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Chapter 8 - Office Evaluation of the Subfertile Male

from Section 2 - Clinical Evaluation of the Infertile Male

Published online by Cambridge University Press:  08 July 2023

Larry I. Lipshultz
Affiliation:
Baylor College of Medicine, Texas
Stuart S. Howards
Affiliation:
University of Virginia
Craig S. Niederberger
Affiliation:
University of Illinois, Chicago
Dolores J. Lamb
Affiliation:
Weill Cornell Medical College, New York
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Summary

Infertility is often a difficult and stressful condition for both clinicians and patients to address. The possibility of being childless often challenges both the male and female partners’ self-esteem. In addition, many clinicians are often unfamiliar with the plethora of diagnostic tests currently available and the interpretation of those tests required to develop a rational management plan.

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Publisher: Cambridge University Press
Print publication year: 2023

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References

Spira, A. Epidemiology of human reproduction. Hum Reprod 1986;1 111–15.Google Scholar
Louis, JF, Thoma, ME, Sørensen, DN, et al. The prevalence of couple infertility in the United States from a male perspective: evidence from a nationally representative sample. Andrology 2013;1:741–8.CrossRefGoogle ScholarPubMed
MacLeod, J. Human male infertility. Obstet Gynecol Surv 1971;25:325.Google Scholar
Mosher, WD. Reproductive impairments in the United States, 1965–1982. Demography 1985;22:415–30.CrossRefGoogle ScholarPubMed
Simmons, FA. Human infertility. N Engl J Med 1956;255:1140–6.Google Scholar
Vine, MF, Tse, CK, Hu, P, Truong, KY. Cigarette smoking and semen quality. Fertil Steril 1996;65:835–42.Google Scholar
Aafjes, JH, van der Vijver, JC, Schenck, PE. The duration of infertility: an important datum for the fertility prognosis of men with semen abnormalities. Fertil Steril 1978;30:423–5.Google Scholar
Wang, R, Danhof, NA, Tion-Kon-Fat, RI, et al. Interventions for unexplained infertility: a systematic review and network meta-analysis. Cochrane Database Syst Rev 2019;9:CD012692.Google Scholar
Wilcox, AJ, Weinberg, CR, Baird, DD. Timing of sexual intercourse in relation to ovulation. Effects on the probability of conception, survival of the pregnancy, and sex of the baby [see comments]. N Engl J Med 1995;333:1517–21.Google Scholar
Goldenberg, RL, White, R. The effect of vaginal lubricants on sperm motility in vitro. Fertil Steril 1975;26:872–3.Google Scholar
Kutteh, WH, Chao, CH, Ritter, JO, Byrd, W. Vaginal lubricants for the infertile couple: effect on sperm activity. Int J Fertil Menopausal Stud. 1996;41:400–4.Google ScholarPubMed
Tagatz, GE, Okagaki, T, Sciarra, JJ. The effect of vaginal lubricants on sperm motility and viability in vitro. Am J Obstet Gynecol 1972;113:8890.Google Scholar
Tulandi, T, Plouffe, L Jr, McInnes, RA. Effect of saliva on sperm motility and activity. Fertil Steril 1982;38:721–3.Google Scholar
Carroll, PR, Whitmore, WF Jr, et al. Endocrine and exocrine profiles of men with testicular tumors before orchiectomy. J Urol 1987;137:420–3.CrossRefGoogle ScholarPubMed
Boyers, SP, Corrales, MD, Huszar, G, DeCherney, AH. The effects of Lubrin on sperm motility in vitro. Fertil Steril 1987;47:882–4.Google Scholar
Mesen, TB, Steiner, AZ. Effect of vaginal lubricants on natural fertility. Curr Opin Obstet Gynecol 2014;26:186–92.Google Scholar
Berger, MH, Messore, M, Pastuszak, AW, Ramasamy, R. Association between infertility and sexual dysfunction in men and women. Sex Med Rev 2016;4:353–65.Google ScholarPubMed
Kolon, FT, Patel, PR, Huff, SD. Cryptorchidism: diagnosis, treatment and long-term prognosis. Urol Clin North Am 2004;31:469–80.Google Scholar
Hadziselimovic, F, Herzog, B. The importance of both and early orchidopexy and germ cell maturation for fertility. Lancet 2001;358:1156–7.CrossRefGoogle ScholarPubMed
Lee, PA. Fertility after cryptorchidism: epidemiology and other outcome studies. Urology 2005;66:427–31.CrossRefGoogle ScholarPubMed
Lee, PA. Fertility in cryptorchidism. Does treatment make a difference? Endocrinol Metab Clin North Am 1993;22:479–90.CrossRefGoogle Scholar
Miller, KD, Coughlin, MT, Lee, PA. Fertility after unilateral cryptorchidism. Paternity, time to conception, pretreatment testicular location and size, hormone and sperm parameters. Horm Res 2001;55:249–53.Google Scholar
Kolon, TF, Herndon, CD, Baker, LA, et al. Evaluation and treatment of cryptorchidism: AUA guideline. J Urol 2014;192:337–45.CrossRefGoogle ScholarPubMed
Ritzén, EM, Bergh, A, Bjerknes, R, et al. Nordic consensus on treatment of undescended testes. Acta Paediatr 2007;96:638–43.Google Scholar
Tekgül, S, Riedmiller, H, Dogan, HS, et al. Guidelines on paediatric urology. Paediatric urology – Update March 2013. European Association of Urology, 2013.Google Scholar
