal interactions in androgen receptor dimerization revealed by mutations that cause androgen insensitivity. Journal of Biological Chemistry 1998;273:92–101., ,
1998;12:1172–83., , , , Functional interactions of the AF-2 activation domain core region of the human androgen receptor with the amino-terminal domain and with the transcriptional coactivator TIF2 (transcriptional intermediary factor2). Molecular Endocrinology
Interaction between the amino- and carboxyl-terminal regions of the rat androgen receptor modulates transcriptional activity and is influenced by nuclear receptor coactivators. Journal of Biological Chemistry 1997;272:29 821–8., ,
Androgen-induced NH2- and COOH-terminal interaction inhibits p160 coactivator recruitment by activation function 2. Journal of Biological Chemistry 2001;276:42 293–301., , ,
2005;102:9802–7., , , et al. The structural basis of androgen receptor activation: intramolecular and intermolecular amino-carboxy interactions. Proceedings of the National Academy of Sciences USA
Compartmentalization of androgen receptor protein-protein interactions in living cells. Journal of Cell Biology 2007;177:63–72., , , et al.
Identification of two transcription activation units in the N-terminal domain of the human androgen receptor. Journal of Biological Chemistry 1995;270:7341–6., , ,
2004;16:425–38., , , et al. Structural basis for androgen receptor interdomain and coactivator interactions suggests a transition in nuclear receptor activation function dominance. Molecular Cell
FXXLF and WXXLF sequences mediate the NH2-terminal interaction with the ligand binding domain of the androgen receptor. Journal of Biological Chemistry 2000;275:22 986–94., ,
1999;31:119–27., , Intracellular localization and trafficking of steroid receptors. Cell Biochemistry and Biophysics
1993;293:761–8., , Nuclear import of the human androgen receptor. Biochemical Journal
1991;5:1396–404., , , et al. Domains of the human androgen receptor involved in steroid binding, transcriptional activation, and subcellular localization. Molecular Endocrinology
1998;94:471–80., , , , Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1. Cell
2003;23:8563–75., , , et al. Acetylation of androgen receptor enhances coactivator binding and promotes prostate cancer cell growth. Molecular and Cellular Biology
2004;1030:587–92., , The hinge region of the androgen receptor plays a role in proteasome-mediated transcriptional activation. Annals of the New York Academy of Science
1995;9:605–15., , Identification of three proline-directed phosphorylation sites in the human androgen receptor. Molecular Endocrinology
2006; 60:520–8. and Post translational modifications of steroid receptors. Biomedicine and Pharmacotherapy
1994;15:391–407. Differential recognition of target genes by nuclear receptor monomers, dimers, and heterodimers. Endocrine Reviews
Zinc coordination scheme for the C-terminal zinc binding site of nuclear hormone receptors. Journal of Steroid Biochemistry and Molecular Biology 1992;42:131–9., , ,
1988;334:543–6., , , et al. The function and structure of the metal coordination sites within the glucocorticoid receptor DNA binding domain. Nature
1991;352:497–505., , , et al. Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA. Nature
1999;341:515–21., , , et al. Differential DNA binding by the androgen and glucocorticoid receptors involves the second Zn-finger and a C-terminal extension of the DNA-binding domains. Biochemical Journal
1989;57:1139–46., Determinants of target gene specificity for steroid/thyroid hormone receptors. Cell
Interaction of the glucocorticoid receptor DNA-binding domain with DNA as a dimer is mediated by a short segment of five amino acids. Journal of Biological Chemistry 1991;266:3107–12., , ,
1991;30:11 620–4., , , et al. 1H NMR studies of DNA recognition by the glucocorticoid receptor: complex of the DNA binding domain with a half-site response element. Biochemistry
1999;13:2065–75., , , 3rd, et al. A C619Y mutation in the human androgen receptor causes inactivation and mislocalization of the receptor with concomitant sequestration of SRC-1 (steroid receptor coactivator 1). Molecular Endocrinology
Differences in DNA binding characteristics of the androgen and glucocorticoid receptors can determine hormone-specific responses. Journal of Biological Chemistry 2000;275:12 290–7., , , et al.
