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  • Print publication year: 2009
  • Online publication date: July 2016

Chapter 14 - Role of the inflammatory process in traumatic brain damage

from Section 3: - Microbiological and traumatic challenges to the CNS

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References

Adams JH, et al. Diffuse axonal injury in head injury: Definition, diagnosis and grading. Histopathology 1989; 15: 49–59.
Aihara N, et al. Altered immunoexpression of microglia and macrophages after mild head injury. J Neurotrauma 1995; 12: 53–63.
Allan SM. Varied actions of proinflammatory cytokines on excitotoxic cell death in the rat central nervous system. J Neurosci Res 2002; 67: 428–34.
Aloisi F, et al. Production of hemolymphopoietic cytokines (IL-6, IL-8, colony-stimulating factors) by normal human astrocytes in response to IL-1 beta and tumor necrosis factor-alpha. J Immunol 1992; 149: 2358–66.
Arand M, et al. Early inflammatory mediator response following isolated traumatic brain injury and other major trauma in humans. Langenbecks Arch Surg 2001; 386: 241–8.
Balasingam V, et al. Reactive astrogliosis in the neonatal mouse brain and its modulation by cytokines. J Neurosci 1994; 14: 846–56.
Balasingam V, Yong VW. Attenuation of astroglial reactivity by interleukin-10. J Neurosci 1996; 16: 2945–55.
Basu A, et al. The type 1 interleukin-1 receptor is essential for the efficient activation of microglia and the induction of multiple proinflammatory mediators in response to brain injury. J Neurosci 2002; 22: 6071–82.
Beaumont A, et al. Bolus tracer delivery measured by MRI confirms edema without blood–brain barrier permeability in diffuse traumatic brain injury. Acta Neurochir Suppl 2006; 96: 171–4.
Beer R, et al. Expression of Fas and Fas ligand after experimental traumatic brain injury in the rat. J Cereb Blood Flow Metab 2000; 20: 669–77.
Bell MJ, et al. Interleukin-6 and interleukin-10 in cerebrospinal fluid after severe traumatic brain injury in children. J Neurotrauma 1997; 14: 451–7.
Benveniste EN. Cytokine actions in the central nervous system. Cytokine Growth Factor Rev 1998; 9: 259–75.
Benveniste EN, et al. Differential regulation of astrocyte TNF-alpha expression by the cytokines TGF-beta, IL-6 and IL-10. Int J Dev Neurosci 1995; 13: 341–9.
Bethea JR, et al. Systemically administered interleukin-10 reduces tumor necrosis factor-alpha production and significantly improves functional recovery following traumatic spinal cord injury in rats. J Neurotrauma 1999; 16: 851–63.
Browne KD, et al. Chronic ibuprofen administration worsens cognitive outcome following traumatic brain injury in rats. Exp Neurol 2006; 201: 301–7.
Bye N, et al. The chemokine MCP-1 modulates post-traumatic inflammation following closed head injury in the mouse (Oral). In 8th International Neurotrauma Symposium, Rotterdam; 2006.
Caggiano A, Kraig RP. Prostaglandin E receptor subtypes in cultured rat microglia and their role in reducing lipopolysaccharide-induced interleukin-1 α production. J Neurochem 1999; 72: 565–75.
Chiaretti A, et al. Interleukin 1beta and interleukin 6 relationship with paediatric head trauma severity and outcome. Childs Nerv Syst 2005; 21: 185–93.
Chung IY, Benveniste EN. Tumor necrosis factor-alpha production by astrocytes. Induction by lipopolysaccharide, IFN-gamma, and IL-1 beta. J Immunol 1990; 144: 2999–3007.
Clark RS, et al. Neutrophil accumulation after traumatic brain injury in rats: Comparison of weight drop and controlled cortical impact models. J Neurotrauma 1994; 11: 499–506.
Colicos MA, Dash PK. Apoptotic morphology of dentate gyrus granule cells following experimental cortical impact injury in rats: Possible role in spatial memory deficits. Brain Res 1996; 739: 120–31.
