In the double-cone ignition scheme of inertial confinement fusion, the head-on collision of two compressed fuel jets from the cone-tips forms an isochoric plasma, which is then heated suddenly by a MeV relativistic electron beam produced by ultra-intense picosecond laser pulses. This fast-heating process was studied experimentally at the Shenguang II upgrade laser facility. By observing temporal-resolved X-ray emission and the spatial-resolved X-ray spectrum, the colliding process and heating process are carefully studied. The colliding plasma was imaged to have dimensions of approximately 86 μm in the implosion direction and approximately 120 μm in the heating direction. By comparing the simulated plasma X-ray spectrum with experimental data, the electron temperature of the heated plasma was found to rapidly increase to 600 ± 50 eV, almost doubling the temperature achieved before the heating laser incidence.

Dyes are toxic and considered to be extremely hazardous to natural environments. Hence, adsorbents to remove dyes from contaminated water are needed. To develop adsorbents with a high adsorption capacity for different dyes, easy separation, and low cost, a novel dye adsorbent was prepared by activating fly ash with NaOH. The adsorbent morphology, structure, and specific surface area were characterized using scanning electron microscopy, X-ray powder diffraction, and surface area measurements using N2 adsorption-desorption. The adsorption abilities of the synthesized adsorbents were examined based on methylene blue and acid fuchsin adsorption from water. The capabilities of the adsorbents as a function of adsorbent use, dye type, dye concentration, time, and pH were investigated and compared. The results for methylene blue and acid fuchsin adsorption were modeled using pseudo-second order kinetics and the Langmuir adsorption isotherm, respectively. These modified adsorbents synthesized from fly ash may provide a promising solution to purify dye-contaminated waste water with the advantages of high efficiency and low cost.

The velocity interferometer system for any reflector (VISAR) coupled with a streaked optical pyrometer (SOP) system is used as a diagnostic tool in inertial confinement fusion (ICF) experiments involving equations of state and shock timing. To validate the process of adiabatically compressing the fuel shell through precise tuning of shocks in experimental campaigns for the double-cone ignition (DCI) scheme of ICF, a compact line-imaging VISAR with an SOP system is designed and implemented at the Shenguang-II upgrade laser facility. The temporal and spatial resolutions of the system are better than 30 ps and 7 μm, respectively. An illumination lens is used to adjust the lighting spot size matching with the target size. A polarization beam splitter and λ/4 waveplate are used to increase the transmission efficiency of our system. The VISAR and SOP work at 660 and 450 nm, respectively, to differentiate the signals from the scattered lights of the drive lasers. The VISAR can measure the shock velocity. At the same time, the SOP system can give the shock timing and relative strength. This system has been used in different DCI campaigns, where the generation and propagation processes of multi-shock are carefully diagnosed.

Collision of two counterflowing gravity currents of equal densities and heights was investigated by means of three-dimensional high-resolution simulations with the goal of understanding the flow structures and energetics in the collision region in more detail. The lifetime of collision is approximately $3 \tilde {H}/\tilde {u}_f$, where $\tilde {H}$ is the depth of heavy and ambient fluids, and $\tilde {u}_f$ is the front velocity of the approaching gravity currents, and the lifetime of collision can be divided into three phases. During Phase I, $-0.2 \leqslant (\tilde {t}-\tilde {t}_c) \tilde {u}_f/\tilde {H} \leqslant 0.5$, where $\tilde {t}$ is the time, and $\tilde {t}_c$ is the time instance at which the two colliding gravity currents have fully osculated, geometric distortions of the gravity current fronts result in stretching of pre-existing vorticity in the wall-normal direction inside the fronts, and an array of vertical vortices extending throughout the updraught fluid column develop along the interface separating the two colliding gravity currents. The array of vertical vortices is responsible for the mixing between the heavy fluids of the two colliding gravity currents and for the production of turbulent kinetic energy in the collision region. The presence of the top boundary deflects the updraughts into the horizontal direction, and a number of horizontal streamwise vortices are generated close to the top boundary. During Phase II, $0.5 \leqslant (\tilde {t}-\tilde {t}_c) \tilde {u}_f/\tilde {H} \leqslant 1.2$, the horizontal streamwise vortices close to the top boundary induce turbulent buoyancy flux and break up into smaller structures. While the production of turbulent kinetic energy weakens, the rate of transfer of energy to turbulent flow due to turbulent buoyancy flux reaches its maximum and becomes the primary supply in the turbulent kinetic energy in Phase II. During Phase III, $1.2 \leqslant (\tilde {t}-\tilde {t}_c) \tilde {u}_f/\tilde {H} \leqslant 2.8$, the collided fluid slumps away from the collision region, while the production of turbulent kinetic energy, turbulent buoyancy flux and dissipation of energy attenuate. From the point of view of energetics, the production of turbulent kinetic energy and turbulent buoyancy flux transfers energy away from the mean flow to the turbulent flow during the collision. Our study complements previous experimental investigations on the collision of gravity currents in that the flow structures, spatial distribution and temporal evolution of the mean flow and turbulent flow characteristics in the collision region are presented clearly. It is our understanding that such complete information on the energy budgets in the collision region can be difficult to attain in laboratory experiments.

