Book contents
- Frontmatter
- Contents
- Contributors
- Preface
- 1 Introduction
- 2 Endothelial Mechanotransduction
- 3 Role of the Plasma Membrane in Endothelial Cell Mechanosensation of Shear Stress
- 4 Mechanotransduction by Membrane-Mediated Activation of G-Protein Coupled Receptors and G-Proteins
- 5 Cellular Mechanotransduction: Interactions with the Extracellular Matrix
- 6 Role of Ion Channels in Cellular Mechanotransduction – Lessons from the Vascular Endothelium
- 7 Toward a Modular Analysis of Cell Mechanosensing and Mechanotransduction
- 8 Tensegrity as a Mechanism for Integrating Molecular and Cellular Mechanotransduction Mechanisms
- 9 Nuclear Mechanics and Mechanotransduction
- 10 Microtubule Bending and Breaking in Cellular Mechanotransduction
- 11 A Molecular Perspective on Mechanotransduction in Focal Adhesions
- 12 Protein Conformational Change
- 13 Translating Mechanical Force into Discrete Biochemical Signal Changes
- 14 Mechanotransduction through Local Autocrine Signaling
- 15 The Interaction between Fluid-Wall Shear Stress and Solid Circumferential Strain Affects Endothelial Cell Mechanobiology
- 16 Micro- and Nanoscale Force Techniques for Mechanotransduction
- 17 Mechanical Regulation of Stem Cells
- 18 Mechanotransduction
- 19 Summary and Outlook
- Index
- Plate Section
- References
17 - Mechanical Regulation of Stem Cells
Implications in Tissue Remodeling
Published online by Cambridge University Press: 05 July 2014
- Frontmatter
- Contents
- Contributors
- Preface
- 1 Introduction
- 2 Endothelial Mechanotransduction
- 3 Role of the Plasma Membrane in Endothelial Cell Mechanosensation of Shear Stress
- 4 Mechanotransduction by Membrane-Mediated Activation of G-Protein Coupled Receptors and G-Proteins
- 5 Cellular Mechanotransduction: Interactions with the Extracellular Matrix
- 6 Role of Ion Channels in Cellular Mechanotransduction – Lessons from the Vascular Endothelium
- 7 Toward a Modular Analysis of Cell Mechanosensing and Mechanotransduction
- 8 Tensegrity as a Mechanism for Integrating Molecular and Cellular Mechanotransduction Mechanisms
- 9 Nuclear Mechanics and Mechanotransduction
- 10 Microtubule Bending and Breaking in Cellular Mechanotransduction
- 11 A Molecular Perspective on Mechanotransduction in Focal Adhesions
- 12 Protein Conformational Change
- 13 Translating Mechanical Force into Discrete Biochemical Signal Changes
- 14 Mechanotransduction through Local Autocrine Signaling
- 15 The Interaction between Fluid-Wall Shear Stress and Solid Circumferential Strain Affects Endothelial Cell Mechanobiology
- 16 Micro- and Nanoscale Force Techniques for Mechanotransduction
- 17 Mechanical Regulation of Stem Cells
- 18 Mechanotransduction
- 19 Summary and Outlook
- Index
- Plate Section
- References
Summary
Introduction
Stem cells, which can self-renew and differentiate into cells with specialized functions, are usually classified as embryonic stem cells (ESCs) and adult stem cells. ESCs are derived from the inner cell mass of a blastocyst, can self-renew indefinitely, and can give rise to cell types of all somatic lineages from the three embryonic germ layers. Adult stem cells have been found in many types of tissues and organs such as bone marrow, blood, muscle, skin, intestine, fat, and brain. Bone marrow is one of the most abundant sources of adult stem cells and progenitor cells. Mesenchymal stem cells (MSCs), hematopoietic stem cells (HSCs), and endothelial progenitor cells (EPCs) can be isolated from bone marrow. These bone marrow MSCs are pluripotent stromal cells. MSCs can be expanded into billions of folds in culture, and can be stimulated to differentiate into a variety of cell types. HSCs give rise to blood cells. These cells, along with EPCs, are mobilized in response to growth factors and cytokines released upon injury in tissues and organs, and therefore can be isolated from peripheral blood in addition to the bone marrow. Both embryonic stem cells and adult stem cells have tremendous potential for cell therapy and tissue repair.
- Type
- Chapter
- Information
- Cellular MechanotransductionDiverse Perspectives from Molecules to Tissues, pp. 403 - 416Publisher: Cambridge University PressPrint publication year: 2009
References
- 3
- Cited by