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The COVID-19 caused a world pandemic, posing a huge threat to global health. Widespread vaccination is the most effective way to control the pandemic. Vaccination with the third dose of the COVID-19 vaccine is currently underway. We aimed to determine the attitude of adolescents toward the third dose of COVID-19 vaccine.
A structured questionnaire was administered between 16 August and 28 October 2021 among adolescents aged 12–17 years in three provinces of eastern region of China based on convenience sampling. The questionnaire was specifically developed to assess the adolescents’ attitude toward and willingness to accept a third dose of the COVID-19 vaccine.
In total, 94.3% (1742/1847) of the adolescents intended to accept the third dose of the COVID-19 vaccine. Age between 15–17 years, no worry about vaccine safety, confidence for vaccine effectiveness, and supporting opinion from parents were independently associated with acceptance of the third dose (p < 0.05).
It is necessary for governments and school administrators to raise adolescents’ and parents’ awareness of the benefits and safety of the third dose of vaccination, which should be effective to increase the vaccination coverage among adolescents.
The purpose of the current study was to investigate associations between spicy food intake and serum lipids levels in Chinese rural population.
Information on spicy food flavour and intake frequency was obtained using a two-item questionnaire survey. Dietary data were collected using a validated thirteen-item FFQ. Fasting blood samples were collected and measured for total cholesterol (TC), TAG, HDL-cholesterol and LDL-cholesterol. Multivariate linear and logistic regression models were employed to examine the relationship between spicy food and serum lipids levels according to the spicy food flavour and intake frequency, respectively.
A cross-sectional study in Henan Province.
38 238 participants aged 18–79 years old.
Spicy flavour and intake frequency were consistently associated with decreased TC and non-HDL-cholesterol levels but mildly associated with elevated TAG levels. Each level increment in spicy flavour was inversely associated with high TC (OR: 0·91; 95 % CI 0·88, 0·93) and high non-HDL-cholesterol (OR: 0·88; 95 % CI 0·85, 0·91) but positively associated with high TAG (OR: 1·04; 95 % CI 1·01, 1·07). Similarly, 1-d increment in spicy food intake frequency was also inversely associated with high TC (OR: 0·92; 95 % CI 0·91, 0·94) and high non-HDL-cholesterol (OR: 0·91; 95 % CI 0·89, 0·93) but positively associated with high TAG (OR: 1·04; 95 % CI 1·02, 1·06).
Spicy food intake was mildly associated with increased risk of abnormal TAG level, significantly associated with decreased risk of abnormal TC and non-HDL levels. Spicy food intake may be contribute to the management of lipid levels.
Pinewood nematode, Bursaphelenchus xylophilus, a pine parasitic nematode, poses a serious threat to its host pine forests globally. When dispersal-stage larvae 4 (dauer, DL4) of B. xylophilus enters the new pine, it moults into propagative adult (dauer recovery) and reproduces quickly to kill the host pine. Here, we found pine chemical volatiles, rather than the common dauer recovery factors of nematodes (e.g. suitable temperatures, nutrient availability or density), promote B. xylophilus dauer recovery. The results showed that volatilization of chemicals in host pines could attract DL4 and promote DL4 recovery. To identify which chemicals promote this process, we determined the stimulated activity of the main volatiles of pines including six monoterpenes and two sesquiterpenes. Results showed that all the six monoterpenes promoted dauer recovery, especially β-pinene and β-myrcene, but the two sesquiterpenes have no effect on the transformation. Furthermore, β-pinene performed gradient effects on dauer recovery. We hypothesized that when DL4 infect pine trees, the pine volatiles released from the feeding wounds are used as chemical signals for DL4 transformation to adult to reproduce and rapidly kill the pines. Our study identified the B. xylophilus dauer recovery chemical signal and may contribute to preventing pine wilt disease.
A large schizophrenia genome-wide association study (GWAS) and a
subsequent extensive replication study of individuals of European
ancestry identified eight new loci with genome-wide significance and
suggested that the MIR137-mediated pathway plays a role
in the predisposition for schizophrenia.
To validate the above findings in a Han Chinese population.
We analysed the single nucleotide polymorphisms (SNPs) in the newly
identified schizophrenia candidate loci and predicted
MIR137 target genes based on our published Han
Chinese populations (BIOX) GWAS data. We then analysed 18 SNPs from the
candidate regions in an independent cohort that consisted of 3585
patients with schizophrenia and 5496 controls of Han Chinese
We replicated the associations of five markers
(P<0.05), including three that were located in the
predicted MIR137 target genes. Two loci
(ITIH3/4: rs2239547, P
=1.17×10–10 and CALN1: rs2944829,
P=9.97×10–9) exhibited genome-wide
significance in the Han Chinese population.
The ITIH3/4 locus has been reported to be of genome-wide
significance in the European population. The successful replication of
this finding in a different ethnic group provides stronger evidence for
the association between schizophrenia and ITIH3/4. We
detected the first genome-wide significant association of schizophrenia
with CALN1, which is a predicted target of
MIR137, and thus provide new evidence for the
associations between MIR137 targets and
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