We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.
To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure no-reply@cambridge.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
The initial flow past an impulsively started rotating and translating circular cylinder is asymptotically analysed using a Brinkman penalization method on the Navier–Stokes equation. In our previous study (J. Fluid Mech., vol. 929, 2021, A31), the asymptotic solution was obtained within the second approximation with respect to the small parameter, $\epsilon$, that is of the order of $1 / \lambda$. Here, $\lambda$ is the penalization parameter. In addition, the Reynolds number based on the cylinder radius and the translating velocity is assumed to be of the order of $\epsilon$. The previous study asymptotically analysed the initial flow past an impulsively started translating circular cylinder and investigated the influence of the penalization parameter $\lambda$ on the drag coefficient. It was concluded that the drag coefficient calculated from the integration of the penalization term exhibits a half-value of the results of Bar-Lev & Yang (J. Fluid Mech., vol. 72, 1975, pp. 625–647) as $\lambda \to \infty$. Furthermore, the derivative of vorticity in the normal direction was found to be discontinuous on the cylinder surface, which is caused by the tangential gradient of the pressure on the cylinder surface. The present study hence aims to investigate the variance on the drag coefficient against the result of Bar-Lev & Yang (1975). First, we investigate the problem of an impulsively started rotating circular cylinder. In this situation, the moment coefficient is independent of the pressure on the cylinder surface so that we can elucidate the role of the pressure to the hydrodynamic coefficients. Then, the problem of an impulsively started rotating and translating circular cylinder is investigated. In this situation, the pressure force induced by the unsteady flow far from the cylinder is found to play a key role on the drag force for the agreement with the result of Bar-Lev & Yang (1975), whereas the variance still exists on the lift force. To resolve the variance, an alternative formula to calculate the hydrodynamic force is derived, assuming that there is the pressure jump between the outside and inside of the cylinder surface. The pressure jump is obtained in this analysis asymptotically. Of particular interest is the fact that this pressure jump can cause the variance on the lift force calculated by the integration of the penalization term.
For low-grade intraepithelial neoplasia cases, pharyngolaryngeal lesions equal to or less than 5 mm in size do not generally progress to invasive carcinoma. However, micro-superficial lesions equal to or less than 5 mm that showed rapid growth have been recently encountered. This study aimed to identify the characteristics of preferential progression of lesions equal to or less than 5 mm in size.
Method
Gross findings, endoscopic findings and pathological results of 55 lesions measuring equal to or less than 5 mm in diameter were retrospectively reviewed to identify factors that distinguish squamous cell carcinoma or high-grade intraepithelial neoplasia from low-grade intraepithelial neoplasia or non-atypia lesions.
Results
The overall sensitivity, specificity, accuracy, and positive and negative predictive value of background colouration and intrapapillary capillary loop pattern in differentiation of squamous cell carcinoma or high-grade intraepithelial neoplasia from low-grade intraepithelial neoplasia or non-atypia lesions were all 100 per cent.
Conclusion
Diagnosis based on background colouration and the intrapapillary capillary loop pattern on narrow-band imaging facilitates the pathological examination of lesions measuring equal to or less than 5 mm.
The initial flow past an impulsively started translating circular cylinder is asymptotically analysed using a Brinkman penalization method on the Navier–Stokes equations. The asymptotic solution obtained shows that the tangential and normal slip velocities on the cylinder surface are of the order of $1/\sqrt {\lambda }$ and $1/\lambda$, respectively, within the second approximation of the present asymptotic analysis, where $\lambda$ is the penalization parameter. This result agrees with the estimation of Carbou & Fabrie (Adv. Diff. Equ., vol. 8, 2003, pp. 1453–1480). Based on the asymptotic solution, the influence of the penalization parameter $\lambda$ is discussed on the drag coefficient that is calculated using the adopted three formulae. It can then be found that the drag coefficient calculated from the integration of the penalization term exhibits a half-value of the results of Bar-Lev & Yang (J. Fluid Mech., vol. 72, 1975, pp. 625–647) as $\lambda \to \infty$.
