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  • Print publication year: 2014
  • Online publication date: June 2014

Chapter 18 - Acute stroke syndromes caused by small vessel disease

from Section 3 - Clinical aspects of cerebral small vessel disease

References

1. Pantoni L. Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges. Lancet Neurol 2010;9:689–701.
2. Norrving B. Long-term prognosis after lacunar infarction. Lancet Neurol 2003;2:238–245.
3. Potter GM, Marlborough FJ, Wardlaw JM. Wide variation in definition, detection, and description of lacunar lesions on imaging. Stroke 2011;42:359–366.
4. Potter GM, Doubal FN, Jackson CA, et al. Counting cavitating lacunes underestimates the burden of lacunar infarction. Stroke 2010;41:267–272.
5. Moreau F, Patel S, Lauzon ML, et al. Cavitation after acute symptomatic lacunar stroke depends on time, location, and MRI sequence. Stroke 2012;43:1837–1842.
6. Kolominsky-Rabas PL, Weber M, Gefeller O, et al. Epidemiology of ischemic stroke subtypes according to TOAST criteria: incidence, recurrence, and long-term survival in ischemic stroke subtypes: a population-based study. Stroke 2001;32:2735–2740.
7. Adams HP, Jr., Bendixen BH, Kappelle LJ, et al. Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. Stroke 1993;24:35–41.
8. Benavente OR, White CL, Pearce L, et al. The Secondary Prevention of Small Subcortical Strokes (SPS3) study. Int J Stroke 2011;6:164–175.
9. Fang XH, Wang WH, Zhang XQ, et al. Incidence and survival of symptomatic lacunar infarction in a Beijing population: a six-year prospective study. Eur J Neurol 2012;19:1114–1120.
10. White CL, Szychowski JM, Roldan A, et al. Clinical features and racial/ethnic differences among the 3020 participants in the Secondary Prevention of Small Subcortical Strokes (SPS3) trial. J Stroke Cerebrovasc Dis 2012.
11. You R, McNeil JJ, O’Malley HM, Davis SM, Donnan GA. Risk factors for lacunar infarction syndromes. Neurology 1995;45:1483–1487.
12. Tanizaki Y, Kiyohara Y, Kato I, et al. Incidence and risk factors for subtypes of cerebral infarction in a general population: the Hisayama study. Stroke 2000;31:2616–2622.
13. Ohira T, Shahar E, Chambless LE, et al. Risk factors for ischemic stroke subtypes: the atherosclerosis risk in communities study. Stroke 2006;37:2493–2498.
14. Shah IM, Ghosh SK, Collier A. Stroke presentation in type 2 diabetes and the metabolic syndrome. Diabetes Res Clin Pract 2008;79:e1–4.
15. Sacco RL, Boden-Albala B, Abel G, et al. Race–ethnic disparities in the impact of stroke risk factors: the Northern Manhattan Stroke Study. Stroke 2001;32:1725–1731.
16. Bravata DM, Wells CK, Gulanski B, et al. Racial disparities in stroke risk factors: the impact of socioeconomic status. Stroke 2005;36:1507–1511.
17. Morgenstern LB, Smith MA, Lisabeth LD, et al. Excess stroke in Mexican Americans compared with non-Hispanic whites: the brain attack surveillance in the Corpus Christi project. Am J Epidemiol 2004;160:376–383.
18. Bailey EL, Smith C, Sudlow CL, Wardlaw JM. Pathology of lacunar ischemic stroke in humans – a systematic review. Brain Pathol 2012;22:583–591.
19. Brisset M, Boutouyrie P, Pico F, et al. Large-vessel correlates of cerebral small-vessel disease. Neurology 2013;80:662–669.
20. Cho KH, Kang DW, Kwon SU, Kim JS. Location of single subcortical infarction due to middle cerebral artery atherosclerosis: proximal versus distal arterial stenosis. J Neurol Neurosurg Psychiatry 2009;80:48–52.
