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  • Print publication year: 2010
  • Online publication date: May 2011

Chapter 18 - Neurobiological factors underlying psychosocial moderators of childhood stress and trauma

from Section 2 - Biological approaches to early life trauma

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1. Bonanno, G. A. (2004). Loss, trauma, and human resilience: Have we underestimated the human capacity to thrive after extremely aversive events? American Psychologist, 59, 20–28.
2. Breslau, N., Kessler, R. C., Chilcoat, H. D. et al. (1998). Trauma and posttraumatic stress disorder in the community: The 1996 detroit area survey of trauma. Archives of General Psychiatry, 55, 626–632.
3. Luthar, S. S., Cicchetti, D. and Becker, B. (2000). The construct of resilience: A critical evaluation and guidelines for future work. Child Development, 71, 543–562.
4. Masten, A. S. (2001). Ordinary magic: Resilience processes in development. American Psychologist, 56, 227–238.
5. Charney, D. S. and Manji, H. K. (2004). Life stress, genes, and depression: Multiple pathways lead to increased risk and new opportunities for intervention. Science’s STKE, (2004) 225, re5.
6. McClellan, J., McCurry, C., Ronnei, M. et al. (1996). Age of onset of sexual abuse: Relationship to sexually inappropriate behaviors. Journal of the American Academy of Child and Adolescent Psychiatry, 35, 1375–1383.
7. Mesches, M. H., Fleshner, M., Heman, K. L., Rose, G. M. and Diamond, D. M. (1999). Exposing rats to a predator blocks primed burst potentiation in the hippocampus in vitro. Journal of Neuroscience, 19, RC18.
8. Vyas, A., Mitra, R., Shankaranarayana Rao, B. S. and Chattarji, S. (2002). Chronic stress induces contrasting patterns of dendritic remodeling in hippocampal and amygdaloid neurons. Journal of Neuroscience, 22, 6810–6818.
9. Ehlert, U., Gaab, J. and Heinrichs, M. (2001). Psychoneuroendocrinological contributions to the etiology of depression, posttraumatic stress disorder, and stress-related bodily disorders: The role of the hypothalamus–pituitary–adrenal axis. Biological Psychology, 57, 141–152.
10. Goldstein, L. E., Rasmusson, A. M., Bunney, B. S. and Roth, R. H. (1996). Role of the amygdala in the coordination of behavioral, neuroendocrine, and prefrontal cortical monoamine responses to psychological stress in the rat. Journal of Neuroscience, 16, 4787–4798.
11. LeDoux, J. E. (1996). The emotional brain: The mysterious underpinnings of emotional life. New York: Simon & Schuster.
12. McEwen, B. S. and Chattarji, S. (2004). Molecular mechanisms of neuroplasticity and pharmacological implications: The example of tianeptine. European Neuropsychopharmacology, 14(Suppl 5), S497–S502.
13. Mitra, R., Jadhav, S., McEwen, B. S., Vyas, A. and Chattarji, S. (2005). Stress duration modulates the spatiotemporal patterns of spine formation in the basolateral amygdala. Proceedings of the National Academy of Sciences USA, 102, 9371–9376.
14. Adamec, R. E., Burton, P., Shallow, T. and Budgell, J. (1998). NMDA receptors mediate lasting increases in anxiety-like behavior produced by the stress of predator exposure: Implications for anxiety associated with posttraumatic stress disorder. Physiology & Behavior, 65, 723–737.
15. Korte, S. M., Koolhaas, J. M., Wingfield, J. C. and McEwen, B. S. (2005). The darwinian concept of stress: Benefits of allostasis and costs of allostatic load and the trade-offs in health and disease. Neuroscience and Biobehavioral Reviews, 29, 3–38.
16. McEwen, B. S. (1999). Stress and hippocampal plasticity. Annual Review of Neuroscience, 22, 105–122.
17. Conrad, C. D., LeDoux, J. E., Magariños, A. M. and McEwen, B. S. (1999). Repeated restraint stress facilitates fear conditioning independently of causing hippocampal CA3 dendritic atrophy. Behavioral Neuroscience, 113, 902–913.
