In 2018, an Ionplus 200 kV MIni-CArbon DAting System (MICADAS) accelerator mass spectrometer (AMS) was installed at the Laboratory of AMS Dating and the Environment, Nanjing University (NJU-AMS Laboratory), China. The NJU-AMS Laboratory is largely devoted to research on radiocarbon dating and 14C analysis in fields of earth, environmental and archaeological sciences. The laboratory has successfully employed various pretreatment methods, including routine pretreatment of tree rings, buried wood and subfossil wood, seeds, charcoal, pollen concentrates, organic matter, and shells. In this study, operational status of the NJU-AMS is presented, and results of radiocarbon measurements made on different sample types are reported. Measurements on international standards, references of known age, and blank samples demonstrate that the NJU-AMS runs stably and has good reproducibility on measurement of single samples. The facility is capable of measuring 14C in samples with the precision and accuracy that meet the requirements for investigating annual 14C changes, history-prehistory age dating, and Late Quaternary stratigraphic chronology research.

Endometrial receptivity is the ability of the endometrium to accept embryos. Thus, endometrial receptivity dysfunction is an important factor leading to embryo implantation failure. A good endometrial receptivity provides a suitable environment for embryo implantation, improving the embryo implantation rate. The “implantation window” stage, or the receptive stage of the endometrium, is regulated by various hormones, genes, proteins and cytokines, among which microRNAs (miRNAs) and their target genes have a regulatory effect on endometrial receptivity. This review outlines the relationship between endometrial receptivity and pregnancy, the mRNAs and related signalling pathways that regulate endometrial receptivity, and the regulatory role of miRNA in endometrial receptivity, providing a deeper understanding of the regulatory mechanisms of miRNA on endometrial receptivity in humans and animals and reference for the endometrial receptivity-related research.

The calcium-sensing receptor (CaSR) is a critical mediator of calcium homeostasis in various tissues. Its role in human reproduction, especially in sperm function and male fertility, remains not fully elucidated. This study investigates the expression patterns of CaSR in normal and abnormal sperm and spermatogenic cells and evaluates its potential effect on sperm motility and morphology. Using immunohistochemistry (IHC), quantitative PCR (qPCR), we assessed the expression levels of CaSR in normal sperm, spermatogonia, and cases of asthenozoospermia, oligozoospermia, and teratozoospermia. In vitro functional assays were performed to analyze the effects of CaSR modulation on sperm motility under varying conditions, including the presence of specific CaSR agonists and antagonists. Our study revealed distinct patterns of CaSR expression in normal sperm and spermatogonia compared with those in abnormal sperm samples, particularly in cases of asthenozoospermia, oligozoospermia, and teratozoospermia. A marked decrease in CaSR expression was evident in these abnormal samples, highlighting its significance in normal sperm functionality. Functional assays further elucidated the role of CaSR in sperm motility. Activation of CaSR through specific agonists enhanced sperm motility, while inhibition by antagonists led to reduced motility. Our findings suggest that CaSR plays a significant role in maintaining sperm functionality and that changes in its expression may be associated with male infertility. These insights into the molecular underpinnings of sperm physiology highlight CaSR as a potential therapeutic target for treating certain forms of male infertility.

Understanding settling motion of coral grains is important in terms of protection of coral reef systems and resotoration of the associated ecosystems. In this paper, a series of laboratory experiments was conducted to investigate the settling motion, using optical microscopy to measure shape parameters of coral grains and the particle-filtering-based object tracking to reconstruct the three-dimensional trajectory. Three characteristic descent regimes, namely, tumbling, chaotic and fluttering, are classified based on the three-dimensional trajectory, the spiral radius variation and the velocity spectrum. It is demonstrated that if one randomly picks up one coral grain, then the probabilities of occurrence of the three regimes are approximately $26\,\%$, $42\,\%$ and $32\,\%$, respectively. We have shown that first, the dimensionless settling velocity generally increases with the non-dimensional diameter and Corey shape factor and second, the drag coefficient generally decreases with the Reynolds number and Corey shape factor. Based on this, the applicability of existing models on predicting settling velocity and drag coefficient for coral grains is demonstrated further. Finally, we have proposed extended models for predicting the settling velocity. This study contributes to better understanding of settling motion and improves our predictive capacity of settling velocity for coral grains with complex geometry.

