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Substitutes for the soul included the self, personality, and the brain. “Self” kept the older issues alive without metaphysical baggage. Calkins’ “self-psychology” held that the self was the basal concept in psychology, and that soul was unnecessary. Allport found that “personality” enabled psychology to address topics vital to soul. The brain is the most significant substitute for the soul. Lashley sought to translate introspective findings into a physicalist language. Lashley retained terms such as meaning and self-consciousness, but articulated them in terms of stimuli and responses of the nervous system. Hebb dismissed introspection altogether. His “cell assembly” theory proposed neural networks as organized patterns of responses to stimuli. Thought is the organized activity of the nervous system. Given the emphasis on organization of neural firing, therein is the brain a substitute for the soul, since in the older psychologies, soul was a principle of form or organization.
Childhood trauma and adversity are common across societies and have strong associations with physical and psychiatric morbidity throughout the life-course. One possible mechanism through which childhood trauma may predispose individuals to poor psychiatric outcomes is via associations with brain structure. This study aimed to elucidate the associations between childhood trauma and brain structure across two large, independent community cohorts.
Methods
The two samples comprised (i) a subsample of Generation Scotland (n=1,024); and (ii) individuals from UK Biobank (n=27,202). This comprised n=28,226 for mega-analysis. MRI scans were processed using Free Surfer, providing cortical, subcortical, and global brain metrics. Regression models were used to determine associations between childhood trauma measures and brain metrics and psychiatric phenotypes.
Results
Childhood trauma associated with lifetime depression across cohorts (OR 1.06 GS, 1.23 UKB), and related to early onset and recurrent course within both samples. There was evidence for associations between childhood trauma and structural brain metrics. This included reduced global brain volume, and reduced cortical surface area with highest effects in the frontal (β=−0.0385, SE=0.0048, p(FDR)=5.43x10−15) and parietal lobes (β=−0.0387, SE=0.005, p(FDR)=1.56x10−14). At a regional level the ventral diencephalon (VDc) displayed significant associations with childhood trauma measures across both cohorts and at mega-analysis (β=−0.0232, SE=0.0039, p(FDR)=2.91x10−8). There were also associations with reduced hippocampus, thalamus, and nucleus accumbens volumes.
Discussion
Associations between childhood trauma and reduced global and regional brain volumes were found, across two independent UK cohorts, and at mega-analysis. This provides robust evidence for a lasting effect of childhood adversity on brain structure.
Japanese whalers use the electric lance as a secondary method of killing minke whales (Balaenoptera acutorostrata). The lances are dropped into the body, and currents varying between 2.2 and 14. OA, with a mean of 6.8A, are applied.
When currents of 5A were applied to the carcasses of dead whales, varying in size from 1.8 to 15.7m in length, no current densities induced in the target organs were sufficient to cause either insensibility (10mA cm−2 in the brain), or to cause ventricular fibrillation (0.5mA cm−2 in the heart), except in a few cases where electrodes were specifically placed to span the heart. When electrodes were placed in positions normally used in whaling operations, no current densities were produced which would have been sufficient to cause brain and cardiac dysfunction.
Further investigations on changes in current density with time post mortem after application of a controlled current of 5A showed, during a 60 hour period, a fourfold increase in the current density in the heart, and more than a twofold increase in the brain. Thus contrary to previous criticisms, if these studies had been carried out on live animals, all current densities would have been below threshold values.
There are no records of signs of epileptic form seizure, which are associated with an effective electrical stun, in whales subjected to the electric lance.
It is concluded that the electric lance as used in whaling operations is ineffective and likely to cause extra pain and suffering to an already distressed animal.
Determining objective measures for proof of consciousness in non-human animals has been helped by improved understanding of neural correlates of human consciousness. Functional imaging and neuropsychological studies have shown remarkable overlap between structures involved in actual perception of social and non-social objects and those involved in forming mental images of them. One area of particular interest is individual face recognition. This involves regions of the temporal lobe that are mainly only activated by actual perception or mental imagery of faces. Using behavioural, neuroanatomical and neurophysiological approaches in sheep, we have found that they have similar specialized abilities for recognizing many individuals from their faces. They have developed the same specialized neural processing regions in the temporal lobe for aiding such recognition. Furthermore, parallel activation of other brain regions controlling behavioural and emotional responses only occurs when they are overtly interested in the individuals whose faces they perceive. Such interest might therefore equate to their becoming consciously aware of them. Preliminary experiments have indicated that sheep may form and use mental images and that the regions of the temporal lobe that respond to faces can also do so under conditions where faces are suggested but do not actually appear. Such similarities between humans and sheep in this form of social recognition make it difficult to claim that humans can form mental images of faces whereas sheep cannot. While the ability to form and use mental imagery is not in itself definitive proof of consciousness, it is an important component part.