21. Chan DK, Silver FL. Basilar artery stenosis mimicking the lacunar syndrome of pure motor hemiparesis. Can J Neurol Sci 2003;30:159–162.
22. Khan A, Kasner SE, Lynn MJ, Chimowitz MI, Warfarin Aspirin Symptomatic Intracranial Disease Trial I. Risk factors and outcome of patients with symptomatic intracranial stenosis presenting with lacunar stroke. Stroke 2012;43:1230–1233.
23. Arboix A, Alio J. Cardioembolic stroke: clinical features, specific cardiac disorders and prognosis. Curr Cardiol Rev 2010;6:150–161.
24. Chowdhury D, Wardlaw JM, Dennis MS. Are multiple acute small subcortical infarctions caused by embolic mechanisms? J Neurol Neurosurg Psychiatry 2004;75:1416–1420.
25. Gan R, Sacco RL, Kargman DE, et al. Testing the validity of the lacunar hypothesis: the Northern Manhattan Stroke Study experience. Neurology 1997;48:1204–1211.
26. Arboix A, Massons J, Garcia-Eroles L, et al. Clinical predictors of lacunar syndrome not due to lacunar infarction. BMC Neurol 2010;10:31.
27. Baumgartner RW, Sidler C, Mosso M, Georgiadis D. Ischemic lacunar stroke in patients with and without potential mechanism other than small-artery disease. Stroke 2003;34:653–659.
28. Mead GE, Lewis SC, Wardlaw JM, Dennis MS, Warlow CP. Severe ipsilateral carotid stenosis and middle cerebral artery disease in lacunar ischaemic stroke: innocent bystanders? J Neurol 2002;249:266–271.
29. Hougaku H, Matsumoto M, Handa N, et al. Asymptomatic carotid lesions and silent cerebral infarction. Stroke 1994;25:566–570.
30. Rajapakse A, Rajapakse S, Sharma JC. Is investigating for carotid artery disease warranted in non-cortical lacunar infarction? Stroke 2011;42:217–220.
31. Kim JS. Pure sensory stroke. Clinical–radiological correlates of 21 cases. Stroke 1992;23:983–987.
32. Tei H, Uchiyama S, Maruyama S. Capsular infarcts: location, size and etiology of pure motor hemiparesis, sensorimotor stroke and ataxic hemiparesis. Acta Neurol Scand 1993;88:264–268.
33. Schonewille WJ, Tuhrim S, Singer MB, Atlas SW. Diffusion-weighted MRI in acute lacunar syndromes. A clinical–radiological correlation study. Stroke 1999;30:2066–2069.
34. Fisher CM. Lacunes: small, deep cerebral infarcts. Neurology 1965;15:774–784.
35. Arboix A, Padilla I, Massons J, et al. Clinical study of 222 patients with pure motor stroke. J Neurol Neurosurg Psychiatry 2001;71:239–242.
36. Fisher CM, Curry HB. Pure motor hemiplegia of vascular origin. Arch Neurol 1965;13:30–44.
37. Fisher CM. Thalamic pure sensory stroke: a pathologic study. Neurology 1978;28:1141–1144.
38. Arboix A, Garcia-Plata C, Garcia-Eroles L, et al. Clinical study of 99 patients with pure sensory stroke. J Neurol 2005;252:156–162.
39. Nasreddine ZS, Saver JL. Pain after thalamic stroke: right diencephalic predominance and clinical features in 180 patients. Neurology 1997;48:1196–1199.
40. Kumar B, Kalita J, Kumar G, Misra UK. Central poststroke pain: a review of pathophysiology and treatment. Anesth Analg 2009;108:1645–1657.
41. Mohr JP, Kase CS, Meckler RJ, Fisher CM. Sensorimotor stroke due to thalamocapsular ischemia. Arch Neurol 1977;34:739–741.
42. Staaf G, Samuelsson M, Lindgren A, Norrving B. Sensorimotor stroke; clinical features, MRI findings, and cardiac and vascular concomitants in 32 patients. Acta Neurol Scand 1998;97:93–98.