Coastal eutrophication and hypoxia remain a persistent environmental crisis despite the great efforts to reduce nutrient loading and mitigate associated environmental damages. Symptoms of this crisis have appeared to spread rapidly, reaching developing countries in Asia with emergences in Southern America and Africa. The pace of changes and the underlying drivers remain not so clear. To address the gap, we review the up-to-date status and mechanisms of eutrophication and hypoxia in global coastal oceans, upon which we examine the trajectories of changes over the 40 years or longer in six model coastal systems with varying socio-economic development statuses and different levels and histories of eutrophication. Although these coastal systems share common features of eutrophication, site-specific characteristics are also substantial, depending on the regional environmental setting and level of social-economic development along with policy implementation and management. Nevertheless, ecosystem recovery generally needs greater reduction in pressures compared to that initiated degradation and becomes less feasible to achieve past norms with a longer time anthropogenic pressures on the ecosystems. While the qualitative causality between drivers and consequences is well established, quantitative attribution of these drivers to eutrophication and hypoxia remains difficult especially when we consider the social economic drivers because the changes in coastal ecosystems are subject to multiple influences and the cause–effect relationship is often non-linear. Such relationships are further complicated by climate changes that have been accelerating over the past few decades. The knowledge gaps that limit our quantitative and mechanistic understanding of the human-coastal ocean nexus are identified, which is essential for science-based policy making. Recognizing lessons from past management practices, we advocate for a better, more efficient indexing system of coastal eutrophication and an advanced regional earth system modeling framework with optimal modules of human dimensions to facilitate the development and evaluation of effective policy and restoration actions.

Pregnancy is a complex biological process. The establishment and maintenance of foetal–maternal interface are pivotal events. Decidual immune cells and inflammatory cytokines play indispensable roles in the foetal–maternal interface. The disfunction of decidual immune cells leads to adverse pregnancy outcome. Tumour necrosis factor (TNF)-α, a common inflammatory cytokine, has critical roles in different stages of normal pregnancy process. However, the relationship between the disorder of TNF-α and adverse pregnancy outcomes, including preeclampsia (PE), intrauterine growth restriction (IUGR), spontaneous abortion (SA), preterm birth and so on, is still indefinite. In this review, we thoroughly reviewed the effect of TNF-α disorder on pathological conditions. Moreover, we summarized the reports about the adverse pregnancy outcomes (PE, IUGR, SA and preterm birth) of using anti-TNF-α drugs (infliximab, etanercept and adalimumab, certolizumab and golimumab) currently in the clinical studies. Overall, IUGR, SA and preterm birth are the most common adverse pregnancy outcomes of anti-TNF-α drugs. Our review may provide insight for the immunological treatment of pregnancy-related complication, and help practitioners make informed decisions based on the current evidences.