Allin, BSR, Dumann, E, Fawkner-Corbett, D, Kwok, C, Skeritt, C; Paediatric Surgery Trainees Research Network. Systematic review and meta-analysis comparing outcomes following orchidopexy for cryptorchidism before or after 1 year of age. BJS Open 2018;2:112.CrossRefGoogle ScholarPubMed
Hanerhoff, BL, Welliver, C. Does early orchidopexy improve fertility? Transl Androl Urol 2014;3:370–6.Google ScholarPubMed
Grasso, M, Buonaguidi, A, Lania, C, Bergamaschi, F, Castelli, M, Rigatti, P. Postpubertal cryptorchidism: review and evaluation of the fertility. Eur Urol 1991;20:126–8.Google Scholar
Okuyama, A, Nonomura, N, Nakamura, M, et al. Surgical management of undescended testis: retrospective study of potential fertility in 274 cases. J Urol 1989;142:749–51.CrossRefGoogle ScholarPubMed
Anderson, JB, Williamson, RC. The fate of the human testes following unilateral torsion of the spermatic cord. Br J Urol 1986;58:698704.CrossRefGoogle ScholarPubMed
Anderson, JB, Williamson, RC. Fertility after torsion of the spermatic cord. Br J Urol 1990;65:225–30.CrossRefGoogle ScholarPubMed
Bartsch, G, Frank, S, Marberger, H, Mikuz, G. Testicular torsion: late results with special regard to fertility and endocrine function. J Urol 1980;124:375–8.Google Scholar
Dondero, F, Lenzi, A, Picardo, M, Pastore, R, Valesini, G. Cell-mediated antisperm immunity in selected forms of male infertility. Andrologia 1980;12:25–9.Google Scholar
Fraser, I, Slater, N, Tate, C, Smart, JG. Testicular torsion does not cause autoimmunization in man. Br J Surg 1985;72:237–8.Google Scholar
Mastrogiacomo, I, Zanchetta, R, Graziotti, P, Betterle, C, Scrufari, P, Lembo, A. Immunological and clinical study of patients after spermatic cord torsion. Andrologia 1982;14:2530.CrossRefGoogle ScholarPubMed
Puri, P, Barton, D, O’Donnell, B. Prepubertal testicular torsion: subsequent fertility. J Pediatr Surg 1985;20:598601.Google Scholar
Thomas, WE, Cooper, MJ, Crane, GA, Lee, G, Williamson, RC. Testicular exocrine malfunction after torsion. Lancet 1984;2:1357–60.Google ScholarPubMed
Hagen, P, Buchholz, MM, Eigenmann, J, Bandhauer, K. Testicular dysplasia causing disturbance of spermiogenesis in patients with unilateral torsion of the testis. Urol Int 1992;49:154–7.Google Scholar
Anderson, MJ, Dunn, JK, Lipshultz, LI, Coburn, M. Semen quality and endocrine parameters after acute testicular torsion. J Urol 1992;147: 1545–50.Google Scholar
Mastrogiacomo, I, Zanchetta, R, Graziotti, P, Betterle, C, Scrufari, P, Lembo, A. Immunological and clinical study of patients after spermatic cord torsion. Andrologia 1982;14:2530.CrossRefGoogle ScholarPubMed
Hadziselimovic, F, Snyder, H, Duckett, J, Howards, S. Testicular histology in children with unilateral testicular torsion. J Urol 1986;136(1 Pt 2):208–10.CrossRefGoogle ScholarPubMed
Laor, E, Fisch, H, Tennenbaum, S, Sesterhenn, I, Mostofi, K, Reid, RE. Unilateral testicular torsion: abnormal histological findings in the contralateral testis – cause or effect? Br J Urol 1990;65:520–3.Google Scholar
Gielchinsky, I, Suraqui, E, Hidas, G, et al. Pregnancy rates after testicular torsion. J Urol 2016;196:852–5.Google Scholar
Masarani, M, Wazait, H, Dinneen, M. Mumps orchitis. J Roy Soc Med 2006;99:5735.CrossRefGoogle ScholarPubMed
Werner, CA. Mumps orchitis and testicular atrophy; a factor in male sterility. Ann Intern Med 1950;32:1075–86.Google ScholarPubMed
Casella, R, Leibundgut, B, Lehmann, K, Gasser, TC. Mumps orchitis: report of a mini-epidemic. J Urol 1997;158:2158–61.CrossRefGoogle ScholarPubMed
Honig, SC, Lipshultz, LI, Jarow, J. Significant medical pathology uncovered by a com- prehensive male infertility evaluation. Fertil Steril 1994;62:1028.Google Scholar
Greene, LF, Kelalis, PP. Retrograde ejaculation of semen due to diabetic neuropathy. J Urol 1967;98:696.Google Scholar
Drucker, WD, Blanc, WA, Rowland, MM, et al. The testis in myotonic muscular dystrophy: a clinical and pathologic study with a comparison with Klinefelter’s syndrome. J Clin Endocrinol Metab 1963;23:59.Google Scholar
Weidner, W, Krause, W, Ludwig, M. Relevance of male accessory gland infection for subsequent fertility with special focus on prostatitis. Hum Reprod Update 1999;5:421–32.Google Scholar
Jung, JH, Kim, MH, Kim, J, et al. Treatment of leukocytospermia in male infertility: a systematic review. World J Mens Health 2016;34:165–72.Google Scholar
Brunner, RJ, Demeter, JH, Sindhwani, P. Review of guidelines for the evaluation and treatment of leukocytospermia in male infertility. World J Mens Health 2019;37:128–37.Google Scholar
Zariwala, MA, Knowles, MR, Leigh, MW. Primary ciliary dyskinesia. In: Adam, MP, Ardinger, HH, Pagon, RA, et al., eds. GeneReviews®. Seattle, WA: University of Washington, 2007. Available from: www.ncbi.nlm.nih.gov/books/Google Scholar
Wilton, LJ, Teichtahl, H, Temple-Smith, PD, De Kretser, DM. Kartagener’s syndrome with motile cilia and immotile spermatozoa: axonemal ultrastructure and function. Am Rev Respir Dis 1986;134:1233–6.Google Scholar