In this paper, we consider a joint drift rate control and two-sided impulse control problem in which the system manager adjusts the drift rate as well as the instantaneous relocation for a Brownian motion, with the objective of minimizing the total average state-related cost and control cost. The system state can be negative. Assuming that instantaneous upward and downward relocations take a different cost structure, which consists of both a setup cost and a variable cost, we prove that the optimal control policy takes an $\left\{ {\!\left( {{s^{\ast}},{q^{\ast}},{Q^{\ast}},{S^{\ast}}} \right),\!\left\{ {{\mu ^{\ast}}(x)\,:\,x \in [ {{s^{\ast}},{S^{\ast}}}]} \right\}} \right\}$ form. Specifically, the optimal impulse control policy is characterized by a quadruple $\left( {{s^{\ast}},{q^{\ast}},{Q^{\ast}},{S^{\ast}}} \right)$, under which the system state will be immediately relocated upwardly to ${q^{\ast}}$ once it drops to ${s^{\ast}}$ and be immediately relocated downwardly to ${Q^{\ast}}$ once it rises to ${S^{\ast}}$; the optimal drift rate control policy will depend solely on the current system state, which is characterized by a function ${\mu ^{\ast}}\!\left( \cdot \right)$ for the system state staying in $[ {{s^{\ast}},{S^{\ast}}}]$. By analyzing an associated free boundary problem consisting of an ordinary differential equation and several free boundary conditions, we obtain these optimal policy parameters and show the optimality of the proposed policy using a lower-bound approach. Finally, we investigate the effect of the system parameters on the optimal policy parameters as well as the optimal system’s long-run average cost numerically.

In this paper, we explore the applications of Tail Variance (TV) as a measure of tail riskiness and the confidence level of using Tail Conditional Expectation (TCE)-based risk capital. While TCE measures the expected loss of a risk that exceeds a certain threshold, TV measures the variability of risk along its tails. We first derive analytical formulas of TV and TCE for a large variety of probability distributions. These formulas are useful instruments for relevant research works on tail risk measures. We then propose a distribution-free approach utilizing TV to estimate the lower bounds of the confidence level of using TCE-based risk capital. In doing so, we introduce sharpened conditional probability inequalities, which halve the bounds of conventional Markov and Cantelli inequalities. Such an approach is easy to implement. We further investigate the characterization of tail risks by TV through an exploration of TV’s asymptotics. A distribution-free limit formula is derived for the asymptotics of TV. To further investigate the asymptotic properties, we consider two broad distribution families defined on tails, namely, the polynomial-tailed distributions and the exponential-tailed distributions. The two distribution families are found to exhibit an asymptotic equivalence between TV and the reciprocal square of the hazard rate. We also establish asymptotic relationships between TCE and VaR for the two families. Our asymptotic analysis contributes to the existing research by unifying the asymptotic expressions and the convergence rate of TV for Student-t distributions, exponential distributions, and normal distributions, which complements the discussion on the convergence rate of univariate cases in [28]. To show the usefulness of our results, we present two case studies based on real data from the industry. We first show how to use conditional inequalities to assess the confidence of using TCE-based risk capital for different types of insurance businesses. Then, for financial data, we provide alternative evidence for the relationship between the data frequency and the tail categorization by the asymptotics of TV.

Turbulent boundary layers (TBLs) over surface perturbations like bumps with roughness – notably altering heat and mass transfer, drag, etc. – are prevalent in nature (mountains, dunes, etc.) and technology. We study a channel flow with a transverse bump on one wall superimposed with small-scale longitudinal grooves via direct numerical simulation (DNS) of incompressible flow. Turbulence statistics and dynamics are compared between grooved wall (GW) and smooth wall (SW) bumps. Streamwise spinning jets emanating from the crests’ corners alter the flow structure within the separation bubble (SB), extending the SB length by 30 % over that for SW, and have lingering effects far downstream. Grooves decrease skin friction but increase the bump's form drag by 25 %. In GW, the peaks of turbulence intensity and production decrease by 20 % and shift downstream, compared with SW. Three regions of negative production, found upstream as well as downstream of the bump, are explained in terms of two separate mechanisms: normal and shear productions. Separation upstream of the bump occurs always for GW, but intermittently for SW. Within the downstream SB, counter-rotating minibubbles form intermittently for SW but always for GW. Interestingly, a minibubble causes streamwise vorticity reversal of the upstream moving secondary flow around each crest corner. The wall pressure in GW is invariant in the spanwise direction and is explained in terms of its non-local nature and its connection with outer structures. The grooved bump unearths rich TBL flow physics – upstream separation, dynamics of the downstream minibubble, altered reattachment dynamics and negative production.