Coogan A, O’Connor JJ. Inhibition of NMDA receptor-mediated synaptic transmission in the rat dentate gyrus in vitro by IL-1 beta. Neuroreport 1997; 8: 2107–10.
Csuka E, et al. Cell activation and inflammatory response following traumatic axonal injury in the rat. Neuroreport 2000; 11: 2587–90.
Csuka E, et al. IL-10 levels in cerebrospinal fluid and serum of patients with severe traumatic brain injury: Relationship to IL-6, TNF-alpha, TGF-beta1 and blood–brain barrier function. J Neuroimmunol 1999; 101: 211–21.
DeKosky ST, et al. Interleukin-1 receptor antagonist suppresses neurotrophin response in injured rat brain. Ann Neurol 1996; 39: 123–7.
Dong Y, Benveniste EN. Immune function of astrocytes. Glia 2001; 36: 180–90.
Faber-Elman A, et al. Vitronectin overrides a negative effect of TNF-alpha on astrocyte migration. FASEB J 1995; 9: 1605–13.
Fan L, et al. Experimental brain injury induces expression of interleukin-1 beta mRNA in the rat brain. Brain Res Mol Brain Res 1995; 30: 125–30.
Fan L, et al. Experimental brain injury induces differential expression of tumor necrosis factor-alpha mRNA in the CNS. Brain Res Mol Brain Res 1996; 36: 287–91.
Fassbender K, et al. Temporal profile of release of interleukin-1beta in neurotrauma. Neurosci Lett 2000; 284: 135–8.
Feuerstein GZ, et al. The role of cytokines in the neuropathology of stroke and neurotrauma. Neuroimmunomodulation 1998; 5: 143–59.
Furukawa T, et al. The glutamate AMPA receptor antagonist, YM872, attenuates cortical tissue loss, regional cerebral edema, and neurological motor deficits after experimental brain injury in rats. J Neurotrauma 2003; 20: 269–78.
Gentleman SM, et al. Long-term intracerebral inflammatory response after traumatic brain injury. Forensic Sci Int 2004; 146: 97–104.
Glabinski AR, et al. Chemokine monocyte chemoattractant protein-1 is expressed by astrocytes after mechanical injury to the brain. J Immunol 1996; 156: 4363–8.
Goodman JC, et al. Elevation of tumor necrosis factor in head injury. J Neuroimmunol 1990; 30: 213–7.
Graham DI, et al. Trauma. In Graham DI, Lantos PL (Eds.) Greenfield’s Neuropathology, vol. 2. London: Arnold, 2002; pp. 823–98.
Griffin DE. Cytokines in the brain during viral infection: Clues to HIV-associated dementia. J Clin Invest 1997; 100: 2948–51.
Hans VH, et al. Interleukin-6 and its soluble receptor in serum and cerebrospinal fluid after cerebral trauma. Neuroreport 1999a; 10: 409–12.
Hans VH, et al. Experimental axonal injury triggers interleukin-6 mRNA, protein synthesis and release into cerebrospinal fluid. J Cereb Blood Flow Metab 1999b; 19: 184–94.
Hausmann R, et al. Neuronal apoptosis following human brain injury. Int J Legal Med 2004; 118: 32–6.
Hauss-Wegrzyniak B, et al. Behavioral and ultrastructural changes induced by chronic neuroinflammation in young rats. Brain Res 2000; 859: 157–66.
Hayakata T, et al. Changes in CSF S100B and cytokine concentrations in early-phase severe traumatic brain injury. Shock 2004; 22: 102–7.
Hensler T, et al. The effect of additional brain injury on systemic interleukin (IL)-10 and IL-13 levels in trauma patients. Inflamm Res 2000; 49: 524–8.
Herx LM, Yong VW. Interleukin-1 beta is required for the early evolution of reactive astrogliosis following CNS lesion. J Neuropathol Exp Neurol 2001; 60: 961–71.
Hillered L, et al. Translational neurochemical research in acute human brain injury: The current status and potential future for cerebral microdialysis. J Neurotrauma 2005; 22: 3–41.