43. Arboix A, Marti-Vilalta JL, Garcia JH. Clinical study of 227 patients with lacunar infarcts. Stroke 1990;21:842–847.
44. Arboix A. [Clinical study of 23 patients with ataxic hemiparesis.] Med Clin (Barc) 2004;122:342–344 [in Spanish].
45. Hiraga A, Uzawa A, Kamitsukasa I. Diffusion weighted imaging in ataxic hemiparesis. J Neurol Neurosurg Psychiatry 2007;78:1260–1262.
46. Emori T, Kuriyama Y, Imakita S, Sawada T. Ataxic hemiparesis following thalamic lacunar infarction. Intern Med 1992;31:889–892.
47. Moulin T, Bogousslavsky J, Chopard JL, et al. Vascular ataxic hemiparesis: a re-evaluation. J Neurol Neurosurg Psychiatry 1995;58:422–427.
48. Gorman MJ, Dafer R, Levine SR. Ataxic hemiparesis: critical appraisal of a lacunar syndrome. Stroke 1998;29:2549–2555.
49. Flint AC, Naley MC, Wright CB. Ataxic hemiparesis from strategic frontal white matter infarction with crossed cerebellar diaschisis. Stroke 2006;37:e1–2.
50. Arboix A, Bell Y, Garcia-Eroles L, et al. Clinical study of 35 patients with dysarthria–clumsy hand syndrome. J Neurol Neurosurg Psychiatry 2004;75:231–234.
51. Martin PJ, Chang HM, Wityk R, Caplan LR. Midbrain infarction: associations and aetiologies in the New England medical center posterior circulation registry. J Neurol Neurosurg Psychiatry 1998;64:392–395.
52. Bogousslavsky J, Maeder P, Regli F, Meuli R. Pure midbrain infarction: clinical syndromes, MRI, and etiologic patterns. Neurology 1994;44:2032–2040.
53. Umasankar U, Huwez FU. A patient with reversible pupil-sparing Weber’s syndrome. Neurol India 2003;51:388–389.
54. Silverman IE, Liu GT, Volpe NJ, Galetta SL. The crossed paralyses. The original brain-stem syndromes of Millard-Gubler, Foville, Weber, and Raymond–Cestan. Arch Neurol 1995;52:635–638.
55. Sitthinamsuwan B, Nunta-Aree S, Sitthinamsuwan P, Suwanawiboon B, Chiewvit P. Two patients with rare causes of Weber’s syndrome. J Clin Neurosci 2011;18:578–579.
56. Patel R, Jha S, Yadav RK. Pleomorphism of the clinical manifestations of neurocysticercosis. Trans R Soc Trop Med Hyg 2006;100:134–141.
57. Broadley SA, Taylor J, Waddy HM, Thompson PD. The clinical and MRI correlate of ischaemia in the ventromedial midbrain: Claude’s syndrome. J Neurol 2001;248:1087–1089.
58. Asakawa H, Yanaka K, Nose T. MRI of Claude’s syndrome. Neurology 2003;61:575.
59. Seo SW, Heo JH, Lee KY, et al. Localization of Claude’s syndrome. Neurology 2001;57:2304–2307.
60. Coppola RJ. Localization of Claude’s syndrome. Neurology 2002;58:1707; author reply 1707–1708.
61. Dhanjal T, Walters M, MacMillan N. Claude’s syndrome in association with posterior cerebral artery stenosis. Scott Med J 2003;48:91–92.
62. Serrano-Pozo A, Montes-Latorre E, Gonzalez-Marcos JR, Gil-Peralta A. Cardiac embolism in a Claude’s syndrome without involvement of the red nucleus. Eur J Neurol 2007;14:e1–2.
63. Song TJ, Suh SH, Cho H, Lee KY. Claude’s syndrome associated with neurocysticercosis. Yonsei Med J 2010;51:978–979.
64. Borras JM, Salazar FG, Grandas F. Oculomotor palsy and contralateral tremor (Benedikt’s syndrome) following a stereotactic procedure. J Neurol 1997;244:272–274.