18. Damasio, A. R. (1997). Towards a neuropathology of emotion and mood. Nature, 386, 769–770.
19. Wellman, C. L. (2001). Dendritic reorganization in pyramidal neurons in medial prefrontal cortex after chronic corticosterone administration. Journal of Neurobiology, 49, 245–253.
20. Radley, J. J., Rocher, A. B., Janssen, W. G. M. et al. (2005). Reversibility of apical dendritic retraction in the rat medial prefrontal cortex following repeated stress. Experimental Neurology, 196, 199–203.
21. Liston, C., Miller, M. M., Goldwater, D. S. et al. (2006). Stress-induced alterations in prefrontal cortical dendritic morphology predict selective impairments in perceptual attentional set-shifting. Journal of Neuroscience, 26, 7870–7874.
22. Izquierdo, A., Wellman, C. L. and Holmes, A. (2006). Brief uncontrollable stress causes dendritic retraction in infralimbic cortex and resistance to fear extinction in mice. Journal of Neuroscience, 26, 5733–5738.
23. Ganzel, B. L., Kim, P., Glover, G. H. and Temple, E. (2008). Resilience after 9/11: Multimodal neuroimaging evidence for stress-related change in the healthy adult brain. Neuroimage, 40, 788–795.
24. Amat, J., Baratta, M. V., Paul, E. et al. (2005). Medial prefrontal cortex determines how stressor controllability affects behavior and dorsal raphe nucleus. Nature Neuroscience, 8, 365–371.
25. Dienstbier, R. A. (1991). Behavioral correlates of sympathoadrenal reactivity: The toughness model. Medicine and Science in Sports and Exercise, 23, 846–852.
26. Southwick, S. M., Bremner, J. D., Rasmusson, A. et al. (1999). Role of norepinephrine in the pathophysiology and treatment of posttraumatic stress disorder. Biological Psychiatry, 46, 1192–1204.
27. Morgan, C. A. III, Rasmusson, A. M., Wang, S. et al. (2002). Neuropeptide-Y, cortisol, and subjective distress in humans exposed to acute stress: Replication and extension of previous report. Biological Psychiatry, 52, 136–142.
28. Morgan, C. A., III, Wang, S., Southwick, S. M. et al. (2000). Plasma neuropeptide-Y concentrations in humans exposed to military survival training. Biological Psychiatry, 47, 902–909.
29. Rasmusson, A. M., Hauger, R. L., Morgan, C. A., III et al. (2000). Low baseline and yohimbine-stimulated plasma neuropeptide Y (NPY) levels in combat-related PTSD. Biological Psychiatry, 47, 526–539.
30. Bing, O., Moller, C., Engel, J. A., Soderpalm, B. and Heilig, M. (1993). Anxiolytic-like action of centrally administered galanin. Neuroscience Letters, 164, 17–20.
31. Möller, C., Sommer, W., Thorsell, A. and Heilig, M. (1999). Anxiogenic-like action of galanin after intra-amygdala administration in the rat. Neuropsychopharmacology, 21, 507–512.
32. Yehuda, R., Brand, S. and Yang, R. K. (2006). Plasma neuropeptide Y concentrations in combat exposed veterans: Relationship to trauma exposure, recovery from PTSD, and coping. Biological Psychiatry, 59, 660–663.
33. Bale, T. L., Contarino, A., Smith, G. W. et al. (2000). Mice deficient for corticotropin-releasing hormone receptor-2 display anxiety-like behaviour and are hypersensitive to stress. Nature Genetics, 24, 410–414.
34. Bale, T. L., Picetti, R., Contarino, A. et al. (2002). Mice deficient for both corticotropin-releasing factor receptor 1 (CRFR1) and CRFR2 have an impaired stress response and display sexually dichotomous anxiety-like behavior. Journal of Neuroscience, 22, 193–199.
