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Breast cancer is a high-risk disease with a high mortality rate among women. Chemotherapy plays an important role in the treatment of breast cancer. However, chemotherapy eventually results in tumours that are resistant to drugs. In recent years, many studies have revealed that the activation of Wnt/β-catenin signalling is crucial for the emergence and growth of breast tumours as well as the development of drug resistance. Additionally, drugs that target this pathway can reverse drug resistance in breast cancer therapy. Traditional Chinese medicine has the properties of multi-target and tenderness. Therefore, integrating traditional Chinese medicine and modern medicine into chemotherapy provides a new strategy for reversing the drug resistance of breast tumours. This paper mainly reviews the possible mechanism of Wnt/β-catenin in promoting the process of breast tumour drug resistance, and the progress of alkaloids extracted from traditional Chinese medicine in the targeting of this pathway in order to reverse the drug resistance of breast cancer.
Bonding strength is commonly measured by various kinds of single cycle tests such as scratch tests or indentation tests. These tests all reflect complex composite properties - both plastic and elastic properties of the film and the substrate - as well as the bonding strength. In many cases experimental critical value of these single cycle tests is controlled by film or substrate strength or ductility rather than bonding strength. In these cases, the single cycle test should be evaluated in terms of the specific property which controls failure and should not be taken as a measure of “bonding strength.” However, the interfacial fatigue strength measured at 5X106 cycles is shown to be measurable over a large range of bonding strengths and composite properties. And further, this interface fatigue strength is insensitive to the composite properties. The complementary nature of these two types of tests is demonstrated for various TiN-based hard coatings on various steel and cemented carbide substrates.
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