Computerized tomographic (CT)-based assessment of cerebral blood flow (CBF) offers many advantages in the care of patients with disorders of the central nervous system. The CT scanner detects small changes in attenuation due to the presence of Xe and the change in density is directly proportional to the concentration of Xe in the tissues. In patients with acute stroke, direct measurement of CBF is potentially helpful to maximize the benefit of acute stroke therapy and reduce the complications. The role of hemodynamic factors in the risk of recurrent stroke in patients with extra cranial carotid occlusive disease remains controversial. Xenon enhanced CT (XeCT) may provide valuable insights into the optimal blood pressure management of patients with Intracerebral hemorrhage (ICH). CT- based systems now offer the ability to provide exquisite tissue and vascular anatomy using conventional CT and CT angiography.