65. Liu GT, Crenner CW, Logigian EL, Charness ME, Samuels MA. Midbrain syndromes of Benedikt, Claude, and Nothnagel: setting the record straight. Neurology 1992;42:1820–1822.
66. Paidakakos NA, Rokas E, Theodoropoulos S, Dimogerontas G, Konstantinidis E. Posttraumatic Benedikt’s syndrome: a rare entity with unclear anatomopathological correlations. World Neurosurg 2012;78:e713–715.
67. Loseke N, Retif J, Noterman J, Flament-Durand J. Inferior red nucleus syndrome (Benedikt’s syndrome) due to a single intramesencephalic metastasis from a prostatic carcinoma. Case report. Acta Neurochir (Wien) 1981;56:59–64.
68. Maduri R, Barbagallo G, Iofrida G, Signorelli M, Signorelli F. Regression of Benedikt’s syndrome after single-stage removal of mesencephalic cavernoma and temporal meningioma: a case report. Clin Neurol Neurosurg, in press.
69. Field TS, Benavente OR. Penetrating artery territory pontine infarction. Rev Neurol Dis 2011;8:30–38.
70. Kumral E, Bayulkem G, Evyapan D. Clinical spectrum of pontine infarction. Clinical–MRI correlations. J Neurol 2002;249:1659–1670.
71. Zaorsky NG, Luo JJ. A case of classic Raymond syndrome. Case Rep Neurol Med 2012;2012:583123.
72. Ogawa K, Suzuki Y, Kamei S. Two patients with abducens nerve palsy and crossed hemiplegia (Raymond syndrome). Acta Neurol Belg 2010;110:270–271.
73. Satake M, Kira J, Yamada T, Kobayashi T. Raymond syndrome (alternating abducent hemiplegia) caused by a small haematoma at the medial pontomedullary junction. J Neurol Neurosurg Psychiatry 1995;58:261.
74. Onbas O, Kantarci M, Alper F, Karaca L, Okur A. Millard–Gubler syndrome: MR findings. Neuroradiology 2005;47:35–37.
75. Matsuyama T, Masuda A. [A rare case of delayed traumatic Millard–Gubler syndrome.] No Shinkei Geka 1992;20:697–699.
76. Gardela G, Kusmiderski J, Slowik S. [Millard–Gubler syndrome in a young man after hemorrhage from arteriovenous hemangioma to the brainstem.] Neurol Neurochir Pol 1989;23:149–152 [in Polish].
77. Kesikburun S, Safaz I, Alaca R. Pontine cavernoma hemorrhage leading to Millard-Gubler syndrome. Am J Phys Med Rehabil 2011;90:263.
78. Prasad R, Kapoor K, Srivastava A, Mishra O. Neurocysticercosis presenting as Millard–Gubler syndrome. J Neurosci Rural Pract 2012;3:375–377.
79. Lee MJ, Park YG, Kim SJ, et al. Characteristics of stroke mechanisms in patients with medullary infarction. Eur J Neurol 2012;19:1433–1439.
80. Fukuoka T, Takeda H, Dembo T, et al. Clinical review of 37 patients with medullary infarction. J Stroke Cerebrovasc Dis 2012;21:594–599.
81. Kim JS. Pure lateral medullary infarction: clinical–radiological correlation of 130 acute, consecutive patients. Brain 2003;126:1864–1872.
82. Swenson AJ, Leira EC. Paroxysmal sneezing at the onset of lateral medullary syndrome: cause or consequence? Eur J Neurol 2007;14:461–463.
83. Sacco RL, Freddo L, Bello JA, et al. Wallenberg’s lateral medullary syndrome. Clinical-magnetic resonance imaging correlations. Arch Neurol 1993;50:609–614.
84. Newman-Toker DE, Kattah JC, Alvernia JE, Wang DZ. Normal head impulse test differentiates acute cerebellar strokes from vestibular neuritis. Neurology 2008;70:2378–2385.