Here we uncover the mysteries of the baby as it develops in the womb, discussing how fetal development is controlled. We give insights into aspects of pregnancy not widely known, from the fetus starting to breathe months before it is born, to the question of whether it sleeps – and dreams. We discuss the ways in which information about the mother’s life and her environment affect the baby’s development. Although birth may seem the first major milestone for a baby, we emphasise that many other milestones have been passed before that, inside the womb, out of sight but over which parents can have substantial influence. We give insights into new discoveries about how the organs of the fetal body develop in prediction of the world in which that individual ‘expects’ to live, and what happens when the prediction turns out to be wrong. The idea that the fetus is preparing for life after birth will get the reader thinking about the long-term consequences of the way a fetus develops. Each of us is unique as a result of our development – and nobody is perfect. Our unique development starts from the moment of conception, which introduces the next chapter on sex.
This chapter explores the fledgling countercultural popular music industry in Germany in the 1960s and 1970s and summarises the economic conditions under which Krautrock developed. Compared to Britain and the United States, Germany was a disadvantaged place for popular music production. The chapter gives an overview of the places, events, and people that prepared the ground for independent popular music production away from the Schlager-focused major labels. The role of music journalist Rolf-Ulrich Kaiser in organising Krautrock’s founding event, the International Essen Song Days in 1968, and his three influential record companies Ohr, Pilz, and Kosmische Kuriere, is highlighted. Independent record labels like Kaiser’s and others such as Brain and Sky enabled musical experimentation and allowed a German avant-garde interpretation of rock music to thrive. The chapter outlines Krautrock’s reception on the international market, considering commercial successes (Tangerine Dream, Kraftwerk) and failures (Faust). Independent record producers, most notably Conny Plank and Dieter Dierks, were indispensable for their creative contribution to many Krautrock records and as intermediaries between Krautrock artists and their record companies.
Aging is a subject of concern to everyone, but is widely misunderstood. If we view it as inevitable, we miss the fact that not everyone is able to grow to an old age. Realization of this reality helps us to understand that aging presents a wonderful opportunity - an opportunity to make choices about how we live which can enhance the aging process and offer a chance to live to our potential. This book clearly presents the four, multiple reserve, factors (cognitive, physical, psychological and social) which impact our ability to have healthy responses to the stresses of aging. By giving the biological basis for the advice given, you will learn the steps to take in your activities, diet and mental outlook to grasp the opportunity that aging offers. Everyone must know that what we do makes a difference.
Chapter 5: Neurocognitive Processing and Reading Ability. This chapter examines the relationship between neurological processing and reading comprehension. Over the past twenty years, there has been an increasing connection between real-time behavioral language (and reading) processing and newer perspectives on neurolinguistic processing. In order to provide an introductory overview, the chapter first described the key physiological features of language in the brain. The goal is to connect neurological processes and cognitive-behavioral research on reading comprehension. Both cortical and sub-cortical contributions are addressed as is the recent turn to networks and pathways (the connectome). The chapter also describes the various measurement methods for examining neurological processing (fMRI, ERP, PET, DTI, TMS, MEG). The chapter also notes distinct, but very similar, language processing when engaged in L2 reading. The last major section focuses more specifically on ERP and fMRI research studies, involving both L1 and L2 reading. This chapter does not note implications for instruction.
Endometriosis is a chronic inflammatory disease with pelvic pain and uncharacteristic accompanying symptoms. Endometriosis-associated pain often persists despite treatment of the disease, thus it brings a deleterious impact on their personal lives as well as imposing a substantial economic burden on them. At present, mechanisms underlie endometriosis-associated pain including inflammatory reaction, injury, aberrant blood vessels and the morphological and functional anomaly of the peripheral and central nervous systems. The nerve endings are influenced by the physical and chemical factors surrounding the lesion, via afferent nerve to the posterior root of the spinal nerve, then to the specific cerebral cortex involved in nociception. However, our understanding of the aetiology and mechanism of this complex pain process caused by endometriosis remains incomplete. Identifying the pathogenesis of endometriosis is crucial to disease management, offering proper treatment, and helping patients to seek novel targets for the maintenance and contributors of chronic pain. The main aim of this review is to focus on every possible mechanism of pain related to endometriosis in both peripheral and central nervous systems, and to present related mechanisms of action from the interaction between peripheral lesions and nerves to the changes in transmission of pain, resulting in hyperalgesia and the corresponding alterations in cerebral cortex and brain metabolism.