Rusz, A, Pilatz, A, Wagenlehner, F, et al. Influence of urogenital infections and inflammation on semen quality and male fertility. World J Urol 2012;30:2330.Google Scholar
Weidner, W, Pilatz, A, Diemer, T, Schuppe, HC, Rusz, A, Wagenlehner, F. Male urogenital infections: impact of infection and inflammation on ejaculate parameters. World J Urol 2013;31:717–23.Google Scholar
Govero, J, Esakky, P, Scheaffer, SM, et al. Zika virus infection damages the testes in mice. Nature 2016;540:438–42.CrossRefGoogle ScholarPubMed
Uraki, R, Hwang, J, Jurado, KA, et al. Zika virus causes testicular atrophy. Sci Adv 2017;3:e1602899.Google Scholar
Donohue, JP, Thornhill, JA, Foster, RS, Rowland, RG, Bihrle, R. Retroperitoneal lymphadenectomy for clinical stage A testis cancer (1965 to 1989): modifications of technique and impact on ejaculation. J Urol 1993;149:237–43.CrossRefGoogle Scholar
Jewett, MA. Nerve-sparing technique for retroperitoneal lymphadenectomy in testis cancer. Urol Clin North Am 1990;17:449–56.CrossRefGoogle ScholarPubMed
Jacobsen, KD, Ous, S, Waehre, H, et al. Ejaculation in testicular cancer patients after post-chemotherapy retroperitoneal lymph node dissection. Br J Cancer 1999;80(1–2):249–55.CrossRefGoogle ScholarPubMed
Shin, D, Lipshultz, LI, Goldstein, M, et al. Herniorrhaphy with polypropylene mesh causing inguinal vasal obstruction: a preventable cause of obstructive azoospermia. Ann Surg 2005;241:553–8.Google Scholar
Kordzadeh, A, Liu, MO, Jayanthia, NV. Male infertility following inguinal hernia repair: a systematic review and pooled analysis. Hernia 2017;21:17.Google Scholar
Berthelsen, JG, Skakkebaek, NE. Gonadal function in men with testis cancer. Fertil Steril 1983;39:6875.Google Scholar
Dubin, L, Amelar, RD. Sexual causes of male infertility. Fertil Steril 1972;23:579–82.Google Scholar
Ohl, DA, Sonksen, J. What are the chances of infertility and should sperm be banked? Semin Urol Oncol 1996;14:3644.Google ScholarPubMed
Howell, SJ, Shalet, SM. Spermatogenesis after cancer treatment: damage and recovery. J Natl Cancer Inst Monogr 2005;34:1217.CrossRefGoogle Scholar
Hahn, EW, Feingold, SM, Simpson, L, Batata, M. Recovery from aspermia induced by low-dose radiation in seminoma patients. Cancer 1982;50:337–40.Google Scholar
Fossa, SD, Aass, N, Kaalhus, O. Long-term morbidity after infradiaphragmatic radiotherapy in young men with testicular cancer. Cancer 1989;64:404–8.Google Scholar
Hallak, J, Kolettis, PN, Sekhon, VS, Thomas, AJ Jr, Agarwal, A. Cryopreservation of sperm from patients with leukemia: is it worth the effort? [see comments]. Cancer 1999;85:1973–8.Google Scholar
Rueffer, U, Breuer, K, Josting, A, et al. Male gonadal dysfunction in patients with Hodgkin’s disease prior to treatment. Ann Oncol 2001;12:1307–11.Google Scholar
Agarwal, A, Allamaneni, SS. Disruption of spermatogenesis by the cancer disease process. J Natl Cancer Inst Monogr 2005;34:912.Google Scholar
Meistrich, ML, Wilson, G, Mathur, K, et al. Rapid recovery of spermatogenesis after mitoxantrone, vincristine, vinblastine, and prednisone chemotherapy for Hodgkin’s disease. J Clin Oncol 1997;15:3488–95.Google Scholar
Anserini, P, Chiodi, S, Spinelli, S, et al. Semen analysis following allogeneic bone marrow transplantation. Additional data for evidence-based counselling. Bone Marrow Transplant 2002;30:447–51.CrossRefGoogle ScholarPubMed
Colpi, GM, Contalbi, GF, Nerva, F, et al. Testicular function following chemo-radiotherapy. Eur J Obstet Gynecol Reprod Biol 2004;113(Suppl 1):S2–6.Google Scholar
Harmon, J, Aliapoulios, MA. Gynecomastia in marihuana users. N Engl J Med 1972;287:936.Google Scholar
Close, CE, Roberts, PL, Berger, RE. Cigarettes, alcohol and marijuana are related to pyospermia in infertile men. J Urol 1990;144:900–3.Google Scholar
Hembree, WC, Zeidenbert, P, Nahas, G, et al. Marijuana effects on human gonadal function. In: Nahas, G, Poton, WDM, Indanpaan-Heittila, J, eds. Marijuana: Chemistry. Biochemistry and Cellular Effects. New York, NY: Springer-Verlag, 1976; pp. 521–7.Google Scholar
Gundersen, TD, Jorgensen, N, Andersson, AM, et al. Association between use of marijuana and male reproductive hormones and semen quality: a Study among 1,215 healthy young men. Am J Epidemiol 2015;182:473–81.Google Scholar
Kasman, AM, Thoma, ME, McLain, AC, et al. Association between use of marijuana and time to pregnancy in men and women : findings from the National Survey of Family Growth. Fertil Steril 2018;109:866–71.Google Scholar
Thistle, JE, Graubard, BI, Braunline, M, et al. Marijuana use and serum testosterone concentrations among U.S. males. Andrology 2017;5:732–8.Google Scholar
Bracken, MB, Eskenazi, B, Sachse, K, et al. Association of cocaine use with sperm concentration, motility, and morphology. Fertil Steril 1990;53:315–22.Google Scholar
Hurd, WW, Kelly, MS, Ohl, DA, et al. The effect of cocaine on sperm motility characteristics and bovine cervical mucus penetration. Fertil Steril 1992;57:178–82.Google Scholar
