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Healthcare personnel (HCP) were recruited to provide serum samples, which were tested for antibodies against Ebola or Lassa virus to evaluate for asymptomatic seroconversion.
From 2014 to 2016, 4 patients with Ebola virus disease (EVD) and 1 patient with Lassa fever (LF) were treated in the Serious Communicable Diseases Unit (SCDU) at Emory University Hospital. Strict infection control and clinical biosafety practices were implemented to prevent nosocomial transmission of EVD or LF to HCP.
All personnel who entered the SCDU who were required to measure their temperatures and complete a symptom questionnaire twice daily were eligible.
No employee developed symptomatic EVD or LF. EVD and LF antibody studies were performed on sera samples from 42 HCP. The 6 participants who had received investigational vaccination with a chimpanzee adenovirus type 3 vectored Ebola glycoprotein vaccine had high antibody titers to Ebola glycoprotein, but none had a response to Ebola nucleoprotein or VP40, or a response to LF antigens.
Patients infected with filoviruses and arenaviruses can be managed successfully without causing occupation-related symptomatic or asymptomatic infections. Meticulous attention to infection control and clinical biosafety practices by highly motivated, trained staff is critical to the safe care of patients with an infection from a special pathogen.
A single-loop spatial mechanism kinematically becomes an open robot, if we separate the grounded joint of the input link which may then be considered as the end effector of the robot. Any position of the end-effector within the workspace of such an open robot can be reached via a number of different configurations of the links. These configurations are called “branches” of the open robot for that particular position of the end effector.
If the open robot is now stretched to a limiting position by a force exerted on the end effector, all the possible branches of the mechanism approach each other. When they become coincident, they form the “limiting configuration”. Any two related branches are at opposite sides of the limiting configuration. From the relationship between the links in th elimiting configuration and in related branches, conditions for aviodance of branching of the original closed-loop mechanism can be obtained. This is necessary in order to assure that a set of consistent relative displacements are specified for the open robot to move displacements are specified for the open robot to move toward the desired end-effector position without jumping from one branch to another. As for the closed-loop mechanism, open robot branching aviodance ensures that a desired sequence of positions of a particular floating link in the loop will be generated without changing the branch of the link configuration.
In this paper, the above approach is applied to RSSR, RRSC, RRSRR, RRRRRRR and RPCRRR spatial closed-loop motion-generator mechanisms and the corresponding conditions for aviodance of branching in the synthesis of the mechanisms are derived.
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