2001;353:611–20., , , et al. Androgen-receptor-specific DNA binding to an element in the first exon of the human secretory component gene. Biochemical Journal
1989;56():335–44. Gene regulation by steroid hormones. Cell
1992;6:2229–35., , A consensus DNA-binding site for the androgen receptor. Molecular Endocrinology
1989;164:833–40., , , et al. Functional characterization of an androgen response element in the first intron of the C3(1) gene of prostatic binding protein. Biochemical and Biophysical Research Communications
The androgen-specific probasin response element 2 interacts differentially with androgen and glucocorticoid receptors. Journal of Biological Chemistry 1996;271:19 013–6., , , et al.
1993;7:23–36., , , et al. Characterization of two cis-acting DNA elements involved in the androgen regulation of the probasin gene. Molecular Endocrinology
1999;13:1558–70., , , et al. Androgen specificity of a response unit upstream of the human secretory component gene is mediated by differential receptor binding to an essential androgen response element. Molecular Endocrinology
Cooperative binding of androgen receptors to two DNA sequences is required for androgen induction of the probasin gene. Journal of Biological Chemistry 1994;269:31 763–9., , , et al.
2003;78:175–85., , Selective DNA recognition by the androgen receptor as a mechanism for hormone-specific regulation of gene expression. Molecular Genetics and Metabolism
2003;369:141–51., , , et al. DNA recognition by the androgen receptor: evidence for an alternative DNA-dependent dimerization, and an active role of sequences flanking the response element on transactivation. Biochemical Journal
2008;22:2373–82., , , The contribution of different androgen receptor domains to receptor dimerization and signaling. Molecular Endocrinology
Delineation of two distinct type 1 activation functions in the androgen receptor amino-terminal domain. Journal of Biological Chemistry 1996;271:26 772–8., ,
1992;12:241–53., , , , Genetic variation at five trimeric and tetrameric tandem repeat loci in four human population groups. Genomics
1999;53:378–80., , Androgen receptor gene CAG repeat length varies in a race-specific fashion in men without prostate cancer. Urology
Effect of the androgen receptor CAG repeat polymorphism on transcriptional activity: specificity in prostate and non-prostate cell lines. Journal of Molecular Endocrinology 2000;25:85–96., , ,
1995;4:523–7., , Evidence for a repressive function of the long polyglutamine tract in the human androgen receptor: possible pathogenetic relevance for the (CAG)n-expanded neuronopathies. Human Molecular Genetics
Long polyglutamine tracts in the androgen receptor are associated with reduced trans-activation, impaired sperm production, and male infertility. Journal of Clinical Endocrinology and Metabolism 1997;82:3777–82., , , ,
2004;13:1677–92., , , et al. Structural and functional consequences of glutamine tract variation in the androgen receptor. Human Molecular Genetics
1991;352:77–9., , , , Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy. Nature
Spinal and bulbar muscular atrophy: androgen receptor dysfunction caused by a trinucleotide repeat expansion. Journal of the Neurological Sciences 1996;135:149–57., ,
1997;94:3320–3., , , et al. The CAG repeat within the androgen receptor gene and its relationship to prostate cancer. Proceedings of the National Academy of Sciences USA
1997;3:1599–608., , , , Androgen receptor variants with short glutamine or glycine repeats may identify unique subpopulations of men with prostate cancer. Clinical Cancer Research
2000;60:5111–16., , , et al. Polymorphic CAG and GGN repeat lengths in the androgen receptor gene and prostate cancer risk: a population-based case-control study in China. Cancer Research
Androgen receptor CAG repeat length and association with prostate cancer risk: results from the prostate cancer prevention trial. Journal of Urology 2010;184:2297–302., , , et al.
A large study of androgen receptor germline variants and their relation to sex hormone levels and prostate cancer risk. Results from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium. Journal of Clinical Endocrinology and Metabolism 2010;95:E121–7., , , et al.