85. Kattah JC, Talkad AV, Wang DZ, Hsieh YH, Newman-Toker DE. Hints to diagnose stroke in the acute vestibular syndrome: three-step bedside oculomotor examination more sensitive than early MRI diffusion-weighted imaging. Stroke 2009;40:3504–3510.
86. Kim JS, Lee JH, Suh DC, Lee MC. Spectrum of lateral medullary syndrome. Correlation between clinical findings and magnetic resonance imaging in 33 subjects. Stroke 1994;25:1405–1410.
87. Norrving B, Cronqvist S. Lateral medullary infarction: prognosis in an unselected series. Neurology 1991;41:244–248.
88. Kim JS, Han YS. Medial medullary infarction: clinical, imaging, and outcome study in 86 consecutive patients. Stroke 2009;40:3221–3225.
89. Kameda W, Kawanami T, Kurita K, et al. Lateral and medial medullary infarction: a comparative analysis of 214 patients. Stroke 2004;35:694–699.
90. Bassetti C, Bogousslavsky J, Mattle H, Bernasconi A. Medial medullary stroke: report of seven patients and review of the literature. Neurology 1997;48:882–890.
91. Toyoda K, Imamura T, Saku Y, et al. Medial medullary infarction: analyses of 11 patients. Neurology 1996;47:1141–1147.
92. Percheron G. [Arteries of the human thalamus. II. Arteries and paramedian thalamic territory of the communicating basilar artery.] Rev Neurol (Paris) 1976;132:309–324 [in French].
93. Percheron G. [Arteries of the human thalamus. I. Artery and polar thalamic territory of the posterior communicating artery.] Rev Neurol (Paris) 1976;132:297–307 [in French].
94. Percheron G. [Arteries of the thalamus in man. Choroidal arteries. III. Absence of the constituted thalamic territory of the anterior choroidal artery. IV. Arteries and thalamic territories of the choroidal and postero-median thalamic arterial system. V. Arteries and thalamic territories of the choroidal and postero-lateral thalamic arterial system.] Rev Neurol (Paris) 1977;133:547–558 [in French].
95. Schmahmann JD. Vascular syndromes of the thalamus. Stroke 2003;34:2264–2278.
96. Carrera E, Bogousslavsky J. The thalamus and behavior: effects of anatomically distinct strokes. Neurology 2006;66:1817–1823.
97. Bogousslavsky J, Regli F, Uske A. Thalamic infarcts: clinical syndromes, etiology, and prognosis. Neurology 1988;38:837–848.
98. Swartz RH, Black SE. Anterior-medial thalamic lesions in dementia: frequent and volume-dependently associated with sudden cognitive decline. J Neurol Neurosurg Psychiatry 2006;77:1307–1312.
99. Gorelick PB, Amico LL, Ganellen R, Benevento LA. Transient global amnesia and thalamic infarction. Neurology 1988;38:496–499.
100. Melo TP, Bogousslavsky J. Hemiataxia-enhypesthesia: a thalamic stroke syndrome. J Neurol Neurosurg Psychiatry 1992;55:581–584.
101. Karnath HO, Himmelbach M, Rorden C. The subcortical anatomy of human spatial neglect: putamen, caudate nucleus and pulvinar. Brain 2002;125:350–360.
102. Neau JP, Bogousslavsky J. The syndrome of posterior choroidal artery territory infarction. Ann Neurol 1996;39:779–788.
103. Ghika J, Bogousslavsky J, Henderson J, Maeder P, Regli F. The “jerky dystonic unsteady hand”: a delayed motor syndrome in posterior thalamic infarctions. J Neurol 1994;241:537–542.
104. Donnan GA, O’Malley HM, Quang L, Hurley S, Bladin PF. The capsular warning syndrome: pathogenesis and clinical features. Neurology 1993;43:957–962.
105. Paul NL, Simoni M, Chandratheva A, Rothwell PM. Population-based study of capsular warning syndrome and prognosis after early recurrent TIA. Neurology 2012;79:1356–1362.