Samplaski, MK, Bachir, BG, Lo, KC, et al. Cocaine use in the infertile male population: a marker for conditions resulting in subfertility. Curr Urol 2015;8:3842.CrossRefGoogle ScholarPubMed
Tidd, MJ, Horth, CE, Ramsay, LE, Shelton, JR, Palmer, RF. Endocrine effects of spironolactone in man. Clin Endocrinol (Oxf) 1978;9:389–99.Google Scholar
Millsop, JW, Heller, MM, Eliason, MJ, Murase, JE. Dermatological medication effects on male fertility. Dermatol Ther 2013;26:337–46.Google Scholar
Benoff, S, Cooper, GW, Hurley, I, et al. The effect of calcium ion channel blockers on sperm fertilization potential. Fertil Steril 1994;62:606–17.Google Scholar
Hershlag, A, Cooper, GW, Benoff, S. Pregnancy following discontinuation of a calcium channel blocker in the male partner. Hum Reprod 1995;10:599606.Google Scholar
Katsoff, D, Check, JH. A challenge to the concept that the use of calcium channel blockers causes reversible male infertility. Hum Reprod 1997;12:1480–2.Google Scholar
Coscrove, MD, Benton, B, Henderson, BE. Male genitourinary abnormalities and maternal diethylstilbestrol. J Urol 1977;117:220–2.Google Scholar
Wilcox, AJ, Baird, DD, Weinberg, CR, Hornsby, PP, Herbst, AL. Fertility in men exposed prenatally to diethylstilbestrol. N Engl J Med 1995;332:1411–16.Google Scholar
Palmer, JR, Herbst, AL, Noller, KL, et al. Urogenital abnormalities in men exposed to diethylstilbestrol in utero: a cohort study. Environ Health 2009;8:37.Google Scholar
Liu, PY, Swerdloff, RS, Christenson, PD, Handelsman, DJ, Wang, C; Hormonal Male Contraception Summit Group. Rate, extent, and modifiers of spermatogenic recovery after hormonal male contraception: an integrated analysis. Lancet 2006;367:1412–20.Google Scholar
Kohn, TP, Louis, MR, Pickett, SM, et al. Age and duration of testosterone therapy predict time to return of sperm count after human chorionic gonadotropin therapy. Fertil Steril 2017;107:3517.e1.Google Scholar
Giuliano, F. Impact of medical treatments for benign prostatic hyperplasia on sexual function. BJU Int 2006;97 Suppl 2:34–8.Google Scholar
Hellstrom, WJG, Sikka, SC. Effects of acute treatment with tamsulosin versus alfuzosin on ejaculatory function in normal volunteers. J Urol 2006;176:1529–33.Google Scholar
Schlegel, PN, Chang, TS, Marshall, FF. Antibiotics: potential hazards to male fertility. Fertil Steril 1991;55:235–42.Google Scholar
Nelson, WO, Steinburger, E. The effect of furadroxyl upon the testis of the rat. Anat Rec 1952;112:367.Google Scholar
Nelson, WO, Bunge, RB. The effect of therapeutic dosages of nitrofurantoin upon spermatogenesis in man. J Urol 1957;77:275–82.Google Scholar
Hargreaves, CA, Rogers, S, Hills, F, et al. Effects of co-trimoxazole, erythromycin, amoxycillin, tetracycline and chloroquine on sperm function in vitro. Hum Reprod 1998;13:1878–86.Google Scholar
Millsop, JW, Heller, MM, Eliason, MJ, Murase, JE. Dermatological medication effects on male fertility. Dermatol Ther 2013;26:337–46.Google Scholar
Birnie, GG, McLeod, TI, Watkinson, G. Incidence of sulphasalazine-induced male infertility. Gut 1981;22:452–5.Google Scholar
Toovey, S, Hudson, E, Hendry, WF, Levi, AJ. Sulphasalazine and male infertility: reversibility and possible mechanism. Gut 1981;22:445–51.Google Scholar
Riley, SA, Lecarpentier, J, Mani, V, et al. Sulphasalazine induced seminal abnormalities in ulcerative colitis: results of mesalazine substitution. Gut 1987;28:1008–12.Google Scholar
Sawyer, D, Conner, CS, Scalley, R. Cimetidine: adverse reactions and acute toxicity. Am J Hosp Pharm 1981;38:188–97.Google ScholarPubMed
Wang, C, Lai, CL, Lam, KC, Yeung, KK. Effect of cimetidine on gonadal function in man. Br J Clin Pharmacol 1982;13:791–4.Google Scholar
Semet, M, Paci, M, Saïas-Magnan, J, et al. The impact of drugs on male fertility: a review. Andrology 2017;5:640–63.Google Scholar
Sarica, K, Suzer, O, Gurler, A, Baltaci, S, Ozdiler, E, Dincel, C. Urological evaluation of Behcet patients and the effect of colchicine on fertility. Eur Urol 1995;27:3942.Google Scholar
Haimov-Kochman, R, Ben Chetrit, E. The effect of colchicine treatment on sperm production and function: a review. Hum Reprod 1998;13:360–2.Google Scholar
Srinivas, M, Agarwala, S, Datta, GS, et al. Effect of cyclosporine on fertility in male rats. Pediatr Surg Int 1998;13(5–6):388–91.Google Scholar
Midtvedt, K, Bergan, S, Reisæter, AV, et al. Exposure to mycophenolate and fatherhood. Transplantation 2017;101:e214–17.Google Scholar
Leroy, C, Rigot, JM, Leroy, M, et al. Immunosuppressive drugs and fertility. Orphanet J Rare Dis 2015;10:136.Google Scholar
Shin, T, Okada, H. Infertility in men with inflammatory bowel disease. World J Gastrointest Pharmacol Ther 2016;7:361–9.Google Scholar
Weber-Schoendorfer, C, Hoeltzenbein, M, Wacker, E, Meister, R, Schaefer, C. No evidence for an increased risk of adverse pregnancy outcome after paternal low-dosemethotrexate: an observational cohort study. Rheumatology (Oxf) 2014;53:757–63.Google Scholar
