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  • Print publication year: 2010
  • Online publication date: August 2010

Lamotrigine

Suggested reading
Barr, PA, Buettiker, VE, Antony, JH. Efficacy of lamotrigine in refractory neonatal seizures. Pediatric Neurology 1999; 20: 161–163.
Barron, TF, Hunt, SL, Hoban, TF, Price, ML. Lamotrigine monotherapy in children. Pediatric Neurology 2000; 23: 160–163.
Brodie, MJ, Yuen, AW. Lamotrigine substitution study: evidence for synergism with sodium valproate? 105 Study Group. Epilepsy Research 1997; 26: 423–432.
Fitton, A, Goa, KL. Lamotrigine: an update of its pharmacology and therapeutic use in epilepsy. Drugs 1995; 50: 691–713.
Frank, LM, Enlow, T, Holmes, GL, Manesco, P, Concannon, S, Chen, C, Womble, G, Casale, EJ. Lamictal (lamotrigine) monotherapy for typical absence seizures in children. Epilepsia 1999; 40: 973–979.
Gamble, C, Williamson, PR, Chadwick, DW, Marson, AG. A meta-analysis of individual patient responses to lamotrigine or carbamazepine monotherapy. Neurology 2006; 66: 1310–1317.
Glaucer, TA, Cnaan, A, Shinnar, S, Hirtz, DG, Dlugos, D, Masur, D, Clark, PO, Capparelli, EV, Adamson, PC. For the Childhood Absence Epilepsy Study Group. Ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsy. New England Journal of Medicine 2010; 362: 790–799.
Guberman, AH, Besag, FM, Brodie, MJ, Dooley, JM, Duchowny, MS, Pellock, JM, Richens, A, Stern, RS, Trevathan, E. Lamotrigine-associated rash: risk/benefit considerations in adults and children. Epilepsia 1999; 40: 985–991.
Johannessen, Landmark C, Patsalos, PN. Drug interactions involving the new second- and third-generation antiepileptic drugs. Expert Reviews in Neurotherapeutics 2010; 10: 119–140.
Marson, AG, Al-Kharusi, AM, Alwaid, M, Appleton, R, Baker, GA, Chadwick, DW, Cramp, C, Cockerell, OC, Cooper, PN, Doughty, J, Eaton, B, Gamble, C, Goulding, PJ, Howell SJ, Hughes A, Jackson, M, Jacoby, A, Kellett, M, Lawson, GR, Leach, JP, Nicolaides, P, Roberts, R, Shackley, P, Shen, J, Smith, DF, Smith, PE, Smith, CT, Vanoli, A, Williamson, PR; SANAD Study Group. The SANAD study of effectiveness of carbamazepine, gabapentin, lamotrigine, oxcarbazepine, or topiramate for treatment of partial epilepsy: an unblinded randomized controlled trial. Lancet 2007; 369: 1000–1015.
Patsalos, PN. Anti-epileptic drug interactions. A clinical guide. Clarius Press: Guildford, UK; 2005.
Patsalos, PN, Berry, DJ, Bourgeois, BFD, Cloyd, JC, Glauser, TA, Johannessen, SI, Leppik, IE, Tomson, T, Perucca, E. Antiepileptic drugs – Best practice guidelines for therapeutic drug monitoring: a position paper by the Subcommission on Therapeutic Drug Monitoring, ILAE Commission on Therapeutic Strategies. Epilepsia 2008; 49: 1239–1276.
Pennell, PB, Newport, DJ, Stowe, ZN, Helmers, SL, Montgomery, JQ, Henry, TR. The impact of pregnancy and childbirth on the metabolism of lamotrigine. Neurology 2004; 62: 292–295.
Sabers, A, Ohman, I, Christensen, J, Tomson, T. Oral contraceptives reduce lamotrigine plasma levels. Neurology 2003; 61: 570–571.
Tomson, T, Luef, G, Sabers, A, Pittschieler, S, Ohman, I. Valproate effects on kinetics of lamotrigine in pregnancy and treatment with oral contraceptives. Neurology 2006; 67: 1297–1299.
Zupanc, ML. Antiepileptic drugs and hormonal contraceptives in adolescent women with epilepsy. Neurology 2006; 66(Suppl 3): S37–S45.