Severe acute respiratory syndrome coronavirus-2 uses angiotensin-converting enzyme-2 as a primary receptor for invasion. This study investigated angiotensin-converting enzyme-2 expression in the sinonasal mucosa of patients with chronic rhinosinusitis, as this could be linked to a susceptibility to severe acute respiratory syndrome coronavirus-2 infection.
Methods
Ethmoid sinus specimens were obtained from 27 patients with eosinophilic chronic rhinosinusitis, 18 with non-eosinophilic chronic rhinosinusitis and 18 controls. The angiotensin-converting enzyme-2 and other inflammatory cytokine and chemokine messenger RNA levels were assessed by quantitative reverse transcription polymerase chain reaction. Angiotensin-converting enzyme-2 positive cells were examined immunohistologically.
Results
The eosinophilic chronic rhinosinusitis patients showed a significant decrease in angiotensin-converting enzyme-2 messenger RNA expression. In the chronic rhinosinusitis patients, angiotensin-converting enzyme-2 messenger RNA levels were positively correlated with tumour necrosis factor-α and interleukin-1β (r = 0.4971 and r = 0.3082, respectively), and negatively correlated with eotaxin-3 (r = −0.2938). Angiotensin-converting enzyme-2 immunoreactivity was mainly localised in the ciliated epithelial cells.
Conclusion
Eosinophilic chronic rhinosinusitis patients with type 2 inflammation showed decreased angiotensin-converting enzyme-2 expression in their sinus mucosa. Angiotensin-converting enzyme-2 regulation was positively related to pro-inflammatory cytokines, especially tumour necrosis factor-α production, in chronic rhinosinusitis patients.
N-acetylaspartate (NAA) levels and serum brain-derived neurotrophic factor (BDNF) levels in patients with first-episode schizophrenia psychosis and age- and sex-matched healthy control subjects were investigated. In addition, plasma levels of homovanillic acid (HVA) and 3-methoxy-4-hydroxyphenylglycol (MHPG) were compared between the two groups.
Method:
Eighteen patients (nine males, nine females; age range: 13–52 years) were enrolled in the study, and 18 volunteers (nine males, nine females; age range: 15–49 years) with no current or past psychiatric history were also studied by magnetic resonance spectroscopy (MRS) as sex- and age-matched controls.
Results:
Levels of NAA/Cr in the left basal ganglia (p = 0.0065) and parieto-occipital lobe (p = 0.00498), but not in the frontal lobe, were significantly lower in patients with first-episode schizophrenia psychosis than in control subjects. No difference was observed between the serum BDNF levels of patients with first-episode schizophrenia psychosis and control subjects. In regard to the plasma levels of catecholamine metabolites, plasma MHPG, but not HVA, was significantly lower in the patients with first-episode psychosis than in control subjects. In addition, a significantly positive correlation was observed between the levels of NAA/Cr of the left basal ganglia and plasma MHPG in all subjects.
Conclusions:
These results suggest that brain NAA levels in the left basal ganglia and plasma MHPG levels were significantly reduced at the first episode of schizophrenia psychosis, indicating that neurodegeneration via noradrenergic neurons might be associated with the initial progression of the disease.
Optical properties of infrared-bright (IR-bright) dust-obscured galaxies (DOGs) are reported. DOGs are faint in optical but very bright in mid-IR, which are powered by active star formation (SF) or active galactic nucleus (AGN), or both. The DOGs is a candidate population that are evolving from a gas-rich merger to a quasar. By combining three catalogs of optical (Subaru Hyper Suprime-Cam), near-IR (VIKING), and mid-IR (ALLWISE), we have discovered 571 IR-bright DOGs. Using their spectral energy distributions, we classified the selected DOGs into the SF-dominated DOGs and the AGN-dominated DOGs. We found that the SF-dominated DOGs show a redder optical color than the AGN-dominated DOGs. Interestingly, some DOGs shows extremely blue color in optical (blue-excess DOGs: bluDOGs). A possible origin for this blue excess is either the leaked AGN light or stellar UV light from nuclear starbursts. The BluDOGs may be in the transition phase from obscured AGNs to unobscured AGNs.
