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Several genome-wide linkage scans have reported that chromosome 22q11-13 might contain susceptibility loci for both schizophrenia and mood disorder.
We genotyped 44 Chinese Han family trios with mixed family history of schizophrenia and mood disorder with 11 DNA microsatellite markers on chromosome 22q11-13. These markers spanned 56.55 cM on 22q11-13 with mean intervals of 5.66 cM and average heterozygosity 0.71.The transmission disequilibrium test (TDT) was used to search for susceptibility loci to schizophrenia and mood disorder.
Including all family trios regardless of proband diagnosis, we found six markers associated with susceptibility to psychotic disorders., including D22S420 (χ2=4.76, df=1, P=0.029)%3001D22S277 (χ2=5.44, df=1, P=0.020)%3001D22s315 (allele 5, χ2=7.00, df=1, P=0.008; allele 7, χ2=-4.83, df=1, P=0.028; allele 11, χ2=4.00, df=1, P=0.046)%3001D22S274 (allele 7, χ2=-5.40, df=1, P=0.020; allele 10, χ2=6.23 df=1, P=0.013)%3001D22S1160 (χ2=-4, df=1, P=0.046) and D22S1161 (χ2=5.14, df=1, P=0.023). When grouped separately into schizophrenia and mood disorder according to proband diagnosis, four markers D22S420(χ2=7.36, df=1, P=0.007) %3001D22S315 (allele 5, χ2=4., df=1, P=0.046; allele 7, χ2=-8.89, df=1, P=0.003)%3001D22S1161(χ2=6.23, df=1, P=0.013) and D22S280 (χ2=4, df=1, P=0.046) were significantly associated with schizophrenia, but were not significantly associated with mood disorder, D22S274(allele 7, χ2=5., df=1, P=0.025; allele 10, χ2=6, df=1, P=0.014) were significantly associated with mood disorder only, and D22S277(χ2=4, df=1, P=0.046) was associated with both schizophrenia and mood disorder.
These results indicate that chromosome 22q11-13 contains the susceptibility loci to schizophrenia and mood disorder, and that overlapping regions may be shared by these disorders.
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