High-resolution simulations are performed for gravity currents propagating on a no-slip boundary to study the merging and splitting processes in the lobe-and-cleft structure at a gravity current head. The simulations reproduce the morphological features observed in the laboratory and provide more detailed flow information to elucidate the merging and splitting processes. Our mean lobe width $\tilde {b}$ and mean maximum lobe width $\tilde {b}_{max}$ satisfy the empirical relationships $\tilde {b}/\tilde {d}=7.4 Re^{-0.39}_f$ and $\tilde {b}_{max}/\tilde {d}=12.6 Re^{-0.38}_f$, respectively, over the front Reynolds number in the range $383 \le Re_f \le 3267$, where the front Reynolds number is defined as $Re_f= \tilde {u}_f \tilde {d} / \tilde {\nu }, \tilde {u}_f$ is the front velocity, $\tilde {d}$ is the height of the gravity current head and $\tilde {\nu }$ is the fluid kinematic viscosity. When measured in terms of the viscous length scale $\tilde {\delta }_\nu = \tilde {\nu }/\tilde {u}^*$, where $\tilde {u}^*$ is the shear velocity at the gravity current head, the mean lobe width and the mean maximum lobe width increase with increasing front Reynolds number and asymptotically approach $126 \tilde {\delta }_\nu$ and $230 \tilde {\delta }_\nu$ at $Re_f=3267$, respectively. The vortical structure inside a lobe has an elongated tooth-like shape and a pair of counter-rotating streamwise vortices are positioned on the left- and right-hand sides of each cleft. For the merging process, it requires the interaction of three tooth-like vortices and the middle tooth-like vortex breaks up and reconnects with the two neighbouring tooth-like vortices. Therefore, a cleft may continually merge with another neighbouring cleft but may never disappear. For the splitting process, even before the new cleft appears, a new born streamwise vortex is created by the parent vortex of opposite orientation and the parent vortex can be either the left part or the right part of the existing tooth-like vortex inside the splitting lobe. The new born streamwise vortex then induces the other counter-rotating streamwise vortex as the new cleft develops. The initiation of the splitting process can be attributed to the Brooke–Hanratty mechanism reinforced by the baroclinic production of vorticity. Depending on the orientation of the parent vortex, the resulting new cleft after the splitting process can shift laterally in the positive or negative spanwise direction along the leading edge of the gravity currents as the lobe-and-cleft structure moves forward in the streamwise direction. For gravity currents propagating on a no-slip boundary, the lobe-and-cleft structure is self-sustaining and the manifestations of the merging and splitting processes are in accord with reported laboratory observations.

Boussinesq and non-Boussinesq gravity currents produced from a finite volume of heavy fluid propagating into an environment of light ambient fluid on unbounded uniform slopes in the range $0\,^\circ \le \theta \le 12\,^\circ$ are reported. The relative density difference $\epsilon = (\rho _1-\rho _0)/\rho _0$ is varied in the range $0.05 \le \epsilon \le 0.15$ in this study, where $\rho _1$ and $\rho _0$ are the densities of the heavy and light ambient fluids, respectively. Our focus is on the influence of the relative density difference on the deceleration phase of the propagation. In the early deceleration phase, the front location history follows the power relationship ${(x_f+x_0)}^2 = {(K_I B)}^{1/2} (t+t_{I})$, where $(x_f+x_0)$ is the front location measured from the virtual origin, $K_I$ an experimental constant, $B$ the total buoyancy, $t$ the time and $t_I$ the $t$ intercept. The dimensionless constant $K_I$ is influenced by the slope angle and the relative density difference. In the late deceleration phase for the gravity currents on the steeper slopes in this study ($12\,^\circ$, $9\,^\circ$ and $6\,^\circ$), an ‘active’ head separates from the body of the current and the front location history follows the power relationship ${(x_f+x_0)}^{8/3} = K_{VS} {B}^{2/3} V^{2/9}_0 {\nu }^{-1/3} ({t+t_{VS}})$, where $K_{VS}$ is an experimental constant, $V_0$ the total volume of heavy fluid, $\nu$ the kinematic viscosity of fluid and $t_{VS}$ the $t$ intercept. The dimensionless constant $K_{VS}$ is shown to be influenced by the slope angle but not significantly influenced by the relative density difference. In the late deceleration phase for the gravity currents on the milder slopes in this study ($3\,^\circ$ and $0\,^\circ$), the gravity currents maintain an integrated shape without violent mixing with the ambient fluid and the front location history follows the power relationship ${(x_f+x_0)}^{4} = K_{VM} {B}^{2/3} V^{2/3}_0 {\nu }^{-1/3} ({t+t_{VM}})$, where $K_{VM}$ is an experimental constant and $t_{VM}$ the $t$ intercept. The dimensionless constant $K_{VM}$ is shown to be influenced by both the slope angle and the relative density difference. While the influence of the relative density difference on $K_{VM}$ is carried along for the gravity currents on the milder slopes in the late deceleration phase, the relative density difference interestingly has no significant influence on $K_{VS}$ for the gravity currents on the steeper slopes in the late deceleration phase. Our results suggest that the non-Boussinesq gravity currents on the milder slopes may remain non-Boussinesq ones in the late deceleration phase while the non-Boussinesq gravity currents on the steeper slopes may have become Boussinesq ones in the late deceleration phase.

