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Next generation high-power laser facilities are expected to generate hundreds-of-MeV proton beams and operate at multi-Hz repetition rates, presenting opportunities for medical, industrial and scientific applications requiring bright pulses of energetic ions. Characterizing the spectro-spatial profile of these ions at high repetition rates in the harsh radiation environments created by laser–plasma interactions remains challenging but is paramount for further source development. To address this, we present a compact scintillating fiber imaging spectrometer based on the tomographic reconstruction of proton energy deposition in a layered fiber array. Modeling indicates that spatial resolution of approximately 1 mm and energy resolution of less than 10% at proton energies of more than 20 MeV are readily achievable with existing 100 μm diameter fibers. Measurements with a prototype beam-profile monitor using 500 μm fibers demonstrate active readouts with invulnerability to electromagnetic pulses, and less than 100 Gy sensitivity. The performance of the full instrument concept is explored with Monte Carlo simulations, accurately reconstructing a proton beam with a multiple-component spectro-spatial profile.
Chronic musculoskeletal pain and anxiety/depression are significant public health problems. We hypothesised that adults with both conditions constitute a group at especially high risk of future cardiovascular health outcomes.
Aim:
To determine whether having comorbid chronic musculoskeletal pain and anxiety/depression is associated with the excess prevalence of selected known cardiovascular health risk behaviours.
Method:
A cross-sectional survey of adults aged 35+ years randomly sampled from 26 GP practice registers in West Midlands, England. Respondents were classified into four groups based on self-reported presence/absence of chronic musculoskeletal pain (pain present on most days for six months) and anxiety or depression (Hospital Anxiety and Depression Score 11+). Standardised binomial models were used to estimate standardised prevalence ratios and prevalence differences between the four groups in self-reported obesity, tobacco smoking, physical inactivity, and unhealthy alcohol consumption after controlling for age, sex, ethnicity, deprivation, employment status and educational attainment. The excess prevalence of each risk factor in the group with chronic musculoskeletal pain–anxiety/depression comorbidity was estimated.
Findings:
Totally, 14 519 respondents were included, of whom 1329 (9%) reported comorbid chronic musculoskeletal pain–anxiety/depression, 3612 (25%) chronic musculoskeletal pain only, 964 (7%) anxiety or depression only, and 8614 (59%) neither. Those with comorbid chronic musculoskeletal pain–anxiety/depression had the highest crude prevalence of obesity (41%), smoking (16%) and physical inactivity (83%) but the lowest for unhealthy alcohol consumption (18%). After controlling for covariates, the standardised prevalence ratios and differences for the comorbid group compared with those with neither chronic musculoskeletal pain nor anxiety/depression were as follows: current smoking [1.86 (95% CI 1.58, 2.18); 6.8%], obesity [1.93 (1.76, 2.10); 18.9%], physical inactivity [1.21 (1.17, 1.24); 14.3%] and unhealthy alcohol consumption [0.81 (0.71, 0.92); –5.0%]. The standardised prevalences of smoking and obesity in the comorbid group exceeded those expected from simple additive interaction.
Class III obesity is associated with increased risk for cognitive impairment. Though hypothesized to be partially attributable to sedentary time (ST), past research examining the association between ST and cognitive function has produced mixed findings. One possible explanation is that studies do not typically account for the highly correlated and almost inverse relationship between ST and light intensity physical activity (LPA), such that ST displaces time engaging in LPA. Therefore, we aimed to evaluate whether: (1) higher ST-to-LPA time ratio associates with poorer performance across multiple cognitive domains in patients with Class III obesity seeking bariatric surgery; and (2) the associations differ by sex.