On the Greenland Ice Sheet, hydrofracture connects the supraglacial and subglacial hydrologic systems, coupling surface runoff dynamics and ice velocity. In recent decades, the growth of low-permeability ice slabs in the wet snow zone has expanded Greenland's runoff zone, but observations suggest that surface-to-bed connections are rare, because meltwater drains through crevasses into the porous firn beneath ice slabs. However, there is little quantitative evidence confirming the absence of surface-to-bed fracture propagation. Here, we use poromechanics to investigate whether water-filled crevasses in ice slabs can propagate vertically through an underlying porous firn layer. Based on numerical simulations, we develop an analytical estimate of the water injection-induced effective stress in the firn given the water level in the crevasse, ice slab thickness, and firn properties. We find that the firn layer substantially reduces the system's vulnerability to hydrofracture because much of the hydrostatic stress is accommodated by a change in pore pressure, rather than being transmitted to the solid skeleton. This result suggests that surface-to-bed hydrofracture will not occur in ice slab regions until all pore space proximal to the initial flaw has been filled with solid ice.

An ultrasonic phased array system is introduced to study the three-dimensional (3-D) movement of a single bubble in a GaInSn alloy under a transverse magnetic field (MF), which is verified by bubble experiments in water. The 3-D motion trajectories of individual bubbles in the GaInSn are obtained under a horizontal MF. As the MF becomes stronger, the bubble successively oscillates in random directions (R mode), a direction perpendicular to the MF (V mode), a direction parallel to the MF (P mode) and finally it rises straight (S mode). The significant anisotropy of the oscillation directions at a moderate MF intensity may be due to the anisotropy of the vortex structure around the bubble. Furthermore, the oscillation amplitude gradually declines with increasing MF intensity until the bubble trajectory finally becomes a straight line. Our measurements allow us to specify the characteristic regions for the observed bubble modes in the $N-Eo-Re$ parameter space (N is the magnetic interaction parameter, Eo is the Eötvös number and Re is the Reynolds number). In addition, more detailed characteristics of bubble terminal velocity are revealed, showing that the bubble velocities are closely related to the motion modes. The increase in bubble velocity at a moderate MF intensity is caused by the weakening oscillation. At a high strength, the MF monotonically suppresses the rise velocity of the bubble with a fixed scaling law.

Introducing soybean cultivars resistant to 2,4-D and dicamba allowed for postemergence applications of these herbicides. These herbicides pose a high risk for off-target movement, and the potential influence on crops such as hemp is unknown. Two studies were conducted from 2020 through 2022 in controlled environments to evaluate hemp response to rates simulating off-target events of 2,4-D and dicamba. The objectives of this study were to: 1) determine the effects of herbicide (2,4-D and dicamba) and rate (1x to 1/100,000x labeled rate) on visible injury, height, and branching, and 2) determine the effect of 2,4-D rate (1x to 1/100,000x labeled rate) on visible injury, height, branching, and reproductive parameters. Herbicides were applied in the early vegetative stage, and evaluations took place 14 and 28 days after treatment (DAT) and at trial termination (42 DAT in the greenhouse trial and at harvest in the growth chamber trial). In the greenhouse trial, 2,4-D and dicamba at the 1x rate and the 1/10x rate caused 68, 78, and 20% injury 28 DAT, respectively. At the time of trial termination 42 DAT, plants treated with 1x rates of 2,4-D and dicamba or 1/10x dicamba were 19, 25, and 9 cm shorter than the nontreated control, respectively. At trial termination, simulated off-target rates of 2,4-D and dicamba did not influence branching or plant weight. In the growth chamber study, the 1x and 1/10x rates of 2,4-D caused 82% and 2% injury 28 DAT, respectively. Plant height, fresh weight, and cannabidiol (CBD) levels of plants treated with simulated off-target rates of 2,4-D were not different from the nontreated control. These studies suggest that hemp grown for CBD exposed to off-target rates of 2,4-D or dicamba in early vegetative stages may not have distinguishable effects 42 DAT or at harvest.

The spatial arrangement of objects in residential environments is a crucial indicator of occupant behavior, shedding light on the complex dynamics of their interaction with the interior. This study introduces an object-based graph method for decoding urban home interiors, examining the co-presence of objects to uncover domestic behavioral patterns through indoor imagery analysis. By integrating centrality metrics with objects in graphs, we gain deeper insights into household behaviors, which provide empirical evidence for future interior design.

Let G be a simply connected semisimple compact Lie group, let X be a simply connected compact Kähler manifold homogeneous under G, and let L be a negative holomorphic line bundle over X. We prove that all G-invariant Kähler metrics on the total space of L arise from the Calabi ansatz. Using this, we show that there exists a unique G-invariant scalar-flat Kähler metric in each G-invariant Kähler class of L. The G-invariant scalar-flat Kähler metrics are automatically asymptotically conical.