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Olfactory dysfunction amongst children and adolescents with laboratory confirmed coronavirus disease 2019: a systematic review

Part of: JLO Coronavirus Collection

Published online by Cambridge University Press:  02 September 2021

J Saniasiaya ,
J Kulasegarah  and
P Narayanan
J Saniasiaya*
Affiliation:
Department of Otorhinolaryngology, Faculty of Medicine, University of Malaya, Jalan Universiti, Kuala Lumpur, Malaysia
J Kulasegarah
Affiliation:
Department of Otorhinolaryngology, Faculty of Medicine, University of Malaya, Jalan Universiti, Kuala Lumpur, Malaysia
P Narayanan
Affiliation:
Department of Otorhinolaryngology, Faculty of Medicine, University of Malaya, Jalan Universiti, Kuala Lumpur, Malaysia
*
Author for correspondence: Dr Jeyasakthy Saniasiaya, Department of Otorhinolaryngology, Faculty of Medicine, University of Malaya, Jalan Universiti, 50603 Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur, Malaysia E-mail: shakthy_18@yahoo.com
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Abstract

Background

Despite the rapidly emerging reports of olfactory dysfunction amongst adult patients with coronavirus disease 2019, cases involving children and adolescents are scarcely reported. The literature was reviewed to elucidate olfactory dysfunction amongst children and adolescents with coronavirus disease 2019.

Methods

A search of the literature published from 1 December 2019 to 30 April 2021 was conducted using four databases, based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and the Cochrane Handbook for Systematic Reviews of Interventions. The search was performed over one month (May 2021).

Results

Only 9 articles were identified, with a total of 316 laboratory confirmed coronavirus disease 2019 positive children and adolescents, of whom 156 reported olfactory dysfunction. Four studies reported olfactory dysfunction based on subjective tests; four studies carried out objective assessment. Most studies reported on olfaction recovery.

Conclusion

The literature review revealed an olfactory dysfunction rate of 49 per cent amongst children and adolescents with coronavirus disease 2019. Persistence of olfactory dysfunction was reported in 7.1 per cent of the patients. Further studies involving objective measures need to be carried out in children and adolescents with coronavirus disease 2019.

Keywords

CoronavirusCOVID-19SmellOlfactory ImpairmentChildrenAdolescentsPediatricsReview
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 135 , Issue 11 , November 2021 , pp. 953 - 957
Copyright
Copyright © The Author(s), 2021. Published by Cambridge University Press

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Footnotes

Dr J Saniasiaya takes responsibility for the integrity of the content of the paper