Guiterrez, JC, Hwang, K. The toxicity of methotrexate in male fertility and paternal teratogenicity. Expert Opin Drug Metab Toxicol 2017;13:51–8.Google Scholar
Niederberger, C. Atorvastatin and male infertility: is there a link? J Androl 2005;26:12.Google Scholar
Keihani, S, Martin, C, Craig, JR, et al. Semen parameters are unaffected by statin use in men evaluated for infertility. Andrologia 2018;50:e12995.Google Scholar
Daniell, HW. Hypogonadism in men consuming sustained-action oral opioids. J Pain 2002;3:377–84.Google Scholar
Roberts, LJ, Finch, PM, Pullan, PT, Bhagat, CI, Price, LM. Sex hormone suppression by intrathecal opioids: a prospective study. Clin J Pain 2002;18:144–8.Google Scholar
Cicero, TJ, Davis, LA, LaRegina, MC, Meyer, ER, Schlegel, MS. Chronic opiate exposure in the male rat adversely affects fertility. Pharmacol Biochem Behav 2002;72:157–63.Google Scholar
Gates, JR. Epilepsy versus antiepileptic drugs and gonadal function in men. Neurology 2004;62:174–5.Google Scholar
Isojärvi, JI, Löfgren, E, Juntunen, KS, et al. Effect of epilepsy and antiepileptic drugs on male reproductive health. Neurology 2004;62:247–53.Google Scholar
Hellstrom, WJ, Sikka, SC. Effects of alfuzosin and tamsulosin on sperm parameters in healthy men: results of a short-term, randomized, double-blind, placebo-controlled, crossover study. J Androl 2009;30:469–74.Google Scholar
Gacci, M, Ficarra, V, Sebastianelli, A, et al. Impact of medical treatments for male lower urinary tract symptoms due to benign prostatic hyperplasia on ejaculatory function: a systematic review and meta-analysis. J Sex Med 2014;11:1554–66.Google Scholar
Shimizu, F, Taguri, M, Harada, Y, Matsuyama, Y, Sase, K, Fujime, M. Impact of dry ejaculation caused by highly selective alpha1a-blocker: randomized, double-blind, placebo-controlled crossover pilot study in healthy volunteer men. J Sex Med 2010;7:1277–83.Google Scholar
Lipshultz, LI, Ross, CE, Whorton, D, Milby, T, Smith, R, Joyner, RE. Dibromochloropropane and its effect on testicular function in man. J Urol 1980;124:464–8.Google Scholar
Strohmer, H, Boldizsar, A, Plockinger, B, Feldner-Busztin, M, Feichtinger, W. Agricultural work and male infertility. Am J Ind Med 1993;24:587–92.Google Scholar
De Celis, R, Feria-Velasco, A, Gonzalez-Unzaga, M, Torres-Calleja, J, Pedron-Nuevo, N. Semen quality of workers occupationally exposed to hydrocarbons. Fertil Steril 2000;73:221–8.Google Scholar
Kim, Y, Park, J, Moon, Y. Hematopoietic and reproductive toxicity of 2-bromopropane, a recently introduced substitute for chlorofluorocarbons. Toxicol Lett 1999;108(2–3):309–13.Google Scholar
Lancranjan, I, Popescu, HI, Gavanescu, O, Klepsch, I, Serbanescu, M. Reproductive ability of workmen occupationally exposed to lead. Arch Environ Health 1975;30:396401.Google Scholar
Telisman, S, Cvitkovic, P, Jurasovic, J, Pizent, A, Gavella, M, Rocic, B. Semen quality and reproductive endocrine function in relation to biomarkers of lead, cadmium, zinc, and copper in men. Environ Health Perspect 2000;108:4553.Google Scholar
Toth, A. Reversible toxic effect of salicylazosulfapyridine on semen quality. Fertil Steril 1979;31:538–40.Google Scholar
Van Thiel, DH, Gavaler, JS, Smith, WI Jr, Paul, G. Hypothalamic–pituitary–gonadal dysfunction in men using cimetidine. N Engl J Med 1979;300:1012–15.Google Scholar
Curtis, KM, Savitz, DA, Arbuckle, TE. Effects of cigarette smoking, caffeine consumption, and alcohol intake on fecundability. Am J Epidemiol 1997;146:3241.Google Scholar
Dunphy, BC, Barratt, CL, Cooke, ID. Male alcohol consumption and fecundity in couples attending an infertility clinic. Andrologia 1991;23:219–21.Google Scholar
Goverde, HJ, Dekker, HS, Janssen, HJ, Bastiaans, BA, Rolland, R, Zielhuis, GA. Semen quality and frequency of smoking and alcohol consumption – an explorative study. Int J Fertil Menopausal Stud 1995;40:135–8.Google ScholarPubMed
Olsen, J, Bolumar, F, Boldsen, J, Bisanti, L. Does moderate alcohol intake reduce fecundability? A European multicenter study on infertility and subfecundity. European Study Group on Infertility and Subfecundity. Alcohol Clin Exp Res 1997;21:206–12.Google Scholar
Jensen, TK, Swan, S, Jørgensen, N, et al. Alcohol and male reproductive health: a cross-sectional study of 8344 healthy men from Europe and the USA. Hum Reprod 2014;29:1801–9.Google Scholar
Muthusami, KR, Chinnaswamy, P. Effect of chronic alcoholism on male fertility hormones and semen quality. Fertil Steril 2005;84:919–24.Google Scholar
Pfeifer, S, Fritz, M, Goldberg, J, et al. Smoking and infertility: a committee opinion. Fertil Steril 2012;98:1400–6.Google Scholar
Chia, SE, Lim, ST, Tay, SK, Lim, ST. Factors associated with male infertility: a case-control study of 218 infertile and 240 fertile men. BJOG 2000;107:5561.Google Scholar
Dikshit, RK, Buch, JG, Mansuri, SM. Effect of tobacco consumption on semen quality of a population of hypofertile males. Fertil Steril 1987;48:334–6.Google Scholar
