Skip to main content Accessibility help
×
Hostname: page-component-7c8c6479df-xxrs7 Total loading time: 0 Render date: 2024-03-28T09:40:19.780Z Has data issue: false hasContentIssue false

Chapter 52 - Malformations of human cerebral cortex

from Section 3 - Symptomatic epilepsy

Published online by Cambridge University Press:  05 March 2012

Simon D. Shorvon
Affiliation:
National Hospital for Neurology and Neurosurgery, London
Frederick Andermann
Affiliation:
Montreal Neurological Hospital and Institute
Renzo Guerrini
Affiliation:
Child Neurology Unit, Meyer Pediatric Hospital, Florence
Get access

Summary

Fetal studies show that a specific malformation, e.g., polymicrogyria or cobblestone cortex, may be the end point of disruption of one of a number of developmental pathways and may have more than one etiology. Histology of the cerebral hemispheres showed, apart from necrosis, failure of neuronal migration with subcortical heterotopia, polymicrogyria, overmigration into the leptomeninges, transmantle dysplasia, and schizencephaly. Malformations resulting from undermigration may be generalized, as in type 1 lissencephaly and subcortical band (double cortex) syndromes, or focal as represented by subcortical and periventricular heterotopias. Focal cortical dysplasia and tuberous sclerosis are lesions restricted to a small region of the cortex and are thought to result from early abnormalities in cell growth and proliferation. Cobblestone cortex (type 2 lissencephaly), bilateral frontoparietal polymicrogyria, MARCKS deficiency, TUBB2B mutation, polymicrogyria and schizencephaly are some of the over migration syndromes.
Type
Chapter
Information
The Causes of Epilepsy
Common and Uncommon Causes in Adults and Children
, pp. 346 - 362
Publisher: Cambridge University Press
Print publication year: 2011

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Save book to Kindle

To save this book to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×