The ALMA twenty-six arcmin2 survey of GOODS-S at one millimeter (ASAGAO) is a deep (1σ ∼ 61μJy/beam) and wide area (26 arcmin2) survey on a contiguous field at 1.2 mm. By combining with archival data, we obtained a deeper map in the same region (1σ ∼ 30μJy/beam−1, synthesized beam size 0.59″ × 0.53″), providing the largest sample of sources (25 sources at 5σ, 45 sources at 4.5σ) among ALMA blank-field surveys. The median redshift of the 4.5σ sources is 2.4. The number counts shows that 52% of the extragalactic background light at 1.2 mm is resolved into discrete sources. We create IR luminosity functions (LFs) at z = 1–3, and constrain the faintest luminosity of the LF at 2 < z < 3. The LFs are consistent with previous results based on other ALMA and SCUBA-2 observations, which suggests a positive luminosity evolution and negative density evolution.
Flow-induced rotation of an S-shaped rotor is investigated using an adaptive numerical scheme based on a vortex particle method. The boundary integral equation with respect to Bernoulli’s function is solved using a panel method for obtaining the pressure distribution on the rotor surface which applies the torque to the rotor. The present work first addresses the validation of the scheme against the previous studies of a rotating circular cylinder. Then, we compute the automatic rotation start of an S-shaped rotor from a quiescent state for various values of the moment of inertia. The computed flow patterns where the rotor supplies (or is supplied with) the torque to (or from) the fluid are shown during one cycle of rotation. The vortex shedding from the tip of the advancing bucket is found to play a key role in generating positive torque on the rotor. A remarkable finding is the fact that, after the rotor reaches a stable rotation, the trajectory of the limit cycle in the present autonomous system accounts for the stable rotating movement of the rotor. Furthermore, the hydrodynamic scenario of the rotor automatically starting up from a quiescent state and entering the limit cycle is elucidated for various values of the moment of inertia and the initial angle of the rotor.
Three-dimensional fluid-attenuated inversion recovery magnetic resonance imaging has been used to detect alterations in the composition of inner-ear fluid. This study investigated the association between hearing level and the signal intensity of pre- and post-contrast three-dimensional fluid-attenuated inversion recovery magnetic resonance imaging in patients with sudden-onset sensorineural hearing loss.
Method:
Three-dimensional fluid-attenuated inversion recovery magnetic resonance imaging was performed in 18 patients with sudden-onset sensorineural hearing loss: 12 patients with mild-to-moderate sensorineural hearing loss (baseline hearing levels of 60 dB or less) and 6 patients with severe-to-profound sensorineural hearing loss (baseline hearing levels of more than 60 dB).
Results:
High-intensity signals in the inner ear were observed in two of the six patients (33 per cent) with severe-to-profound sensorineural hearing loss, but not in those with mild-to-moderate sensorineural hearing loss (mid-p test, p = 0.049). These signals were observed on magnetic resonance imaging scans 6 or 18 days after sensorineural hearing loss onset.
Conclusion:
The results indicate that three-dimensional fluid-attenuated inversion recovery magnetic resonance imaging is not a useful tool for detecting inner-ear abnormalities in patients with mild sensorineural hearing loss.
We have developed a new method to approach the missing baryons problem. We assume that the missing baryons reside in a form of Warm Hot Intergalactic Medium, i.e. the WHIM. Our method consists of (a) detecting the coherent large scale structure in the spatial distribution of galaxies that traces the Cosmic Web and that in hydrodynamical simulations is associated to the WHIM, (b) mapping its luminosity into a galaxy luminosity density field, (c) using numerical simulations to relate the luminosity density to the density of the WHIM, (d) applying this relation to real data to trace the WHIM using the observed galaxy luminosities in the Sloan Digital Sky Survey and 2dF redshift surveys. In our application we find evidence for the WHIM along the line of sight to the Sculptor Wall, at redshifts consistent with the recently reported X-ray absorption line detections. Our indirect WHIM detection technique complements the standard method based on the detection of characteristic X-ray absorption lines, showing that the galaxy luminosity density is a reliable signpost for the WHIM. For this reason, our method could be applied to current galaxy surveys to optimise the observational strategies for detecting and studying the WHIM and its properties. Our estimates of the WHIM hydrogen column density NH in Sculptor agree with those obtained via the X-ray analysis. Due to the additional NH estimate, our method has potential for improving the constrains of the physical parameters of the WHIM as derived with X-ray absorption, and thus for improving the understanding of the missing baryons problem.