35. Yehuda, R. (2002). Current status of cortisol findings in post-traumatic stress disorder. Psychiatric Clinics of North America, 25, 341–368.
36. Sapolsky, R. M. (2003). Stress and plasticity in the limbic system. Neurochemical Research, 28, 1735–1742.
37. Charney, D. S. (2004). Psychobiological mechanism of resilience and vulnerability: Implications for successful adaptation to extreme stress. American Journal of Psychiatry, 161, 195–216.
38. Wolkowitz, O. M., Reus, V. I., Keebler, A. et al. (1999). Double-blind treatment of major depression with dehydroepiandrosterone. American Journal of Psychiatry, 156, 646–649.
39. Morgan, C. A., III, Southwick, S., Hazlett, G. et al. (2004). Relationships among plasma dehydroepiandrosterone sulfate and cortisol levels, symptoms of dissociation, and objective performance in humans exposed to acute stress. Archives of General Psychiatry, 61, 819–825.
40. Rasmusson, A. M., Vasek, J., Lipschitz, D. S. et al. (2004). An increased capacity for adrenal DHEA release is associated with decreased avoidance and negative mood symptoms in women with PTSD. Neuropsychopharmacology, 29, 1546–1557.
41. Rasmusson, A. M., Pinna, G., Paliwal, P. et al. (2006). Decreased cerebrospinal fluid allopregnanolone levels in women with posttraumatic stress disorder. Biological Psychiatry, 60, 704–713.
42. Yehuda, R., Brand, S. R., Golier, J. A. and Yang, R. K. (2006). Clinical correlates of DHEA associated with post-traumatic stress disorder. Acta Psychiatrica Scandinavica, 114, 187–193.
43. Dienstbier, R. A. (1989). Arousal and physiological toughness: Implications for mental and physical health. Psychological Review, 96, 84–100.
44. Parker, K. J., Buckmaster, C. L., Schatzberg, A. F. and Lyons, D. M. (2004). Prospective investigation of stress inoculation in young monkeys. Archives of General Psychiatry, 61, 933–941.
45. Perrin, M. A., DiGrande, L., Wheeler, K. et al. (2007). Differences in PTSD prevalence and associated risk factors among world trade center disaster rescue and recovery workers. American Journal of Psychiatry, 164, 1385–1394.
46. Southwick, S. M., Vythilingam, M. and Charney, D. S., III (2005). The psychobiology of depression and resilience to stress: Implications for prevention and treatment. Annual Review of Clinical Psychology, 1, 255–291.
47. Bremner, J. D. and Vermetten, E. (2001). Stress and development: Behavioral and biological consequences. Development and Psychopathology, 13, 473–489.
48. Kaufman, J., Plotsky, P. M., Nemeroff, C. B. and Charney, D. S. (2000). Effects of early adverse experiences on brain structure and function: Clinical implications. Biological Psychiatry, 48, 778–790.
49. Caldji, C., Tannenbaum, B., Sharma, S., et al. (1998). Maternal care during infancy regulates the development of neural systems mediating the expression of fearfulness in the rat. Proceedings of the National Academy of Sciences USA, 95, 5335–5340.
50. Kuhn, C. M. and Schanberg, S. M. (1998). Responses to maternal separation: Mechanisms and mediators. International Journal of Developmental Neuroscience, 16, 261–270.
51. Zubin, J. and Spring, B. (1977). Vulnerability: A new view of schizophrenia. Journal of Abnormal Psychology, 86, 103–126.
52. True, W. R., Rice, J., Eisen, S. A. et al. (1993). A twin study of genetic and environmental contributions to liability for posttraumatic stress symptoms. Archives of General Psychiatry, 50, 257–264.
53. Stein, M. B., Jang, K. L., Taylor, S., Vernon, P. A. and Livesley, W. J. (2002). Genetic and environmental influences on trauma exposure and posttraumatic stress disorder symptoms: A twin study. American Journal of Psychiatry, 159, 1675–1681.
