Weed control and cotton yield with a herbicide program of sethoxydim and DPX-PE350 applied postemergence over-the-top was compared with that of a standard herbicide program of trifluralin applied PPI plus fluometuron applied PRE plus methazole and MSMA applied postemergence-directed. Control of pitted and entireleaf morningglory, smooth pigweed, and prickly sida was similar with the postemergence over-the-top program and the standard herbicide program when DPX-PE350 was applied to cotton in the V2 or V4 growth stages. Less weed control and lower yield were observed when DPX-PE350 was applied to V6-stage cotton. Good control of annual grasses was obtained with all herbicide programs.