The transfer of sericulture into Byzantium is a critical episode in the global dissemination of silk production technology. However, it is now widely accepted that the explanatory model portraying the transfer as a one-off event is at odds with the historical facts. This article seeks to reassess the transfer of this technology through the lens of appropriation, interpreted as a process. Based on a detailed analysis of the limited evidence available, it attempts to reconstruct the process from transregional and diachronic perspectives, embracing, on the one hand, the transmission of sericulture from China to Byzantium and, on the other, its development in Byzantium over time. This reconstruction offers an explanation for unresolved historical problems. It also constitutes a template for modelling the global transfer of technology in the premodern world, potentially of great value for an in-depth understanding of the transfer.