1993;7:4–11., Steroid receptors and their associated proteins. Molecular Endocrinology
2002;7:55–64., , , Effect of geldanamycin on androgen receptor function and stability. Cell Stress Chaperones
1997;18:306–60., Steroid receptor interactions with heat shock protein and immunophilin chaperones. Endocrine Reviews
Selective DNA binding by the androgen receptor as a mechanism for hormone-specific gene regulation. Journal of Steroid Biochemistry and Molecular Biology 2001;76:23–30., , , et al.
2001;13:274–80., Mediator complexes and transcription. Current Opinion in Cell Biology
Androgen receptor coregulators and their involvement in the development and progression of prostate cancer. International Journal of Cancer 2006;120: 719–33., , , et al.
2007;27:380–92., , , et al. A hierarchical network of transcription factors governs androgen receptor-dependent prostate cancer growth. Molecular Cell
2007;8:871–8., , , et al. New androgen receptor genomic targets show an interaction with the ETS1 transcription factor. EMBO Reports
2009;16:381–9., Cistromics of hormone-dependent cancer. Endocrine-Related Cancer
2008;29:169–81., , Non-genomic actions of androgens. Frontiers in Neuroendocrinology
2002;16:2181–7., The roles of androgen receptors and androgen-binding proteins in nongenomic androgen actions. Molecular Endocrinology
Androgen receptor mediates non-genomic activation of phosphatidylinositol 3-OH kinase in androgen-sensitive epithelial cells. Journal of Biological Chemistry 2004;9:14 579–86., , , et al.
2000;19:5406–17., , , et al. Steroid-induced androgen receptor-oestradiol receptor beta-Src complex triggers prostate cancer cell proliferation. EMBO Journal
2010;16: 543–58., , Molecular insights into androgen actions in male and female reproductive function from androgen receptor knockout models. Human Reproduction Update
2002;99:13 498–503., , , et al. Generation and characterization of androgen receptor knockout (ARKO) mice: an in vivo model for the study of androgen functions in selective tissues, Proceedings of the National Academy of Sciences USA
Study of androgen action in bone by analysis of androgen-receptor deficient mice. Journal of Bone and Mineral Metabolism 2002;20:326–30., ,
Genomic actions of the androgen receptor are required for normal male sexual differentiation in a mouse model. Journal of Molecular Endocrinology 2005;35:547–55., , , et al.
2004;131:459–67., Androgen receptor function is required in Sertoli cells for the terminal differentiation of haploid spermatids. Development
Androgen receptor functions from reverse genetic models. Journal of Steroid Biochemistry and Molecular Biology 2003;85:95–9., , ,
2004;101:1673–8., , , et al. Brain masculinization requires androgen receptor function Proceedings of the National Academy of Sciences USA
Abnormal mammary gland development and growth retardation in female mice and MCF7 breast cancer cells lacking androgen receptor. Journal of Experimental Medicine 2003;198:1899–908., , , et al.
2004;101:11 209–14., , , et al. Subfertility and defective folliculogenesis in female mice lacking androgen receptor. Proceedings of the National Academy of Sciences USA
2006;103:224–9., , , et al. Premature ovarian failure in androgen receptor-deficient mice. Proceedings of the National Academy of Sciences USA
2007;148:3674–84., , , et al. Female mice haploinsufficient for an inactivated androgen receptor (AR) exhibit age-dependent defects that resemble the AR null phenotype of dysfunctional late follicle development, ovulation, and fertility. Endocrinology
2009;150:3274–82., , , et al. Subfertile female androgen receptor knockout mice exhibit defects in neuroendocrine signaling, intraovarian function, and uterine development but not uterine function. Endocrinology
2007;148:2264–72., , , et al. Disruption of prostate epithelial androgen receptor impedes prostate lobe-specific growth and function. Endocrinology
Androgen sensitivity of prostate epithelium is enhanced by postnatal androgen receptor inactivation. American Journal of Physiology, Endocrinology and Metabolism 2009;296: E1335–43., , ,
2007; 104:12 679–84., , , et al. Increased prostate cell proliferation and loss of cell differentiation in mice lacking prostate epithelial androgen receptor. Proceedings of the National Academy of Sciences USA