106. Abetz L, Allen R, Follet A, et al. Evaluating the quality of life of patients with restless legs syndrome. Clin Ther 2004;26:925–935.
107. Lee J, Albers GW, Marks MP, Lansberg MG. Capsular warning syndrome caused by middle cerebral artery stenosis. J Neurol Sci 2010;296:115–120.
108. Chen ZC, Sun JZ, Shi ZH, Lou M. Capsular warning syndrome caused by spontaneous middle cerebral artery dissection. CNS Neurosci Ther 2012;18:702–704.
109. Tang CW, Wang PN, Lin KP, et al. Microscopic polyangiitis presenting with capsular warning syndrome and subsequent stroke. J Neurol Sci 2009;277:174–175.
110. Ferro JM, Falcao F, Melo TP, Campos JG. Dural sinus thrombosis mimicking “capsular warning syndrome.” J Neurol 2000;247:802–803.
111. Farrar J, Donnan GA. Capsular warning syndrome preceding pontine infarction. Stroke 1993;24:762.
112. Saposnik G, Noel de Tilly L, Caplan LR. Pontine warning syndrome. Arch Neurol 2008;65:1375–1377.
113. Muengtaweepongsa S, Singh NN, Cruz-Flores S. Pontine warning syndrome: case series and review of literature. J Stroke Cerebrovasc Dis 2010;19:353–356.
114. Staaf G, Geijer B, Lindgren A, Norrving B. Diffusion-weighted MRI findings in patients with capsular warning syndrome. Cerebrovasc Dis 2004;17:1–8.
115. Del Bene A, Palumbo V, Lamassa M, et al. Progressive lacunar stroke: review of mechanisms, prognostic features, and putative treatments. Int J Stroke 2012;7:321–329.
116. Chalela JA, Ezzeddine M, Latour L, Warach S. Reversal of perfusion and diffusion abnormalities after intravenous thrombolysis for a lacunar infarction. J Neuroimaging 2003;13:152–154.
117. National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. Tissue plasminogen activator for acute ischemic stroke. N Engl J Med 1995;333:1581–1587.
118. Shobha N, Fang J, Hill MD. Do lacunar strokes benefit from thrombolysis? Evidence from the Registry of the Canadian Stroke Network. Int J Stroke 2013; 8(Suppl A100):45–9.
119. Mustanoja S, Meretoja A, Putaala J, et al. Outcome by stroke etiology in patients receiving thrombolytic treatment: descriptive subtype analysis. Stroke 2011;42:102–106.
120. Lee SJ, Saver JL, Liebeskind DS, et al. Safety of intravenous fibrinolysis in imaging-confirmed single penetrator artery infarcts. Stroke 2010;41:2587–2591.
121. Vivanco-Hidalgo RM, Rodriguez-Campello A, Ois A, et al. Thrombolysis in capsular warning syndrome. Cerebrovasc Dis 2008;25:508–510.
122. Nguyen TH, Vo D, Ngo MB, et al. Thrombolysis in recurrent lacunar stroke: a case example. Eur J Neurol 2008;15:1409–1411.
123. Mistri AK, Robinson TG, Potter JF. Pressor therapy in acute ischemic stroke: systematic review. Stroke 2006;37:1565–1571.
124. Lalive PH, Mayor I, Sztajzel R. The role of blood pressure in lacunar strokes preceded by TIAs. Cerebrovasc Dis 2003;16:88–90.
125. Lim TS, Hong JM, Lee JS, et al. Induced-hypertension in progressing lacunar infarction. J Neurol Sci 2011;308:72–76.
126.Canadian Stroke Strategy. Canadian Best Practice Recommendations for Stroke Care: update 2010. http://www.strokebestpractices.ca/wp-content/uploads/2011/04/2010BPR_ENG.pdf (accessed May 5, 2013).
127. The International Stroke Trial (IST). A randomised trial of aspirin, subcutaneous heparin, both, or neither among 19 435 patients with acute ischaemic stroke. International Stroke Trial Collaborative Group. Lancet 1997;349:1569–1581.