Evans, HJ, Fletcher, J, Torrance, M, Hargreave, TB. Sperm abnormalities and cigarette smoking. Lancet 1981;1:627–9.Google Scholar
Marshburn, PB, Sloan, CS, Hammond, MG. Semen quality and association with coffee drinking, cigarette smoking, and ethanol consumption. Fertil Steril 1989;52:162–5.Google Scholar
Osser, S, Beckman-Ramirez, A, Liedholm, P. Semen quality of smoking and non-smoking men in infertile couples in a Swedish population. Acta Obstet Gynecol Scand 1992;71:215–18.Google Scholar
Hull, MG, North, K, Taylor, H, Farrow, A, Ford, WC. Delayed conception and active and passive smoking. The Avon Longitudinal Study of Pregnancy and Childhood Study Team. Fertil Steril 2000;74:725–33.Google Scholar
Zitzmann, M, Rolf, C, Nordhoff, V, et al. Male smokers have a decreased success rate for in vitro fertilization and intracytoplasmic sperm injection. Fertil Steril 2003;79 Suppl 3:1550–4.Google Scholar
Jensen, TK, Henriksen, TB, Hjollund, NH, et al. Adult and prenatal exposures to tobacco smoke as risk indicators of fertility among 430 Danish couples. Am J Epidemiol 1998;148:992–7.Google Scholar
Jensen, TK, Henriksen, TB, Hjollund, NH, et al. Caffeine intake and fecundability: a follow-up study among 430 Danish couples planning their first pregnancy. Reprod Toxicol 1998;12:289–95.Google Scholar
Dias, TR, Alves, MG, Bernardino, RL, et al. Dose-dependent effects of caffeine in human Sertoli cells metabolism and oxidative profile: relevance for male fertility. Toxicology 2015;328:1220.Google Scholar
Jensen, TK, Swan, SH, Skakkebaek, NE, Rasmussen, S, Jørgensen, N. Caffeine intake and semen quality in a population of 2,554 young Danish men. Am J Epidemiol 2010;171:883–91.Google Scholar
Ricci, E, Vigano, P, Cipriani, S, et al. Coffee and caffeine intake and male infertility: a systematic review. Nutr J 2017;16:37.Google Scholar
Brown-Woodman, PD, Post, EJ, Gass, GC, White, IG. The effect of a single sauna exposure on spermatozoa. Arch Androl 1984;12:915.Google Scholar
Lue, YH, Lasley, BL, Laughlin, LS, et al. Mild testicular hyperthermia induces profound transitional spermatogenic suppression through increased germ cell apoptosis in adult cynomolgus monkeys (Macaca fascicularis). J Androl 2002;23:799805.Google Scholar
Saikhun, J, Kitiyanant, Y, Vanadurongwan, V, Pavasuthipaisit, K. Effects of sauna on sperm movement characteristics of normal men measured by computer-assisted sperm analysis. Int J Androl 1998;21:358–63.Google Scholar
Velez de la Calle, JF, Rachou, E, le Martelot, MT, Ducot, B, Multigner, L, Thonneau, PF. Male infertility risk factors in a French military population. Hum Reprod 2001;16:481–6.Google Scholar
Wang, C, McDonald, V, Leung, A, et al. Effect of increased scrotal temperature on sperm production in normal men. Fertil Steril 1997;68:334–9.Google Scholar
Garolla, A, Torino, M, Sartini, B, et al. Seminal and molecular evidence that sauna exposure affects human spermatogenesis. Hum Reprod 2013;28:877–85.Google Scholar
Shefi, S, Tarapore, PE, Walsh, TJ, Croughan, M, Turek, PJ. Wet heat exposure: a potentially reversible cause of low semen quality in infertile men. Int Braz J Urol 2007;33:50–7.Google Scholar
Lipshultz, LI Corriere, JN Jr. Progressive testicular atrophy in the varicocele patient. J Urol 1977;117:175–6.Google Scholar
Charny, CW. The spermatogenic potential of the undescended testis before and after treatment. J Urol 1960;83 697705.Google Scholar
Gunalp, S, Onculoglu, C, Gurgan, T, Kruger, TF, Lombard, CJ. A study of semen parameters with emphasis on sperm morphology in a fertile population: an attempt to develop clinical thresholds. Hum Reprod 2001;16:110–14.Google Scholar
Lubs, HA. Testicular size in Klinefelter’s syndrome in men over fifty. N Engl J Med 1962;267:326–31.Google Scholar
Guzick, DS, Overstreet, JW, Factor-Litvak, P, et al. Sperm morphology, motility, and concentration in fertile and infertile men. N Engl J Med 2001;345:1388–93.Google Scholar
Smith, KD, Rodriguez-Rigau, LJ, Steinberger, E. Relation between indices of semen analysis and pregnancy rate in infertile couples. Fertil Steril 1977;28:1314–19.Google Scholar
Battin, D, Vargyas, JM, Sato, F, Brown, J, Marrs, RP. The correlation between in vitro fertilization of human oocytes and semen profile. Fertil Steril 1985;44:835–8.CrossRefGoogle ScholarPubMed
Matson, PL, Turner, SR, Yovich, JM, Tuvik, AI, Yovich, JL. Oligospermic infertility treated by in-vitro fertilization. Aust N Z J Obstet Gynaecol 1986;26:84–7.Google Scholar
Carlsen, E, Petersen, JH, Andersson, AM, Skakkebaek, NE. Effects of ejaculatory frequency and season on variations in semen quality. Fertil Steril 2004;82:358–66.Google Scholar
Koburi, Y. Home testing for male factor infertility: a review of current options. Fertil Steril 2019;111:864–70.Google Scholar
Santomauro, AG, Sciarra, JJ, Varma, AO. A clinical investigation of the role of the semen analysis and postcoital test in the evaluation of male infertility. Fertil Steril 1972;23:245–51.Google Scholar