Holmin S, Hojeberg B. In situ detection of intracerebral cytokine expression after human brain contusion. Neurosci Lett 2004; 369: 108–14.
Holmin S, et al. Delayed cytokine expression in rat brain following experimental contusion. J Neurosurg 1997; 86: 493–504.
Hua LL, et al. Modulation of astrocyte inducible nitric oxide synthase and cytokine expression by interferon beta is associated with induction and inhibition of interferon gamma-activated sequence binding activity. J Neurochem 2002; 83: 1120–8.
Jones NC, et al. Antagonism of the interleukin-1 receptor following traumatic brain injury in the mouse reduces the number of nitric oxide synthase-2-positive cells and improves anatomical and functional outcomes. Eur J Neurosci 2005; 22: 72–8.
Kamm K, et al. The effect of traumatic brain injury upon the concentration and expression of interleukin-1beta and interleukin-10 in the rat. J Trauma 2006; 60: 152–7.
Kita T, et al. The expression of tumor necrosis factor-alpha in the rat brain after fluid percussive injury. Int J Legal Med 1997; 110: 305–11.
Knoblach SM, Faden AI. Interleukin-10 improves outcome and alters proinflammatory cytokine expression after experimental traumatic brain injury. Exp Neurol 1998; 153: 143–51.
Knoblach SM, et al. Early neuronal expression of tumor necrosis factor-alpha after experimental brain injury contributes to neurological impairment. J Neuroimmunol 1999; 95: 115–25.
Kossmann T, et al. Intrathecal and serum interleukin-6 and the acute-phase response in patients with severe traumatic brain injuries. Shock 1995; 4: 311–7.
Kossmann T, et al. Interleukin-6 released in human cerebrospinal fluid following traumatic brain injury may trigger nerve growth factor production in astrocytes. Brain Res 1996; 713: 143–52.
Kossmann T, et al. Interleukin-8 released into the cerebrospinal fluid after brain injury is associated with blood–brain barrier dysfunction and nerve growth factor production. J Cereb Blood Flow Metab 1997; 17: 280–9.
Kremlev SG, Palmer C. Interleukin-10 inhibits endotoxin-induced pro-inflammatory cytokines in microglial cell cultures. J Neuroimmunol 2005; 162: 71–80.
Kushi H, et al. IL-8 is a key mediator of neuroinflammation in severe traumatic brain injuries. Acta Neurochir Suppl 2003; 86: 347–50.
Lee JI, Burckart GJ. Nuclear factor kappa B: Important transcription factor and therapeutic target. J Clin Pharmacol 1998; 38: 981–93.
Lewen A, et al. Free radical pathways in CNS injury. J Neurotrauma 2000; 17: 871–90.
Liberto CM, et al. Pro-regenerative properties of cytokine-activated astrocytes. J Neurochem 2004; 89: 1092–100.
Lin HW, et al. Astrogliosis is delayed in type 1 interleukin-1 receptor-null mice following a penetrating brain injury. J Neuroinflammation 2006; 3: 15.
Lu KT, et al. Extracellular signal-regulated kinase-mediated IL-1-induced cortical neuron damage during traumatic brain injury. Neurosci Lett 2005a; 386: 40–5.
Lu KT, et al. Effect of interleukin-1 on traumatic brain injury-induced damage to hippocampal neurons. J Neurotrauma 2005b; 22: 885–95.
Maier B, et al. Delayed elevation of soluble tumor necrosis factor receptors p75 and p55 in cerebrospinal fluid and plasma after traumatic brain injury. Shock 2006; 26: 122–7.
Maier B, et al. Differential release of interleukins 6, 8, and 10 in cerebrospinal fluid and plasma after traumatic brain injury. Shock 2001; 15: 421–6.
Mantovani A, et al. The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol 2004; 25: 677–86.
Marciano PG, et al. Neuron-specific mRNA complexity responses during hippocampal apoptosis after traumatic brain injury. J Neurosci 2004; 24: 2866–76.