Participants and Methods:
Participants (N = 121, 21-65 years of age, BMI > 40 kg/m2) scheduled for either Roux-en-Y Gastric Bypass (RYGB) or Sleeve Gastrectomy (SG) completed the NIH Toolbox, a computerized neuropsychological assessment battery and wore a waist-mounted ActiGraph monitor during waking hours for 7 days to measure minutes/day spent in ST, LPA, and moderate-to-vigorous physical activity (MVPA). A ratio of time spent in ST-to-LPA was calculated by dividing the percentage of daily wear time spent in sedentary behavior (SB) by the percentage of daily wear time spent in LPA.
Results:
On average, participants (mean age = 43.22 years old and BMI = 45.83 kg/m2) wore the accelerometer for 909±176 minutes/day and spent 642±174 minutes/day in ST, 254±79 minutes/day in LPA, and 14±13 minutes/day in MVPA. Mean daily ST-to-LPA time ratio was 2.81 ± 1.3 (0.73-7.11). Overall, bivariate Pearson correlations found no significant relationships between LPA and cognitive performance on any of the NIH Toolbox subtests (r values = -.002 to -.158, all p values >.05). Additionally, bivariate Pearson correlations also found no significant relationships between daily ST-to-LPA time ratio and cognitive performance on any of the subtests (r values = .003 to .108, all p values >.05). However, higher ST-to-LPA was associated with lower scores on the Dimensional Change Card Sort Test in women (r = -.26, p = .01).
Conclusions:
Results showed that participants’ mean daily time spent in ST was 2.5 times higher than that spent in LPA and a higher ratio of ST-to-LPA was associated with poorer set-shifting in women with Class III obesity. Future studies should look to clarify underlying mechanisms, particularly studies examining possible sex differences in the cognitive benefits of PA. Similarly, intervention studies are also needed to determine if increasing LPA levels for individuals with Class III obesity would lead to improved cognitive performance by means of reducing ST.
This special issue looks at how cognitive bias matters to international law. We wish to shed light on the legal frames, labels, and cognitive biases that shape our understanding of international rules, the application of these rules, and outcomes of international adjudicatory processes. Adopting the behavioral approach to international law, we focus on actual behavior rather than assumed behavior of actors taking part in the international legal process. The central idea of this approach is that human cognitive capacities are limited—or bounded—by a variety of cognitive, emotional and social, or group-based biases. Our aim is to explore how these biases operate on the individual, group, and state level in various spheres of international law. This Symposium therefore looks beyond the traditional understanding of international law as applying between states, and focuses on how individuals, as actors in the international sphere, use international law language to influence other people, to create communities, and to shape identities.
This Introduction first serves to explain the type of shortcuts we make in our decision-making. This description of biases is followed by an overview of behavioral literature in international law that has thus far examined how bias operates in different aspects of international law—in relation to sources, to compliance, and individuals taking part in the international legal process. We then turn to introduce the Symposium and explain its contribution to the existing literature.
This article reports on a new project to investigate the activities of early Homo sapiens in the area of the Chotts ‘megalake’ in southern Tunisia. Excavations in 2015 and 2019 at Oued el Akarit revealed one of a number of Middle Stone Age (MSA) horizons near the top of a long sequence of Upper Pleistocene deposits. The site identified as Oued el Akarit (Sondage 8) consists of lithic artefacts, bone fragments of large ungulates and pieces of ostrich eggshell. Many of the objects are burnt. Excavation of about nine square metres revealed that these were associated with a lightly trampled and combusted occupation surface. Amongst the identified artefacts were Levallois flakes some of which could be refitted, thereby indicating the generally undisturbed nature of the occupation. The lithic finds also included side scrapers and other tools diagnostic of the MSA but significantly no bifacial or tanged tools. OSL (Optically Stimulated Luminescence) dating of the sediments and AMS (Accelerator Mass Spectrometry) radiocarbon dating of ostrich eggshell have produced uncalibrated age determinations in the range 37,000–40,000 years ago, one of the youngest ages for MSA sites in the region. This is the first example of a securely dated later MSA occupation in a riparian environment in south-eastern Tunisia.
