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Chapter 15 - The Role of In Vitro Maturation in Polycystic Ovary Syndrome

Published online by Cambridge University Press:  13 May 2022

Gabor T. Kovacs
Monash University, Melbourne, Australia
Bart Fauser
University Medical Center, Utrecht, Netherlands
Richard S. Legro
Penn State Medical Center, Hershey, PA, USA
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In vitro maturation of oocytes (IVM) describes a process whereby immature oocytes that have been collected as part of an assisted reproductive treatment cycle are matured in a laboratory. After maturation, they are usually fertilized with sperm, via intracytoplasmic sperm injection (ICSI), and the resulting embryos cultured. The perceived benefits of this technology are that it involves a shorter duration of time between the commencement of a treatment cycle and oocyte collection, and it avoids the risk of ovarian hyperstimulation syndrome (OHSS). OHSS is a very serious medical condition that women with polycystic ovary syndrome (PCOS) are particularly susceptible to developing. IVM technology has been used for several decades, but in the last ten years there has been a resurgence of interest in its use with the development of enhanced maturation media to assist the IVM process and the initiation of several randomized trials to compare potential benefits and drawbacks in comparison to the standard in vitro fertilization (IVF) approach.

Publisher: Cambridge University Press
Print publication year: 2022

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