128. Chinese Acute Stroke Trial (CAST) Collaborative Group. Randomised placebo-controlled trial of early aspirin use in 20 000 patients with acute ischaemic stroke. Lancet 1997;349:1641–1649.
129. Chen ZM, Sandercock P, Pan HC, et al. Indications for early aspirin use in acute ischemic stroke: a combined analysis of 40 000 randomized patients from the Chinese Acute Stroke Trial and the International Stroke Trial. On behalf of the CAST and IST Collaborative Groups. Stroke 2000;31:1240–1249.
130. Kennedy J, Hill MD, Ryckborst KJ, et al. Fast Assessment of Stroke and Transient Ischaemic Attack to Prevent Early Recurrence (FASTER): a randomised controlled pilot trial. Lancet Neurol 2007;6:961–969.
131. Dengler R, Diener HC, Schwartz A, et al. Early treatment with aspirin plus extended-release dipyridamole for transient ischaemic attack or ischaemic stroke within 24 h of symptom onset (EARLY trial): a randomised, open-label, blinded-endpoint trial. Lancet Neurol 2010;9:159–166.
132. Fahey CD, Alberts MJ, Bernstein RA. Oral clopidogrel load in aspirin-resistant capsular warning syndrome. Neurocrit Care 2005;2:183–184.
133. Asil T, Ir N, Karaduman F, Cagli B, Tuncel S. Combined antithrombotic treatment with aspirin and clopidogrel for patients with capsular warning syndrome: a case report. Neurologist 2012;18:68–69.
134. Philipps J, Thomalla G, Glahn J, Schwarze M, Rother J. Treatment of progressive stroke with tirofiban – experience in 35 patients. Cerebrovasc Dis 2009;28:435–438.
135. Martin-Schild S, Shaltoni H, Abraham AT, et al. Safety of eptifibatide for subcortical stroke progression. Cerebrovasc Dis 2009;28:595–600.
136. Dobkin BH. Heparin for lacunar stroke in progression. Stroke 1983;14:421–423.
137. Haley EC, Jr., Kassell NF, Torner JC. Failure of heparin to prevent progression in progressing ischemic infarction. Stroke 1988;19:10–14.
138. Chimowitz MI, Lynn MJ, Derdeyn CP, et al. Stenting versus aggressive medical therapy for intracranial arterial stenosis. N Engl J Med 2011;365:993–1003.
139. Saposnik G, Hassan KA, Selchen D, et al. Stroke unit care: does ischemic stroke subtype matter? Int J Stroke 2011;6:244–250.
140. Smith EE, Hassan KA, Fang J, et al. Do all ischemic stroke subtypes benefit from organized inpatient stroke care? Neurology 2010;75:456–462.
141. Lansberg MG, Albers GW, Beaulieu C, Marks MP. Comparison of diffusion-weighted MRI and CT in acute stroke. Neurology 2000;54:1557–1561.
142. Albers GW, Lansberg MG, Norbash AM, et al. Yield of diffusion-weighted MRI for detection of potentially relevant findings in stroke patients. Neurology 2000;54:1562–1567.
143. Wessels T, Rottger C, Jauss M, et al. Identification of embolic stroke patterns by diffusion-weighted MRI in clinically defined lacunar stroke syndromes. Stroke 2005;36:757–761.
144. Kang DW, Chalela JA, Ezzeddine MA, Warach S. Association of ischemic lesion patterns on early diffusion-weighted imaging with TOAST stroke subtypes. Arch Neurol 2003;60:1730–1734.
145. Campbell BC, Weir L, Desmond PM, et al. CT perfusion improves diagnostic accuracy and confidence in acute ischaemic stroke. J Neurol Neurosurg Psychiatry 2013;84:613–618.
146. Lin K, Do KG, Ong P, et al. Perfusion CT improves diagnostic accuracy for hyperacute ischemic stroke in the three-hour window: study of 100 patients with diffusion MRI confirmation. Cerebrovasc Dis 2009;28:72–79.