54. Comings, D. E., Muhleman, D. and Gysin, R. (1996). Dopamine D2 receptor (DRD2) gene and susceptibility to posttraumatic stress disorder: A study and replication. Biological Psychiatry, 40, 368–372.
55. Gelernter, J., Southwick, S., Goodson, S. et al. (1999). No association between D2 dopamine receptor (DRD2) “A” system alleles, or DRD2 haplotypes, and posttraumatic stress disorder. Biological Psychiatry, 45, 620–625.
56. Young, R. M., Lawford, B. R., Noble, E. P. et al. (2002). Harmful drinking in military veterans with post-traumatic stress disorder: Association with the D2 dopamine receptor A1 allele. Alcohol and Alcoholism, 37, 451–456.
57. Segman, R. H., Cooper-Kazaz, R., Macciardi, F. et al. (2002). Association between the dopamine transporter gene and posttraumatic stress disorder. Molecular Psychiatry, 7, 903–907.
58. Lanius, R. A., Hopper, J. W. and Menon, R. S. (2003). Individual differences in a husband and wife who developed PTSD after a motor vehicle accident: A functional MRI case study. American Journal of Psychiatry, 160, 667–669.
59. Lensvelt-Mulders, G. and Hettema, J. (2001). Genetic analysis of autonomic reactivity to psychologically stressful situations. Biological Psychology, 58, 25–40.
60. Finley, J. C. Jr., O’Leary, M., Wester, D. et al. (2004). A genetic polymorphism of the alpha2-adrenergic receptor increases autonomic responses to stress. Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology, 96, 2231–2239.
61. Kallio, J., Pesonen, U., Kaipio, K. et al. (2001). Altered intracellular processing and release of neuropeptide Y due to leucine 7 to proline 7 polymorphism in the signal peptide of preproneuropeptide Y in humans. FASEB Journal, 15, 1242–1244.
62. Caspi, A., Sugden, K., Moffitt, T. E. et al. (2003). Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene. Science, 301, 386–389.
63. Risch, N., Herrell, R., Lehner, T. et al. (2009). Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: A meta-analysis. Journal of the American Medical Association, 301, 2462–2471.
64. Kaufman, J., Yang, B. Z., Douglas-Palumberi, H. et al. (2006). Brain-derived neurotrophic factor-5–HTTLPR gene interactions and environmental modifiers of depression in children. Biological Psychiatry, 59, 673–680.
65. Binder, E. B., Bradley, R. G., Liu, W. et al. (2008). Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults. Journal of the American Medical Association, 299, 1291–1305.
66. Yehuda, R., Golier, J. A., Yang, R. K. and Tischler, L. (2004). Enhanced sensitivity to glucocorticoids in peripheral mononuclear leukocytes in posttraumatic stress disorder. Biological Psychiatry, 55, 1110–1116.
67. Egan, M. F., Kojima, M., Callicott, J. H. et al. (2003). The BDNF Val66Met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell, 112, 257–269.
68. Lavond, D. G. and Steinmetz, J. E. (2003). Handbook of classical conditioning. Boston, MA: Kluwer Academic.
69. Hermans, D., Craske, M. G., Mineka, S. and Lovibond, P. F. (2006). Extinction in human fear conditioning. Biological Psychiatry, 60, 361–368.
70. Bremner, J. D., Vermetten, E., Schmahl, C. et al. (2005). Positron emission tomographic imaging of neural correlates of a fear acquisition and extinction paradigm in women with childhood sexual-abuse-related post-traumatic stress disorder. Psychological Medicine, 35, 791–806.
71. Buchel, C., Dolan, R. J., Armony, J. L. and Friston, K. J. (1999). Amygdala-hippocampal involvement in human aversive trace conditioning revealed through event-related functional magnetic resonance imaging. Journal of Neuroscience, 19, 10869–10876.
