This chapter discusses the aspects of treatment of complex post-traumatic stress disorder (CPTSD). The literature on the diagnosis and treatment of dissociative disorders (DD), particularly dissociative identity disorder (DID), has developed mostly in parallel with that on CPTSD. CPTSD is a multidimensional construct that crosses a number of fourth edition of Diagnostic and Statistical Manual (DSM-IV) diagnoses. General principles of treatment for CPTSD may be similar among different clinical groups, and there are many similar difficulties faced by survivors of different types of cumulative trauma. Clinicians should understand the risk-management aspects of working with this population, including informed consent. In addition, patients may need a variety of psychotherapeutic interventions for stabilizing PTSD and dissociative symptoms. These may include psychoeducation, cognitive therapy, dialectical behavior therapy, psychodynamic interventions and techniques from family systems theory such as reframing symptoms as adaptations, among others.