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  • Print publication year: 2013
  • Online publication date: October 2013

Chapter 37 - Hypoxic-ischemic encephalopathy

from Section 6 - Clinical Encephalopathy Syndromes


1. XiongW, HoeschRE, GeocadinRG. Post-cardiac arrest encephalopathy. Semin Neurol 2011;31:216–25.
2. ThomT, HaaseN, RosamondW, et al. Heart disease and stroke statistics – 2006 update. Circulation 2006;113:85–151.
3. LevyPD, YeH, ComptonS, et al. Factors associated with neurologically intact survival for patients with acute heart failure and in-hospital cardiac arrest. Circ Heart Fail 2009;2:572–81.
4. AdrieC, LaurentI, MonchiM, et al. Postresuscitation disease after cardiac arrest: a sepsis-like syndrome?Curr Opin Crit Care 2004;10:208–12.
5. LaverS, FarrowC, TurnerD, NolanJ. Mode of death after admission to an intensive care unit following cardiac arrest. Intensive Care Med 2004;30:2126–8.
6. IllievichUM, ZornowMH, ChoiKT, SchellerMS, StrnatMA. Effects of hypothermia metabolic suppression on hippocampal glutamate concentrations after transient global cerebral ischemia. Anesth Analg 1994;78:905–11.
7. WagnerSR, IV, LanierWL. Metabolism of glucose, glycogen, and high-energy phosphates during complete cerebral ischemia. A comparison of normoglycemic, chronically hyperglycemic diabetic and acutely hyperglycemic rats. Anesthesiology 1994;81:1516–26.
8. GlobusMY, GinsbergMD, BustoR. Excitotoxic index – a biochemical marker of selective vulnerability. Neurosci Lett 1991;127:39–42.
9. TraystmanRJ, KirschJR, KoehlerRC. Oxygen radical mechanisms of brain injury following ischemia and reperfusion. J Appl Physiol 1991;71:1185–95.
10. MartinLJ, BrambrinkAM, PriceAC, et al. Neuronal death in newborn striatum after hypoxia-ischemia is necrosis and evolves with oxidative stress. Neurobiol Dis 2000;7:169–91.
11. IadecolaC, AnratherJ. The immunology of stroke:from mechanisms to translation. Nat Med 2011;17:796–808.
12. TuYF, TsaiYS, WangLW, et al. Overweight worsens apoptosis, neuroinflammation and blood–brain barrier damage after hypoxic ischemia in neonatal brain through JNK hyperactivation. J Neuroinflammation 2011;8:40.
13. ChioCC, KuoJR, HsiaoSH, ChangCP, LinMT. Effect of brain cooling on brain ischemia and damage markers after fluid percussion brain injury in rats. Shock 2007;28:284–90.
14. AmesA, III, WrightRL, KowadaM, ThurstonJM, MainoG. Cerebral ischemia. the no-reflow phenomenon. Am J Pathol 1968;52:437–53.
15. WijdicksEF, CampeauNG, MillerGM. MR imaging in comatose survivors of cardiac resuscitation. AJNR Am J Neuroradiol 2001;22:1561–65.
16. FujiokaM, OkuchiK, SakakiT, et al. Specific changes in human brain following reperfusion after cardiac arrest. Stroke 1994;25:2091–5.
17. LevyDE, CaronnaJJ, SingerBH, et al. Predicting outcome from hypoxic-ischemic coma. JAMA 1985;253:1420–6.
18. OddoM, RossettiAO. Predicting neurological outcome after cardiac arrest. Curr Opin Crit Care 2011;17:254–9.
19. GreerDM. Mechanisms of injury in hypoxic-ischemic encephalopathy: implications to therapy. Semin Neurol 2006;26:373–9.
20. AdrieC, HaouacheH, SalehM, et al. An underrecognized source of organ donors: patients with brain death after successfully resuscitated cardiac arrest. Intensive Care Med 2008;34:132–7.
21. AdrieC, CariouA, MourvillierB, et al. Predicting survival with good neurological recovery at hospital admission after successful resuscitation of out-of-hospital cardiac arrest: the OHCA score. Eur Heart J 2006;27:2840–5.