References

Wee, LE, Chan, YFZ, Teo, NWY, Cherng, BPZ, Thien, SY, Wong, HM et al. The role of self-reported olfactory and gustatory dysfunction as a screening criterion for suspected COVID-19. Eur Arch Otorhinolaryngol 2020;277:2389–90CrossRefGoogle ScholarPubMed
Moher, D, Liberati, A, Tetzlaff, J, Altman, DG;, PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ 2009;339:b2535CrossRefGoogle ScholarPubMed
Higgins, JP, Green, S, eds. Cochrane Handbook for Systematic Reviews of Interventions, Version 5.1.0 (updated March 2011). London: Cochrane Collaboration, 2011Google Scholar
Bernaola Abraira, M, Bartha De Las Peñas, I, López-Araujo, GA, Escudero Diez, C, Rodríguez Del Río, P, Morales-Cabeza, C et al. Olfactory and gustatory dysfunction in pediatric patients with coronavirus disease (COVID-19). J Investig Allergol Clin Immunol 2021;31:277–9CrossRefGoogle Scholar
Concheiro-Guisan, A, Fiel-Ozores, A, Novoa-Carballal, R, González-Duran, ML, Portugués de la Red, M, Martínez-Reglero, C et al. Subtle olfactory dysfunction after SARS-CoV-2 virus infection in children. Int J Pediatr Otorhinolaryngol 2021;140:110539CrossRefGoogle ScholarPubMed
Kasuga, Y, Nishimura, K, Go, H, Nakazaki, K, Shimizu, S, Kanezawa, K et al. Severe olfactory and gustatory dysfunctions in a Japanese pediatric patient with coronavirus disease (COVID-19). J Infect Chemother 2021;27:110–12CrossRefGoogle Scholar
Kumar, L, Kahlon, N, Jain, A, Kaur, J, Singh, M, Pandey, AK. Loss of smell and taste in COVID-19 infection in adolescents. Int J Pediatr Otorhinolaryngol 2021;142:11062610.1016/j.ijporl.2021.110626CrossRefGoogle ScholarPubMed
Mak, PQ, Chung, KS, Wong, JS, Shek, CC, Kwan, MY. Anosmia and ageusia: not an uncommon presentation of COVID-19 infection in children and adolescents. Pediatr Infect Dis J 2020;39:e199–200CrossRefGoogle ScholarPubMed
Maniaci, A, Iannella, G, Vicini, C, Pavone, P, Nunnari, G, Falsaperla, R et al. A case of COVID-19 with late-onset rash and transient loss of taste and smell in a 15-year-old boy. Am J Case Rep 2020;21:e925813CrossRefGoogle ScholarPubMed
Marhaeni, W, Wijaya, AB, Kusumaningtyas, P, Mapianto, RS. Thalassemic child presenting with anosmia due to COVID-19. Indian J Pediatr 2020;87:750CrossRefGoogle ScholarPubMed
Qiu, C, Cui, C, Hautefort, C, Haehner, A, Zhao, J, Yao, Q et al. Olfactory and gustatory dysfunction as an early identifier of COVID-19 in adults and children: an international multicenter study. Otolaryngol Head Neck Surg 2020;164:714–21CrossRefGoogle Scholar
Rusetsky, Y, Meytel, I, Mokoyan, Z, Fisenko, A, Babayan, A, Malyavina, U. Smell status in children infected with SARS-CoV-2. Laryngoscope 2021;131:E2475–80CrossRefGoogle ScholarPubMed
Pinto, JM. Olfaction. Proc Am Thorac Soc 2011;8:46–52CrossRefGoogle ScholarPubMed
Ruijschop, RM, Boelrijk, AE, de Graaf, C, Westerterp-Plantenga, MS. Retronasal aroma release and satiation: a review. J Agric Food Chem 2009;57:9888–94CrossRefGoogle ScholarPubMed
Brämerson, A, Johansson, L, Ek, L, Nordin, S, Bende, M. Prevalence of olfactory dysfunction: the Skövde population-based study. Laryngoscope 2004;114:733–7CrossRefGoogle ScholarPubMed
Deems, DA, Doty, RL, Settle, RG, Moore-Gillon, V, Shaman, P, Mester, AF et al. Smell and taste disorders, a study of 750 patients from the University of Pennsylvania Smell and Taste Center. Arch Otolaryngol Head Neck Surg 1991;117:519–28CrossRefGoogle ScholarPubMed
Schriever, VA, Agosin, E, Altundag, A, Avni, H, Cao Van, H, Cornejo, C et al. Development of an international odor identification test for children: The Universal Sniff Test. J Pediatr 2018;198:265–72CrossRefGoogle ScholarPubMed
Bennetto, L, Kuschner, ES, Hyman, SL. Olfaction and taste processing in autism. Biol Psychiatry 2007;62:1015–2110.1016/j.biopsych.2007.04.019CrossRefGoogle ScholarPubMed
Karsz, FR, Vance, A, Anderson, VA, Brann, PG, Wood, SJ, Pantelis, C et al. Olfactory impairments in child attention-deficit/ hyperactivity disorder. J Clin Psychiatry 2008;69:1462–8CrossRefGoogle ScholarPubMed
Roberts, MA, Simcox, AF. Assessing olfaction following pediatric traumatic brain injury. Appl Neuropsychol 1996;3:86–8CrossRefGoogle ScholarPubMed
Richman, RA, Sheehe, PR, McCanty, T, Vespasiano, M, Post, EM, Guzi, S et al. Olfactory deficits in boys with cleft palate. Pediatrics 1998;82:840–4Google Scholar
Saniasiaya, J, Islam, MA, Abdullah, B. Prevalence of olfactory dysfunction in coronavirus disease 2019 (COVID-19): a meta-analysis of 27,492 patients. Laryngoscope 2021;131:865–78CrossRefGoogle Scholar
Bunyavanich, S, Do, A, Vicencio, A. Nasal gene expression of angiotensin-converting enzyme 2 in children and adults. JAMA 2020;323:2427–9CrossRefGoogle ScholarPubMed
Calvo-Henríquez, C, Chiesa-Estomba, C, Martinez-Capoccioni, G, Lechien, JR, Mota-Rojas, X, Mayo-Yáñez, M et al. Methods to assess olfaction in pediatric patients: a systematic review from the International YO-IFOS Study Group. Eur Arch Otorhinolaryngol 2020;277:313–21CrossRefGoogle ScholarPubMed
Thomas-Danguin, T, Rouby, C, Sicard, G, Vigouroux, M, Farget, V, Johanson, A et al. Development of the ETOC: a European test of olfactory capabilities. Rhinology 2003;41:142–51Google ScholarPubMed
Ramasamy, K, Saniasiaya, J, Abdul Gani, N. Olfactory and gustatory dysfunctions as a clinical manifestation of coronavirus disease 2019 in a Malaysian tertiary center. Ann Otol Rhinol Laryngol 2021;130:513–19CrossRefGoogle Scholar
Hummel, T, Whitcroft, KL, Andrews, P, Altundag, A, Cinghi, C, Costanzo, RM et al. Position paper on olfactory dysfunction. Rhinology 2016;56:1–30Google ScholarPubMed