The preceding chapters demonstrate that domestic law has been used by international courts and tribunals in a variety of different ways to interpret international legal rules or instruments. Each instance of comparative reasoning is inextricably linked to the legal and historical context in which it occurs and in which the court or tribunal operates. The novelty of the specific legal regime, the presumed knowledge of other states parties or the presence of nebulous treaty standards are all factors that have led to the use of domestic law as a means of interpretation. As such, drawing general conclusions from a study such as this is difficult.
The Dispute Settlement Mechanism (DSM) of the World Trade Organization (WTO) is the compulsory, binding inter-state adjudicatory system for disputes between member states related to WTO law. The panels and the Appellate Body (AB) that work under the framework of the DSM have gained a reputation for judicious and effective dispute resolution in the international sphere, leading them to be hailed as a guiding light for other international courts and tribunals. Although fact-intensive cases are the norm in the WTO DSM, the legal questions that come before panels and the AB are primarily questions of treaty interpretation and hence hold interest for any study of legal interpretation.3
Of the courts and tribunals surveyed in this book, those that deal with inter-state disputes have been most reticent to invoke domestic law to interpret international law. Some commentators have suggested that this may be due to a concern of bias towards the cited countries, a remark that certainly seems to have weight and perhaps explains why the courts and tribunals examined in this and the following chapter have tightly circumscribed their reference to domestic law, generally limiting the cited law to the parties to the case at hand.
However, other factors would also seem to distinguish inter-state courts and tribunals from those examined in subsequent chapters. The most obvious of these is the weaker analogy between domestic law and international law related to inter-state affairs, insofar as the latter aims to regulate the actions of states, not individuals. Whilst international criminal law, human rights law and international investment law arguably have clear parallels with domestic criminal law, constitutional law and public and administrative law, respectively, the rules regulating inter-state conduct have traditionally been analogised to domestic private law, especially to the law of contracts and trusts, and more recently to constitutional and public law. Yet, there are evident limits to how far these analogies are applicable to inter-state relations.
This chapter and the following chapter explore the use of domestic law by two inter-state courts and tribunals. This chapter examines the jurisprudence of the International Court of Justice (ICJ), whilst the following chapter analyses the case law of the panels and Appellate Body of the World Trade Organization (WTO). Although the cases examined vary significantly in terms of subject matter, certain common themes are identifiable. In particular, the relatively rare instances in which domestic law has been used raise questions regarding the circumstances in which domestic law may indicate the intention of a state.
In the late spring of 1992, the Secretary-General of the UN delivered a report to the Security Council that captured the attention of the international community. Yugoslavia – from which Croatia and Slovenia had declared independence less than a year before – had fallen into a pitched civil war fuelled by bitter ethnic tensions between Serb, Croat and Muslim communities. Nestled in the centre of the former unified state, the nascent republic of Bosnia-Herzegovina became the scene of atrocities not seen since the Second World War. The Serbs of Bosnia-Herzegovina, the Secretary-General reported, were making a ‘concerted effort … to create “ethnically pure” regions’ in the Republic,2 employing tactics that ‘were as brutal as they were effective’. Reports on the situation documented the grim scene: the killing or displacement of 2.1 million Bosnians by the summer of 1993, the systematic rape of women and girls and the operation of 715 detention centres in which rape, torture and execution was commonplace.
The interaction between domestic law and international law is a topic of perennial interest for international lawyers. Domestic law has long been recognised as a source of international law, an inspiration for legal developments or the benchmark against which a legal system is to be assessed. Often, it is simply treated as mere fact, indicative of the legality of a state’s actions. Academic commentary normally re-traces these well-trodden paths, leaving one with the impression that the interaction between domestic and international law has been thoroughly mapped, and is unworthy of further enquiry. However, a different – and surprisingly pervasive – nexus between the two spheres has been largely overlooked: the use of domestic law in the interpretation of international law. The present book aims to fill that gap in the literature.