Marion DW. Traumatic Brain Injury. New York: Thieme, 1999.
Marklund N, et al. Administration of monoclonal antibodies neutralizing the inflammatory mediators tumor necrosis factor alpha and interleukin-6 does not attenuate acute behavioral deficits following experimental traumatic brain injury in the rat. Restor Neurol Neurosci 2005; 23: 31–42.
Marmarou A. Pathophysiology of traumatic brain edema: Current concepts. Acta Neurochir Suppl 2003; 86: 7–10.
Mattson MP, et al. Roles of nuclear factor kappaB in neuronal survival and plasticity. J Neurochem 2000; 74: 443–56.
Merrill JE, Benveniste EN. Cytokines in inflammatory brain lesions: Helpful and harmful. Glia 1996; 19: 331–8.
Minambres E, et al. Correlation between transcranial interleukin-6 gradient and outcome in patients with acute brain injury. Crit Care Med 2003; 31: 933–8.
Modur V, et al. Retrograde inflammatory signaling from neutrophils to endothelial cells by soluble interleukin-6 receptor alpha. J Clin Invest 1997; 100: 2752–6.
Molina-Holgado E, et al. Induction of COX-2 and PGE(2) biosynthesis by IL-1beta is mediated by PKC and mitogen-activated protein kinases in murine astrocytes. Br J Pharmacol 2000; 131: 152–9.
Morganti-Kossmann CM, et al. Production of cytokines following brain injury: Beneficial and deleterious for the damaged tissue. Mol Psychiat 1997; 2: 133–6.
Morganti-Kossmann CM, et al. TGF-beta is elevated in the CSF of patients with severe traumatic brain injuries and parallels blood–brain barrier function. J Neurotrauma 1999; 16: 617–28.
Morganti-Kossmann MC, et al. Cytokines and neuropathology. Trends Pharmacol Sci 1992; 13: 286–91.
Morganti-Kossmann MC, et al. Role of cerebral inflammation after traumatic brain injury: A revisited concept. Shock 2001; 16: 165–77.
Nakajima K, Kohsaka S. Microglia: Neuroprotective and neurotrophic cells in the central nervous system. Curr Drug Targets Cardiovasc Haematol Disord 2004; 4: 65–84.
Narayan RK, et al. Clinical trials in head injury. J Neurotrauma 2002; 19: 503–57.
Neidhardt R, et al. Relationship of interleukin-10 plasma levels to severity of injury and clinical outcome in injured patients. J Trauma 1997; 42: 863–70.
Norris JG, et al. Signal transduction pathways mediating astrocyte IL-6 induction by IL-1 beta and tumor necrosis factor-alpha. J Immunol 1994; 152: 841–50.
O’Neill LAJ, Greene C. Signal transduction pathways activated by the IL-1 receptor family: Ancient signaling machinery in mammals, animals and plants. J Leukoc Biol 1998; 63: 650–7.
Otto VI, et al. sICAM-1 and TNF-alpha induce MIP-2 with distinct kinetics in astrocytes and brain microvascular endothelial cells. J Neurosci Res 2000; 60: 733–42.
Penkowa M, et al. Impaired inflammatory response and increased oxidative stress and neurodegeneration after brain injury in interleukin-6-deficient mice. Glia 2000; 32: 271–85.
Penkowa M, et al. Strongly compromised inflammatory response to brain injury in interleukin-6-deficient mice. Glia 1999; 25: 343–57.
Pinteaux E, et al. Expression of interleukin-1 receptors and their role in interleukin-1 actions in murine microglial cells. J Neurochem 2002; 83: 754–63.
Plata-Salaman CR, Ffrench-Mullen JM. Interleukin-1 beta depresses calcium currents in CA1 hippocampal neurons at pathophysiological concentrations. Brain Res Bull 1992; 29: 221–3.
Pleines UE, et al. Soluble ICAM-1 in CSF coincides with the extent of cerebral damage in patients with severe traumatic brain injury. J Neurotrauma 1998; 15: 399–409.