2010;24:1393–403.; Granulosa cell-specific androgen receptors are critical regulators of ovarian development and function. Molecular Endocrinology
2009;69:6131–40., , , et al. Androgen receptor inhibits estrogen receptor-alpha activity and is prognostic in breast cancer. Cancer Research
2003;10:292–8., , , et al. A physiologic role for testosterone in limiting estrogenic stimulation of the breast. Menopause
2002;193:121–8., , , et al. Breast cancer: from estrogen to androgen receptor. Molecular and Cellular Endocrinology
1995;92:3439–43., , , et al. Prostate cancer in a transgenic mouse, Proceedings of the National Academy of Sciences USA
1996;56:4096–102., , , et al. Metastatic prostate cancer in a transgenic mouse. Cancer Research
2008;105:12 188–93., , , et al. Targeting the stromal androgen receptor in primary prostate tumors at earlier stages. Proceedings of the National Academy of Sciences USA
2001;98:10 823–28., , , , Prostatic intraepithelial neoplasia in mice expressing an androgen receptor transgene in prostate epithelium. Proceedings of the National Academy of Sciences USA
2006;20:1248–60., , , Replacing the mouse androgen receptor with human alleles demonstrates glutamine tract length-dependent effects on physiology and tumorigenesis in mice. Molecular Endocrinology
2008;17:98–110., , , et al. Glutamine tract length of human androgen receptors affects hormone-dependent and -independent prostate cancer in mice. Human Molecular Genetics
Hormone status selects for spontaneous somatic androgen receptor variants that demonstrate specific ligand and cofactor dependent activities in autochthonous prostate cancer. Journal of Biological Chemistry 2001;276:11 204–13., , , et al.
2005;102:1151–6., , , et al. Mutation of the androgen receptor causes oncogenic transformation of the prostate. Proceedings of the National Academy of Sciences USA
2008;6:1691–701., , et al. Profiling human androgen receptor mutations reveals treatment effects in a mouse model of prostate cancer. Molecular Cancer Research
1998;26:234–8., , , et al. The Androgen Receptor Gene Mutations Database. Nucleic Acids Research
2001;179:105–9. Molecular basis of androgen insensitivity. Molecular and Cellular Endocrinology
2004;23:527–33., , , Trifiro M. The androgen receptor gene mutations database (ARDB): 2004 update. Human Mutation
Mutation of the androgen-receptor gene in metastatic androgen-independent prostate cancer. New England Journal of Medicine 1995;332: 1393–8., , , et al.
2009;69:4434–42., , , et al. Treatment-dependent androgen receptor mutations in prostate cancer exploit multiple mechanisms to evade therapy. Cancer Research
2010;56:1492–5., , , , Detection of androgen receptor mutations in circulating tumor cells in castration-resistant prostate cancer. Clinical Chemistry
2000;60:944–9., , , et al. Androgen receptor mutations in prostate cancer. Cancer Research
Androgen receptor gene mutations in human prostate cancer. Journal of Steroid Biochemistry and Molecular Biology 1993;46:759–65., , , et al.
1993;7:1541–50., , , et al. Mutant androgen receptor detected in an advanced-stage prostatic carcinoma is activated by adrenal androgens and progesterone. Molecular Endocrinology
Androgen receptor gene mutations in hormone-refractory prostate cancer. Journal of Pathology 1999;189:559–63., , , ,
1993;77:119–23., , , , Androgen receptor gene mutations and p53 gene analysis in advanced prostate cancer. Verhandlung der Deutschen Gesellschaft für Pathologie
1996;2:277–85., , , Mutations in the androgen receptor gene are associated with progression of human prostate cancer to androgen independence. Clinical Cancer Research
1999;59:2511–15., , , et al. Selection for androgen receptor mutations in prostate cancers treated with androgen antagonist. Cancer Research
Genetic alterations of androgen receptor gene in Japanese human prostate cancer. Japanese Journal of Clinical Oncology 1997;27:389–93., , , et al.
Mutated human androgen receptor gene detected in a prostatic cancer patient is also activated by estradiol. Journal of Clinical Endocrinology and Metabolism 1995;80:3494–500., , , et al.
