In a knowledge age, the flow of ideas and innovations around the world is essential to business growth and renewal, but also poses complex management and design challenges. How can companies manage the process of global innovation? This chapter examines the issue of “global recombination,” moving ideas from one part of the world to another or combining sets of ideas into innovations. The challenge is that while knowledge must move globally, it is still often contained within tight, geographically anchored communities. The authors identify four essential elements for making recombination work: access to diverse knowledge elements; the capacity to absorb knowledge from communities of practice; the ability to adapt such knowledge to different local contexts before recombining it; and ensuring that localized pockets of knowledge are integrated so that recombination actually takes place. The authors provide frameworks for managers to explore how their enterprises are positioned to recombine knowledge that already exists to create value for customers and wealth for the enterprise.