Pober JS, Cotran RS. Cytokines and endothelial cell biology. Physiol Rev 1990; 70: 427–51.
Povlishock JT, Christman CW. The pathobiology of traumatically induced axonal injury in animals and humans: A review of current thoughts. J Neurotrauma 1995; 12: 555–64.
Probert L, et al. TNF-alpha transgenic and knockout models of CNS inflammation and degeneration. J Neuroimmunol 1997; 72: 137–41.
Rancan M, et al. Upregulation of ICAM-1 and MCP-1 but not of MIP-2 and sensorimotor deficit in response to traumatic axonal injury in rats. J Neurosci Res 2001; 63: 438–46.
Ransohoff RM, Tani M. Do chemokines mediate leukocyte recruitment in post-traumatic CNS inflammation? Trends Neurosci 1998; 21: 154–9.
Rhodes JK, et al. Expression of interleukin-6 messenger RNA in a rat model of diffuse axonal injury. Neurosci Lett 2002; 335: 1–4.
Robinson TE, Justice JB Jr. Microdialysis in the Neurosciences. Amsterdam: Elsevier, 1991.
Romano M, et al. Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment. Immunity 1997; 6: 315–25.
Rosenberg GA, et al. Tumor necrosis factor-alpha-induced gelatinase B causes delayed opening of the blood–brain barrier: An expanded therapeutic window. Brain Res 1995; 703: 151–5.
Ross SA, et al. The presence of tumor necrosis factor in CSF and plasma after severe head injury. Br J Neurosurg 1994; 8: 419–25.
Rostworowski M, et al. Astrogliosis in the neonatal and adult murine brain post-trauma: elevation of inflammatory cytokines and the lack of requirement for endogenous interferon-gamma. J Neurosci 1997; 17: 3664–74.
Rothwell N. Interleukin-1 and neuronal injury: Mechanisms, modification, and therapeutic potential. Brain Behav Immun 2003; 17: 152–7.
Rothwell NJ. Functions and mechanisms of interleukin 1 in the brain. Trends Pharmacol Sci 1991; 12: 430–6.
Rothwell NJ. Cytokines – killers in the brain? J Physiol 1999; 514: 3–17.
Sahuquillo J, et al. Diffuse axonal injury after severe head trauma. A clinico-pathological study. Acta Neurochir (Wien) 1989; 101: 149–58.
Scherbel U, et al. Differential acute and chronic responses of tumor necrosis factor-deficient mice to experimental brain injury. Proc Natl Acad Sci USA 1999; 96: 8721–6.
Schmidt OI, et al. Tumor necrosis factor-mediated inhibition of interleukin-18 in the brain: A clinical and experimental study in head-injured patients and in a murine model of closed head injury. J Neuroinflam 2004; 1: 13.
Sherwood ER, Prough DS. Interleukin-8, neuroinflammation, and secondary brain injury. Crit Care Med 2000; 28: 1221–3.
Shimonkevitz R, et al. Transient monocyte release of interleukin-10 in response to traumatic brain injury. Shock 1999; 12: 10–6.
Shohami E, et al. Inhibition of tumor necrosis factor alpha (TNFalpha) activity in rat brain is associated with cerebroprotection after closed head injury. J Cereb Blood Flow Metab 1996; 16: 378–84.
Shohami E, et al. Cytokine production in the brain following closed head injury: Dexanabinol (HU-211) is a novel TNF-alpha inhibitor and an effective neuroprotectant. J Neuroimmunol 1997; 72: 169–77.
Shohami E, et al. Dual role of tumor necrosis factor alpha in brain injury. Cytokine Growth Factor Rev 1999; 10: 119–30.
Shohami E, et al. Closed head injury triggers early production of TNF alpha and IL-6 by brain tissue. J Cereb Blood Flow Metab 1994; 14: 615–9.
Singhal A, et al. Association between cerebrospinal fluid interleukin-6 concentrations and outcome after severe human traumatic brain injury. J Neurotrauma 2002; 19: 929–37.
