Skip to main content Accessibility help
×
Hostname: page-component-7c8c6479df-xxrs7 Total loading time: 0 Render date: 2024-03-29T01:22:08.470Z Has data issue: false hasContentIssue false

Section 3 - Pediatric MS Biology

Published online by Cambridge University Press:  11 April 2011

Dorothée Chabas
Affiliation:
University of California, San Francisco
Emmanuelle L. Waubant
Affiliation:
University of California, San Francisco
Get access

Summary

This chapter summarizes immune mechanisms and disease biomarkers of pediatric multiple sclerosis (MS) and acute demyelinating syndromes as well as future directions for research. In adult-onset MS, the hallmark of MS pathology has historically been the perivascular inflammatory lesion, associated with demyelination and axonal injury. Cerebrospinal fluid (CSF) profiles including cellular profiles, oligoclonal bands and IgG Index have been used to characterize MS and differentiate it from other diseases. A study of a large cohort of children with inflammatory demyelination and controls, demonstrated that children with inflammatory central nervous system (CNS) demyelination as well as children with autoimmune diabetes, exhibited heightened peripheral T-cell responses to a wide array of self-antigens. Clinically useful biological markers of inflammation are lacking in both adult- and pediatric-onset MS. N-acetylaspartate (NAA) is selectively synthesized in neurons and considered a marker of the functional integrity of neuronal mitochondrial metabolism.
Type
Chapter
Information
Publisher: Cambridge University Press
Print publication year: 2011

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Save book to Kindle

To save this book to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

  • Pediatric MS Biology
  • Edited by Dorothée Chabas, University of California, San Francisco, Emmanuelle L. Waubant, University of California, San Francisco
  • Book: Demyelinating Disorders of the Central Nervous System in Childhood
  • Online publication: 11 April 2011
  • Chapter DOI: https://doi.org/10.1017/CBO9780511974373.016
Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

  • Pediatric MS Biology
  • Edited by Dorothée Chabas, University of California, San Francisco, Emmanuelle L. Waubant, University of California, San Francisco
  • Book: Demyelinating Disorders of the Central Nervous System in Childhood
  • Online publication: 11 April 2011
  • Chapter DOI: https://doi.org/10.1017/CBO9780511974373.016
Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

  • Pediatric MS Biology
  • Edited by Dorothée Chabas, University of California, San Francisco, Emmanuelle L. Waubant, University of California, San Francisco
  • Book: Demyelinating Disorders of the Central Nervous System in Childhood
  • Online publication: 11 April 2011
  • Chapter DOI: https://doi.org/10.1017/CBO9780511974373.016
Available formats
×