22. FugateJE, RabinsteinAA, ClaassenDO, WhiteRD, WijdicksEF. The FOUR score predicts outcome in patients after cardiac arrest. Neurocrit Care 2010;13:205–10.
23. BoothCM, BooneRH, TomlinsonG, DetskyAS. Is this patient dead, vegetative, or severely neurologically impaired? Assessing outcome for comatose survivors of cardiac arrest. JAMA 2004;291:870–9.
24. ZandbergenEG, HijdraA, KoelmanJH, et al. Prediction of poor outcome within the first 3 days of postanoxic coma. Neurology 2006;66:62–8.
25. RossettiAO, UrbanoLA, DelodderF, KaplanPW, OddoM. Prognostic value of continuous EEG monitoring during therapeutic hypothermia after cardiac arrest. Crit Care 2010;14:R173.
26. TiainenM, RoineRO, PettilaV, TakkunenO. Serum neuron-specific enolase and S-100B protein in cardiac arrest patients treated with hypothermia. Stroke 2003;34:2881–6.
27. WeissN, GalanaudD, CarpentierA, NaccacheL, PuybassetL. Clinical review: prognostic value of magnetic resonance imaging in acute brain injury and coma. Crit Care 2007;11:230.
28. BernardSA, GrayTW, BuistMD, et al. Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. N Engl J Med 2002;346:557–63.
29. HACA Study Group. Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med 2002;346:549–56.
30. NeumarRW, NolanJP, AdrieC, et al. Post-cardiac arrest syndrome: epidemiology, pathophysiology, treatment, and prognostication. A consensus statement from the International Liaison Committee on Resuscitation (American Heart Association, Australian and New Zealand Council on Resuscitation, European Resuscitation Council, Heart and Stroke Foundation of Canada, InterAmerican Heart Foundation, Resuscitation Council of Asia, and the Resuscitation Council of Southern Africa); the American Heart Association Emergency Cardiovascular Care Committee; the Council on Cardiovascular Surgery and Anesthesia; the Council on Cardiopulmonary, Perioperative, and Critical Care; the Council on Clinical Cardiology; and the Stroke Council. Circulation 2008;118:2452–83.
31. DumasF, GrimaldiD, ZuberB, et al. Is hypothermia after cardiac arrest effective in both shockable and nonshockable patients? Insights from a large registry. Circulation 2011;123:877–86.
32. CariouA, ClaessensYE, PeneF, et al. Early high-dose erythropoietin therapy and hypothermia after out-of-hospital cardiac arrest. a matched control study. Resuscitation 2008;76:397–404.
33. PiotC, CroisilleP, StaatP, et al. Effect of cyclosporine on reperfusion injury in acute myocardial infarction. N Engl J Med 2008;359:473–81.
34. KilgannonJH, JonesAE, ShapiroNI, et al. Association between arterial hyperoxia following resuscitation from cardiac arrest and in-hospital mortality. JAMA 2010;303:2165–71.
35. SafarP, XiaoF, RadovskyA, et al. Improved cerebral resuscitation from cardiac arrest in dogs with mild hypothermia plus blood flow promotion. Stroke 1996;27:105–13.
36. Cueni-VillozN, DevigiliA, DelodderF, et al. Increased blood glucose variability during therapeutic hypothermia and outcome after cardiac arrest. Crit Care Med 2011;39(10):2225–31.
37. ArrichJ, ZeinerA, SterzF, et al. Factors associated with a change in functional outcome between one month and six months after cardiac arrest. a retrospective cohort study. Resuscitation 2009;80:876–80.
38. BunchTJ, WhiteRD, GershBJ, et al. Long-term outcomes of out-of-hospital cardiac arrest after successful early defibrillation. N Engl J Med 2003;348:2626–33.