Stahel PF, et al. Intracerebral complement C5a receptor (CD88) expression is regulated by TNF and lymphotoxin-alpha following closed head injury in mice. J Neuroimmunol 2000a; 109: 164–72.
Stahel PF, et al. Experimental closed head injury: Analysis of neurological outcome, blood–brain barrier dysfunction, intracranial neutrophil infiltration, and neuronal cell death in mice deficient in genes for pro-inflammatory cytokines. J Cereb Blood Flow Metab 2000b; 20: 369–80.
Stamatovic SM, et al. Monocyte chemoattractant protein-1 regulation of blood–brain barrier permeability. J Cereb Blood Flow Metab 2005; 25: 593–606.
Stover JF, et al. Temporal profile of cerebrospinal fluid glutamate, interleukin-6, and tumor necrosis factor-alpha in relation to brain edema and contusion following controlled cortical impact injury in rats. Neurosci Lett 2000; 288: 25–8.
Sullivan PG, et al. Exacerbation of damage and altered NF-kappaB activation in mice lacking tumor necrosis factor receptors after traumatic brain injury. J Neurosci 1999; 19: 6248–56.
Swartz KR, et al. Interleukin-6 promotes post-traumatic healing in the central nervous system. Brain Res 2001; 896: 86–95.
Tasci A, et al. Prognostic value of interleukin-1 beta levels after acute brain injury. Neurol Res 2003; 25: 871–4.
Taupin V, et al. Increase in IL-6, IL-1 and TNF levels in rat brain following traumatic lesion. Influence of pre- and post-traumatic treatment with Ro5 4864, a peripheral-type (p site) benzodiazepine ligand. J Neuroimmunol 1993; 42: 177–85.
Tchelingerian JL, et al. Differential oligodendroglial expression of the tumor necrosis factor receptors in vivo and in vitro. J Neurochem 1995; 65: 2377–80.
Teasdale G, Jennett B. Assessment of coma and impaired consciousness. A practical scale. Lancet 1974; 2: 81–4.
Tehranian R, et al. Improved recovery and delayed cytokine induction after closed head injury in mice with central overexpression of the secreted isoform of the interleukin-1 receptor antagonist. J Neurotrauma 2002; 19: 939–51.
Thibeault I, et al. Regulation of the gene encoding the monocyte chemoattractant protein 1 (MCP-1) in the mouse and rat brain in response to circulating LPS and proinflammatory cytokines. J Comp Neurol 2001; 434: 461–77.
Toulmond S, Rothwell NJ. Interleukin-1 receptor antagonist inhibits neuronal damage caused by fluid percussion injury in the rat. Brain Res 1995; 671: 261–6.
Unterberg AW, et al. Edema and brain trauma. Neuroscience 2004; 129: 1021–9.
Whalen MJ, et al. Interleukin-8 is increased in cerebrospinal fluid of children with severe head injury. Crit Care Med 2000; 28: 929–34.
Winter CD, et al. A microdialysis method for the recovery of IL-1beta, IL-6 and nerve growth factor from human brain in vivo. J Neurosci Meth 2002; 119: 45–50.
Winter CD, et al. Raised parenchymal interleukin-6 levels correlate with improved outcome after traumatic brain injury. Brain 2004; 127: 315–20.
Woiciechowsky C, et al. Sympathetic activation triggers systemic interleukin-10 release in immunodepression induced by brain injury. Nat Med 1998; 4: 808–13.
Woodroofe MN, et al. Detection of interleukin-1 and interleukin-6 in adult rat brain, following mechanical injury, by in vivo microdialysis: Evidence of a role for microglia in cytokine production. J Neuroimmunol 1991; 33: 227–36.
Xiao BG, et al. Shift from anti- to proinflammatory cytokine profiles in microglia through LPS- or IFN-gamma-mediated pathways. Neuroreport 1996; 7: 1893–8.
Yatsiv I, et al. Elevated intracranial IL-18 in humans and mice after traumatic brain injury and evidence of neuroprotective effects of IL-18-binding protein after experimental closed head injury. J Cereb Blood Flow Metab 2002; 22: 971–8.