1996;29: 153–8., , , et al. Codon 877 mutation in the androgen receptor gene in advanced prostate cancer: relation to antiandrogen withdrawal syndrome. Prostate
1994;54:2861–4., , , et al. Frequent detection of codon 877 mutation in the androgen receptor gene in advanced prostate cancers. Cancer Research
1992;89:6319–23., , , et al. Androgen receptor gene mutations in human prostate cancer. Proceedings of the National Academy of Sciences USA
2001;20:207–23., , , Contribution of the androgen receptor to prostate cancer predisposition and progression. Cancer Metastasis Reviews
2002;62: 1496–502., , , , Functional analysis of 44 mutant androgen receptors from human prostate cancer. Cancer Research
2001;7:1273–81., , , et al. Collocation of androgen receptor gene mutations in prostate cancer. Clinical Cancer Research
2004;11:459–76., , , , Targeting the androgen receptor: improving outcomes for castration-resistant prostate cancer. Endocrine-Related Cancer
2009;30:145–57., Pleiotropic functional properties of androgen receptor mutants in prostate cancer. Human Mutation
2005;65:8487–96., , et al. Decreased androgen receptor levels and receptor function in breast cancer contribute to the failure of response to medroxyprogesterone acetate. Cancer Research
2007;21:2285–93., , , , Disruption of androgen receptor signaling by synthetic progestins may increase risk of developing breast cancer. FASEB Journal
Medroxyprogesterone acetate therapy in advanced breast cancer: the predictive value of androgen receptor expression. Journal of Clinical Oncology 1995;13:1572–7., , , ,
Identification of a novel germline missense mutation of the androgen receptor in African American men with familial prostate cancer. Asian Journal of Andrology 2010;123:336–43., , , et al.
2000;60:6479–81., , , et al. Two percent of Finnish prostate cancer patients have a germ-line mutation in the hormone-binding domain of the androgen receptor gene. Cancer Research
Germline mutation analysis of the androgen receptor gene in Finnish patients with prostate cancer. Journal of Urology 2004;171:431–3., , , et al.
1992;2:132–4., , , et al. A germline mutation in the androgen receptor gene in two brothers with breast cancer and Reifenstein syndrome. Nature Genetics
1993;2:1799–802., , , et al. Androgen receptor gene mutation in male breast cancer. Human Molecular Genetics
2001;15:46–56., , , et al. Mutations at the boundary of the hinge and ligand binding domain of the androgen receptor confer increased transactivation function. Molecular Endocrinology
2007;104:16 074–9., , , et al. A surface on the androgen receptor that allosterically regulates coactivator binding. Proceedings of the National Academy of Sciences USA
1990;173:534–40., , , et al. A mutation in the ligand binding domain of the androgen receptor of human LNCaP cells affects steroid binding characteristics and response to anti-androgens. Biochemical and Biophysical Research Communications
Effects of antiandrogens on transformation and transcription activation of wild-type and mutated (LNCaP) androgen receptors. Journal of Steroid Biochemistry and Molecular Biology 1993;46:731–6., ,
The androgen receptor in LNCaP cells contains a mutation in the ligand binding domain which affects steroid binding characteristics and response to antiandrogens. Journal of Steroid Biochemistry and Molecular Biology 1992;41:665–9., , , et al.
Androgen receptor mutations in androgen-independent prostate cancer: Cancer and Leukemia Group B Study 9663. Journal of Clinical Oncology 2003;21:2673–8., , , et al.
Constitutive activation of the androgen receptor by a point mutation in the hinge region: a new mechanism for androgen-independent growth in prostate cancer. International Journal of Cancer 2004;108:152–7., , , et al.
Probing the functional link between androgen receptor coactivator and ligand-binding sites in prostate cancer and androgen insensitivity. Journal of Biological Chemistry 2006;281:6648–63., , , et al.