In schizophrenia, abnormal synaptic pruning during adolescence may be due to an altered Complement system activity. While this hypothesis is supported by C4 overexpression in various brain regions of individuals with schizophrenia, such alterations should be replicated and extended to other brain regions relevant to schizophrenia. Moreover, transcriptional studies of genes coding for proteins regulating the Complement system activity are lacking. Furthermore, it remains unknown whether cerebral and peripheral expression of C4 and Complement control proteins (CCP) are related.
Objectives
To identify altered expression of C4 and CCP (CSMD1, CSMD2, CD46) coding genes at the cerebral and peripheral levels in schizophrenic individuals.
Methods
We explored C4 and CCP coding genes expression at the cerebral and peripheral levels. Using shinyGEO application we analyzed gene expression from eight Gene Expression Omnibus datasets obtained from 196 schizophrenic individuals and 182 control subjects. First, we compared gene expression between schizophrenic patients and controls in postmortem cerebral samples from 7 different brain regions. Then, we compared gene expression between schizophrenic patients and controls in 4 peripheral tissues.
Results
We observed C4 overexpression in the DLPFC, parietal, temporal cortex and associative striatum of schizophrenic individuals. We report altered transcriptional patterns of CCP genes in the DLPFC, hippocampus and cerebellum of schizophrenic individuals. CD46 expression was altered in opposite directions between brain and blood of schizophrenic individuals. No significant alteration of C4 expression was observed in peripheral tissues.
Conclusions
Our results support the hypothesis of an altered Complement system activity in various brain regions of schizophrenic individuals which may disrupt the synaptic pruning process during adolescence.
Exposure to alcohol causes imbalances in neuroimmune function and impaired brain development.
Objectives
Alcohol activates neuroimmune molecules, expressed and secreted by glial cells in the brain, alter neuronal function and stimulate alcoholic behavior.
Methods
The study involved women aged 25-41 years-did not drink alcohol 1 month before and during pregnancy – 1-st group; women with I-II degree of alcoholism 3-13 years – 2-nd group. Embryonic material were obtained 8-15 weeks of igestation. 2-nd group were divided into subgroups. Group Alcohol (A)-alcoholic women,s embrious, included 2 subgroups: A1-embryos 8-9 weeks, A2-10-11 weeks of gestation (n=12). The Control group (K) includ control samples K1-8–9, K2-10-11 weeks (n=14). The analysis of changes in morphometric parameters was used to identify quantitative changes among glioblasts, correlation between the degree of differentiation components and the degree of influence of alcohol. For this, the program AxioVision 4.8 was used Parameters of GABAA/benzodiazepine receptors were studied by the radio-receptor assay of [3H]-flunitrazepam with synaptoneurosomes.
Results
Changes in glioblasts tof human brain embryos and fetuses were revealed under conditions of chronic prenatal alcoholization with an increase in gestational age compared to the control subgroups: a significant increase in the average number of glioblasts, the length of the perimeters of the presynaptic terminal, postsynaptic density, presynaptic terminal areas were significantly less (p<0, 01) in the study group than in the control. Exposure to ethanol reduces the affinity of GABAA/benzodiazepine receptors, which affects neuronal plasticity associated with the development of glioblasts and neuroblasts during embryogenesis.
Conclusions
Changes in microglial cause disruption of the neuronal activity
Previous neuroimaging studies of individuals with nonsyndromic oral clefts have revealed subtle brain structural differences compared to matched controls. Additional studies strongly suggest that the higher incidence of neuropsychiatric issues observed in these individuals may be explained by these neuroanatomical differences. Currently there are no studies that have assessed the overall empirical evidence of the effect of oral clefts on the brain.
Objectives
Our aim was to summarize available evidence on potential brain structure differences in individuals with nonsyndromic oral clefts and their matched controls. In the current presentation, we discuss the results of regional brain structural differences.
Methods
Five databases were systematically searched in September 2020 for case-control studies that reported neuroimaging in healthy individuals and individuals with nonsyndromic oral clefts. Duplicate study selection, data extraction, random effects meta-analyses of mean differences (MDs) and their 95% confidence intervals were performed in order to compare regional brain MRI volumes.
Results
We have identified 245 records following the database searches, from which 12 records met the inclusion criteria. Quantitative data on brain structure were available in three studies.The cerebellum, occipital and temporal lobes were significantly smaller in the cleft group compared to controls (MD: -12.46, 95% CI: -18.26, -6.67, n=3 studies; MD:-7.39, 95% CI: -12.80, -1.99, n=2 studies; MD: -10.53, 95% CI: -18.23, -2.82, n=2 studies, respectively).
Conclusions
There may be structural brain differences between individuals with nonsyndromic oral clefts and their controls based on the available evidence.
