We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.
To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure no-reply@cambridge.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
Echinochloa crus-galli var. crus-galli (L.) P. Beauv. (EC), Echinochloa crus-galli var. mitis (Pursh) Petermann (ECM), and Echinochloa glabrescens Munro ex Hook. f. (EG) are all serious rice (Oryza sativa L.) weeds, which are usually treated as a single species in weed management practices. To determine interspecific and intraspecific differences in seed germination responding to different temperatures among the three Echinochloa weeds, we conducted field surveys and collected 66 EC, 141 ECM, and 120 EG populations from rice fields of East China in 2022; and tested their seed germination under 28/15C (day/night), 30/20C, and 35/25C regimes, simulating temperatures of rice planting periods for double-cropping early rice, single-cropping rice, and double-cropping late rice, respectively. In EC, ECM, and EG, seed percentage germination (cumulative percent of germinated seed) and germination index (sum of the ratio of germinated seeds to the corresponding days) increased with increasing temperatures. At 28/15C, the average percentage germination of EC populations (67.5%) was significantly (P < 0.05) higher than ECM (46.4%) and EG (43.7%); GD50 (duration for 50% total germination) for EC populations (5.2 d) was significantly shorter than ECM (5.9 d) and EG (5.8 d). At 35/25C, the percentage germination of EC (90.7%), ECM (80.5%), and EG (80.3%) were all significantly the highest among the three temperature treatments, respectively, and the GD50 values for EC (2.5 d), ECM (2.6 d), and EG (2.7 d) were all significantly the lowest. At 30/20C and 35/25C, average germination percentage of populations collected from transplanted rice fields were significantly higher than that of populations collected from direct-seeded rice fields. Moreover, among EG populations, the longitudes and latitudes of collection locations were significantly correlated with seed percentage germination and germination indices. According to the interspecific differences and intraspecific variations of Echinochloa species, weed management strategies should also be customized according to the species and population characteristics in seed germination.
Attention-deficit/hyperactivity disorder (ADHD) patients exhibit characteristics of impaired working memory (WM) and diminished sensory processing function. This study aimed to identify the neurophysiologic basis underlying the association between visual WM and auditory processing function in children with ADHD.
Methods
The participants included 86 children with ADHD (aged 6–15 years, mean age 9.66 years, 70 boys, and 16 girls) and 90 typically developing (TD) children (aged 7–16 years, mean age 10.30 years, 66 boys, and 24 girls). Electroencephalograms were recorded from all participants while they performed an auditory discrimination task (oddball task). The visual WM capacity and ADHD symptom severity were measured for all participants.
Results
Compared with TD children, children with ADHD presented a poorer visual WM capacity and a smaller mismatch negativity (MMN) amplitude. Notably, the smaller MMN amplitude in children with ADHD predicted a less impaired WM capacity and milder inattention symptom severity. In contrast, the larger MMN amplitude in TD children predicted a better visual WM capacity.
Conclusions
Our results suggest an intimate relationship and potential shared mechanism between visual WM and auditory processing function. We liken this shared mechanism to a total cognitive resource limit that varies between groups of children, which could drive correlated individual differences in auditory processing function and visual WM. Our findings provide a neurophysiological correlate for reports of WM deficits in ADHD patients and indicate potential effective markers for clinical intervention.
Working memory deficit, a key feature of schizophrenia, is a heritable trait shared with unaffected siblings. It can be attributed to dysregulation in transitions from one brain state to another.
Aims
Using network control theory, we evaluate if defective brain state transitions underlie working memory deficits in schizophrenia.
Method
We examined average and modal controllability of the brain's functional connectome in 161 patients with schizophrenia, 37 unaffected siblings and 96 healthy controls during a two-back task. We use one-way analysis of variance to detect the regions with group differences, and correlated aberrant controllability to task performance and clinical characteristics. Regions affected in both unaffected siblings and patients were selected for gene and functional annotation analysis.
Results
Both average and modal controllability during the two-back task are reduced in patients compared to healthy controls and siblings, indicating a disruption in both proximal and distal state transitions. Among patients, reduced average controllability was prominent in auditory, visual and sensorimotor networks. Reduced modal controllability was prominent in default mode, frontoparietal and salience networks. Lower modal controllability in the affected networks correlated with worse task performance and higher antipsychotic dose in schizophrenia (uncorrected). Both siblings and patients had reduced average controllability in the paracentral lobule and Rolandic operculum. Subsequent out-of-sample gene analysis revealed that these two regions had preferential expression of genes relevant to bioenergetic pathways (calmodulin binding and insulin secretion).
Conclusions
Aberrant control of brain state transitions during task execution marks working memory deficits in patients and their siblings.