The long-time viscous flow about two identical rotating circular cylinders in a side-by-side arrangement is investigated using an adaptive numerical scheme based on the vortex method. The Stokes solution of the steady flow about the two-cylinder cluster produces a uniform stream in the far field, which is the so-called Jeffery’s paradox. The present work first addresses the validation of the vortex method for a low-Reynolds-number computation. The unsteady flow past an abruptly started purely rotating circular cylinder is therefore computed and compared with an exact solution to the Navier–Stokes equations. The steady state is then found to be obtained for $t\gg 1$ with ${\mathit{Re}}_{\omega } {r}^{2} \ll t$, where the characteristic length and velocity are respectively normalized with the radius ${a}_{1} $ of the circular cylinder and the circumferential velocity ${\Omega }_{1} {a}_{1} $. Then, the influence of the Reynolds number ${\mathit{Re}}_{\omega } = { a}_{1}^{2} {\Omega }_{1} / \nu $ about the two-cylinder cluster is investigated in the range $0. 125\leqslant {\mathit{Re}}_{\omega } \leqslant 40$. The convection influence forms a pair of circulations (called self-induced closed streamlines) ahead of the cylinders to alter the symmetry of the streamline whereas the low-Reynolds-number computation (${\mathit{Re}}_{\omega } = 0. 125$) reaches the steady regime in a proper inner domain. The self-induced closed streamline is formed at far field due to the boundary condition being zero at infinity. When the two-cylinder cluster is immersed in a uniform flow, which is equivalent to Jeffery’s solution, the streamline behaves like excellent Jeffery’s flow at ${\mathit{Re}}_{\omega } = 1. 25$ (although the drag force is almost zero). On the other hand, the influence of the gap spacing between the cylinders is also investigated and it is shown that there are two kinds of flow regimes including Jeffery’s flow. At a proper distance from the cylinders, the self-induced far-field velocity, which is almost equivalent to Jeffery’s solution, is successfully observed in a two-cylinder arrangement.
A large fraction of the AGN output power is emitted in the X-rays, in a region very close to the supermassive black hole (SMBH). The most distinctive feature of the X-ray spectra of AGN is the iron Kα line, often observed as the superposition of a broad and a narrow component. While the broad component is found in only ~ 35–45% of bright nearby AGN, the narrow component has been found to be ubiquitous. The narrow Fe Kα line is thought to be produced in the circumnuclear material, likely in the molecular torus. Given its origin, this feature is possibly the most important tracer of neutral matter surrounding the SMBH. One of the most interesting characteristics of the narrow Fe Kα line is the decrease of its equivalent width with the continuum luminosity, the so-called X-ray Baldwin effect (Iwasawa & Taniguchi 1993). This trend has been found by many studies of large samples of type-I AGN, and very recently also in type-II AGN (Ricci et al. 2013c, submitted to ApJ). The slope of the X-ray Baldwin effect in type-II AGN is the same of their unobscured counterparts, which implies that the mechanism at work is the same. Several hypothesis have been put forward in the last decade to explain the X-ray Baldwin effect: i) a luminosity-dependent variation in the ionisation state of the iron-emitting material (Nandra et al. 1997); ii) the decrease of the number of continuum photons in the iron line region with the Eddington ratio, as an effect of the well known correlation between the photon index and the Eddington ratio (Ricci et al. 2013b, submitted to MNRAS); iii) the decrease of the covering factor of the torus with the luminosity (e.g., Page et al. 2004, Ricci et al. 2013a A&A 553, 29) as expected by luminosity-dependent unification models (e.g., Ueda et al. 2003). In my talk I will review the main characteristics of the narrow Fe K? line, and present the results of our recent works aimed at explaining the X-ray Baldwin effect using iron-line emitting physical torus models (Ricci et al. 2013a, b), and at understanding the origin of the Fe K? line (Ricci et al. 2013c). I will focus in particular on the importance of the Fe Kα line as a probe of the evolution of the physical characteristics of the molecular torus with the luminosity.
