In recent years, the aviation industry has taken a leading role in the integration of composite structures to develop lighter and more fuel efficient aircraft. Among the leading concepts to achieve this goal is the Pultruded Rod Stitched Efficient Unitized Structure (PRSEUS) concept. The focus of most PRSEUS studies has been on developing an hybrid wing body structure, with only a few discussing the application of PRSEUS to a tube-wing fuselage structure. Additionally, the majority of investigations for PRSEUS have focused on experimental validation of anticipated benefits rather than developing a methodology to capture the behavior of stitched structure analytically. This paper presents an overview of a numerical methodology capable of accurately describing PRSEUS’ construction and how it may be implemented in a barrel fuselage platform resorting to high-fidelity mesoscale modeling techniques. The methodology benefits from fresh user defined strategies developed in a commercially available finite element analysis environment. It further proposes a new approach for improving the ability to predict deformation in stitched composites, allowing for a better understanding of the intricate behavior and subtleties of stitched aerospace structures.