The emerging era of big data in radio astronomy demands more efficient and higher-quality processing of observational data. While deep learning methods have been applied to tasks such as automatic radio frequency interference (RFI) detection, these methods often face limitations, including dependence on training data and poor generalization, which are also common issues in other deep learning applications within astronomy. In this study, we investigate the use of the open-source image recognition and segmentation model, Segment Anything Model (SAM), and its optimized version, HQ-SAM, due to their impressive generalization capabilities. We evaluate these models across various tasks, including RFI detection and solar radio burst (SRB) identification. For RFI detection, HQ-SAM (SAM) shows performance that is comparable to or even superior to the SumThreshold method, especially with large-area broadband RFI data. In the search for SRBs, HQ-SAM demonstrates strong recognition abilities for Type II and Type III bursts. Overall, with its impressive generalization capability, SAM (HQ-SAM) can be a promising candidate for further optimization and application in RFI and event detection tasks in radio astronomy.
Cross-language internet memes have emerged as a unique and popular mode of online communication, combining bilingual elements with visually textual components. These memes exhibit distinctive characteristics at semantic, syntactic, and pragmatic levels, rendering them a noteworthy semiotic phenomenon in contemporary digital culture. To deepen our understanding of cross-language internet memes, this study investigates user perceptions through a questionnaire, employing SPSS Statistics software for analysis. Applying a social semiotic approach, we decipher the semiotic mechanisms of cross-language memes, shedding light on their potential implications for identity construction. Additionally, we reflect on two prominent trends in internet meme development: the shift from monomodal to multimodal communication and from monolingual to multilingual expressions. This research hopes to provide insights for meme research and online discourse investigations.
The family Streblidae is a significant grouping of dipteran insects within the superfamily Hippoboscoidea, which parasitizes the body surface of bats. With the global spread of bat-related pathogens in recent years, Streblidae has gained increasing attention due to its potential for pathogen transmission. A sample of Brachytarsina amboinensis was sequenced on the B. amboinensis were obtained, compared with available Streblidae mitogenomes, and the phylogeny of Hippoboscoidea was reconstructed. The results indicate that the mitochondrial genome of B. amboinensis exhibits a relatively high degree of conservation, with an identical gene count, arrangement, and orientation as the ancestral insect's genome. Base composition analysis revealed a strong bias towards A and T in the base composition. Selection pressure analysis indicated strong purifying selection acting on cox1. Pairwise genetic distance analysis showed that cox1 evolved at a relatively slow rate. Regarding phylogenetic relationships, the constructed phylogenetic trees using Bayesian inference and Maximum Likelihood methods supported the monophyly of the Hippoboscoidea, Glossinidae, Hippoboscidae, and Nycteribiidae clades, with high nodal support values. Our research confirmed the paraphyly of the families Streblidae. In the familial relations between Nycteribiidae and Streblidae, New World Streblidae share a closer kinship with Nycteribiidae. This contrasts with prior findings which indicated that Old World Streblidae share a closer kinship with Nycteribiidae. This study not only enhances the molecular database for bat flies but also provides a valuable reference for the identification and phylogenetic analysis of Streblidae.
This study aimed to demonstrate the utilization value of 1PN embryos. The 1PN zygotes collected from December 2021 to September 2022 were included in this study. The embryo development, the pronuclear characteristics, and the genetic constitutions were investigated. The overall blastocyst formation and good-quality blastocyst rates in 1PN zygotes were 22.94 and 16.24%, significantly lower than those of 2PN zygotes (63.25 and 50.23%, respectively, P = 0.000). The pronuclear characteristics were found to be correlated with the developmental potential. When comparing 1PN zygotes that developed into blastocysts to those that arrested, the former exhibited a significantly larger area (749.49 ± 142.77 vs. 634.00 ± 119.05, P = 0.000), a longer diameter of pronuclear (29.81 ± 3.08 vs. 27.30 ± 3.00, P = 0.000), and a greater number of nucleolar precursor body (NPB) (11.56 ± 3.84 vs. 7.19 ± 2.73, P = 0.000). Among the tested embryos, the diploidy euploidy rate was significantly higher in blastocysts in comparison with the arrested embryos (66.67 vs. 11.76%, P = 0.000), which was also significantly higher in IVF-1PN blastocysts than in ICSI-1PN blastocysts (75.44 vs. 25.00%, P = 0.001). However, the pronuclear characteristics were not found to be linked to the chromosomal ploidy once they formed blastocysts.
In summary, while the developmental potential of 1PN zygotes is reduced, our study shows that, in addition to the reported pronuclear area and diameter, the number of NPB is also associated with their developmental potential. The 1PN blastocysts exhibit a high diploidy euploidy rate, are recommend to be clinically used post genetic testing, especially for patients who do not have other 2PN embryos available.
We present a practical verification method for safety analysis of the autonomous driving system (ADS). The main idea is to build a surrogate model that quantitatively depicts the behavior of an ADS in the specified traffic scenario. The safety properties proved in the resulting surrogate model apply to the original ADS with a probabilistic guarantee. Given the complexity of a traffic scenario in autonomous driving, our approach further partitions the parameter space of a traffic scenario for the ADS into safe sub-spaces with varying levels of guarantees and unsafe sub-spaces with confirmed counter-examples. Innovatively, the partitioning is based on a branching algorithm that features explainable AI methods. We demonstrate the utility of the proposed approach by evaluating safety properties on the state-of-the-art ADS Interfuser, with a variety of simulated traffic scenarios, and we show that our approach and existing ADS testing work complement each other. We certify 5 safe scenarios from the verification results and find out 3 sneaky behavior discrepancies in Interfuser which can hardly be detected by safety testing approaches.