We explore the relationships between the 3.3 μm polycyclic aromatic hydrocarbon (PAH) feature and active galactic nucleus (AGN) properties of a sample of 54 hard X-ray selected bright AGNs, including both Seyfert 1 and Seyfert 2 type objects, using the InfraRed Camera (IRC) on board the infrared astronomical satellite AKARI. The sample is selected from the 9-month Swift/BAT survey in the 14-195 keV band and all of them have measured X-ray spectra at E ≲ 10 keV. These X-ray spectra provide measurements of the neutral hydrogen column density (NH) towards the AGNs. We use the 3.3 μm PAH luminosity (L3.3μm) as a proxy for star formation activity and hard X-ray luminosity (L14-195keV) as an indicator of the AGN activity. We searched for possible difference of star-formation activity between type 1 (un-absorbed) and type 2 (absorbed) AGNs. Our regression analysis of log L14-195keV versus log L3.3μm shows a positive correlation and the slope seems steeper for type 1/unobscured AGNs than that of type 2/obscured AGNs. The same trend has been found for the log (L14-195keV/MBH) versus log (L3.3μm/MBH) correlation. Our analysis show that the circum-nuclear star-formation is more enhanced in type 2/absorbed AGNs than type 1/un-absorbed AGNs for low X-ray luminosity/low Eddington ratio AGNs.
Protective immunity of homologous challenge infection was examined in jirds after drug-abbreviated infection with Brugia pahangi. Mebendazole (MBZ) treatment at the early prepatent (5–7 weeks of post infection) or the late prepatent (7–9 weeks of post infection) period was highly effective in causing almost complete eradication of the primary infection. After challenge infection, the worm burden was significantly reduced 19% (31·1 in average) and 77% (9·5) to that of the controls (38·8 and 41·7), respectively. The magnitude of eosinophil response paralleled the degree of protection. No or only a few microfilariae were seen after challenge infection in jirds treated during the prepatent periods. They were also resistant to intravenous challenge with the microfilariae of B. pahangi. MBZ treatment at the patent period was, on the contrary, incomplete against primarily infected adult worms, and was not able to induce either significant protection (30·1 vs 33·1 in control) or eosinophil response to the challenge infection.
Cholesterol granuloma is an intractable ear disease. Many studies of this condition have been published since the initial report by Manasse. However, the pathogenesis of this condition is unclear. This study reviewed the treatment of middle-ear cholesterol granuloma in 16 patients undergoing surgical treatment at Kurume University Hospital.
The relationship between patients' pre-operative tympanic membrane findings and post-operative course was analysed. Patients with swollen tympanic membranes had significantly poorer outcomes. Patients with retracted tympanic membranes and those undergoing ossicular chain reconstruction had significantly better outcomes. The patients' overall hearing success rate at approximately two weeks post-operatively was 75 per cent. However, by six months post-operatively, the overall hearing success rate had declined to 62.5 per cent. Patients with poor hearing two weeks post-operatively did not acquire better hearing.
Epithelioid sarcoma is an aggressive, malignant tumour of the soft tissue which tends to arise in proximity to large tendons and aponeuroses. We report the case of a patient presenting with an epithelioid sarcoma arising in the neck. A 56-year-old man was referred with a three-year history of a sensory disorder as well as a slowly growing mass in his right neck. The patient underwent resection of the tumour by means of a conservative neck dissection. The final diagnosis, based on the histological and immunohistochemical findings, was epithelioid sarcoma. Radiotherapy was performed after the operation. The post-operative course was uneventful, and there was no local recurrence or distant metastasis.
Previously, the treatment of carcinoma of the external auditory canal has mainly involved surgical resection. In order to enable organ preservation and to obtain cancer-free surgical margins, we introduced the use of superselective, intra-arterial, rapid infusion chemotherapy combined with radiotherapy to treat this condition.
We reviewed our patients' tumour stages, feeding arteries and clinical outcomes. Tumours were staged according to the Pittsburgh staging system. Chemotherapy was administered intra-arterially in the angiography suite via transfemoral catheterisation of the feeding arteries. Four patients underwent superselective, intra-arterial, rapid infusion chemo-radiotherapy. A complete response was obtained in all four patients. The overall toxic side effects were modest.
Superselective, intra-arterial, rapid infusion chemotherapy can be an effective, organ-preserving treatment for external auditory canal carcinoma, with a high cure rate.