Munuce, MJ, Bregni, C, Carizza, C, Mendeluk, G. Semen culture, leukocytospermia, and the presence of sperm antibodies in seminal hyperviscosity. Arch Androl 1999;42:21–8.Google Scholar
Mahmoud, AM, Depoorter, B, Piens, N, Comhaire, FH. The performance of 10 different methods for the estimation of sperm concentration. Fertil Steril 1997;68:340–5.Google Scholar
Imade, GE, Towobola, OA, Sagay, AS, Otubu, JA. Discrepancies in sperm count using improved Neubauer, Makler, and Horwells counting chambers. Arch Androl 1993;31:1722.Google Scholar
MacLeod, J. Human seminal cytology as a sensitive indicator of the germinal epithelium. Int J Fertil 1964;9:281–95.Google Scholar
Fredricsson, B, Bjork, G. Morphology of postcoital spermatozoa in the cervical secretion and its clinical significance. Fertil Steril 1977;28:841–5.Google Scholar
Liu, DY, Baker, HW. Morphology of spermatozoa bound to the zona pellucida of human oocytes that failed to fertilize in vitro. J Reprod Fertil 1992;94:7184.Google Scholar
Menkveld, R, Stander, FS, Kotze, TJ, Kruger, TF, van Zyl, JA. The evaluation of morphological characteristics of human spermatozoa according to stricter criteria. Hum Reprod 1990;5:586–92.Google Scholar
Mortimer, D, Leslie, EE, Kelly, RW, Templeton, AA. Morphological selection of human spermatozoa in vivo and in vitro. J Reprod Fertil 1982;64:391–9.Google Scholar
Van Waart, J, Kruger, TF, Lombard, CJ, Ombelet, W. Predictive value of normal sperm morphology in intrauterine insemination (IUI): a structured literature review. Hum Reprod Update 2001;7:495500.Google Scholar
Spiessens, C, Vanderschueren, D, Meuleman, C, D’Hooghe, T. Isolated teratozoospermia and intrauterine insemination. Fertil Steril 2003;80:1185–9.Google Scholar
Shibahara, H, Obara, H, Ayustawati, , et al. Prediction of pregnancy by intrauterine insemination using CASA estimates and strict criteria in patients with male factor infertility. Int J Androl 2004;27:63–8.Google Scholar
Lemmens, L, Kos, S, Beijer, C, et al. Predictive value of sperm morphology and progressively motile sperm count for pregnancy outcomes in intrauterine insemination. Fertil Steril 2016;105:1462–8.Google Scholar
Roux, A, Siebert, TI, Van der Merwe, JP, Kruger, TF. Interstitial pregnancy managed medically. J Obstet Gynaecol 2004;24:587–9.Google Scholar
Kovac, JR, Smith, RP, Cajipe, M, Lamb, DJ, Lipshultz, LI. Men with a complete absence of normal sperm morphology exhibit high rates of success without assisted reproduction. Asian J Androl 2017;19:3942.Google Scholar
Yeung, CH, Cooper, TG, Nieschlag, E. A technique for standardization and quality control of subjective sperm motility assessments in semen analysis. Fertil Steril 1997;67:1156–8.Google Scholar
Yanagimachi, R. The movement of golden hamster spermatozoa before and after capacitation. J Reprod Fertil 1970;23:193–6.Google Scholar
Suarez, SS, Ho, HC. Hyperactivation of mammalian sperm. Cell Mol Biol (Noisy-le-grand) 2003;49:351–6.Google Scholar
Keel, BA, Quinn, P, Schmidt, CF Jr, et al. Results of the American Association of Bioanalysts national proficiency testing programme in andrology. Hum Reprod 2000;15:680–6.Google Scholar
Amann, RP, Katz, DF. Reflections on CASA after 25 years. J Androl 2004;25:317–25.Google Scholar
Davis, RO, Katz, DF. Computer-aided sperm analysis: technology at a crossroads [editorial]. Fertil Steril 1993;59:953–5.Google Scholar
Krause, W. Computer-assisted semen analysis systems: comparison with routine evaluation and prognostic value in male fertility and assisted reproduction. Hum Reprod 1995;10 Suppl 1:60–6.Google Scholar
Talarczyk-Desole, J, Berger, A, Taszarek-Hauke, G, Hauke, J, Pawelczyk, L, Jedrzejczak, P. Manual vs. computer-assisted sperm analysis: can CASA replace manual assessment of human semen in clinical practice? Ginekol Pol 2017;88:5660.Google Scholar
Gunn, DD, Bates, GW. Evidence-based approach to unexplained infertility: a systematic review. Fertil Steril 2016;105:156674.e1.Google Scholar
Corea, M, Campagnone, J, Sigman, M. The diagnosis of azoospermia depends on the force of centrifugation. Fertil Steril 2005;83:920–2.Google Scholar
Oates, RD, Amos, JA. The genetic basis of congenital bilateral absence of the vas deferens and cystic fibrosis. J Androl 1994;15:18.Google Scholar
Schlegel, PN, Shin, D, Goldstein, M. Urogenital anomalies in men with congenital absence of the vas deferens. J Urol 1996;155:1644–8.Google Scholar
Schoor, RA, Elhanbly, S, Niederberger, CS, Ross, LS. The role of testicular biopsy in the modern management of male infertility. J Urol 2002;167:197200.Google Scholar
Gordetsky, J, van Wijngaarden, E, O’Brien, J. Redefining abnormal follicle-stimulating hormone in the male infertility population. BJU Int 2012;110:568–72.Google Scholar
Jarow, JP. Transrectal ultrasonography in the diagnosis and management of ejaculatory duct obstruction. J Androl 1996;17:467–72.Google Scholar
