To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure firstname.lastname@example.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
Previous studies have reported the association between advanced paternal
age at birth and the risk of autistic-spectrum disorder in offspring,
including offspring with intellectual disability.
To test whether an association between advanced paternal age at birth is
found in offspring with high-functioning autistic-spectrum disorder (i.e.
offspring without intellectual disability).
A case–control study was conducted in Japan. The participants consisted
of individuals with full-scale IQ ⩾ 70, with a DSM–IV autistic disorder
or related diagnosis. Unrelated healthy volunteers were recruited as
controls. Parental ages were divided into tertiles (i.e. three age
classes). Odds ratios and 95% confidence intervals were estimated using
logistic regression analyses, with an adjustment for age, gender and
Eighty-four individuals with autistic-spectrum disorder but without
intellectual disability and 208 healthy controls were enrolled. Increased
paternal, but not maternal, age was associated with an elevated risk of
high-functioning autistic-spectrum disorder. A one-level advance in
paternal age class corresponded to a 1.8-fold increase in risk, after
adjustment for covariates.
Advanced paternal age is associated with an increased risk for
high-functioning autistic-spectrum disorder.
Immune dysfunction has been proposed as a mechanism for the pathophysiology
of autistic-spectrum disorders. The selectin family of adhesion molecules
plays a prominent role in immune/inflammatory responses. We determined the
serum levels of three types of soluble-form selectin (sP, sL and sE) in 15
men with high-functioning autism and 22 age-matched healthy controls by
enzyme-linked immunosorbent assay. Levels of sP-selectin and sL-selectin
were significantly lower in patients than in controls. Furthermore,
sP-selectin levels were negatively correlated with impaired social
development during early childhood.
Email your librarian or administrator to recommend adding this to your organisation's collection.