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  • Print publication year: 2005
  • Online publication date: August 2009

11 - Discovering Medicines: Infinite Variety through Chemistry

Summary

The strangely audacious notion that human sickness could be cured with concoctions made from natural products existed in most ancient civilisations. This fantastic dream began to come true in the twentieth century, as chemistry and pharmacology were harnessed to make reproducibly effective versions of folk medicines. Prospects for discovering useful drugs greatly improved with the discovery of the first antibiotics and the realisation that these were representatives of a chemical universe of hitherto unimagined richness containing molecules of extraordinary biological potency. With inspiration from nature and growing sophistication, synthetic chemists have learnt how to generate vast libraries of chemicals, which the drug discovery industry screens for useful medicines. We will consider the prospects of protein medicines in the following chapter.

The Power of Chemistry

Experimentation with the physiological effects of natural products must be as old as human civilisation. Alcohol, narcotics, mind-affecting drugs, poisons, and many other natural products with pharmacological effects were widely known in ancient times. More puzzling, though, is why the ancients thought these products might cure human sickness. The ancient Egyptian Ebers' papyrus lists many medicines; whether they were efficacious we shall never know, but the betting must surely be not. One offering contains human excrement! The puritanical Hebrews, who would have known the Egyptian predilection for medicine, seemed to reject this kind of hocus-pocus along with alcohol.