The clinical high risk for psychosis (CHR-p) syndrome enables early identification of individuals at risk of schizophrenia and related disorders. We differentiate between the stigma associated with the at-risk identification itself (‘labelling-related’ stigma) versus stigma attributed to experiencing mental health symptoms (‘symptom-related’ stigma) and examine their relationships with key psychosocial variables.
Aims
We compare labelling- and symptom-related stigma in rates of endorsement and associations with self-esteem, social support loss and quality of life.
Method
We assessed stigma domains of shame-related emotions, secrecy and experienced discrimination for both types of stigma. Individuals at CHR-p were recruited across three sites (N = 150); primary analyses included those who endorsed awareness of psychosis risk (n = 113). Paired-sample t-tests examined differences in labelling- versus symptom-related stigma; regressions examined associations with psychosocial variables, controlling for covariates, including CHR-p symptoms.
Results
Respondents reported greater symptom-related shame, but more labelling-related secrecy. Of the nine significant associations between stigma and psychosocial variables, eight were attributable to symptom-related stigma, even after adjusting for CHR-p symptoms.
Conclusions
Stigma attributed to symptoms had a stronger negative association with psychosocial variables than did labelling-related stigma among individuals recently identified as CHR-p. That secrecy related to the CHR-p designation was greater than its symptom-related counterpart suggests that labelling-related stigma may still be problematic for some CHR-p participants. To optimise this pivotal early intervention effort, interventions should address the holistic ‘stigmatising experience’ of having symptoms, namely any harmful reactions received as well as participants’ socially influenced concerns about what their experiences mean, in addition to the symptoms themselves.
Web3 is a new frontier of internet architecture emphasizing decentralization and user control. This text for MBA students and industry professionals explores key Web3 concepts, starting from foundational principles and moving to advanced topics like blockchain, smart contracts, tokenomics, and DeFi. The book takes a clear, practical approach to demystify the tech behind NFTs and DAOs as well as the complex regulatory landscape. It confronts challenges of blockchain scalability, a barrier to mainstream adoption of this transformative technology, and examines smart contracts and the growing ecosystem leveraging their potential. The book also explains the nuances of tokenomics, a vital element underpinning Web3's new economic model. This book is ideal for readers seeking to stay on top of emerging trends in the digital economy.
Chapter 7 highlights key concepts in Decentralized Finance (DeFi) and compares it to traditional finance. It discusses major DeFi applications such as decentralized exchanges, lending/borrowing platforms, derivatives, prediction markets, and stablecoins. DeFi offers advantages, including open access, transparency, programmability, and composability. It enables peer-to-peer financial transactions without intermediaries, unlocking financial inclusion, efficiency gains, and innovation. However, risks such as smart contract vulnerabilities, price volatility, regulatory uncertainty, and lack of accountability persist. As DeFi matures, enhanced governance, security audits, regulation, and insurance will be vital to address these challenges. DeFi is poised to reshape finance if balanced with prudence. Important metrics to track growth include total value locked, trading volumes, active users, and loans outstanding. Research tools such as Dune Analytics, DeFi Llama, and DeFi Pulse provide data-driven insights. Overall, DeFi represents a profoundly transformative blockchain application, but responsible evolution is key. The chapter compares DeFi to traditional finance and analyzes major applications, benefits, risks, and metrics in this emerging field.
Chapter 1 provides an overview of the concepts and definitions inherent to Web3. It presents a deep exploration into the phenomenon of "Convergence of Convergence," a term coined to denote the convergence of various dimensions within Web3, such as technology, data, user interactions, business models, identity, and organizational structures. The chapter also offers a comparative study of Web3 from different perspectives – tracing its evolution in the Internet era, analyzing its implications for user experience, evaluating its regulatory aspects, and understanding its scalability. Each of these aspects is explored in a detailed, standalone section, allowing readers to comprehend the multifaceted nature of Web3. The overarching aim of this chapter is to foster a comprehensive understanding of Web3, delineating its significance as a major shift in the Internet paradigm and its potential for creating more decentralized, user-empowered digital ecosystems.
Chapter 11 envisions the future potential of Web3 technologies in reshaping the web. It covers key areas such as generative AI, DeFi, mobile apps, cloud infrastructure, and the Metaverse. In DeFi, the focus is on scalability, interoperability, regenerative finance, decentralized identity, and its integration with social networks. The convergence of generative AI and Web3 is examined through case studies and applications, while mobile apps are explored as nodes for consensus algorithms, providing decentralized and secure networks. The impact of Web3 on cloud infrastructure includes decentralized storage, blockchain-based authentication and authorization, decentralized computing resources, and token-based incentives. Lastly, the chapter delves into the Metaverse, discussing decentralized ownership, token economies, identity and privacy considerations, interoperability, and decentralized governance. Through these explorations, the chapter highlights the transformative potential of Web3 in fostering decentralization, inclusivity, and innovation in the digital era.