Spatial profiles of impurity emission measurements in the extreme ultraviolet (EUV) spectroscopic range in radiofrequency (RF)-heated discharges are combined with one-dimensional and three-dimensional transport simulations to study the effects of resonant magnetic perturbations (RMPs) on core impurity accumulation at EAST. The amount of impurity line emission mitigation by RMPs appears to be correlated with the ion Z for lithium, carbon, iron and tungsten monitored, i.e. stronger suppression of accumulation for heavier ions. The targeted effect on the most detrimental high-Z impurities suggests a possible advantage using RMPs for impurity control. Profiles of transport coefficients are calculated with the STRAHL one-dimensional impurity transport code, keeping $\nu /D$ fixed and using the measured spatial profiles of $\textrm{F}{\textrm{e}^{20 + }}$, $\textrm{F}{\textrm{e}^{21 + }}$ and $\textrm{F}{\textrm{e}^{22 + }}$ to disentangle the transport coefficients. The iron diffusion coefficient ${D_{\textrm{Fe}}}$ increases from $1.0- 2.0\;{\textrm{m}^2}\;{\textrm{s}^{ - 1}}$ to $1.5- 3.0\;{\textrm{m}^2}\;{\textrm{s}^{ - 1}}$ from the core region to the edge region $(\rho \gt 0.5)$ after the onset of RMPs. Meanwhile, an inward pinch of iron convective velocity ${\nu _{\textrm{Fe}}}$ decreases in magnitude in the inner core region and increases significantly in the outer confined region, simultaneously contributing to preserving centrally peaked $\textrm{Fe}$ profiles and exhausting the impurities. The ${D_{\textrm{Fe}}}$ and ${\nu _{\textrm{Fe}}}$ variations lead to reduced impurity contents in the plasma. The three-dimensional edge impurity transport code EMC3-EIRENE was also applied for a case of RMP-mitigated high-Z accumulation at EAST and compared to that of low-Z carbon. The exhaust of ${\textrm{C}^{6 + }}$ toward the scrape-off layer accompanying an overall suppression of heavier ${\textrm{W}^{30 + }}$ is observed when using RMPs.

An acute gastroenteritis (AGE) outbreak caused by a norovirus occurred at a hospital in Shanghai, China, was studied for molecular epidemiology, host susceptibility and serological roles. Rectal and environmental swabs, paired serum samples and saliva specimens were collected. Pathogens were detected by real-time polymerase chain reaction and DNA sequencing. Histo-blood group antigens (HBGA) phenotypes of saliva samples and their binding to norovirus protruding proteins were determined by enzyme-linked immunosorbent assay. The HBGA-binding interfaces and the surrounding region were analysed by the MegAlign program of DNAstar 7.1. Twenty-seven individuals in two care units were attacked with AGE at attack rates of 9.02 and 11.68%. Eighteen (78.2%) symptomatic and five (38.4%) asymptomatic individuals were GII.6/b norovirus positive. Saliva-based HBGA phenotyping showed that all symptomatic and asymptomatic cases belonged to A, B, AB or O secretors. Only four (16.7%) out of the 24 tested serum samples showed low blockade activity against HBGA-norovirus binding at the acute phase, whereas 11 (45.8%) samples at the convalescence stage showed seroconversion of such blockade. Specific blockade antibody in the population played an essential role in this norovirus epidemic. A wide HBGA-binding spectrum of GII.6 supports a need for continuous health attention and surveillance in different settings.