Jarow, JP, Espeland, MA, Lipshultz, LI. Evaluation of the azoospermic patient. J Urol 1989;142:62–5.Google Scholar
Sharlip, ID, Jarow, JP, Belker, AM, et al. Best practice policies for male infertility. Fertil Steril 2002;77:873–82.Google Scholar
Meacham, RB, Hellerstein, DK, Lipshultz, LI. Evaluation and treatment of ejaculatory duct obstruction in the infertile male. Fertil Steril 1993;59:393–7.Google Scholar
Blickenstorfer, K, Voelkle, M, Xie, M, Fröhlich, A, Imthurn, B, Leeners, B. Are WHO recommendations to perform 2 consecutive semen analyses for reliable diagnosis of male infertility still valid? J Urol 2019;201:783–91.Google Scholar
Sigman, M. Introduction: ejaculatory problems and male infertility. Fertil Steril 2015;104:1049–50.Google Scholar
Corea, M, Campagnone, J, Sigman, M. The diagnosis of azoospermia depends on the force of centrifugation. Fertil Steril 2005;83:920–2.Google Scholar
Mehta, A, Jarow, JP, Maples, P, Sigman, M. Defining the “normal” postejaculate urinalysis. J Androl 2012;33:917–20.Google Scholar
Belker, AM, Steinbock, GS. Transrectal prostate ultrasonography as a diagnostic and therapeutic aid for ejaculatory duct obstruction. J Urol 1990;144(2 Pt 1):356–8.Google Scholar
Wosnitzer, MS. Genetic evaluation of male infertility. Transl Androl Urol 2014;3:1726.Google Scholar
Bollendorf, A, Check, JH, Katsoff, D, Fedele, A. The use of chymotrypsin/galactose to treat spermatozoa bound with anti-sperm antibodies prior to intra-uterine insemination. Hum Reprod 1994;9:484–8.Google Scholar
Pereira, R, Barbosa, T, Alves, Â, Santos, R, Oliveira, J, Sousa, M. Unveiling the genetic etiology of primary ciliary dyskinesia: when standard genetic approach is not enough. Adv Med Sci 2019;65:111.Google Scholar
Singh, G. Ultrastructural features of round-headed human spermatozoa. Int J Fertil 1992;37:99102.Google Scholar
Fesahat, F, Henkel, R, Agarwal, A. Globozoospermia syndrome: an update. Andrologia 2019;14:e13459.Google Scholar
Shabtaie, S, Gerkowicz, SA, Kohn, PT, Ramasamy, R. Role of abnormal sperm morphology in predicting pregnancy outcomes. Curr Urol Rep 2016;17:67.Google Scholar
Kim, FY, Goldstein, M. Antibacterial skin preparation decreases the incidence of false-positive semen culture results. J Urol 1999;161:819–21.Google Scholar
Koh, SB, Park, HJ, Seo, JT, Treatment of leukocytospermia in male infertility: a systematic review. World J Mens Health 2016;34:165-–72.Google Scholar
Sigman, M Jarow, JP. Endocrine evaluation of infertile men. Urology 1997;50:659–64.Google Scholar
Bain, J, Langevin, R, D’Costa, M, Sanders, RM, Hucker, S. Serum pituitary and steroid hormone levels in the adult male: one value is as good as the mean of three. Fertil Steril 1988;49:123–6.Google Scholar
Tomlinson, MJ, Barratt, CL, Cooke, ID. Prospective study of leukocytes and leukocyte subpopulations in semen suggests they are not a cause of male infertility [see comments]. Fertil Steril 1993;60:1069–75.Google Scholar
Berger, RE, Karp, LE, Williamson, RA, Koehler, J, Moore, DE, Holmes, KK. The relationship of pyospermia and seminal fluid bacteriology to sperm function as reflected in the sperm penetration assay. Fertil Steril 1982;37:557–64.Google Scholar
Maruyama, DK Jr, Hale, RW, Rogers, BJ. Effects of white blood cells on the in vitro penetration of zona-free hamster eggs by human spermatozoa. J Androl 1985;6:127–35.Google Scholar
Rodin, DM, Larone, D, Goldstein, M. Relationship between semen cultures, leukospermia, and semen analysis in men undergoing fertility evaluation. Fertil Steril 2003;79 Suppl 3:1555–8.Google Scholar
Sigman, M, Lopes, L. The correlation between round cells and white blood cells in the semen. J Urol 1993;149(5 Pt 2):1338–40.Google Scholar
Yanushpolsky, EH, Politch, JA, Hill, JA, Anderson, DJ. Antibiotic therapy and leukocytospermia: a prospective, randomized, controlled study. Fertil Steril 1995;63:142–7.Google Scholar
Matson, PL, Junk, SM, Spittle, JW, Yovich, JL. Effect of antispermatozoal antibodies in seminal plasma upon spermatozoal function. Int J Androl 1988;11:101–6.Google Scholar
Menge, AC, Beitner, O. Interrelationships among semen characteristics, antisperm antibodies, and cervical mucus penetration assays in infertile human couples. Fertil Steril 1989;51:486–92.Google Scholar
Kremer, J, Jager, S. The significance of antisperm antibodies for sperm-cervical mucus interaction. Hum Reprod 1992;7:781–4.Google Scholar
Lee, R, Goldstein, M, Ullery, BW, et al. Value of serum antisperm antibodies in diagnosing obstructive azoospermia. J Urol 2009;181:264–9.Google Scholar
Agarwal, A, Saleh, RA, Bedaiwy, MA. Role of reactive oxygen species in the pathophysiology of human reproduction. Fertil Steril 2003;79:829–43.Google Scholar
Ramasamy, R, Scovell, JM, Kovac, JR, Cook, PJ, Lamb, DJ, Lipshultz, LI. Fluorescence in situ hybridization detects increased sperm aneuploidy in men with recurrent pregnancy loss. Fertil Steril 2015;103:9069.e1.Google Scholar

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