According to the social brain hypothesis, the human brain includes a network designed for the processing of social information. This network includes several brain regions that elaborate social cues, interactions and contexts, i.e. prefrontal paracingulate and parietal cortices, amygdala, temporal lobes and the posterior superior temporal sulcus. We will explore neuroimaging studies that investigated social isolation in healthy subjects.
Edited by
Irene Cogliati Dezza, University College London,Eric Schulz, Max-Planck-Institut für biologische Kybernetik, Tübingen,Charley M. Wu, Eberhard-Karls-Universität Tübingen, Germany
Recent advancements in psychology, behavioral economics, and neuroscience have shown the human pursuit of knowledge to be an essential aspect of human cognition. It drives intellectual development, is integral to social interactions, and is crucial for learning, decision-making, and goal-directed behavior. Information appears to be valuable in and of itself, even when it has no apparent use, whereas at other times, instrumental information is actively and paradoxically avoided. With this complex role, a wide range of neural mechanisms can be deployed to assign value to information and drive decisions to seek (or avoid) information. Evidence points toward key roles for the mesolimbic system and the prefrontal cortex in these processes. Specifically, two different networks appear to be involved in the implementation of information-seeking behaviors. One network, overlapping with areas involved in processing primary and monetary rewards, appears to drive a general preference for information, as well as valence-dependent information-seeking. The other network, independent of reward processing, is recruited when information is acquired to reduce uncertainty. In this chapter, we review some of the most recent discoveries in the field to provide an overview of the neural basis of information-seeking.
Approaching AN from a temperament-based neurobiological perspective provides a biological foundation and conceptual framework from which to view symptoms and the underlying mechanisms that drive behavior. Temperament informs targeted interventions directed at the cause of the behavior, rather than the behavior itself. This is a paradigm shift for many. TBT-S has five core principles derived from neurobiological research. (1) Eating disorders are brain and biologically based illnesses. (2) Treat to the trait or the temperament underpinnings. (3) Food is medicine. (4) Supports are needed and a necessary part of the treatment process. d (5) Action or movement is fundamental to change.
The first therapy session holds the unique opportunity to introduce neurobiological underpinnings of identified ED symptoms while assessing client traits that impact long-term change.
Already as infants humans are more fearful than our closest living primate relatives, the chimpanzees. Yet heightened fearfulness is mostly considered maladaptive, as it is thought to increase the risk of developing anxiety and depression. How can this human fear paradox be explained? The fearful ape hypothesis presented herein stipulates that, in the context of cooperative caregiving and provisioning unique to human great ape group life, heightened fearfulness was adaptive. This is because from early in ontogeny fearfulness expressed and perceived enhanced care-based responding and provisioning from, while concurrently increasing cooperation with, mothers and others. This explanation is based on a synthesis of existing research with human infants and children, demonstrating a link between fearfulness, greater sensitivity to and accuracy in detecting fear in others, and enhanced levels of cooperative behaviors. These insights critically advance current evolutionary theories of human cooperation by adding an early-developing affective component to the human cooperative makeup. Moreover, the current proposal has important cultural, societal and health implications, as it challenges the predominant view in WEIRD societies that commonly construe fearfulness as a maladaptive trait, potentially ignoring its evolutionary adaptive functions.
This chapter focuses on brain and behavioural correlates of psychopathy and antisocial personality that inform us about their motivational and emotional underpinnings. Findings related to the three components of the triarchic psychopathy model – boldness, meanness and disinhibition – are reviewed. An important distinction is drawn between ‘primary’ and ‘secondary’ variants of psychopathy, which should not be viewed as a unitary construct.
The Winter Conference 2021 focused on the theme of obesity and the brain, with symposia on the consequences of obesity on brain function, developments in behavioural change interventions, neurobiology of appetite regulation and obesity treatment, and personalised medicine for obesity prevention and treatment. The first plenary lecture discussed sweetness perceptions and how non-nutritive sweeteners may lead to a mismatch between metabolic signals and reward systems in the brain, and the second plenary lecture presented novel approaches to the treatment of binge-eating disorders. This short report summarises the content of these scientific sessions.
An individual’s recovery from alcohol use disorder (AUD) occurs within the context of changes in drinking behavior as well as changes in physical and mental health. This chapter considers how drinking behavior change can arise from, and be supported by, functional improvements in the brain and in peripheral organ systems. The chapter proposes that arousal serves as a common process that can either support or hinder recovery through its link to executive control, negative emotionality, and cue salience; arousal is measurable through overt human behavior, physiological reactivity, and neural activation; and arousal modulation may serve as a holistic intervention target to help sustain recovery. The chapter considers how the arousal construct may be used to identify more homogeneous subgroups of persons in recovery, such as those who may benefit from arousal-modulation adjuvants to bolster executive cognitive control, affect regulation, and flexible responses to contextual cues.