72. LeDoux, J. E. and Gorman, J. M. (2001). A call to action: Overcoming anxiety through active coping. American Journal of Psychiatry, 158, 1953–1955.
73. Orr, S. P., Metzger, L. J., Lasko, N. B. et al. (2000). De novo conditioning in trauma-exposed individuals with and without posttraumatic stress disorder. Journal of Abnormal Psychology, 109, 290–298.
74. Guthrie, R. M. and Bryant, R. A. (2006). Extinction learning before trauma and subsequent posttraumatic stress. Psychosomatic Medicine, 68, 307–311.
75. Aldwin, C. M., Levenson, M. R. and Spiro, A., III. (1994). Vulnerability and resilience to combat exposure: Can stress have lifelong effects? Psychology and Aging, 9, 34–44.
76. Davis, C. G., Wortman, C. B., Lehman, D. R. and Silver, R. C. (2000). Searching for meaning in loss: Are clinical assumptions correct. Death Studies, 24, 497–540.
77. Cruess, D. G., Antoni, M. H., McGregor, B. A., et al. (2000). Cognitive-behavioral stress management reduces serum cortisol by enhancing benefit finding among women being treated for early stage breast cancer. Psychosomatic Medicine, 62, 304–308.
78. Travis, L. A., Lyness, J. M., Shields, C. G., King, D. A. and Cox, C. (2004). Social support, depression, and functional disability in older adult primary-care patients. American Journal of Geriatric Psychatry, 12, 265–271.
79. Mitchinson, A. R., Kim, H. M., Geisser, M., Rosenberg, J. M. and Hinshaw, D. B. (2008). Social connectedness and patient recovery after major operations. Journal of the American College of Surgeons, 206, 292–300.
80. Boscarino, J. A. (1995). Post-traumatic stress and associated disorders among vietnam veterans: The significance of combat exposure and social support. Journal of Traumatic Stress, 8, 317–336.
81. Bartz, J. A. and Hollander, E. (2006). The neuroscience of affiliation: Forging links between basic and clinical research on neuropeptides and social behavior. Hormones and Behavior, 50, 518–528.
82. Insel, T. R. and Shapiro, L. E. (1992). Oxytocin receptor distribution reflects social organization in monogamous and polygamous voles. Proceedings of the National Academy of Sciences USA, 89, 5981–5985.
83. Francis, D. D., Champagne, F. C. and Meaney, M. J. (2000). Variations in maternal behaviour are associated with differences in oxytocin receptor levels in the rat. Journal of Neuroendocrinology, 12, 1145–1148.
84. Neumann, I. D., Torner, L. and Wigger, A. (2000). Brain oxytocin: Differential inhibition of neuroendocrine stress responses and anxiety-related behaviour in virgin, pregnant and lactating rats. Neuroscience, 95, 567–575.
85. Heinrichs, M., Baumgartner, T., Kirschbaum, C. and Ehlert, U. (2003). Social support and oxytocin interact to suppress cortisol and subjective responses to psychosocial stress. Biological Psychiatry, 54, 1389–1398.
86. Rozanski, A., Blumenthal, J. A. and Kaplan, J. (1999). Impact of psychological factors on the pathogenesis of cardiovascular disease and implications for therapy. Circulation, 99, 2192–2217.
87. Phillips, A. C., Gallagher, S. and Carroll, D. (2009). Social support, social intimacy, and cardiovascular reactions to acute psychological stress. Annals of Behavioral Medicine, 37, 38–45.
88. Ladd, C. O., Thrivikraman, K. V., Huot, R. L. and Plotsky, P. M. (2005). Differential neuroendocrine responses to chronic variable stress in adult Long Evans rats exposed to handling–maternal separation as neonates. Psychoneuroendocrinology, 30, 520–533.
89. Sanchez, M. M., Hearn, E. F., Do, D., Rilling, J. K. and Herndon, J. G. (1998). Differential rearing affects corpus callosum size and cognitive function of rhesus monkeys. Brain Research, 812, 38–49.