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isobolographic analysis

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10 - Methods for assessing pharmacodynamic interactions
from Part III - Pharmacodynamic interactions
- By Blaise F. D. Bourgeois, Harvard Medical School, Division of Epilepsy and Clinical Neurophysiology, Children's Hospital, Boston, MA, USA
Edited by Jerzy Majkowski, Blaise F. D. Bourgeois, Harvard University, Massachusetts, Philip N. Patsalos, Institute of Neurology, London, Richard H. Mattson, Yale University, Connecticut
Book:

Antiepileptic Drugs

Published online:

07 September 2009

Print publication:

26 May 2005, pp 193-207
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Summary

Assessing a pharmacodynamic interaction between two drugs requires a valid quantitative measurement of a specific drug effect for the two drugs individually, as well as a quantitative measurement of the effect of the two drugs administered together. The isobolographic analysis is widely used to determine the various types of pharmacodynamic interaction in experimental animal models, in particular for antiepileptic drugs. Besides the isobolographic analysis, various other methods have been used to assess pharmacodynamic interactions. One of them is the fractional effective concentration (FEC) index. The difficulties encountered in the assessment of pharmacodynamic interactions in experimental animals are compounded when interactions are to be studied clinically in patients, especially for antiepileptic drugs. The discussion on designs of clinical trials to study pharmacodynamic interactions between antiepileptic drugs is based on the assumption that the studies are to be clinically relevant.