Modulation of androgen receptor activation function 2 by testosterone and dihydrotesto-sterone. Journal of Biological Chemistry 2007;282: 25 801–16., , , ,
2005;19:2943–54., Mutation of histidine 874 in the androgen receptor ligand-binding domain leads to promiscuous ligand activation and altered p160 coactivator interactions. Molecular Endocrinology
2000;60:2317–22., , , , Ligand responsiveness in human prostate cancer: structural analysis of mutant androgen receptors from LNCaP and CWR22 tumors. Cancer Research
Structural basis for the glucocorticoid response in a mutant human androgen receptor (AR(ccr)) derived from an androgen-independent prostate cancer. Journal of Medicinal Chemistry 2002;45:1439–46., , , et al.
2008;27: 2941–50., , Mechanisms of androgen receptor activation in advanced prostate cancer: differential co-activator recruitment and gene expression. Oncogene
2002;143:1889–900., , , et al. A glucocorticoid-responsive mutant androgen receptor exhibits unique ligand specificity: therapeutic implications for androgen-independent prostate cancer. Endocrinology
Systematic structure-function analysis of androgen receptor Leu701 mutants explains the properties of the prostate cancer mutant L701H. Journal of Biological Chemistry 2010; 285: 5097–105., , , et al.
Somatic mutations at the trinucleotide repeats of androgen receptor gene in male hepatocellular carcinoma. International Journal of Cancer 2007;120:1610–17., , , et al.
2006;63: 487–97., , , et al. Unfaithfulness and promiscuity of a mutant androgen receptor in a hormone-refractory prostate cancer. Cellular and Molecular Life Sciences
2007;67:591–602., , The oncogenic potential of a prostate cancer-derived androgen receptor mutant, Prostate
2007;67:4514–23., , , , The hinge region regulates DNA binding, nuclear translocation, and transactivation of the androgen receptor. Cancer Research
1999;140:3097–105., , , , Transcription activating and repressing functions of the androgen receptor are differentially influenced by mutations in the deoxyribonucleic acid-binding domain. Endocrinology
1997;130:43–51, , , , Functional and structural analysis of R607Q and R608K androgen receptor substitutions associated with male breast cancer. Molecular and Cellular Endocrinology
2009;150:2674–82., , , et al. A novel androgen receptor amino terminal region reveals two classes of amino/carboxyl interaction-deficient variants with divergent capacity to activate responsive sites in chromatin. Endocrinology
2005;19:2273–82., , , et al. Androgen receptor mutations identified in prostate cancer and androgen insensitivity syndrome display aberrant ART-27 coactivator function. Molecular Endocrinology
2005;12:645–55., , , et al. Molecular analysis of the androgen receptor gene in testicular cancer. Endocrine-Related Cancer
2002;62: 6606–14., , , et al. Characterization of a novel androgen receptor mutation in a relapsed CWR22 prostate cancer xenograft and cell line. Cancer Research
2008;68:5469–77., , , , Splicing of a novel androgen receptor exon generates a constitutively active androgen receptor that mediates prostate cancer therapy resistance. Cancer Research
2010;31:74–80., , , et al. Identification of novel truncated androgen receptor (AR) mutants including unreported pre-mRNA splicing variants in the 22Rv1 hormone-refractory prostate cancer (PCa) cell line. Human Mutation
2009;69:16–22., , , et al. Ligand-independent androgen receptor variants derived from splicing of cryptic exons signify hormone-refractory prostate cancer. Cancer Research
2010;107:16 759–65., , , et al. Constitutively active androgen receptor splice variants expressed in castration-resistant prostate cancer require full-length androgen receptor. Proceedings of the National Academy of Sciences USA
Castration resistance in human prostate cancer is conferred by a frequently occurring androgen receptor splice variant. Journal of Clinical Investigation 2010;120:2715–30., , , et al.
2007;148: 4334–43., , , et al. A splicing variant of the androgen receptor detected in a metastatic prostate cancer exhibits exclusively cytoplasmic actions. Endocrinology
2008;617:529–34., , , et al. Specific properties of a C-terminal truncated androgen receptor detected in hormone refractory prostate cancer. Advances in Experimental Medicine and Biology
Unexpected paracrine action of prostate cancer cells harboring a new class of androgen receptor mutation–a new paradigm for cooperation among prostate tumor cells. International Journal of Cancer 2007;121:1238–44., , , et al.